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| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Fibrosing cholestatic hepatitis following cytotoxic chemotherapy for small-cell lung cancer显示文摘Fibrosing cholestatic hepatitis(FCH) is a variant of viral hepatitis reported in hepatitis B virus or hepatitis C virus infected liver,renal or bone transplantation recipients and in leukemia and lymphoma patients after conventional cytotoxic chemotherapy.FCH constitutes a well-described form of fulminant hepatitis having extensive fibrosis and severe cholestasis as its most characteristic pathological findings.Here,we report a case of a 49-year-old patient diagnosed with small-cell lung cancer who developed this condition following conventional chemotherapy-induced immunosuppression.This is the first reported case in the literature of FCH after conventional chemotherapy for a solid tumor.In addition to a detailed report of the case,a physiopathological examination of this potentially life-threatening condition and its treatment options are discussed. | Jaime Ceballos-Viro José M López-Picazo José L Pérez-Gracia Jesús J Sola Gregorio Aisa Ignacio Gil-Bazo | 2009 | World Journal of Gastroenterology2009，15，18： | 3 |
| 3 | Characterization of intrapelvic pressure during ureteropyeloscopy with ureteral access sheaths显示文摘 | Jamil Rehman Manoj Monga Jaime Landman David I Lee Tamer Felfela Marius C Conradie Rajamahanty Srinivas Chandru P Sundaram Ralph V Clayman | 2003 | Urology2003，，4： | 2 |
| 4 | Managing Solitarg Pulmonarg nodules显示文摘 | Jaim P KathaWalla S A Arroliga A c | 1998 | Cleve Clin J Med1998，65，6： | 1 |
| 5 | Methods of analysis and separation of chiral flavonoids显示文摘 | JAIME A Y ANDREWS P K DAVIES N M | 2007 | Journal of Chromatography B2007，848，： | 1 |
| 6 | Frequencies of virus-specific CD4 + and CD8 + T lymphocytes secreting gamma interferon after acute natural rotavirus infection in children and adults显示文摘 | Jaimes MC Rojas OL González AM Cajiao I Charpilienne A Pothier P | 2002 | J Virol2002，76，10： | 1 |
| 7 | Population genetic structure of the Humboldt squid ( Dosidicus gigas d' Orbigny, 1835 ) inferred by mitochondrial DNA analysis 显示文摘 | Sandoval-Castellanos E Uribe-Alcocer M Dfaz- Jaimes P | 2010 | Experimental Marine Biology and Ecology2010，385，12： | 1 |
| 8 | Human glomerular endothelium : interplay among glucose, free fatty acids, angiotensin II, and oxidative stress 显示文摘 | Jaimes EA Hua P Tian RX | 2010 | Am J Physiol Renal Physiol2010，298，1： | 1 |
| 9 | Grazing effect on diversity of annual plant communities in a semi-arid rangeland:Interactions with small-scale spatial and temporal variation in primary productivity显示文摘 | YAGIL O AVI P JAIME K | 2002 | Journal of Ecology2002，90，： | 1 |
| 10 | Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation显示文摘 | Jaime L Tartar Christopher P Ward James T McKenna | | 0，，10： | 1 |
| 11 | Elemental composition,biochemical composition and caloric value of Antarctic krill:Implications in energetics and carbon balances显示文摘 | Jaime F L Raymond G Mayzaud P | 2009 | Journal of Marine Systems2009，，78： | 1 |
| 12 | Detailed and averaged models for a 401-level MMC-HVDC system显示文摘 | JAIME P HANI S SEBASTIEN D | 2012 | IEEE Transactions on Power Delivery2012，27，3： | 1 |
| 13 | Site productivity and plant size explain the response of annual species to grazing exclusion in a Mediterranean semiarid rangeland显示文摘 | YAGIL O AVI P JAIME K | 2004 | Journal of Ecology2004，92，： | 1 |
| 14 | Engineering geological mapping developed in the Fortaleza Metropolitan Region, State of Ceara, Brazil显示文摘 | Lazaro V Z Osni J P Jaime S C | 2004 | Engineering Geology2004，71，： | 1 |
| 15 | Carbon-13 NMR chemical shifts:a single rule to determine theconformation of calix arenas显示文摘 | Jaime C De Mendoza Javier Prados P et a l | 1991 | J Org Chem1991，56，10： | 1 |
| 16 | The application of synchrotron-based spectroscopic techniques to the study of chromate conversion coatings 显示文摘 | Vasquez Jaime M Halada G P | 2002 | Electrochimica Acta2002，47，19： | 1 |
| 17 | The shell microstructure, mineralogyy and isotopic composition of Amussiopecten baranensis (Pectinidae, Bivalvia) from the miocene of span: a valuable paleoenvironmental tool显示文摘 | Isabel Z Jaime D P Antonio V | 1996 | Geobios1996，29，6： | 1 |
| 18 | Parallelized multilevel characteristic basis function method for solving electromagnetic scattering problems 显示文摘 | Jaime L Marcos R P and Raj M et aL | 2009 | Microwave and Optical Technology Letters2009，51，12： | 1 |
| 19 | Potential sources of error in parentage assessment of terbot ( Scophthalmus maximus ) using microsatellite loci 显示文摘 | Jaime C Carmen B Pablo P | 2004 | Aquaculture2004，242，： | 1 |
| 20 | Exploringthe driving forces behind deforestation in the state ofMexico (Mexico) using geographically weighted regres-sion显示文摘 | Jaimes N B P Sendra J B Delgado M G | 2010 | Applied Geography2010，30，： | 1 |
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