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| 1 | Pyrrolidine dithiocarbamate reduces ischemia-reperfusion injury of the small intestine显示文摘AIM: To evaluate whether pyrrolidine dithiocarbamate (PDTC), an enhancer of HO production, attenuates intestinal IR injury.METHODS: Eighteen male rats were randomly allocated into three groups: (a) sham; (b) IR, consisting of 30 min of intestinal ischemia, followed by 2-h period of reperfusion; and (c) PDTC treatment before IR. Intestinal microvascular perfusion (IMP) was monitored continuously by laser Doppler fiowmetry. At the end of the reperfusion, serum samples for lactate dehydrogenase (LDH) levels and biopsies of ileum were obtained. HO activity in the ileum was assessed at the end of the reperfusion period.RESULTS: At the end of the reperfusion in the IR group,IMP recovered partially to 42.5% of baseline (P<0.05vs sham), whereas PDTC improved IMP to 67.3% of baseline (P<0.01 vs IR). There was a twofold increase in HO activity in PDTC group (2 062.66±106.11) as compared to IR (842.3±85.12) (P<0.001). LDH was significantly reduced (P<0.001) in PDTC group (585.6±102.4)as compared to IR group (1 973.8±306.5). Histological examination showed that the ileal mucosa was significantly less injured in PDTC group as compared with IR group.CONCLUSION: Our study demonstrates that PDTC improves the IMP and attenuates IR injury of the intestine possibly via HO production. Additional studies are warranted to evaluate the clinical efficacy of PDTC in the prevention of IR injury of the small intestine. | Ismail H Mallick Wen-Xuan Yang Marc C Winslet Alexander M Seifalian | 2005 | World Journal of Gastroenterology2005，11，46： | 8 |
| 2 | A survey of trust and reputation systems for online service provision显示文摘 | Josang A Ismail R Boyd C | 2007 | Preprint of Article Published in Decision Support Systems2007，43，2： | 1 |
| 3 | Review of interfer- ence avoidance schemes in femtocell networks 显示文摘 | ISMAIL S NG C K NOORDIN N K | 2011 | Scientific Re- search and Essays2011，6，15： | 1 |
| 4 | Impact of a nurse-led clinic for chronic constipation in children显示文摘 | Ismail N Ratchford I Proudfoot C | | 0，，： | 1 |
| 5 | Modeling and optimization IV:Investigation of reaction kinetics and kinetic constants using a program in which artificial neural network (ANN) was integrated显示文摘 | DENIZ B FAHRIYE C D ISMAIL H B | | 0，，： | 1 |
| 6 | Effects of oleoresin-tocopherol combinations on lipid oxidation, off-odor, and color of irradiated raw and cooked pork patties 显示文摘 | Nam K C Ko K Y Min B R Ismail H Lee E J Cordray J Ahn D U | 2007 | Meat Science2007，，： | 1 |
| 7 | Maternal and perinatal outcomes in women with gestational diabetes mcllitus as compared to nondiabetic controls显示文摘 | Fatih S Mustafa C Ismail M | 2001 | Reprod Med2001，46，12： | 1 |
| 8 | A Survey of Trust and Reputation Systems for Online Service Provision显示文摘 | Josang A Ismail R Boyd C | 2007 | Decision Support Systems2007，43，2： | 1 |
| 9 | Thermal characterization of Al2O3 and ZnO reinforced silicone rubber as thermal pads for heat dissipation purposes 显示文摘 | Sim L C Ramanan S R Ismail H | 2005 | Thermochimia Acta2005，430，12： | 1 |
| 10 | Rapid and sensitive assay method for simultaneous quantification of urinary nicotine and cotinine using gas chromatography-mass spectrometry显示文摘 | MAN C N GAM L H ISMAIL S | 2006 | Journal of Chromatography B2006，844，： | 1 |
| 11 | Thermal characterization of Al2O3 and ZnO reinforced silicone rubber as thermal pads for heat dissipation purposes显示文摘 | SIM L C RAMANAN S R ISMAIL H | 2005 | Thermochimia Acta2005，430，12： | 1 |
| 12 | Thermal characterization of A1203 and ZnO reinforced silicone rubber as thermal pads for heat dissipation purposes 显示文摘 | Sim L C Ramanan S R Ismail H | 2005 | ThermochimicaActa2005，430，12： | 1 |
| 13 | A survey of trust and reputation systems for online service provision显示文摘 | Jφsang A Ismail R Boyd C | 2007 | Decision Support Systems2007，43，2： | 1 |
| 14 | The genetic basis of congenital hyperinsulinism显示文摘 | James C Kapoor RR Ismail D | | 0，，05： | 1 |
| 15 | Determination of opti- mum De-link R concentration in a recycled rubber com- pound显示文摘 | U S Ishiaku C S Chong H Ismail | 1999 | Polymer Testing1999，18，8： | 1 |
| 16 | Background concentrations of Cd, Cu, Pb and Zn in the green-lipped mussel Perna viridis (Linnaeus) from Peninsular Malaysia显示文摘 | Yap C K Ismail A | 2003 | Baseline/Marine Pollution Bulletin2003，46，： | 1 |
| 17 | Survey of trust and reputation systems for online service provision显示文摘 | J?sang A Ismail R Boyd C | 2007 | Decision Support Systems2007，43，2： | 1 |
| 18 | Crack Damage Detection of Reinforced Concrete Beams Using Local Stiffness Indicator显示文摘 | ISMAIL Z ONG A Z C RAHMAN A G A | 2011 | Scientific Research and Essays2011，6，34： | 1 |
| 19 | A Survey of Trust and Reputation Systems for Online Service Provision显示文摘 | Josang A Ismail R Boyd C | 2007 | Decision Support Systerns2007，43，2： | 1 |
| 20 | Modeling andoptimization III:Reaction rate estimation using artificial neural network (ANN) without a kinetic mode显示文摘 | DENIZ B FAHRIVE C D ISMAIL H B | | 0，，： | 1 |
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