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| 1 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 2 | Three-year results of small incision lenticule extraction and wavefront-guided femtosecond laser-assisted laser in situ keratomileusis for correction of high myopia and myopic astigmatism显示文摘AIM: To compare and calculate the 3-year refractive results, higher-order aberrations(HOAs), contrast sensitivity(CS) and dry eye parameters after small incision lenticule extraction(SMILE) and wavefront-guided femtosecond laser-assisted laser in situ keratomileusis(FS-LASIK) for correction of high myopia and myopic astigmatism.METHODS: In this prospective, non-randomized comparative study, 78 eyes with spherical equivalent(SE) of-8.11±1.09 diopters(D) received a SMILE surgery, and 65 eyes with SE of-8.05±1.12 D received a wavefront-guided FS-LASIK surgery with the Visu Max femtosecond laser(Carl Zeiss Meditec, Jena, Germany) for flap cutting. Visual acuity, manifest refraction, CS, HOAs, ocular surface disease index(OSDI) and tear break-up time(TBUT) were evaluated during a 3-year follow-up.RESULTS: The difference of uncorrected distance visual acuity(UDVA) postoperatively was achieved at 1 mo and at3 mo, whereas the difference of the mean UDVA between two groups at 3 y were not statistically significant(t=-1.59,P=0.13). The postoperative change of SE was 0.89 D in the FS-LASIK group(t=5.76, P=0.00), and 0.14 D in the SMILE group(t=0.54, P=0.59) from 1 mo to 3 y after surgery.At 3-year postoperatively, both HOAs and spherical aberrations in the SMILE group were obviously less than those in the FS-LASIK group(P=0.00), but the coma root mean square(RMS) was higher in the SMILE group(0.59±0.26) than in the FS-LASIK group(0.29±0.14, P=0.00).The mesopic CS values between two groups were not statistically significant at 3 y postoperatively. Comparedwith the FS-LASIK group, lower OSDI scores and longer TBUT values were found in the SMILE group at 1 mo and 3 mo postoperatively. With regard to safety, no eye lost any line of CDVA in both groups at 3 y after surgery. CONCLUSION: Both SMILE and wavefront-guided FSLASIK procedures provide good visual outcomes. Both procedures are effective and safe, but SMILE surgery achieve more stable long-term refractive outcome and better control of early postoperative dry eye as compared to FS-LASIK. | Li-Kun Xia Jing Ma He-Nan Liu Ce Shi Qing Huang | 2018 | International Journal of Ophthalmology(English edition)2018，11，3： | 16 |
| 3 | Potential of multi-pass ECAP on improving the mechanical properties of a high-calcium-content Mg-Al-Ca-Mn alloy显示文摘In this study,the multi-pass equal channel angular pressing(ECAP)was employed on a high-calcium-content Mg-Al-Ca-Mn alloy to tailor its microstructure and mechanical properties.The obtained results showed that the network-shaped Mg2Ca and(Mg,Al)2Ca eutectic compounds in as-cast alloy were gradually crushed into ultra-fine particles after ECAP,which exhibited a bimodal particle size distribution and most aggregated at original grain boundaries.Dynamic recrystallization(DRX)of α-Mg occurred during hot deformation via a particle stimulated mechanism,and the almost complete DRX with an average grain size around 1.5μm was obtained after 12p-ECAP.Moreover,abundant nano-sized acicular and spherical precipitates were dynamically precipitated withinα-Mg grains during ECAP.Tensile test results indicated that the maximum strength and ductility were acquired for 12p-ECAP alloy with ultimate tensile strength of 372 MPa and fracture elongation of 8%.The enhanced strength of the alloy could be ascribed to fine DRX grains,ultra-fine Ca-containing particles and dynamically precipitated nano-precipitates,while the improved ductility was mainly due to the refined and homogeneous microstructure,and weak texture with high average Schmid factors. | He Huang Huan Liu Ce Wang Jiapeng Sun Jing Bai Feng Xue Jinghua Jiang Aibin Ma | 2019 | Journal of Magnesium and Alloys2019，7，4： | 10 |
| 4 | Improving toughness of a Mg_(2)Ca-containing Mg-Al-Ca-Mn alloy via refinement and uniform dispersion of Mg_(2)Ca particles显示文摘In this work,two wrought Mg-3.66Al-4.25Ca-0.43 Mn(wt%)alloys with different morphology and distribution of Mg_(2)Ca particles were fabricated by hot extrusion and multi-pass(32)equal channel angular pressing(ECAP).The as-extruded alloy exhibits a banded microstructure with alternately arranged Mg_(2)Ca particle bands,fine α-Mg dynamically recrystallized(DRX)grain bands,and coarse α-Mg deformed grain bands.The Mg_(2)Ca bands are composed of broken Mg_(2)Ca particles which are aggregated and aligned along extrusion direction.The microstructure of ECAP alloy contains complete α-Mg DRX grains and refined Mg_(2)Ca particles which are dispersedly distributed at grain boundaries.Tensile test results show that the as-extruded alloy possesses high ultimate tensile strength(UTS)of 420 MPa and poor fracture elongation of 7%,while the ECAP alloy exhibits improved toughness with UTS of 347 MPa and fraction elongation of 16%.The higher strength of as-extruded alloy is mainly ascribed to the contribution of coarse deformed grains with strong texture,and its poor toughness is resulted from the formation of Mg_(2)Ca bands within which microcracks could form and extend rapidly.On the contrary,the refined and dispersedly distributed Mg_(2)Ca particles are effective to retard crack initiation and impede crack propagation,thereby enhancing the toughness of ECAP alloy significantly. | Huan Liu Chao Sun Ce Wang Yuhua Li Jing Bai Feng Xue Aibin Ma Jinghua Jiang | 2020 | Journal of Materials Science & Technology2020，59，24： | 7 |
| 5 | Microstructure and Mechanical Properties of Mg–RE–TM Cast Alloys Containing Long Period Stacking Ordered Phases: A Review显示文摘Casting magnesium alloys hold the greatest share of magnesium application products due to their short processing period, low cost and near net shape forming. Compared with conventional commercial magnesium alloys or other Mg–RE-based alloys, the novel Mg–RE–TM cast alloys with long period stacking ordered(LPSO) phases usually possess a higher strength and are promising candidates for aluminum alloy applications. Up to now, two ways: alloying design and casting process control(including subsequent heat treatments), have been predominantly employed to further improve the mechanical properties of these alloys. Alloying with other elements or ceramic particles could alter the solidifi cation pattern of alloys, change the morphology of LPSO phases and refi ne the microstructures. Diff erent casting techniques(conventional casting, rapidly solidifi cation, directional solidifi cation, etc.) introduce various microstructure characteristics, such as dendritic structure, nanocrystalline, metastable phase, anisotropy. Further heat treatments could activate the transformation of various LPSO structures and precipitation of diverse precipitates. All these evolutions exert great impacts on the mechanical properties of the LPSO-containing alloys. However, the underlying mechanisms still remain a subject of debate. Therefore, this review mainly provides the state of the art of the casting magnesium alloys research and the accompanying challenges and summarizes some topics that merit future investigation for developing high-performance Mg–RE–TM cast alloys. | Huan Liu He Huang Jia-Peng Sun Ce Wang Jing Bai Ai-Bin Ma Xian-Hua Chen | 2019 | Acta Metallurgica Sinica(English Letters)2019，32，3： | 6 |
| 6 | Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23显示文摘Three new drimane sesquiterpenoids(1–3)together with the known 2a-hydroxyisodrimeninol(4),and a new isochromone derivative(5),were obtained from the solid cultures of fungal strain Pestalotiopsis sp.M-23,an endophytic fungus isolated from the leaves of Leucosceptrum canum(Labiatae).Their structures were determined by comprehensive 1D and 2D NMR,and MS analyses.The metabolites were evaluated for their antibacterial activities,and compound 3 showed weak inhibitory activity against Bacillus subtilis. | Ce Kuang Shu-Xi Jing Yan Liu Shi-Hong Luo Sheng-Hong Li | 2016 | Natural Products and Bioprospecting2016，6，3： | 3 |
| 7 | Multiple active components synergistically driven heteroatom-doped porous carbon as high-performance counter electrode in dye-sensitized solar cells显示文摘A facile template-free in situ self-activation approach for the multiple active components synergistically driven porous carbon was presented via a feasible annealing process.The biomass-derived carbon without additional activation reagents was fabricated using K-rich pomelo peel(PP)as the carbon source,which possesses a high electric conductivity where abundant functional hetero-metal atoms are doped into the carbon framework that playing the role of catalytic graphitization.The K^+that exists within the biomass can induce self-activation during pyrolysis apart from the activating gases during the pyrolysis process.The resulting electrocatalyst of PP-850(PP was pyrolyzed at 850°C in an N_2atmosphere)with abundant heteroatoms possesses a higher power conversion efficiency(PCE)of 7.81%as the counter electrode(CE)of dye-sensitized solar cells(DSCs)compared with the CEs calcinated at other temperatures and a similar PCE with Pt counterpart(8.24%)based on the liquid I_3^-/I^-electrolyte.The better electrocatalytic performance is attributed to the synergistic effect between self-activation and the co-doping of nitrogen,sulfur and phosphorus all together in a carbon matrix.Due to the feasibility of large-scale production,rich heteroatom doping,the PP-derived carbon,which simplifies the procedure and decreases the cost,has a potential application for an alternative electrocatalyst for high-performance photovoltaic devices. | Hongyu Jing Danyang Wu Suxia Liang Xuedan Song Yonglin An Ce Hao Yantao Shi | 2019 | Journal of Energy Chemistry2019，28，4： | 2 |
| 8 | The characteristic and dynamic electrocardiogram changes on hyperkalemia in a hemodialysis patient with heart failure:a case report显示文摘Hyperkalemia,usually associated with predisposing chronic diseases as heart failure(HF),severe kidney disease or diabetes mellitus(DM),[1]is defined as an elevation of potassium concentration more than 5.5 mmol/L,[2]. | Rui ZHAO Xin HAO Fei WANG Jing FENG Jing PAN Ce JING Ming-Ren MA Yan LIU Ling MA Xiao-Qing CAI | 2022 | Journal of Geriatric Cardiology2022，19，2： | 2 |
| 9 | Polyaniline-based electrocatalysts through emulsion polymerization:Electrochemical and electrocatalytic performances显示文摘One of the major challenges associated with fuel cells is the design of highly efficient electrocatalysts to reduce the high overpotential of the oxygen reduction reaction(ORR). Here we report Polyaniline(PANI)based micro/nanomaterials with or without transition metals, prepared by the emulsion polymerization and subsequent heat treatment. PANI microspheres with the diameter of about 0.7 μm have been prepared in basic(NH3solution) condition, using two different types of surfactant(CTAB, SDS) as the stabilizer, ammonium persulphate(APS) as oxidant with aniline/surfactants molar ratio at 1/1 under the hydrothermal treatment. PANI nanorods, Fe–PANI, and Fe–Co–PANI have been synthesized in acidic(HCl)medium with aniline/surfactants molar ratio at 1/2 and polymerization carried out without stirring for24 h. Products mainly Fe–Co–PANI have shown high current density with increasing sweep rate and excellent specific capacitance 1753 F/g at the scan rate of 1 m V/s. Additionally, it has shown high thermal stability by thermogravimetric analysis(TGA). Fe–PANI has been investigated for excellent performance toward ORR with four electron selectivity in the basic electrolyte. The PANI-based catalysts from emulsion polymerization demonstrate that the method is valuable for making non-precious metal heterogeneous electrocatalysts for ORR or energy storage and conversion technology. | Shehnaz Xuedan Song Suzhen Ren Ying Yang Yanan Guo Hongyu Jing Qing Mao Ce Hao | 2017 | Journal of Energy Chemistry2017，26，1： | 1 |
| 10 | Molten salt as ultrastrong polar solvent enables the most straightforward pyrolysis towards highly efficient and stable single-atom electrocatalyst显示文摘Currently,pyrolysis as the most widely used method still has some key issues not well resolved for synthesis of carbon-supported single-atom catalysts(C-SACs),e.g.,the sintering of metal atoms at high temperature as well as the high cost and complicated preparations of precursors.In this report,molten salts are demonstrated to be marvellous medium for preparation of C-SACs by pyrolysis of small molecular precursors(ionic liquid).The ultrastrong polarity on one hand establishes robust interaction with precursor and enables better carbonization,resulting in largely enhanced yield.On the other hand,the aggregation of metal atoms is effectively refrained while no nanoparticle or cluster is formed.By this strategy,a C-SAC with atomically dispersed Fe-N_(4) sites and a high specific area over 2000 m^(2) g^(-1) is obtained,which illustrates high ORR activity in both acid and alkaline media.Moreover,this SAC exhibits superior methanol tolerance and stability after acid soaking at 85℃ for 48 h.It is believed that the molten-salts-assisted pyrolysis can be developed into a routine strategy as it not only can largely simply the synthesis of C-SACs,but also can be extended to prepare other types of SACs. | Nannan Li Wei Liu Chao Zhu Ce Hao Jingya Guo Hongyu Jing Jinwen Hu Cuncun Xin Danyang Wu Yantao Shi | 2021 | Journal of Energy Chemistry2021，30，3： | 1 |
| 11 | Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia显示文摘Despite high initial response rates,acute myeloid leukemia(AML)treated with the BCL-2-selective inhibitor venetoclax(VEN)alone or in combinations commonly acquires resistance.We performed gene/protein expression,metabolomic and methylation analyses of isogenic AML cell lines sensitive or resistant to VEN,and identified the activation of RAS/MAPK pathway,leading to increased stability and higher levels of MCL-1 protein,as a major acquired mechanism of VEN resistance. | Qi Zhang Bridget Riley-Gillis Lina Han Yanan Jia Alessia Lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.Konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova Kenneth Dunner Jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh Charles Lu Wencai Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma Connie CWeng Cassandra LRamage Natalia Baran Ce Shi Tianyu Cai Richard Eric Davis Venkata L.Battula Yingchang Mi Jing Wang Courtney D.DiNardo Michael Andreeff Jeffery W.Tyner Aaron Schimmer Anthony Letai Rose Ann Padua Carlos E.Bueso-Ramos Stefano Tiziani Joel Leverson Relja Popovic Marina Konopleva | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 1 |
| 12 | Direct evidence that suspensor cells have embryogenic potential that is suppressed by the embryo proper during normal embryogenesis显示文摘 | Yuan Liua b Xinbo Lia Jing Zhaoa Xingchun Tanga c Shujuan Tiana Junyi Chena Ce Shia Wei Wanga Liyao Zhanga Xianzhong Fengb and Meng-Xiang Suna 1 | 2015 | PNAS2015，，： | 1 |
| 13 | 定量血流分数对PCI术后血流功能学评估作用的回顾性研究显示文摘在DEFER和FAME等临床研究支持下[1~3],血流储备分数(fractional flow reserve,FFR)已成为评估冠脉血流功能学状况,明确需否介入干预的金标准,从而将焦点从以往血运解剖转向功能重建[4]。另一方面,FFR作为连续变量,其初始值提示缺血与否,而经皮冠脉介入治疗(percutaneous coronary intervention,PCI)术后的FFR值与患者术后主要不良事件发生率呈负相关[5],以往研究认为术后FFR>0.90表征较为理想的功能学结局。定量血流分数(quantitative flow ratio,QFR)是一种结合三维重建冠脉造影技术和流体力学模型的类FFR技术,以往研究已证实QFR对于缺血与否具有很高的诊断准确度[6]。该研究中,我们以术后FFR值>0.90作为PCI术后理想血流功能学重建结局,研究PCI术后靶血管QFR值与FFR的相关性如何,并尝试找出PCI术后理想血流功能学重建的QFR界值。 | 冯菁 张作鹏 庄凯鹏 ZHAO Ying JING Ce MA Ling WANG Fei 蔡晓庆 | 2023 | 心脏杂志2023，35，3： | 0 |
| 14 | Pipeline Defect Detection Cloud System Using Role Encryption and Hybrid Information显示文摘Pipeline defect detection systems collect the videos from cameras of pipeline robots,however the systems always analyzed these videos by offline systems or humans to detect the defects of potential security threats.The existing systems tend to reach the limit in terms of data access anywhere,access security and video processing on cloud.There is in need of studying on a pipeline defect detection cloud system for automatic pipeline inspection.In this paper,we deploy the framework of a cloud based pipeline defect detection system,including the user management module,pipeline robot control module,system service module,and defect detection module.In the system,we use a role encryption scheme for video collection,data uploading,and access security,and propose a hybrid information method for defect detection.The experimental results show that our approach is a scalable and efficient defection detection cloud system. | Ce Li Xinyu Shang Liguo Zhang Feng Yang Jing Zheng Xianlei Xu | 2019 | Computers, Materials & Continua2019，，9： | 0 |
| 15 | Underground Disease Detection Based on Cloud Computing and Attention Region Neural Network显示文摘Detecting the underground disease is very crucial for the roadbed health monitoring and maintenance of transport facilities,since it is very closely related to the structural health and reliability with the rapid development of road traffic.Ground penetrating radar(GPR)is widely used to detect road and underground diseases.However,it is still a challenging task due to data access anywhere,transmission security and data processing on cloud.Cloud computing can provide scalable and powerful technologies for large-scale storage,processing and dissemination of GPR data.Combined with cloud computing and radar detection technology,it is possible to locate the underground disease quickly and accurately.This paper deploys the framework of a ground disease detection system based on cloud computing and proposes an attention region convolution neural network for object detection in the GPR images.Experimental results of the precision and recall metrics show that the proposed approach is more efficient than traditional objection detection method in ground disease detection of cloud based system. | Pinjie Xu Ce Li Liguo Zhang Feng Yang Jing Zheng Jingwu Feng | 2019 | Journal on Artificial Intelligence2019，1，1： | 0 |
| 16 | Tuned single atom coordination structures mediated by polarization force and sulfur anions for photovoltaics显示文摘Impeding high temperature sintering is challengeable for synthesis of carbon-supported single-atom catalysts (C-SACs), which requires high-cost precursor and strictly-controlled procedures. Herein, by virtue of the ultrastrong polarity of salt melts, sintering of metal atoms is effectively suppressed. Meanwhile, doping with inorganic sulfur anions not only produces sufficient anchoring sites to achieve high loading of atomically dispersed Co up to 13.85 wt.%, but also enables their electronic and geometric structures to be well tuned. When served as a cathode catalyst in dye-sensitized solar cells, the C-SAC with Co-N4-S2 moieties exhibits high activity towards the iodide reduction reaction (IRR), achieving a higher power conversion efficiency than that of conventional Pt counterpart. Density function theory (DFT) calculations revealed that the superior IRR activity was ascribed to the unique structure of Co-N4-S2 moieties with lower reaction barriers and moderate binding energy of iodine on the Co center, which was beneficial to I2 dissociation. | Hongyu Jing Zhengyan Zhao Chunyang Zhang Wei Liu Danyang Wu Chao Zhu Ce Hao Jiangwei Zhang Yantao Shi | 2021 | Nano Research2021，14，11： | 0 |
| 17 | Fabrication of three-dimensional islet models by geometry-controlled hanging drop method显示文摘Hanging-drop method has been widely used to fabricate three-dimensional (3D) in vitro tissue models due to its advantages such as being easy to perform, inexpensive, and permitting precise control of cell spheroid formation. The geometry of hanging drop may play a critical role on the formation of cell spheroids, which, however, has not been explored. In this study, we developed a modified hanging-drop platform that enables the production of cell spheroids in a high-throughput manner by controlling hanging drop geometry with defined spreading ring. The surface tension force is proportional to the spreading ring and gravitational force is determined by the droplet volume, and the geometry can be determined by the balance between surface tension and gravity.β-TC-6 cell spheroids with optimized diameters were fabricated as 3D in vitro islet models. The models show morphology similar to primary islets and have functionality that more closely resembles primary islets than two-dimensional cell culture. The developed platform holds great potential for engineering well-controlled in vitro tissue models for various applications such as physiological and pathological studies, drug screening, as well as transplantation for treatment purpose. | Bin Gao Ce Jing Kelvin Ng Belinda Pingguan-Murphy Qingzhen Yang | 2019 | Acta Mechanica Sinica2019，35，2： | 0 |
| 18 | Paired quasi-periodic pulsations of hard X-ray emission in a solar flare显示文摘We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 UT.Several subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak struc-tures.These subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive phase.The periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence level.The paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our observation.The precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands. | Hai-Sheng Zhao Dong Li Shao-Lin Xiong Yan-Qiu Zhang Yang Su Wei Chen Yi Zhao Xiao-Bo Li Jia-Cong Liu Wen-Xi Peng Rui Qiao Xin-Qiao Li Xiang-Yang Wen Li-Ming Song Shi-Jie Zheng Xin-Ying Song Xiao-Yun Zhao Yue Huang Shuang-Nan Zhang Shuo Xiao Ce Cai Zheng-Hua An Can Chen Gang Chen Wei Chen Yan-Qi Du Min Gao Ke Gong Dong-Ya Guo Zhi-Wei Guo Jian-Jian He Bin Li Chao Li Chao-Yang Li Gang Li Jian-Hui Li Lu Li Qing-Xin Li Yan-Guo Li Jing Liang Xiao-Hua Liang Jin-Yuan Liao Xiao-Jing Liu Ya-Qing Liu Qi Luo Xiang Ma Bin Meng Ge Ou Dong-Li Shi Jing-Yan Shi Gong-Xing Sun Xi-Lei Sun You-Li Tuo Chen-Wei Wang Hui Wang Jin Wang Jin-Zhou Wang Ping Wang Wen-Shuai Wang Hong Wu Sheng-Lun Xie Yan-Bing Xu Yu-Peng Xu Wang-Chen Xue Sheng Yang Min Yao Jian-Ying Ye Qi-Bin Yi Chao-Yue Zhang Da-Li Zhang Fan Zhang Fei Zhang Hong-Mei Zhang Kai Zhang Peng Zhang Xiao-Lu Zhang Zhen Zhang Guo-Ying Zhao Shi-Yi Zhao Chao Zheng Xing Zhou Yue Zhu | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，5： | 0 |
| 19 | Single-cell Long Non-coding RNA Landscape of T Cells in Human Cancer Immunity显示文摘The development of new biomarkers or therapeutic targets for cancer immunotherapies requires deep understanding of Tcells.To date,the complete landscape and systematic characterization of long noncoding RNAs(lncRNAs)in T cells in cancer immunity are lacking.Here,by systematically analyzing full-length single-cell RNA sequencing(scRNA-seq)data of more than 20,000 libraries of T cells across three cancer types,we provided the first comprehensive catalog and the functional repertoires of lncRNAs in human T cells.Specifically,we developed a custom pipeline for de novo transcriptome assembly and obtained a novel lncRNA catalog containing 9433 genes.This increased the number of current human lncRNA catalog by 16%and nearly doubled the number of lncRNAs expressed in T cells.We found that a portion of expressed genes in single T cells were lncRNAs which had been overlooked by the majority of previous studies.Based on metacell maps constructed by the MetaCell algorithm that partitions scRNA-seq datasets into disjointed and homogenous groups of cells(metacells),154 signature lncRNA genes were identified.They were associated with effector,exhausted,and regulatory T cell states.Moreover,84 of them were functionally annotated based on the co-expression networks,indicating that lncRNAs might broadly participate in the regulation of T cell functions.Our findings provide a new point of view and resource for investigating the mechanisms of T cell regulation in cancer immunity as well as for novel cancer-immune biomarker development and cancer immunotherapies. | Haitao Luo Dechao Bu Lijuan Shao Yang Li Liang Sun Ce Wang Jing Wang Wei Yang Xiaofei Yang Jun Dong Yi Zhao Furong Li | 2021 | Genomics, Proteomics & Bioinformatics2021，19，3： | 0 |
| 20 | Hydroxyl-terminated Polyethylenes Bearing Functional Side Groups:Facile Synthesis and Their Properties显示文摘A series of hydroxyl-terminated polyethylenes(HTPE)bearing various functional side groups(e.g.carboxyl,ester and butane groups)were synthesized by the combination of ring opening metathesis polymerization(ROMP)and visible light photocatalytic thiol-ene reaction.The products are named as a,w-dihydroxyl-polyllpropionyloxythio)methinetrimethylene](HTPECarboxy),a,w dihydroxy-poly(methylpropionatethio)methinetrimethylene](HTPEeser)and a,wdihydroxyl-poly[(butylthio)methinetrimethylene](HTPEbutane)respectively.The investigation of ROMP indicated that the molecular weight of resultant hydroxy-terminated polybutadiene(HTPB)can be tailored by varying the feed ratios of monomer to chain transfer agent(CTA).The exploration of the photocatalytic thiol-ene reaction between HTPB precursor and methyl-3-mercaptopropionate revealed that blue light as well as oxygen accelerated the reaction.1H-NMR and 13C-NMR results verified all the double bonds in HTPB can be modified,and the main chain of resultant polymer can be considered as polyethylene.Subsequently,relationship between the structure of side groups and the thermal properties of functional PEs was studied.And the results suggested that the Tg was in the order of HTPEbuane | Wan-Bin Zhang Jie Luo Yan-Meng Wang Xiu-Zhong Zhu Ce Zhang Jing Liu Mei-Le Ni Guang-Hua Zhang | 2021 | Chinese Journal of Polymer Science2021，39，8： | 0 |
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