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| 1 | Agrin在神经系统损伤后修复中的作用显示文摘神经系统主要由中枢神经系统(central nervous system,CNS)和周围神经系统(peripheral nervous systems,PNS)两大部分组成。CNS损伤包括脊髓损伤和脑神经损伤,主要以后者为主,具有发病率高、致残率高和死亡率高的特点。此外,CNS损伤后会引起包括DNA降解和细胞膜磷脂酰丝氨酸残基早期暴露在内的一系列程序性细胞死亡的病理过程, | 杨利强 张彭跃 | 2016 | 中国病理生理杂志2016，32，6： | 3 |
| 2 | 中枢神经系统损伤后修复的内在机制研究显示文摘成年哺乳动物中枢神经系统(CNS)轴突受损后很难修复,最终导致神经元的死亡和神经环路功能性的缺损。前期的研究集中于探讨受损环境的抑制性因素,而对细胞内再生相关基因的调控很少涉及。本文从低等脊椎动物促进轴突再生的分子机制谈起,总结了近年来内源性神经再生的相关研究,以期为中枢轴突损伤后再生的基础和临床研究提供新的思路和研究方向。 | 汪晶 朱青 胡波 曹非 | 2015 | 神经损伤与功能重建2015，10，2： | 3 |
| 3 | Bioinformatic identification of key candidate genes and pathways in axon regeneration after spinal cord injury in zebrafish显示文摘Zebrafish and human genomes are highly homologous;however,despite this genomic similarity,adult zebrafish can achieve neuronal proliferation,regeneration and functional restoration within 6–8 weeks after spinal cord injury,whereas humans cannot.To analyze differentially expressed zebrafish genes between axon-regenerated neurons and axon-non-regenerated neurons after spinal cord injury,and to explore the key genes and pathways of axonal regeneration after spinal cord injury,microarray GSE56842 was analyzed using the online tool,GEO2R,in the Gene Expression Omnibus database.Gene ontology and protein-protein interaction networks were used to analyze the identified differentially expressed genes.Finally,we screened for genes and pathways that may play a role in spinal cord injury repair in zebrafish and mammals.A total of 636 differentially expressed genes were obtained,including 255 up-regulated and 381 down-regulated differentially expressed genes in axon-regenerated neurons.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment results were also obtained.A protein-protein interaction network contained 480 node genes and 1976 node connections.We also obtained the 10 hub genes with the highest correlation and the two modules with the highest score.The results showed that spectrin may promote axonal regeneration after spinal cord injury in zebrafish.Transforming growth factor beta signaling may inhibit repair after spinal cord injury in zebrafish.Focal adhesion or tight junctions may play an important role in the migration and proliferation of some cells,such as Schwann cells or neural progenitor cells,after spinal cord injury in zebrafish.Bioinformatic analysis identified key candidate genes and pathways in axonal regeneration after spinal cord injury in zebrafish,providing targets for treatment of spinal cord injury in mammals. | Jia-He Li Zhong-Ju Shi Yan Li Bin Pan Shi-Yang Yuan Lin-Lin Shi Yan Hao Fu-Jiang Cao Shi-Qing Feng | 2020 | Neural Regeneration Research2020，15，1： | 2 |
| 4 | 蝌蚪断尾后脊髓的细胞形态学显示文摘目的 :探讨蝌蚪断尾后脊髓神经细胞的形态学变化。方法 :蝌蚪尾部石蜡切片,H-E染色、尼氏染色、Golgi染色观察蝌蚪尾部再生细胞结构的变化以及再生尾长度变化。结果 :蝌蚪再生尾中细胞的来源大多是增殖分化的室管膜胶质细胞;再生前期有大量的细胞死亡。随着增殖分化的不断进行,轴突再生,尾部不断延伸,功能恢复。再生尾的长度比原生尾短2 mm。结论 :蝌蚪再生的尾部比原生尾短,但不影响功能,室管膜胶质细胞增殖分化为神经细胞,完成尾部再生。 | 王迪 龙滨 张妮 汤枭 高曼 刘文静 阮健 李君 | 2023 | 解剖学杂志2023，46，3： | 0 |
| 5 | 转录后调控在神经轴突损伤后修复中的作用显示文摘和发育阶段相比,受损的轴突再生面临更为艰难的挑战。细胞内各种信号通路需要精巧的协同,在时空上调控蛋白的表达和运输,从而不断适应外部环境的变化。相较于转录水平的调控,转录后调控对新蛋白的合成和组装,以及对运输进行时时地的控制具有不可替代的优势,是轴突成功再生必不可少的条件。本文从转录后调控的两个基本元素(miRNAs和RBPs)出发,阐述其作用机制,探讨它们如何在神经轴突再生的过程中发挥重要作用,以期为临床神经再生的基础研究和新药开发提供新的思路和方向。 | 高芮 韩星 冯星 | 2016 | 齐齐哈尔医学院学报2016，37，3： | 0 |
| 6 | 成年斑马鱼脊髓损伤模型的制备和评估显示文摘目的:建立一种成年斑马鱼脊髓损伤(SCI)模型。方法:将成年斑马鱼随机分为正常组、假手术组和SCI组。SCI组进行脊髓完全横断手术,假手术组对斑马鱼的脊髓只暴露而不切断,正常组不做特殊处理。通过测试处理后斑马鱼的自由游泳能力和顺行轴突追踪来评估神经再生的情况。结果:假手术组与正常组斑马鱼5 min游泳路径的平均距离比较,差异无统计学意义(P>0.05),与第1周相比,SCI组斑马鱼第6周的5 min游泳路径的平均距离显著增加(P<0.05)。顺行神经示踪显示SCI组斑马鱼在损伤后2周出现可观察的轴突恢复。结论:成年斑马鱼具有显著的SCI恢复能力,本实验建立的成年斑马鱼SCI模型技术成熟、容易复制,可应用于SCI的相关研究。 | 邓豪 滕益霖 刘槃 席德双 宗少晖 | 2024 | 广西医科大学学报2024，41，2： | 0 |
| 7 | Dual Oxidase Mutant Retards Mauthner-Cell Axon Regeneration at an Early Stage via Modulating Mitochondrial Dynamics in Zebrafish显示文摘Dual oxidase(duox)-deriyed reactive oxygen species(ROS)have been correlated with neuronal polarity,cerebellar development,and neuroplasticity.However,there have not been many comprehensive studies of the effect of individual duox isoforms on central-axon regenerationin vivo.Here,we explored this question in zebrafish,an excellent model organism for central-axon regeneration studies.In our research,mutation of the duox gene with CRISPR/Cas9 significantly retarded the singleaxon regeneration of the zebrafish Mauthner cell in vivo.Using deep transcriptome sequencing,we found that the expression levels of related functional enzymes in mitochondria were down-regulated in duox mutant fish.In vivo imaging showed that duox mutants had significantly disrupted mitochondrial transport and redox state in single Mauthner-cell axon.Our research data provide insights into how duox is involved in central-axon regeneration by changing mitochondrial transport. | Lei-Qing Yang Min Chen Da-Long Ren Bing Hu | 2020 | Neuroscience Bulletin2020，36，12： | 0 |
| 8 | 斑马鱼作为模式生物在脊髓损伤修复研究中的应用显示文摘脊髓损伤常常导致严重的和永久性残疾,不仅降低患者的生活质量,还给社会和家庭带来沉重的负担。脊髓损伤的修复和治疗一直是世界研究的热点和难点,如何有效地促进脊髓的修复一直是神经科学领域研究的难题。不同的物种之间再生能力差异很大。近年来,斑马鱼作为一种新兴模式生物,显示出了很大的优越性。与人和高等脊椎动物相比,斑马鱼具有非凡的组织再生能力,脊髓损伤后显示出了强大的神经修复能力,是研究脊髓损伤的理想动物模型。 | 李萌 张慧 黄玉琴 陈银海 | 2015 | 广东医学2015，36，14： | 0 |
| 9 | An update on spinal cord injury research显示文摘Spinal cord injury (SCI) is an ever-increasing challenge. Severe injury can cause long-term loss of sensory and motor functions, as well as other chronic conditions, such as neuropathic pain and autonomic dysreflexia. So far, most research has been focused on acute injury. However, due to the lack of treatment, | Yimin Zou | 2013 | Neuroscience Bulletin2013，29，4： | 0 |
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