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173篇 您的检索式：作者名="J Rutkowski"

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	题名	作者	年代	出处	被引量
1	Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9显示文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors.	Anat Kohn Timothy P Rutkowski Zhaoyang Liu Anthony J Mirando Michael J Zuscik Regis J O'Keefe Matthew J Hilton	2015	Bone Research2015，3，3：	8
2	UPR pathways combine to pre- vent hepatic steatosis caused by ER stress - mediated suppression of transcriptional master regulators 显示文摘	Rutkowski DT Wu J Back SH	2008	Dev Cell2008，15，6：	1
3	Preservation of facial nerve function after resection of vestibular schwannoma显示文摘	Sughrue ME Yang I Rutkowski M J	2010	Br J Neurosurg2010，24，6：	1
4	Imatinib mesy- late in advanced dermatofibrosarooma protuberans: pooled analysis of two phase Ⅱ clinical trials显示文摘	Rutkowski P Van Glabbeke M Rankin C J	2010	J Clin Oneol2010，28，10：	1
5	Evaluation of mast cells and hypoxia inducible factor-1 expression in meningiomas of various grades in correlation with peritumoral brain edema 显示文摘	Reszec J Hermanowicz A Rutkowski R	2013	J Neurooncol2013，115，1：	1
6	Cytokine and cytokine receptor serum levels in adult bone sarcoma patients:correlations with local tumor extent and prognosis显示文摘	Rutkowski P Kaminska J Kowalska M		0，，03：	1
7	A trip to the ER:coping with stress显示文摘	Rutkowski D T Kaufman R J	2004	Trends in Cell Biology2004，14，：	1
8	Mortality following spinal cord injury显示文摘	Yeo JD Walsh J Rutkowski S	1998	Spinal Cord1998，36，5：	1
9	Genetic algorithm based method for optimal analog test points selection 显示文摘	Golonek T Rutkowski J	2007	IEEE Transactions on Circuits and Systems Ⅱ : Express Briefs2007，54，2：	1
10	Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance显示文摘	Rutkowsky J M Wallace B K Wise P M	2011	Am J Physiol Cell Physiol2011，301，1：	1
11	A fast training algorithm for neuralne tworks显示文摘	Rutkowski L	1998	IEEE Transactions on Circuits and Systems-Ⅱ:Analog and Digital Signal Processing1998，15，6：	1
12	Cytokine and cytokine receptor serum levels in adult bone sarcoma patients:correlations with local tumor extent and prognosis 显示文摘	Rutkowski P Kaminska J Kowalska M	2003	J Surg Oncol2003，84，3：	1
13	High skills pay off: the changing wage structure during economic transition in Poland 显示文摘	RUTKOWSKI J	1996	Economics of Transition1996，，4：	1
14	Co-treatment of no-volac and resole-type phenolic resins with coal-tar pitch for por-ous carbons显示文摘	Machnikowski J Rutkowski P Diez M A	2006	J Anal Appl Pyrol2006，76，：	1
15	Genetic-algorithm- based method for optimal analog test points selection 显示文摘	GOLONEK T RUTKOWSKI J	2007	IEEE Transactions on Circuits and Systems Ⅱ: Express Briefs2007，54，2：	1
16	Planar junction formation in HgCdTe infrared detectors 显示文摘	J Rutkowski	2004	Opto-Electronics Review2004，12，1：	1
17	High skills pay off:the changing wage structure during economic transition in Poland显示文摘	Rutkowski J	1996	Economics of Transition1996，，4：	1
18	Transgenic expression of TNF by astrocytes increase mechanical allodynia in a mouse neu- ropathy model显示文摘	Deleonora J A Rutkowski M D	2006	Neuroreport2006，11，3：	1
19	Pladar junction formation in HgCdTe infrared detectors显示文摘	J Rutkowski	2004	Opto-Electronics Review2004，12，1：	1
20	Cytokiness serum levels in softtissure sarcoma pations:correlations with clincio-pathological features and prognosis显示文摘	Rutkowski P Kaminska J Kowalska M	2002	Int J Cancer2002，100，4：	1

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