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| 1 | Warpage and Shrinkage Optimization of Injection-Molded Plastic Spoon Parts for Biodegradable Polymers Using Taguchi, ANOVA and Artificial Neural Network Methods显示文摘In this study, it is attempted to give an insight into the injection processability of three self-prepared polymers from A to Z. This work presents material analysis, injection molding simulation, design of experiments alongside considering all interaction effects of controlling parameters carefully for green biodegradable polymeric systems, including polylactic acid(PLA), polylactic acid-thermoplastic polyurethane(PLA-TPU) and polylactic acid-thermoplastic starch(PLA-TPS). The experiments were carried out using injection molding simulation software Autodesk Moldflow?in order to minimize warpage and volumetric shrinkage for each of the mentioned systems. The analysis was conducted by changing five significant processing parameters, including coolant temperature, packing time, packing pressure, mold temperature and melt temperature. Taguchi's L27(35) orthogonal array was selected as an efficient method for design of simulations in order to consider the interaction effects of the parameters and reduce spurious simulations. Meanwhile, artificial neural network(ANN) was also used for pattern recognition and optimization through modifying the processing conditions. The Taguchi coupled analysis of variance(ANOVA) and ANN analysis resulted in definition of optimum levels for each factor by two completely different methods. According to the results, melting temperature, coolant temperature and packing time had significant influence on the shrinkage and warpage. The ANN optimal level selection for minimization of shrinkage and/or warpage is in good agreement with ANOVA optimal level selection results. This investigation indicates that PLA-TPU compound exhibits the highest resistance to warpage and shrinkage defects compared to the other studied compounds. | Erfan Oliaei Behzad Shiroud Heidari Seyed Mohammad Davachi Mozhgan Bahrami Saeed Davoodi Iman Hejazi Javad Seyfi | 2016 | Journal of Materials Science & Technology2016，32，8： | 26 |
| 2 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 3 | Biological response to prosthetic debris显示文摘Joint arthroplasty had revolutionized the outcome of orthopaedic surgery. Extensive and collaborative work of many innovator surgeons had led to the development of durable bearing surfaces, yet no single material is considered absolutely perfect. Generation of wear debris from any part of the prosthesis is unavoidable. Implant loosening secondary to osteolysis is the most common mode of failure of arthroplasty. Osteolysis is the resultant of complex contribution of the generated wear debris and the mechanical instability of the prosthetic components. Roughly speaking, all orthopedic biomaterials may induce a universal biologic hostresponse to generated wear débris with little specific characteristics for each material; but some debris has been shown to be more cytotoxic than others. Prosthetic wear debris induces an extensive biological cascade of adverse cellular responses, where macrophages are the main cellular type involved in this hostile inflammatory process. Macrophages cause osteolysis indirectly by releasing numerous chemotactic inflammatory mediators, and directly by resorbing bone with their membrane microstructures. The bio-reactivity of wear particles depends on two major elements: particle characteristics(size, concentration and composition) and host characteristics. While any particle type may enhance hostile cellular reaction, cytological examination demonstrated that more than 70% of the debris burden is constituted of polyethylene particles. Comprehensive understanding of the intricate process of osteolysis is of utmost importance for future development of therapeutic modalities that may delay or prevent the disease progression. | Diana Bitar Javad Parvizi | 2015 | World Journal of Orthopedics2015，6，2： | 16 |
| 4 | Application of artificial neural networks to the prediction of tunnel boring machine penetration rate显示文摘Rate of penetration of a Tunnel Boring Machine(TBM) in a rock environment is generally a key parameter for the successful accomplishment of a tunneling project.This paper presents the results of a study into the application of an Artificial Neural Network(ANN) technique for modeling the penetration rate of tunnel boring machines.A database,including actual,measured TBM penetration rates,uniaxial compressive strengths of the rock,the distance between planes of weakness in the rock mass and rock quality designation was established.Data collected from three different TBM projects(the Queens Water Tunnel,USA,the Karaj-Tehran water transfer tunnel,Iran,and the Gilgel Gibe II hydroelectric project,Ethiopia).A five-layer ANN was found to be optimum,with an architecture of three neurons in the input layer,9,7 and 3 neurons in the first,second and third hidden layers,respectively,and one neuron in the output layer.The correlation coefficient determined for penetration rate predicted by the ANN was 0.94. | JAVAD Gholamnejad NARGES Tayarani | 2010 | Mining Science and Technology2010，20，5： | 14 |
| 5 | 针刀松解法对第3腰椎横突综合征大鼠下丘脑前阿黑皮素mRNA、前脑啡肽原mRNA表达的影响显示文摘目的:探讨针刀松解法治疗第3腰椎横突综合征的部分中枢镇痛机制。方法:SD雄性大鼠24只,随机分为正常组、模型组、针刀组及电针组。采用左侧第3腰椎横突尖部埋置明胶海绵法建立第3腰椎横突综合征模型,针刀组和电针组分别给予针刀松解和电针左侧'肾俞''腰阳关'治疗。应用原位杂交方法检测大鼠下丘脑前阿黑皮素(POMC)mRNA、前脑啡肽原(PPE)mRNA阳性细胞的表达。结果:造模后大鼠下丘脑POMC mRNA、PPE mRNA的阳性细胞表达较正常组增多(P<0.01),针刀组和电针组大鼠下丘脑POMC mRNA、PPE mRNA阳性细胞表达较模型组进一步增多(P<0.01)。结论:针刀松解法与电针可能通过促进下丘脑POMC mRNA、PPE mRNA的表达,参与其镇痛过程。 | 郭长青 曹榕娟 孙红梅 Seyed Javad Mojtabavi 马惠芳 吴海霞 许红 李晓泓 刘乃刚 张义 岳利锋 乔晋琳 陈占禄 | 2010 | 针刺研究2010，35，5： | 13 |
| 6 | Simultaneous effects of joint spacing and joint orientation on the penetration rate of a single disc cutter显示文摘This paper describes the influence of joint spacing and joint orientation on the penetration rate of a Tunnel Boring Machine(TBM) disc cutter as modeled by the Discrete Element Method(DEM).The input data for the simulations were obtained from the sandstone along the Alborz tunnel that is currently being excavated in Iran using a 5.2 m diameter open TBM.Three joint spacings,150,200,and 300 mm,were modeled together with seven values of joint orientation;0°,15°,30°,45°,60°,75°,and 90°.The results show that the penetration increases when joint orientation increases from 0° to 75°,but it decreases as the joint orientation increases further from 75° to 90°.This is true for each joint spacing.In addition,for a given joint orientation increasing the joint spacing causes the TBM penetration to decrease.The optimum joint orientation,from the viewpoint of TBM penetration,is about 60-75°. | Bejari Hadi Kakaie Reza Ataei Mohammad Khademi-Hamidi Javad | 2011 | Mining Science and Technology2011，21，4： | 13 |
| 7 | Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response显示文摘AIM: To investigate the co-incidence of apoptosis, autophagy, and unfolded protein response(UPR) in hepatitis B(HBV) and C(HCV) infected hepatocytes.METHODS: We performed immunofluorescence confocal microscopy on 10 liver biopsies from HBV and HCV patients and tissue microarrays of HBV positive liver samples. We used specific antibodies for LC3β, cleaved caspase-3, BIP(GRP78), and XBP1 to detect autophagy, apoptosis and UPR, respectively. AntiHCV NS3 and anti-HBs antibodies were also used to confirm infection. We performed triple blind counting of events to determine the co-incidence of autophagy(LC3β punctuate), apoptosis(cleaved caspase-3), and unfolded protein response(GRP78) with HBV and HCV infection in hepatocytes. All statistical analyses were performed using SPSS software for Windows(Version 16 SPSS Inc, Chicago, IL, United States). P-values < 0.05 were considered statistically significant. Statistical analyses were performed with Mann-Whitney test to compare incidence rates for autophagy, apoptosis, and UPR in HBV- and HCV-infected cells and adjacent noninfected cells.RESULTS: Our results showed that infection of hepatocytes with either HBV and HCV induces significant increase(P < 0.001) in apoptosis(cleavage of caspase-3), autophagy(LC3β punctate), and UPR(increase in GRP78 expression) in the HCV- and HBVinfected cells, as compared to non-infected cells of the same biopsy sections. Our tissue microarray immunohistochemical expression analysis of LC3β in HBV^(Neg) and HBV^(Pos) revealed that majority of HBVinfected hepatocytes display strong positive stainingfor LC3β. Interestingly, although XBP splicing in HBVinfected cells was significantly higher(P < 0.05), our analyses show a slight increase of XBP splicing was in HCV-infected cells(P > 0.05). Furthermore, our evaluation of patients with HBV and HCV infection based on stage and grade of the liver diseases revealed no correlation between these pathological findings and induction of apoptosis, autophagy, and UPR.CONCLUSION: The results of this study indicate that HCV and HBV infection activates apoptosis, autophagy and UPR, but slightly differently by each virus. Further studies are warranted to elucidate the interconnections between these pathways in relation to pathology of HCV and HBV in the liver tissue. | Behzad Yeganeh Adel Rezaei Moghadam Javad Alizadeh Emilia Wiechec Seyed Moayed Alavian Mohammad Hashemi Bita Geramizadeh Afshin Samali Kamran Bagheri Lankarani Martin Post Payam Peymani Kevin M Coombs Saeid Ghavami | 2015 | World Journal of Gastroenterology2015，21，47： | 13 |
| 8 | Resistance of Helicobacter pylori to furazolidone and levofloxacin: A viewpoint显示文摘In their review, Arslan et al[1] did not describe the status of Helicobacter pylori(H. pylori) treatment with furazolidone and the resistance to this antibiotic. We have presented different surveys showing the resistance of H. pylori to furazolidone from Asia and South America. The resistance rates varied but were mostly low(< 5%). There are not enough data on its efficacy and resistance in the United States and Europe. H. pylori mutations occurring in the oor D gene, including A041 G, A122 G, C349A(G), A78 G, A112 G, A335 G, C156 T and C165 T, and in the por D gene, including G353 A, A356 G, C357 T, C347 T, C347 G and C346 A, have been indicated to be possibly related to the observed resistance. Additionally, to complete Arslan et al 's statement regarding levofloxacin resistance, it should be noted that compound mutations of N87 A, A88 N and V65 I at codon Asn-87 were recently observed in the gyr A gene for the first time. However, the results on these topics are not sufficient, and more worldwide studies are suggested. | Mohammad Zamani Arash Rahbar Javad Shokri-Shirvani | 2017 | World Journal of Gastroenterology2017，23，37： | 10 |
| 9 | An efficient hybrid evolutionary optimization algorithm based on PSO and SA for clustering显示文摘The K-means algorithm is one of the most popular techniques in clustering. Nevertheless, the performance of the Kmeans algorithm depends highly on initial cluster centers and converges to local minima. This paper proposes a hybrid evolutionary programming based clustering algorithm, called PSO-SA, by combining particle swarm optimization (PSO) and simulated annealing (SA). The basic idea is to search around the global solution by SA and to increase the information exchange among particles using a mutation operator to escape local optima. Three datasets, Iris, Wisconsin Breast Cancer, and Ripley's Glass, have been considered to show the effectiveness of the proposed clustering algorithm in providing optimal clusters. The simulation results show that the PSO-SA clustering algorithm not only has a better response but also converges more quickly than the K-means, PSO, and SA algorithms. | Taher NIKNAM Babak AMIRI Javad OLAMAEI Ali AREFI | 2009 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2009，10，4： | 9 |
| 10 | Achalasia: A review of Western and Iranian experiences显示文摘Achalasia is a primary motor disorder of the eso-phagus, in which esophageal emptying is impaired. Diagnosis of achalasia is based on clinical fi ndings. The diagnosis is confirmed by radiographic, endoscopic, and manometric evaluations. Several treatments for achalasia have been introduced. We searched the PubMed Database for original articles and meta-analyses about achalasia to summarize the current knowledge regarding this disease, with particular focus on different procedures that are used for treatment of achalasia. We also report the Iranian experience of treatment of this disease, since it could be considered as a model for medium-resource countries. Myotomy, particularly laparoscopic myotomy with fundoplication, is the most effective treatment for achalasia. Compared to other treatments, however, the initial cost of myotomy is usually higher and the recovery period is longer. When performing myotomy is not indicated or not possible, graded pneumatic dilation with slow rate of balloon inflation seems to be an effective and safe initial alternative. Injection of botulinum toxin into the lower esophageal sphincter before pneumatic dilation may increase remission rates. However, this needs to be conf irmed in further studies. Due to lack of adequate information regarding the role of expandable stents in the treatment of achalasia, insertion of stents does not currently seem to be a recommended treatment. In summary, laparoscopic myotomy can be considered as the procedure of choice for treatment of achalasia. Graded pneumatic dilation is an effective alternative when the performance of myotomy is not possible for any reason. | Javad Mikaeli Farhad Islami Reza Malekzadeh | 2009 | World Journal of Gastroenterology2009，15，40： | 9 |
| 11 | Automatic Guidance of an Agricultural Tractor along with the Side Shift Control of the Attached Row Crop Cultivator显示文摘 | Javad Robati Hossein Navid Mahdi Rezaei Amir Rikhtehgar Ghiasi | 2012 | Journal of Agricultural Science and Technology(B)2012，2，1： | 8 |
| 12 | Zinc oxide nanoparticles:A highly efficient and readily recyclable catalyst for the synthesis of xanthenes显示文摘为 1,8-dioxooctahydroxanthenes 和 14-aryl-14H-dibenzo 的合成的一条新奇、有效的线路[一, j ] 氧杂蒽在没有溶剂的条件下面用 ZnO nanoparticles 与各种各样的芳基醛通过 dimedone 和 2 萘粉的一个壶多部件反应被描述。这个方法在装载的优秀收益,短反应时间,可重用性和低催化剂的条款为氧杂蒽的合成提供一条新奇、改进的小径。 | Javad Safaei-Ghomi Mohammad Ali Ghasemzadeh | 2012 | Chinese Chemical Letters2012，23，11： | 7 |
| 13 | Application of analytical hierarchy process to selection of primary crusher显示文摘Selection of crusher required a great deal of design based on the mining plan and operation input.Selection of the best primary crusher from all of available primary crushers is a Multi-Criterion Decision Making(MCDM) problem. In this paper, the Analytical Hierarchy Process(AHP) method was used to selection of the best primary crusher for Golegohar Iron Mine in Iran. For this reason, gyratory, double toggle jaw, single toggle jaw, high speed roll crusher, low speed sizer, impactor, hammer mill and feeder breaker crushers were considered as alternatives and capacity, feed size, product size, rock compressive strength, abrasion index and mobility of crusher were considered as criteria. As a result of our study, the gyratory crusher was offered as the best primary crusher for the studied mine. | Rahimdel Mohammad Javad Ataei Mohammad | 2014 | International Journal of Mining Science and Technology2014，24，4： | 6 |
| 14 | Scale adaptive simulation of vortex structures past a square cylinder显示文摘The scale adaptive simulation(SAS) turbulence model is evaluated on a turbulent flow past a square cylinder using the open-source CFD package OpenF OAM 2.3.0. Two and three-dimensional simulations are performed to determine global quantities like drag and lift coefficients and Strouhal number in addition to mean and fluctuating velocity profiles in the recirculation and wake regions. SAS model is evaluated against the Shear Stress Transport k-w(SST) model and also compared with previously reported results based on DES, LES and DNS turbulence approaches. Results show that global quantities along with mean velocity profiles are well-captured by 2-D SAS model. The 3-D SAS model also succeeded in providing comparable results with recently published DES study on Reynolds shear stress and velocity fluctuation components using about 12 times lower computational cost. It is shown that large values of the SAS model constant result in too dissipative behavior, so that proper calibration of the SAS model constant for different turbulent flows is vital. | Javad Aminian | 2018 | Journal of Hydrodynamics2018，30，4： | 6 |
| 15 | 纳米SiO_2负载Preyssler杂多酸催化剂对水杨酸与苄醇或脂肪醇酯化反应的催化性能(英文)显示文摘An efficient and environmentally benign procedure for the catalytic esterification of salicylic acid with aliphatic alcohols, CnH2n+1OH(n=1-5)and benzylic alcohols,RC6H4CH2OH(R=H,NO2,OCH3,Br,Cl,Me)was developed using nano-SiO2-supported Preyssler heteropolyacid both under thermal conditions and microwave irradiation.Silica nanostructures were obtained through a sol-gel method and were characterized by transmission electron microscopy and powder X-ray diffraction.The effects of various parameters such as solvent type,molar ratio of substrates,Preyssler heteropolyacid loading on silica,catalyst amount,temperature,and reaction time were studied and the optimum conditions were obtained.It has been found that the catalyst with 30 wt%loading is highly active and shows high yields in esterification reactions.The use of nano-SiO2-supported Preyssler heteropolyacid coupled with microwave irradiation allows a solvent-free,rapid(3 min),and high-yielding reaction.This catalyst can be easily recovered and reused for many times without a significant loss in its activity. | Fatemeh F. BAMOHARRAM Majid M. HERAVI Javad EBRAHIMI Ali AHMADPOUR Mojtaba ZEBARJAD | 2011 | 催化学报2011，32，5： | 6 |
| 16 | Occult hepatitis B virus infection and cryptogenic chronic hepatitis in an area with intermediate prevalence of HBV infection显示文摘瞄准:在伊朗的病人在长期的肝炎的致病估计秘密 HBV 感染的可能的角色。方法:在自体免疫、新陈代谢、病毒的病原学的排除以后,有 histologic 和长期的肝炎和否定 HBsAg 的生物化学的特征的 104 个连续成年病人在学习被注册。有 150 x 10 的敏感(3 ) 的质的 PCR copies/L,用二,为 Pre-S 和核心区域的教材被使用在病人的浆液测量 HBV DNA 的存在。结果:所有 104 个病人完成了学习。质的 HBV DNA 在二个病人(1.9%) 是积极的。结论:秘密 HBV 感染在伊朗的病人在起因不明的长期的肝炎的致病有可以忽略的角色。 | Mohammad Javad Kaviani Behzad Behbahani Mohammad Jafar Mosallaii Fatemeh Sari-Aslani Seyed Alireza Taghavi | 2006 | World Journal of Gastroenterology2006，12，31： | 6 |
| 17 | Preconcentration of rare earth elements from Iranian monazite ore by spiral separator using multi-response optimization method显示文摘The present work dealt with the preconcentration of rare earth elements in Saghand ore(Yazd province,Iran)which was achieved by Humphrey spiral using orthogonal optimization method after scrubbing the sample at 45%solid pulp density for 30 min.The pulp was diluted and was fed to a Humphrey spiral for upgrading.The process parameters considered were feed size,feed solids and feed rate,and Taguchi’s L9(34)orthogonal array(OA)was selected for optimization of the process.The results show that the feed rate and feed size were more significant than the other operation parameters of the process.It was also found that under optimal conditions,the concentrate grade of rare earth elements increased from2860 10 6to 6050 10 6and recovery reached to 58%. | Khanchi Ali Reza Sedighi Hassan Ansar Sheida Fasihi Javad | 2014 | International Journal of Mining Science and Technology2014，24，1： | 5 |
| 18 | Tempering Behavior of 4.5Cr-2W-0.25V Steel显示文摘The tempering behavior of a Cr-W-V steel was investigated in this research.This new alloy with the composition of Fe-4.5Cr-2W-0.25V-0.1C was austenitized at 1000 ℃ for 30 min and tempered at 600 and 700 ℃ for different time up to 100 h.An OM analysis of the microstructure of air cooled and water quenched specimens before tempering showed that although under both conditions fully martensitic matrix formed,finer structure had formed in the water quenched specimens.The XRD and TEM results showed that the most stable carbides formed during tempering of the steel were M23C6 and M7C3,respectively.Other carbides such as M3C and M2C,formed in the first stages of tempering,and stable MC were also observed.The results showed that when the tempering time,temperature and cooling rate were increased,mass percent of extracted precipitates was increased.In addition,the formation rate of the stable carbides such as M23C6 and dissolution rate of the metastable carbides such as M3C and M2C were increased. | Mohsen Asadi Asadabad Shahram Kheirandish Abdul Javad Novinrooz | 2010 | Journal of Iron and Steel Research(International)2010，17，10： | 5 |
| 19 | 近视眼准分子激光角膜切削术后的对比敏感度评价(英文)显示文摘目的:评价近视患者PRK术后的对比敏感度变化。方法:应用CSV-1000E图表对41例接受NidekEC-5000型准分子激光仪行PRK手术的患者,行单眼对比敏感度测量。患者术前平均屈光度为-2.62±1.33D(范围从-0.75至-4.00D)。应用CSV-1000E对比敏感度仪分别在术前,术后1wk;1,3,6mo行对比敏感度检查。结果:将每个空间频率的对比敏感度对数值进行统计学分析,并应用图表与正常值进行比较。结果显示对比敏感度在术后1wk及术后1mo时明显降低,从第1mo开始,对比敏感度尤其是低空间频率的对比敏感度快速恢复,在第3mo,只有6和12cpd两种空间频率的对比敏感度明显降低,在术后6mo时,所有频率的对比敏感度功能都明显增加。结论:PRK术后患者第1mo对比敏感度功能明显降低,但在术后6mo时对比敏感度功能即恢复至术前水平。 | Mahmoud Jabbarvand Javad Bakhshi Mohammad Taher Rajabi | 2007 | 国际眼科杂志2007，7，4： | 5 |
| 20 | Fuzzy TOPSIS method to primary crusher selection for Golegohar Iron Mine(Iran)显示文摘Selection of the crusher required a great deal of design regarding to the mine planning. Selection of suitable primary crusher from all of available primary crushers is a multi-criterion decision making(MCDM) problem. The present work explores the use of technique for order performance by similarity to ideal solution(TOPSIS) with fuzzy set theory to select best primary crusher for Golegohar Iron Mine in Iran. Gyratory, double toggle jaw, single toggle jaw, high speed roll crusher, low speed sizer, impact crusher, hammer mill and feeder breaker crushers have been considered as alternatives. Also, the capacity, feed size, product size, rock compressive strength, abrasion index and application of primary crusher for mobile plants were considered as criteria for solution of this MCDM problem. To determine the order of the alternatives, closeness coefficient is defined by calculating the distances to the fuzzy positive ideal solution(FPIS) and fuzzy negative ideal solution(FNIS). Results of our work based on fuzzy TOPSIS method show that the gyratory is the best primary crusher for the studied mine. | Mohammad Javad Rahimdel Mohammad Karamoozian | 2014 | Journal of Central South University2014，21，11： | 5 |
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