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| 1 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 2 | 叶酸与甲酰四氢叶酸用于减少甲氨蝶呤治疗副作用(摘要)显示文摘1 背景 甲氨蝶呤用于治疗许多风湿病,其短期疗效已被证实。但毒性使不少患者不能从中受益,其中叶酸缺乏可增加其毒性。类风湿关节炎患者常有叶酸缺乏,经甲氨蝶呤治疗后叶酸储备就进一步减少。甲氨蝶呤的胃肠道和血液学副作用都与叶酸缺乏有关,可以预见,叶酸补充疗法将有助改善低剂量甲氨蝶呤治疗的副作用。对此,已有不少试验开展,并提出不同的副作用减少率。 | Ortiz Z SheaB Suarez Almazor M Moher D Wells G Tugwell P 姚如愚 | 2001 | 循证医学2001，1，1： | 4 |
| 3 | A rapid and sensitive method for simultaneous determination of lamivudine and zidovudine in human serum by on-line solid phase extraction coupled to liquid chromatography/tandem mass spectrometry detection 显示文摘 | Estrela RdeC Salvadori MC Suarez Kurtz G | 2004 | Rapid Commun Mass Spectrom2004，18，10： | 1 |
| 4 | Glutamine synthetase in brain:effect of ammonia显示文摘 | Suarez I Bodega G Fernandez B | 2002 | Neurochem Int2002，41，23： | 1 |
| 5 | Effect of age of feed restriction and microelement supplementa- tion to control ascites on production and carcass charac- teristics of broilers 显示文摘 | Camacho M A Suarez M E Herrera J G | 2004 | Poultry Science2004，，83： | 1 |
| 6 | Phospholipase A2-activating protein (PLAA) enhances crsplatin-induced apoptosis in HeLa cells显示文摘 | Zhang F Suarez G Sha J | 2009 | Cell Signal2009，21，7： | 1 |
| 7 | Usefulness of the myocardial performance index for early detection of anthracycline-induced cardiotoxicity in children 显示文摘 | Eidem B W Sapp B G Suarez C R | 2001 | Am J Cardiol2001，87，9： | 1 |
| 8 | CD34^+ cells from acute myeloid leukemia,myelodysplastic syndromes,and normal bone marrow display different apoptosis and drug resistance-associated phenotypes显示文摘 | Suarez L Vidriales MB Garcia-Larana J Sanz G Moreno MS Lopez A | 2004 | Clin Cancer Res2004，10，22： | 1 |
| 9 | The Internation- al Federation of Digital Seismograph Networks (FDSN) : An Integrated System of Seismological Observatories 显示文摘 | Suarez G van Eck T Giardini D | 2008 | Systems Journal IEEE2008，2，3： | 1 |
| 10 | Plasminogen activator inhibitor-1 :physiological role, regulation, and the influence of common pharmacologic agents 显示文摘 | TSIKOURIS J P SUAREZ J A MEYERROSE G E | 2002 | J Clin Pharmacol2002，42，11： | 1 |
| 11 | Hypotensive action of an aqueous extract of Pimenta dioica (Myrtaceae) in rats显示文摘 | Suarez A Ulate G Ciccio JF | 2000 | Rev Biol Trop2000，48，1： | 1 |
| 12 | Use of dynamic compliance for open lung positive end - expiratory pressure titration in an experimental study 显示文摘 | Suarez Sipmann F Bohm S H Tusman G | 2007 | Crit Care Med2007，35，1： | 1 |
| 13 | Corona loss characteristics of contaminated conductors in fair weather显示文摘 | Membello E E Ratta G Suarez H D | 2001 | Electric Power Systems Research2001，59，1： | 1 |
| 14 | Down-regulation of astroglial proteins in the rat cerebellum after portacaval anastomosis 显示文摘 | Suarez I Bodega G Rubio M | 2005 | Neuropathol Appl Neurobiol2005，31，2： | 1 |
| 15 | Development of a real-time reverse-transcription PCR for deteetien of Newcastle disease virus RNA in clinical samples显示文摘 | Wise M G Suarez D L Seal B S | 2004 | J Clin Microbiol2004，42，： | 1 |
| 16 | Neuroblastoma, gan- glioneuroblastoma and ganglioneuroma: radiologic-pathologic cor relation显示文摘 | Lonergan G J Schwab CM Suarez ES | 2002 | RadioGraphics2002，22，4： | 1 |
| 17 | Expression of B7-H1 on gastric epithelial cells : its potential role in regulating T cells during Helicobacter pylori infection显示文摘 | Das S Suarez G Beswick E | 2006 | J Immunol2006，176，5： | 1 |
| 18 | Persistence of HPV infection and risk of high-grade cervical intraepithelial neo plasia in a cohort of Colombian women显示文摘 | Munoz N Hernandez Suarez G Mendez F | 2009 | British J Cancer2009，，100： | 1 |
| 19 | Helicobaeter pylori Ca- gA-dependent macrophage migration inhibitory factor produced by gastric epithelial cells binds to CD74 and stimulates procarcino- genie events 显示文摘 | Beswick E J Pinchuk IV Suarez G | 2006 | J Immunol2006，176，11： | 1 |
| 20 | Phospholipase A2-activating protein (PLAA) enhances cisplatin-induced apoptosis in HeLa cells显示文摘 | Zhang F Suarez G Sha J | 2009 | Cell Signal2009，21，7： | 1 |
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