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| 1 | Blood glucose response after oral intake of lactulose in healthy volunteers:A randomized,controlled,cross-over study显示文摘AIM To investigate possible changes of blood glucose levels after oral intake of lactulose in healthy subjects.METHODS The study was performed as prospective, randomized, two-part study with 4-way cross-over design with n = 12 in each study arm. Capillary blood glucose levels were determined over a time period of 180 min after intake of a single dose of 10 g or 20 g lactulose provided as crystal or liquid formulation. During the manufacturing process of lactulose, impurities with sugars(e.g., lactose, fructose, galactose) occur. Water and 20 g glucose were used as control and reference. Because lactulose is used as a functional food ingredient, it may also be consumed by people with impaired glucose tolerance, including diabetics. Therefore, it is of interest to determine whether the described carbohydrate impurities may increase blood glucose levels after ingestion. RESULTS The blood glucose concentration-time curves after intake of 10 g lactulose, 20 g lactulose, and water were almost identical. None of the three applications showed any changes in blood glucose levels. After intake of 20 g glucose, blood glucose concentration increased by approximately 3 mmol/L(mean Cmax = 8.3 mmol/L), reaching maximum levels after approximately 30 min and returning to baseline within approximately 90 min, which was significantly different to the corresponding 20 g lactulose formulations(P < 0.0001). Comparing the two lactulose formulations, crystals and liquid, in the dosage of 10 g and 20 g, there was no difference in the blood glucose profile and calculated pharmacokinetic parameters despite the different amounts of carbohydrate impurities(1.5% for crystals and 26.45% for liquid). Anyhow, the absolute amount of single sugars was low with 0.3 g in crystals and 5.29 g in liquid formulation in the 20 g dosages. Lactulose was well tolerated by most volunteers, and only some reported mild to moderate mainly gastrointestinal side effects. CONCLUSION The unchanged blood glucose levels after lactulose intake in healthy subjects suggest its safe use in subjects with impaired glucose tolerance. | Jasmin Steudle Christiane Schon Manfred Wargenau Lioba Pauly Susann Schwejda-Güttes Barbara Gaigg Angelika Kuchinka-Koch John F Stover | 2018 | World Journal of Gastrointestinal Pharmacology and Therapeutics2018，9，3： | 4 |
| 2 | Whole-genome amplification enables accurate genotyping for microarray-based high-density single nuclcotide polymorphism array显示文摘 | Jasmine F Ahsan H Andrulis IL | 2008 | Cancer Epidemiol Biomarkers Prev2008，17，12： | 1 |
| 3 | Commercial- ization of the hydrolytic kinetic resolution of racemic ep- oxides: toward the economical large - scale productionof enantiopure epichlorohydrin 显示文摘 | Larrow J F Hemberger K E Jasmin S | 2003 | Tetrahedron : Asym- metry2003，14，： | 1 |
| 4 | Contractual govern- ance relational governance, and the performance of in- terfirm service exchanges: the influence of boundary- spanner closeness显示文摘 | Ronald J F Michele P Jasmin B | 2005 | Journal of the Academy of Mar- keting Science2005，33，2： | 1 |
| 5 | Severely reduced female fertility in CD9-deficient mice 显示文摘 | Le Naour F Rubinstein E Jasmin C Prenant M & Boucheix C | 2000 | Science2000，287，： | 1 |
| 6 | Severely reduced female fertility in CDg-deficient mice 显示文摘 | LE NAOUR F RUBINSTEIN E JASMIN C | 2000 | Science2000，287，： | 1 |
| 7 | Ultracision versus electrocaatery in performing modified radical mastectomy and axillary lymph node dissection for breast cancer: a prospective randomized control trial显示文摘 | Rohaizak M Khan F J Jasmin JS | 2013 | Med J Malaysia2013，68，3： | 1 |
| 8 | Effects of an- tioxidant components of AREDS vitamins and zinc ions on endothe- lial cell activation:implications for macular degeneration显示文摘 | Zeng Shemin Hern6ndez Jasmine MuUins Robert F | 2012 | Inves- tigative ophthalmology & visual science2012，53，2： | 1 |
| 9 | Analysis of stress in bone and microimplants during en-masse retraction of maxillary and mandibular anterior teeth with different insertion angulations:a 3-dimensional finite element analysis study显示文摘 | Jasmine MIF Yezdani AA Tajir F | 2012 | Am J Orthod Dentofacial Orthop2012，141，1： | 1 |
| 10 | A study on the heavy metal fixation on fly ash blended显示文摘 | Jasmine F Show K Y Koel | 2005 | Inst Energy2005，45，1： | 1 |
| 11 | Multffoeality and recurrence risk:A quantitative model of field eaneerization显示文摘 | Jasmine F Kevin L Mare DR | 2014 | J Theor Bio12014，21，355： | 1 |
| 12 | Lung structural re modeling and pulmonary hypertension after myocardial infarction: complete reversal with irbesartan 显示文摘 | Jasmin J F Calderone A Leung T K | 2003 | Cardiovase Res2003，58，3： | 1 |
| 13 | Changes in gene expression profiles in responseto selenium supplementation among individuals with arsenic-induced premalignantskin lesions显示文摘 | Kibriya MG Jasmine F Argos M | 2007 | Toxicol Lett2007，169，： | 1 |
| 14 | Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic- induced pre- malignant skin lesions显示文摘 | Kibriya MG Jasmine F Argos M | 2007 | Toxicol Lett2007，169，2： | 1 |
| 15 | Framework stability of nanocrystalline Na Y in aqueous solution at varying Ph显示文摘 | ANTON P JASMINE F SARAH C L | 2010 | Langmuir2010，，9： | 1 |
| 16 | Contractual Governance, Relational Governance, and the performance of interfirm service exchanges : The influence of Boundary - Spanner Closeness 显示文摘 | RONALD J F MICHELE P JASMIN B | 2005 | Journal of the Academy of Marketing Science2005，33，2： | 1 |
| 17 | Commercialization of the hydrolytic kinetic resolution of racemic epoxides: Toward the economical large-scale production of enantiopure epichlorohydrin显示文摘 | LARROW J F HEMBERGER K E JASMIN S | 2003 | Tetrahedron: Asymmetry2003，14，22： | 1 |
| 18 | Caveolin-1 deficiency increases cerebral ischemic injury 显示文摘 | Jasmin J F Malhotra S Singh D M | 2007 | Circ Res2007，100，5： | 1 |
| 19 | Analysis of stress in bone and micro implants during en-masse retraction of maxillary and mandibular anteriorteeth with different inser-tion angulations:a 3-dimensional finite element analysis study 显示文摘 | Jasmine MI Yezdani AA Tajir F | 2012 | Am J Orthod Dentofacial Orthop2012，141，1： | 1 |
| 20 | Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, double-blind, placebo-controlled trial显示文摘 | Jean-Claude Tardif John JV McMurray Eric Klug Robert Small Jennifer Schumi Jasmine Choi Jim Cooper Robert Scott Eldrin F Lewis Philippe L L’Allier Marc A Pfeffer | 2008 | The Lancet2008，，9626： | 1 |
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