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| 1 | Hypoglycemic and anti-hyperglycemic study of Gynura procumbens leaf extracts显示文摘Objective:To study the antidiabetic activity of Gynura procumbens(G.procumbens)used in the traditional management of diabetes in Southern Asia.Methods:G.procumbens leaves were extracted sequentially with graded percentage of ethanol in water(95%,75%,50%,25%and 0%),and the extracts were tested for antidiabetic activity using acute(7 h),subcutaneous glucose tolerance test and sub-chronic(14 d)test in non-diabetic and streptozotocin-induced diabetic rats.The extracts were further subjected to phytochemical studies.Results:In acute dose(1 g/kg),the extracts significantly lowered fasting blood glucose(FBG)in streptozotocin-induced diabetic rats(P<0.05).However,the FBG-lowering effect of the 25%extract compared to the other extracts,was rapid(47%after 2 h)and the highest:53%,53%and 60%in the 3rd,5th,and 7th h,respectively(P<0.05),comparable only to the effect of metformin.Furthermore,the extracts suppressed peak FBG in subcutaneous glucose tolerance test,but only the 0%and 25%extracts,and metformin sustained the decrease until the 90th min(P<0.05).Moreover,in the 14 days study,the 25%extract exerted the highest FBG-lowering effect,namely 49.38%and 65.43%on days 7 and 14,respectively(P<0.05),similar to the effect of metformin(46.26%and 65.42%).Total flavanoid and phenolic contents in the extracts were found to decrease with increase in polarity of extraction solvents.The composition of reference compounds(chlorogenic acid,rutin,astragalin and kaempferol-3-O-nrtinoside)followed a similar trend.Conclusions:G.procumbens contains antidiabetic principles,most extracted in 25%ethanol.Interaction among active components appears to determine the antidiabetic efficacy,achieved likely by a metformin-like mechanism. | Khalid Algariri Kuong Y Meng Item J Atangwho Mohd Z Asmawi Amirin Sadikun Vikneswaran Murugaiyah Norhyati Ismail | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，5： | 4 |
| 2 | K-means-type algorithm显示文摘 | Selim S Z Ismail M A | 1994 | IEEE Trans Pattern Anal Mach Intell1994，6，1： | 2 |
| 3 | Characterizing the Saltol quantitative trait locus for salinity tolerance in rice 显示文摘 | Thomson M J Ocampo M Egdane J Rahman M A Sajise A G Adorada D L Tumimbang-Raiz E Blumwald E Seraj Z I Singh R K Gregorio G B Ismail A M | 2010 | Rice2010，3，2： | 1 |
| 4 | The effects of different extraction solvents of varying polarities on polyphenols of orthosiphon stamineus and evaluation of the free radical -scavenging activity显示文摘 | AKOWUAH G A ISMAIL Z NORHAYATII | 2005 | Food Chemistry2005，93，： | 1 |
| 5 | Association of plasmino-gen activator inhibitor-1 and tissue plasminogen activator with type2 iabetes and metabolic syndrome in Malaysian subjects 显示文摘 | Al-Hamodi Z Ismail IS Saif-Ali R | 2011 | Cardio-vasc Diabetol2011，10，： | 1 |
| 6 | Use o{ plastic waste in concrete mixture as aggregate replacement显示文摘 | Ismail Z Z A1-Hashmi E A | 2008 | Waste Manage2008，28，： | 1 |
| 7 | Modified weighted for enrollment forecasting based on fuzzy time series显示文摘 | Lee M I I Efendi R Ismail Z | 2009 | Matematlka2009，25，1： | 1 |
| 8 | Characterization of Styrene Butadiene Rubber/Recycle Dacrylonitrile-Butadiene Rubber (SBR/NBRr) Blends: The Effects of Epoxidized Natural Rubber (ENR-50) as a Compatibitizer显示文摘 | Noriman N Z Ismail H Rashid A A | 2010 | Polymer Testing2010，29，2： | 1 |
| 9 | Crack Damage Detection of Reinforced Concrete Beams Using Local Stiffness Indicator显示文摘 | ISMAIL Z ONG A Z C RAHMAN A G A | 2011 | Scientific Research and Essays2011，6，34： | 1 |
| 10 | Group B strepto- coccal bacteremia in a major teaching hospital in Malaysia: a case series of eighteen patients 显示文摘 | Eskandarian N Neela V Ismail Z | 2013 | Int J Infect Dis2013，17，9： | 1 |
| 11 | Effect of silane-based coupling agents and acrylic acid based compatibilizers on mechanical properties of oil palm empty fruit bunch filled high-density polyethylene composites显示文摘 | MOHD ISHAK Z A AMINULLAH A ISMAIL H | 1998 | J Appl Polym Sci1998，68，13： | 1 |
| 12 | Delusions increase functionalimpairment in Alzheimer's disease显示文摘 | Fischer CE Ismail Z Schweizer TA | 2012 | Dement Geriatr CognDisord2012，33，6： | 1 |
| 13 | Enhancement of titania by doping rare earth for photodegradation of organic dye (Direct Blue) 显示文摘 | El-Bahy Z M Ismail A A Mohamed R M | 2009 | Journal of Hazardous Materials2009，166，1： | 1 |
| 14 | Cytotoxic activity of Catharanthus roseus (Apocynaceae) crude extracts and pure compounds against human colorectal carcinoma cell line 显示文摘 | Siddiqui M J Ismail Z Aisha A F A | 2010 | lntern J Pharmacol2010，6，1： | 1 |
| 15 | Non-linear dynam- ics of the lithosphere and intermediate-term earth quake prediction显示文摘 | Keilis B Vladimir Ismail Z | 2001 | Tectonophysics2001，338，34： | 1 |
| 16 | Thermal reshaping of gold nanorods in micelles 显示文摘 | Mona B Mohamed Kamal Z Ismail Stephan Link | 1998 | JPhysChemB1998，102，： | 1 |
| 17 | K-means-type algorithm 显示文摘 | Selim S Z Ismail M A | 1994 | IEEE Trans Pattern Anal Mach Intell1994，6，1： | 1 |
| 18 | The performance of a solar regenerated open cycle desiccant bed grain cooling system显示文摘 | Ismail M Z Angus D E Thorpe G R | 1991 | Solar Energy1991，46，2： | 1 |
| 19 | K-Means type algorithms:a generalized convergence theorem and characterization of local optimality显示文摘 | Selim S Z Ismail M A | 1984 | IEEE Transactions on Pattern Analysis Machine Intelligence1984，6，1： | 1 |
| 20 | Consolidation of Heat Transfer Coefficients of Viscoelastic Simulated Food Solutions in Helical Exchangers 显示文摘 | ISMAIL Z KARIM R | 2012 | Journal of Food Engineer- ing2012，108，1： | 1 |
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