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| 1 | H pylori and host interactions that influence pathogenesis显示文摘H pylori is probably the most prevalent human patho- gen worldwide. Since it was initially suggested in 1983 by Marshall and Warren to be implicated in gastritis and peptic ulcer disease, H pylori has also been implicated in gastric carcinoma and was classified as a class I car- cinogen. In the last two decades, a noteworthy body of research has revealed the multiple processes that this gram negative bacterium activates to cause gastroduo- denal disease in humans. Most infections are acquired early in life and may persist for the life of the individual. While infected individuals mount an inflammatory re- sponse that becomes chronic, along with a detectable adaptive immune response, these responses are ineffec- tive in clearing the infection. H pylori has unique features that allow it to reside within the harsh conditions of the gastric environment, and also to evade the host immune response. In this review, we discuss the various virulence factors expressed by this bacterium and how they inter- act with the host epithelium to influence pathogenesis. | Ellen J Beswick Giovanni Suarez Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，35： | 20 |
| 2 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 3 | H pylori receptor MHC classⅡcontributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC classⅡin the modulation of gastric epithelial cell apoptosis induced by H pylon infection. METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specific for MHC classⅡand CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a fluorometric assay, a cytometric bead array, and confocal microscopy, respectively. RESULTS: Pretreatment of N87 cells with the anti-MHC classⅡIgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class n resulted in markedly reduced caspase activation, while simple ligation of MHC classⅡdid not. Crosslinking of MHC class n also resulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC classⅡIgM blocked the recruitment of FADD to the cell surface. CONCLUSION: The ability of MHC class n to modulate gastric epithelial apoptosis is at least partially dependent on its crosslinking. The crosslinking of this molecule has anti-apoptotic effects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC classⅡto modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 4 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 5 | H pylori receptor MHC class Ⅱ contributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC class Ⅱ in the modulation of gastric epithelial cell apoptosis induced by H pylori infection.METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specifi c for MHC class Ⅱ and CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a ? uorometric assay, a cytometric bead array, and confocal microscopy, respectively.RESULTS: Pretreatment of N87 cells with the anti-MHC class Ⅱ IgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class Ⅱ resulted in a marked re-duced caspase activation, while simple ligation of MHC class Ⅱ did not. Crosslinking of MHC class Ⅱ also re-sulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC class Ⅱ IgM blocked the recruitment of FADD to the cell surface.CONCLUSION: The results presented here demonstrate that the ability of MHC class Ⅱ to modulate gastric epi-thelial apoptosis is at least partially dependent on its crosslinking. Furthermore, while previous research has demonstrated that MHC class Ⅱ signaling can be pro-apoptotic during extended ligation, we have shown that the crosslinking of this molecule has anti-apoptotic ef-fects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC class Ⅱ to modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，33： | 2 |
| 6 | Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis显示文摘 | Suarez Y Fernandez Hernando C Yu J | 2008 | Proc Natl Acad Sci USA2008，105，14： | 1 |
| 7 | Biochemical traits and antimicrobial susceptibility of Streptococcus suis isolated from slaughtered pigs显示文摘 | Prieto C Garcia F J Suarez P | 1994 | J Vet Med1994，41，9： | 1 |
| 8 | Effect of transglutaminase- induced cross - linking on gelation of myofibrillar/soy protein mixtures 显示文摘 | Ramirez- Suarez J C Xiong Y L | 2003 | Meat Science2003，65，： | 1 |
| 9 | Ni- tric oxide synthase inhibition and food intake effects on motivation to eat and in female mice 显示文摘 | MORLEY J E FARR S A SUAREZ M D | 1995 | Pharma- cology Biochemistry and Behavior1995，50，3： | 1 |
| 10 | Effect of age of feed restriction and microelement supplementa- tion to control ascites on production and carcass charac- teristics of broilers 显示文摘 | Camacho M A Suarez M E Herrera J G | 2004 | Poultry Science2004，，83： | 1 |
| 11 | Ethyl carbamate production by selected yeasts and lactic acid bacteria in red wine显示文摘 | UTHURRY C A SUAREZ LEPE J A | 2006 | Food Chem2006，94，2： | 1 |
| 12 | Thermal and narrowband multispectral remote sensing for vegetation monitoring from an un- manned aerial vehicle显示文摘 | Berni J Zarco-Tejada P J Suarez L | 2009 | IEEE Transactions on Geoscience and Re- mote Sensing2009，47，3： | 1 |
| 13 | A simple framework for examing the interannual variability of land surface moisture flux-es显示文摘 | Koster R D Suarez M J | | 0，，12： | 1 |
| 14 | Effect of pH on saturated hydraulic conductivity and soil dispersion显示文摘 | Suarez D L Rhoades J D Savado R | 1984 | Soil Sci Soc Am J1984，，48： | 1 |
| 15 | Phospholipase A2-activating protein (PLAA) enhances crsplatin-induced apoptosis in HeLa cells显示文摘 | Zhang F Suarez G Sha J | 2009 | Cell Signal2009，21，7： | 1 |
| 16 | Selective catalytic hydrodimerization of 1, 3-butadiene by palladium compounds dissolved in ionic liquids 显示文摘 | Dullius J E L Suarez P A Z Einloft S | 1998 | Organometalllcs1998，17，5： | 1 |
| 17 | Strategies for survival in fast changing industries显示文摘 | CHRISTENSEN C SUAREZ F UTTERBACK J | 1998 | Management Science1998，44，8： | 1 |
| 18 | Ultrasonic endoscope显示文摘 | DiMagno E P Buxton J L Regan P T Hattery R R Wilson D A Suarez J R | 1980 | Lancet1980，1，： | 1 |
| 19 | Design and Performance Analysis of a Massively Parallel Atmospheric General Circulation Model显示文摘 | Schaffer D S Suarez M J | 2000 | Scientific Programming2000，8，1： | 1 |
| 20 | Ionic liquid(molten salt) phase organometallic catalysis显示文摘 | Dupont J Souza R F D Suarez P A Z | 2002 | Chem Rev2002，102，： | 1 |
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