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| 1 | Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells显示文摘AIM:To determine the effect of ellagic acid on apop-tosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid. METHODS:The effect of ellagic acid on apoptosis was assessed by measuring Phosphatidylserine externalization,caspase activity,mitochondrial membrane potential and DNA fragmentation;and proliferation by measuring DNA thymidine incorporation. Mitochondrial membrane potential was measured in permeabilized cells,and in isolated mitochondria. Nuclear factor kB(NF-kB) activity was measured by electromobility shift assay(EMSA) . RESULTS:We show that ellagic acid,a polyphenolic compound in fruits and berries,at concentrations 10 to 50 mmol/L stimulates apoptosis in human pancreatic adenocarcinoma cells. Further,ellagic acid decreases proliferation by up to 20-fold at 50 mmol/L. Ellagic acid stimulates the mitochondrial pathway of apoptosis associated with mitochondrial depolarization,cytochrome C release,and the downstream caspaseactivation. Ellagic acid does not directly affect mitochondria. Ellagic acid dose-dependently decreased NF-kB binding activity. Furthermore,inhibition of NF-kB activity using IkB wild type plasmid prevented the effect of ellagic acid on apoptosis. CONCLUSION:Our data indicate that ellagic acid stimulates apoptosis through inhibition of the prosu-rvival transcription factor NF-kB. | Mouad Edderkaoui Irina Odinokova Izumi Ohno Ilya Gukovsky Vay Liang W Go Stephen J Pandol Anna S Gukovskaya | 2008 | World Journal of Gastroenterology2008，14，23： | 30 |
| 2 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 3 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 4 | The role of hypofractionation radiotherapy for diffuse intrinsic brainstem glioma in children: a pilot study显示文摘 | Janssens GO Gidding CE Van Lindert E J Oldenburger FR Erasmus CE Schouten-Meeteren A Y Kaanders JH | 2009 | 中国神经肿瘤杂志2009，7，3： | 8 |
| 5 | Endoscopic and anesthetic feasibility of EUS and ERCP combined in a single session versus two different sessions显示文摘AIM:To discuss the feasibility of single session endoscopic ultrasonography(EUS) to discuss and endoscopic retrograde cholangiopancreatography(ERCP) execution.METHODS:Retrospective endoscopic and anesthetic outcome comparison of performing both EUS and ERCP in a single endoscopic session(Group Ⅰ) versus performing each procedure in two different sessions(Group Ⅱ) was made.The following variables were evaluated:epidemiological variables,American Society of Anesthesiologists Physical Status Classification(ASA) level,procedural time,propofol dose,anesthetic complications,endoscopic complications and diagnostic yield,and therapeutic procedures on both groups.T-student,ChiSquare and Fisher test were used for comparison.RESULTS:We included 39 patients in Group Ⅰ(mean age:69.85 ± 9.25;27 men) and 46 in Group Ⅱ(mean age:67.46 ± 12.57;25 men).Procedural time did not differ significantly between both groups(Group Ⅰvs Group Ⅱ:93 ± 32.78 vs 98.98 ± 38.17;P >0.05) but the dose of propofol differed(Group Ⅰ vs Group Ⅱ:322.28 ± 250.54 mg vs 516.96 ± 289.06 mg;P = 0.001).Three patients had normal findings on both explorations.Three anesthetic complications [O2 desaturation(2),broncoaspiration(1)] and 9 endoscopic complications [pancreatitis(6),bleeding(1),perforation(1),cholangitis(1)] occurred without significant differences between both groups(P > 0.05).We did not find any significant difference regarding age,sex,ASA scale level,diagnostic yield or therapeutic maneuvers between both groups.CONCLUSION:The performance of EUS and ERCP in a single session offers a similar diagnostic and therapeutic yield,does not entail a higher complication risk and requires a significantly smaller dose of propofol for sedation compared with performing each exploration in a different session. | Juan J Vila Marcos Kutz Silvia Goi Miriam Ostiz Edurne Amorena Carlos Prieto Cristina Rodriguez Ignacio Fernández-Urien Francisco J Jiménez | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，3： | 3 |
| 6 | Reactivity of blast-furnace slag in Portland cement blends hydrated under different conditions 显示文摘 | Escalantea J I Go'meza L Y Johalb K K | 2001 | Cement and Concrete Research2001，31，10： | 2 |
| 7 | Insulin- leptin - visceral fat relation during weight loss显示文摘 | Yip I Go V L Hershman J M | 2001 | Pancreas2001，23，： | 1 |
| 8 | Critical evaluation of bcl-6 protein expression in diffuse large B-cell lymphoma of the stomach and small intestine显示文摘 | Kwon M S Go J H Choi J S | 2003 | Am J Surg Pathol2003，27，： | 1 |
| 9 | OCT-d controls cell-cycle pro- gression of embryonic stem cells 显示文摘 | Lee J Go Y Kang I | 2010 | Biochem J2010，426，： | 1 |
| 10 | Ecologicallimits to plant phenotypic plasticity 显示文摘 | Valladares F Gianoli E Go mez J M | 2007 | NewPhytologist2007，176，4： | 1 |
| 11 | Assessment of vegetation indices for regional crop green LAI estimation from Landsat images over multiple growing seasons显示文摘 | Jiangui Liu Elizabeth Pattey Guillaume Jégo | 2012 | Remote Sensing of Environment2012，，： | 1 |
| 12 | Flammability limit measurements for dusts in 20-L and 1 m3 vessels显示文摘 | Going J E Chatrathi K Cashdollar K L | 2000 | Journal ofLoss Prevention in the Process Industries2000，13，3： | 1 |
| 13 | Three-tesla imaging of the knee:initial experience显示文摘 | Craig JG Go L Blechinger J | 2005 | Skeletal Radiol2005，34，8： | 1 |
| 14 | Loss of heterozygosity on hromosome 11 and 17 are markers of re curence in TCC of the bladder显示文摘 | Edwards J Duncan P Going J J | 2001 | Br J Cancer2001，85，12： | 1 |
| 15 | Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer显示文摘 | WITTON C J REEVES J R GOING J J | | 0，，03： | 1 |
| 16 | Pediatric tibia I eminence fractures:evaluation and management显示文摘 | Lafrance RM Giordano B Go Idblatt J | | 0，，07： | 1 |
| 17 | Physical Activity Assessment in American Indian Schoolchildren in The Pathways Study 显示文摘 | Going SB Levin S Harrell J oral | 1999 | Am J Clin Nutr1999，，： | 1 |
| 18 | Identification and Re- duction of Gear Whine Noise of the Axle System inaPas- senger Van显示文摘 | LEE S K GO S K YU D J | 2005 | SAE2005，，1： | 1 |
| 19 | Effect of laser shock processing on fatigue crack growth and fracture toughness of 6061-T6 aluminum alloy显示文摘 | Rubio-Gonzalez C Ocan'a J L Go mez-Rosas G | | 0，，1： | 1 |
| 20 | Simplified model of the dynamics of magneto-rheological dampers 显示文摘 | Alexandridis A Go dasz J | 2005 | Mechanics2005，24，2： | 1 |
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