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3102篇 您的检索式:作者名="JEFFERY"
    题名 作者 年代 出处 被引量
1基于相似性和接近性视角的新型灰色关联分析模型显示文摘以笔者1992年提出的灰色绝对关联度模型为基础,构造出分别从相似性和接近性两个不同视角测度序列之间的相互关系和影响的灰色关联分析模型,并研究了灰色相似关联度和灰色接近关联度的计算及性质,最后给出一个算例.新模型克服了原模型存在的问题,更易于实际应用.相似关联度主要用于测度序列折线在几何形状上的相似程度;接近关联度用于测度序列折线在空间中的接近程度.需要说明的是,接近关联度仅适用于序列的意义、量纲完全相同的情形,当序列的意义、量纲不同时,研究其接近关联度没有意义.刘思峰 谢乃明 FORREST Jeffery 2010系统工程理论与实践2010,30,5:112
2如何管理一个繁忙的急诊科显示文摘1背景 急诊科是医院内最不具有确定性和最繁忙的的一个部门。自上世纪九十年代始,急诊科就诊病人数逐年增长,Bernstein SL等人统计,美国2003年急诊病人流量较10年前增加了27%:在北京协和医院急诊科(东院区),病人流量则由2000年的146人次/日(危重症114例/月),剧增到2005年的300人次/日(危重症190例/月)。病人流量的增加是造成急诊科拥挤最基本因素,“拥挤(crowding)”是指急诊病人的需求(即等待急诊临床决策,如分诊、候诊、留观、治疗、安置等)超过了急诊科的处理能力。此外病情的严重程度、急诊科容纳量、人员配备也是造成急诊科拥挤、繁忙的重要因素。徐腾达 王仲 王厚力 Jeffery Smith 于学忠 2006世界急危重病医学杂志2006,3,6:19
3Size distribution and diffuse pollution impacts of PAHs in street dust in urban streams in the Yangtze River Delta显示文摘Particles of dust washed off streets by stormwater are an important pathway of polyaromatic hydrocarbons(PAHs) into urban streams.This article presented a comprehensive assessment of the size distribution of PAHs in street dust particles,the potential risks of the particles in urban streams,and the sources and sinks of PAHs in the stream network.This assessment was based on measurements of 16 PAHs from the USEPA priority list in street dust particles and river sediments in Xincheng,China.The content of total PAHs ranged from 1629 to 8986 μg/kg in street dust particles,where smaller particles have a higher concentrations.Approximately 55% of the total PAHs were associated with particles less than 250 μm which accounted for 40% of the total mass of street dust.The PAH quantities increased from 2.41 to 46.86 μg/m2 in the sequence of new residential,rising through main roads,old town residential,commercial and industrial areas.The sediments in stream reaches in town were found to be sinks for street dust particle PAHs.The research findings suggested that particle size,land use and the hydrological conditions in the stream network were the factors which most influenced the total loads of PAH in the receiving water bodies.ZHAO Hongtao YIN Chengqing CHEN Meixue WANG Weidong Jefferies Chris SHAN Baoqing 2009Journal of Environmental Sciences2009,21,2:17
4多中心临床试验伦理审查模式:实践与启示显示文摘国际临床研究格局向多中心合作发展,逐渐形成了几种针对多中心临床试验的机构审查委员会审查模式,即中心机构审查委员会伦理审查、区域机构审查委员会伦理审查、依赖协议审查和独立伦理审查模式,美国政府从政策法规上也积极推动这些模式的应用。由于我国人体研究伦理审查制度援引自美国,探讨其伦理审查模式的发展趋势对我国具有一定意义。进而以我国伦理审查模式现状为基础,论述了单一伦理审查模式改革的必要性、先决条件与实施路径。梁虹 Jeffery Cohen 时占祥 2016中国医学伦理学2016,29,3:14
5高粱(Sorghum bicolor)分子图谱的构建及寄生草(Striga asiatica)萌发诱导物基因的定位显示文摘高粱是世界上第五大主要粮食作物,也是非洲国家的主要粮食来源之一,Striga asiatica是一种寄生于高粱等主要农作物的野生草之一。选用两个对寄生草抗性表现差异的 高粱品系“山桂红”和“SRN39”作亲本,构建了一个重组近交系群体(Recombinant inbred, RI),并随机筛选出94个系用于构建分子连锁图谱和基因定位。在应用的286个多态性标记 中,有251个标记分别标定在10条不同的连锁群上,标记间的平均图距为7.1cm,总图谱覆盖 了高粱基因组的1779cm,是目前国际上几个比较完整的高粱分子连锁图谱之一。群体的共 分离分析表明,与寄生草抗性有关的萌发诱导物基因(Germinination stimulant gene-GermStim) 位于高粱的遗传连锁群J上,相距较近的分子标记为13cm。进一步的精细定位分析,发现有 两个分子标记分别位于基因的两侧,距离为1.6和2.1个cm。徐吉臣 Yohan M. Weerasuriya Jeffery L. Bennetzen 2001Acta Genetica Sinica2001,28,9:13
6Endocrine impact of Helicobacter pylori:Focus on ghrelin and ghrelin o-acyltransferase显示文摘Ghrelin is predominantly produced by the gastric enteroendocrine cell compartment and is octanoylated by the recently discovered ghrelin o-acyltransferase (GOAT) before secretion into the bloodstream. This octanoylation is essential for many of the biological properties of ghrelin including appetite stimulation and anti-inflammatory properties as only the acylated form of ghrelin binds to the ghrelin receptor, the growth hormone secretagogue receptor (GHS-R). Given the gastric location of ghrelin production, it is perhaps not surprising that insult to the gastric mucosa affects circulating ghrelin levels in humans. Helicobacter pylori (H. pylori) infects more than f ifty percent of the world's population and once established within the gastric mucosa, can persist for life. Infection is associated with chronic gastritis, gastric atrophy and ulceration, reduced appetite and a lower body mass index (BMI). The large majority of studies investigating levels of circulating ghrelin and ghrelin expression in the stomach in patients with H. pylori infection indicate that the bacterium has a negative impact on ghrelin production and/or secretion. Eradication of infection restores ghrelin, improves appetite and increases BMI in some studies, however, a causative relationship between H. pylori-associated serum ghrelin decline and food intake and obesity has not been established. Most studies measure total ghrelin in the circulation although the measurement of the ratio of acyl/total ghrelin gives a clearer indication that the ghrelin acylation process is altered during infection and atrophy. GOAT is essential for the production of biologically-active, acyl ghrelin and the impact of H. pylori on GOAT expression and activity will be highly informative in the future.Penny L Jeffery Michael A McGuckin Sara K Linden 2011World Journal of Gastroenterology2011,17,10:12
7Kevlar对位芳纶浆粕增强橡胶的研究显示文摘研究Kevlar对位芳纶浆粕和精切短纤维对天然橡胶胶料的补强效果。结果表明:随着纤维用量的增大,Kevlar对位芳纶浆粕补强的胶料储能模量增加幅度大于损耗模量增加幅度,损耗角和损耗因子随着浆粕用量的增大而降低,这种效果有利于低滚动阻力轮胎或其他轮胎部件的胶料配方设计,在提高胶料定伸模量的同时不会增加滞后生热;Kevlar对位芳纶浆粕表现出的一种独特手风琴效应可能是低滞后生热的原因。Jeffery S. Downey Constantine W. Tsimpris Andrew L. Pollard Chloe F. Wilson Jocelyn Willis-Papi Christiane K. Hohenwarter Qin Lin 黎学东 2012轮胎工业2012,32,7:11
8A computational platform for considering the effects of aerodynamic and seismic load combination for utility scale horizontal axis wind turbines显示文摘The wide deployment of wind turbines in locations with high seismic hazard has led engineers to take into account a more comprehensive seismic design of such structures.Turbine specific guidelines usually use simplified methods and consider many assumptions to combine seismic demand with the other operational loads effecting the design of these structures.As the turbines increase in size and capacity,the interaction between seismic loads and aerodynamic loads becomes even more important.In response to the need for a computational tool that can perform coupled simulations of wind and seismic loads,a seismic module is developed for the FAST code and described in this research.This platform allows engineers working in this industry to directly consider interaction between seismic and other environmental loads for turbines.This paper details the practical application and theory of this platform and provides examples for the use of different capabilities.The platform is then used to show the suitable earthquake and operational load combination with the implicit consideration of aerodynamic damping by estimating appropriate load factors.Mohammad-Amin Asareh Ian Prowell Jeffery Volz William Schonberg 2016Earthquake Engineering and Engineering Vibration2016,15,1:11
9Axonal regeneration after spinal cord injury in zebrafish and mammals: differences, similarities, translation显示文摘Spinal cord injury (SCI) in mammals results in functional deficits that are mostly permanent due in part to the inability of severed axons to regenerate. Several types of growth-inhibitory molecules expressed at the injury site contribute to this regeneration failure. The responses of axons to these inhibitors vary greatly within and between organisms, reflecting axons' characteristic intrinsic propensity for regeneration. In the zebrafish (Danio rerio) many but not all axons exhibit successful regeneration after SCi. This review presents and compares the intrinsic and extrinsic determinants of axonal regeneration in the injured spinal cord in mammals and zebrafish. A better understanding of the molecules and molecular pathways underlying the remarkable individualism among neurons in mature zebrafish may support the development of therapies for SCI and their translation to the clinic.Katarina Vajn Jeffery A Plunkett Alexis Tapanes-Castillo Martin oudega 2013Neuroscience Bulletin2013,29,4:9
10Genomic landscape and genetic manipulation of the black soldier fly Hermetia illucens,a natural waste recycler显示文摘The black soldier fly(BSF),Hermetia illucens(Diptera:Stratiomyidae),is renowned for its bioconversion of organic waste into a sustainable source of animal feed.We report a high-quality genome of 1.1 Gb and a consensus set of 16,770 gene models for this beneficial species.Compared to those of other dipteran species,the BSF genome has undergone a substantial expansion in functional modules related to septic adaptation,including immune system factors,olfactory receptors,and cytochrome P450s.We further profiled midgut transcriptomes and associated microbiomes of BSF larvae fed with representative types of organic waste.We find that the pathways related to digestive system and fighting infection are commonly enriched and that Firmicutes bacteria dominate the microbial community in BSF across all diets.To extend its potential practical applications,we further developed an efficient CRISPR/Cas9-based gene editing approach and implemented this to yield flightless and enhanced feeding capacity phenotypes,both of which could expand BSF production capabilities.Our study provides valuable genomic and technical resources for optimizing BSF lines for industrialization.Shuai Zhan Gangqi Fang Minmin Cai Zongqing Kou Jun Xu Yanghui Cao Liang Bai Yixiang Zhang Yongmao Jiang Xingyu Luo Jian Xu Xia Xu Longyu Zheng Ziniu Yu Hong Yang Zhijian Zhang Sibao Wang Jeffery K.Tomberlin Jibin Zhang Yongping Huang 2020Cell Research2020,30,1:9
11种族主义者的爱显示文摘美国“白人至上论”的种族主义歧视机制,摈弃了对付黑人、印第安人等的暴力手段,而是用所谓的“爱”柔化华裔,强加给了华裔一个“自惭形秽”的形象和“双重身份”的观念,每一本由华裔出版于美国的著作都是这一观念的产物。而且,“双重身份”也剥夺了华裔寻求自我认同的语言手段,这种语言独裁渗透到有意替少数族群在主流文化内寻求身份认同的创作企图中。于是,华裔美国的艺术创作就表现出对华裔社区的轻蔑和对华裔文化的疏离。Frank Chin Jeffery Paul Chan 李贵苍 徐纪阳 2005华文文学2005,,3:8
12Not Ready for Convergence in Data Infrastructures显示文摘Much research is dependent on Information and Communication Technologies(ICT).Researchers in different research domains have set up their own ICT systems(data labs)to support their research,from data collection(observation,experiment,simulation)through analysis(analytics,visualisation)to publication.However,too frequently the Digital Objects(DOs)upon which the research results are based are not curated and thus neither available for reproduction of the research nor utilization for other(e.g.,multidisciplinary)research purposes.The key to curation is rich metadata recording not only a description of the DO and the conditions of its use but also the provenance-the trail of actions performed on the DO along the research workflow.There are increasing real-world requirements for multidisciplinary research.With DOs in domain-specific ICT systems(silos),commonly with inadequate metadata,such research is hindered.Despite wide agreement on principles for achieving FAIR(findable,accessible,interoperable,and reusable)utilization of research data,current practices fall short.FAIR DOs offer a way forward.The paradoxes,barriers and possible solutions are examined.The key is persuading the researcher to adopt best practices which implies decreasing the cost(easy to use autonomic tools)and increasing the benefit(incentives such as acknowledgement and citation)while maintaining researcher independence and flexibility.Keith Jeffery Peter Wittenburg Larry Lannom George Strawn Claudia Biniossek Dirk Betz Christophe Blanchi 2021Data Intelligence2021,3,1:7
13煤矿井下水处理反渗透膜的污染机理研究显示文摘随着反渗透技术广泛应用于煤矿井下水处理系统,矿井水的水质复杂性容易造成反渗透膜污染,大幅度地影响了膜组件的除盐效率及使用寿命。为探讨造成山东新巨龙煤矿综采工作面集成供液系统水处理装置反渗透膜组件失效的原因,通过对源水水样中浊度、硬度、阴阳离子浓度及总有机物等进行检测和分析,依据Visual MINTEQ计算环境水化学平衡工具,初步建立了污染物预测模型。采取肉眼检测、烧矢量(LOI)、扫描电镜(SEM)和藤原测试方法,揭示出反渗透系统运行失败的机理。基于膜元件内部在浓水通道和膜表面发现大量固体颗粒,反渗透膜片存在由颗粒物造成的不同程度的机械损伤,推断其前端的保安过滤器存在失效的可能。考虑到膜表面污染物组成多为结晶状态下的无机盐,膜片存在少量有机污染现象,无氧化性污染物进入反渗透系统,排除了有机物污染造成系统失效的可能性。基于Visual MINTEQ的化学平衡模型对结垢物组成进行分析,结果显示其主要成分为钙离子,通过对膜结垢样品组成进行定量分析试验,验证了污染物预测模型的准确性。结果表明,该矿井下供水的浊度和硬度较高,造成反渗透膜的表面结垢及颗粒沉积是系统运行失效的主要原因。针对失效原因,提出了定期对保安过滤器进行检查维护、在RO预处理阶段增加阻垢剂等措施和新型水处理工艺的研究方向。韦文术 ZHANG Jeffery 张健恺 邹湘 吕顺之 李然 赵康康 刘雪菲 王远 2021煤炭科学技术2021,49,4:7
14Update on global epidemiology of viral hepatitis and preventive strategies显示文摘Viral hepatitis is one of the major public health concerns around the world but until recently it has drawn little attention or funding from global health policymakers.Every year 1.4 million people die from viral hepatitisrelated cirrhosis and liver cancer.However,the majority of the infected population are unaware of their condition.This population have significant obstacles to overcome such as lack of awareness,vulnerability,increased migration,disease stigma,discrimination,as well as poor health resources,conflict in policy development and program implementation.Despite implementing infection control measures over the last few decades eradication or significant disease reduction remains elusive.This study aims to present the current global prevalence status and examines potential elimination strategies.The information for this research were obtained through a systematic review,published scientific literatures,the official websites of various government organisations,international public health organisations and internationally recognised regulatory bodies over a period of 40 years between 1978 and2018.Meryem Jefferies Bisma Rauff Harunor Rashid Thao Lam Shafquat Rafiq 2018World Journal of Clinical Cases2018,6,13:6
15急诊医学专业住院医师培训课程的标准化探讨显示文摘目前,国内绝大多数医院设有急诊科(室),但其运行和管理模式千差万别,急诊医师也缺乏专业训练,这一现状加剧了急诊工作环境的恶化,制约了急诊医疗质量的提高。急诊住院医师培训课程的标准化则是住院医师培训质量和急诊医疗质量的有力保证。本研究的目的是在急诊住院医师培训年限、核心课程、相关制度等方面对急诊住院医师培训课程标准化进行初步探讨。徐腾达 Veronica Pei 于学忠 Jeffery Smith 马遂 王仲 2006中华急诊医学杂志2006,15,12:6
16Development of time series stacks of Landsat images for reconstructing forest disturbance history显示文摘Forest dynamics is highly relevant to a broad range of earth science studies,many of which have geographic coverage ranging from regional to global scales.While the temporally dense Landsat acquisitions available in many regions provide a unique opportunity for understanding forest disturbance history dating back to 1972,large quantities of Landsat images will need to be analysed for studies at regional to global scales.This will not only require effective change detection algorithms,but also highly automated,high level preprocessing capabilities to produce images with subpixel geolocation accuracies and best achievable radiometric consistency,a status called imagery-ready-to-use(IRU).This paper describes a streamlined approach for producing IRU quality Landsat time series stacks(LTSS).This approach consists of an image selection protocol,high level preprocessing algorithms and IRU quality verification procedures.The high level preprocessing algorithms include updated radiometric calibration and atmospheric correction for calculating surface reflectance and precision registration and orthorectification routines for improving geolocation accuracy.These automated routines have been implemented in the Landsat Ecosystem Disturbance Adaptive System(LEDAPS)designed for processing large quantities of Landsat images.Some characteristics of the LTSS developed using this approach are discussed.Chengquan Huang Samuel N.Goward Jeffrey G.Masek Feng Gao Eric F.Vermote Nancy Thomas Karen Schleeweis Robert E.Kennedy Zhiliang Zhu Jeffery C.Eidenshink John R.G.Townshend 2009International Journal of Digital Earth2009,2,3:5
17Jejunal diverticulosis is not always a silent spectator:A report of 4 cases and review of the literature显示文摘Jejunal diverticulosis (JD) is a rare clinical entity. The potential complications of this condition are discussed here through a series of cases presented to our centre. A retrospective analysis of four cases, which were diagnosed and treated, was performed. These included two cases of gastrointestinal haemorrhage, one case of perforation and one case of enterolith obstruction. All of these cases were secondary to jejunal diverticulosis and treated surgically. This was accompanied by a literature search to identify the different modalities for diagnosis and treatment of this condition. JD is rare and may lead to a diagnostic delay. Awareness of the wide spectrum of potential complications can prevent this delay.Vishal Arun Patel Helen Jefferis Ben Spiegelberg Quamar Iqbal Ashish Prabhudesai Simon Harris 2008World Journal of Gastroenterology2008,14,38:4
18Appraisal of needle-based confocal laser endomicroscopy inthe diagnosis of pancreatic cysts显示文摘Nearly 2.5% of cross-sectional imaging studies will report a finding of a cystic pancreatic lesion. Eventhough most of these are incidental findings, it remains very concerning for both patients and treating clinicians. Differentiating and predicting malignant transformation in pancreatic cystic lesions is clinically challenging. Current evaluation of suspicious cystic lesions includes a combination of radiologic imaging, endoscopic ultrasound(EUS) and cyst fluid analyses. Despite these attempts, precise diagnostic stratification among nonmucinous, mucinous, and malignant cystic lesions is often not possible until surgical resection. EUS-guided needle based confocal laser endomicroscopy(n CLE) for evaluation of pancreatic cysts is emerging as a powerful technique with remarkable potential. Though limited imaging data from 3 large clinical trials(INSPECT, DETECT and CONTACT) are currently the reference standard for n CLE imaging, nonetheless these have not been validated in large studies. The aim of this review article is to review the evolving role of EUS-guided n CLE in management of pancreatic cystic lesions in terms of its significance, adverse events, limitations, and implications.Somashekar G Krishna Jeffery H Lee 2016World Journal of Gastroenterology2016,22,4:4
19强化初始培训在医学生向急诊住院医生转换中的作用显示文摘目的初始培训是住院医师开始临床工作前的培训。探讨不同的初始培训方式对医学生向临床医生角色转换的作用。方法 15名上岗前的住院医师随机分成2组,强化培训8人,进行系统的基本知识和技能的培训,常规培训组7人,沿用传统的方法,在培训前后分别进行理论考核,1及3个月后针对自我能力评价和主治医师评价进行问卷调查打分。结果初始培训后的考核成绩分别为78.25±5.90和59.71±3.90(P<0.05),强化培训组对于急诊知识和技能的掌握情况更好。3个月后强化培训组在临床工作中的自信心评价结果为91.20±8.76,显著高于常规训练组的75.46±6.56(P<0.05)。结论针对毕业的医学生进行强化初始培训能更好地帮助他们完成由学生向医生的转变,尽快树立信心,提高临床工作能力,改善患者的满意度和降低医疗风险。刘继海 于学忠 朱华栋 王仲 徐腾达 Veronica PEI Jeffery SMITH 2011基础医学与临床2011,31,5:4
20Nosema ceranae is a long-present and wide-spread microsporidian infection of the European honey bee ( Apis mellifera ) in the United States显示文摘Yanping Chen Jay D. Evans I. Bart Smith Jeffery S. Pettis 2007Journal of Invertebrate Pathology2007,,2:4
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