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| 1 | Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets显示文摘AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet model.METHODS: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus infected.After one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber analyses.RESULTS: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P < 0.05).Three days post-infection,marked diarrhea and weight loss were accompanied by sharp reductions in villus height(59%) and lactase activity(91%) and increased crypt depth(21%) in infected compared with non-infected pigs(P < 0.05).Malnutrition also increased crypt depth(21%) compared to full-fed piglets.Villus:crypt ratio was reduced(67%) with viral infection.There was a trend for reduction in transepithelial electrical resistance with rotavirus infection and malnutrition(P = 0.1).3H-mannitol flux was significantly increased(50%;P < 0.001) in rotavirus-infected piglets compared to non-infected piglets,but there was no effect of nutritional status.Furthermore,rotavirus infection reduced localization of the tight junction protein,occludin,in the cell membrane and increased localization in the cytosol.CONCLUSION: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. | Sheila K Jacobi Adam J Moeser Anthony T Blikslager J Marc Rhoads Benjamin A Corl Robert J Harrell Jack Odle | 2013 | World Journal of Gastroenterology2013，19，31： | 4 |
| 2 | Comparison of a computerized physical activity recall with a triaxial motion sensor in middle - school youth 显示文摘 | McMurray R G Harrell J S | 1998 | Med Sci Sports Exerc1998，30，8： | 1 |
| 3 | Physical Activity Assessment in American Indian Schoolchildren in The Pathways Study 显示文摘 | Going SB Levin S Harrell J oral | 1999 | Am J Clin Nutr1999，，： | 1 |
| 4 | Effect of metal additives on L10 ordering of chemically synthesized FePt nanoparticles显示文摘 | Harrell J W Nikles D E Kang S S | 2005 | Scripta Materialla2005，53，： | 1 |
| 5 | Evidence of lung surfactant abnormality in respiratory failure:study of bronchoalveolar Lavage phospholipids,surface activity,phospholipase activity,and plasma myoinositol显示文摘 | Hallman M Spragg R Harrell J H | 1982 | J Clin Invest1982，70，： | 1 |
| 6 | A physical short-channel threshold voltage model for undoped symmetric double-gate MOSFETs显示文摘 | Qiang C Harrell E M I Meindl J D | 2003 | IEEE Transactions on Electron Devices2003，50，7： | 1 |
| 7 | Long-term survival in young women: hazards and competing risks after thyroid cancer 显示文摘 | Stroup AM Harrell C J Herget KA | 2012 | J Cancer Epidemiol2012，2012，64： | 1 |
| 8 | Trace mineral nutrition in poultry and swine 显示文摘 | RICHARDS J D ZHAO J M HARRELL R J | 2010 | Asi- an-Australasian Journal of Animal Sciences2010，23，11： | 1 |
| 9 | Effect of animal plasma proteins on intestinal damage and recovery of neonatal pigs infected with rotavirus显示文摘 | Corl B A Harrell R J Moon H K | 2007 | J Nutr Bio2007，18，： | 1 |
| 10 | Obesity and cholesterol in Japanese,French,and US children显示文摘 | Bingham M O Harrell J S Takada H | | 0，，4： | 1 |
| 11 | On the Fundamental Eigenvalue Ratio of the p- Laplacian显示文摘 | Fleckinger J Evans M Harrell II Thelin F | 2007 | Bull Sci math2007，131，7： | 1 |
| 12 | Maintaining regular physical activity in women:evidence to date显示文摘 | Speck B J Harrell J S | 2003 | Journal of Cardiovascular Nursing2003，18，4： | 1 |
| 13 | Leisure time activities of elementary school children显示文摘 | HARRELL J S GANSKY S A BRADLWY C B | 1997 | Nurs Res1997，46，5： | 1 |
| 14 | Speed of Sound and Equation of State for Fluid Oxygen to 10 GPa 显示文摘 | Abramson E H Slutsky L J Harrell M D | 1999 | J Chem Phys1999，110，10： | 1 |
| 15 | 显示文摘 | Wu E S Strickler J H Harrell W R | 1992 | SPIE-Int Soc Opt Eng1992，1674，： | 1 |
| 16 | Ex- ternal fixation of subglottic tracheal stents显示文摘 | Colt HG Harrell J Neuman TR | 1994 | Chest1994，105，6： | 1 |
| 17 | Intestinal ribosomal p70 (S6K) signaling is increased in piglet rotavirus enteritis显示文摘 | RHOADS J M CORL B A HARRELL R | 2007 | American Journal of Physiology:Gastrointestinal and Liver Physiology2007，292，3： | 1 |
| 18 | Effect of animal plasma proteins on intestinal damage and recovery of neonatal pigs infected with rotavirus显示文摘 | Corl B A Harrell R J Moon H K | 2007 | The Journal of Nutritional Biochemistry2007，18，12： | 1 |
| 19 | 显示文摘 | Wu E S Strickler J H Harrell W R | 1992 | SPIE Proc1992，1674，： | 1 |
| 20 | Vertical transmission of channel catfish virus显示文摘 | Wise J A Harrell S F Busch R L | 1988 | Am J Vet Res1988，49，9： | 1 |
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