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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | p53 antibodies,metallothioneins,and oxidative stress markers in chronic ulcerative colitis with dysplasia显示文摘AIM:To investigate the role of p53 antibodies (p53Abs),metallothioneins (MTs) and oxidative stress markers in the early detection of dysplasia in chronic ulcerative colitis (UC).METHODS:The study included 30 UC patients,15 without dysplasia (group Ⅱ) and 15 with dysplasia (group Ⅲ),in addition to 15 healthy volunteers (group Ⅰ,control subjects).The enzyme-linked immunosorbent assay technique was used to measure serum p53Abs and MTs,while advanced oxidation protein products (AOPPs),and reduced glutathione (GSH) levels were measured by spectrophotometric method in all subjects.RESULTS:In group Ⅱ and group Ⅲ compared to group Ⅰ,there were significant increases in serum levels of AOPPs (145.94 ± 29.86 μmol/L and 192.21 ± 46.71 μmol/L vs 128.95 ± 3.06 μmol/L,P < 0.002 and P <0.001,respectively),MTs (8.18 ± 0.35 μg/mL and 9.20 ± 0.58 μg/mL vs 6.12 ± 0.25 μg/mL,P < 0.05 and P < 0.05,respectively),and p53Abs (20.19 ± 3.20 U/mL and 34.66 ± 1.34 U/mL vs 9.42 ± 1.64 U/mL,P < 0.001 and P < 0.001,respectively).There were significantly higher levels of AOPPs (P < 0.05) and p53Abs (P < 0.001) in UC patients with dysplasia compared to those without dysplasia,while MTs showed no significant difference between the 2 groups (P > 0.096).In contrast,GSH levels showed a significant decrease in both patients' groups (1.87 ± 0.02 μmol/mL and 1.37 ± 0.09 μmol/mL vs 2.49 ± 0.10 μmol/mL,P < 0.05 and P < 0.05 in groups Ⅱ and Ⅲ,respectively) compared with group Ⅰ,and the levels were significantly lower in group Ⅲ than group Ⅱ (P < 0.05).There was a positive correlation between AOPPs and both MTs (r=0.678,P < 0.001) and p53Abs (r=0.547,P < 0.001),and also between p53Abs and MTs (r=0.739,P < 0.001).There was a negative correlation between AOPPs and GSH (r =-0.385,P < 0.001),and also between GSH and both MTs (r=-0.662,P < 0.001) and p53Abs (r=-0.923,P < 0.001).CONCLUSION:Oxidative stress and oxidative cellular damage play an important role in the pathogenesis of chronic UC and the associated carcinogenetic process.p53Abs levels could help in early detection of dysplasia in these conditions. | Hala E Hamouda Soha S Zakaria Saber A Ismail Mahmoud A Khedr Wael W Mayah | 2011 | World Journal of Gastroenterology2011，17，19： | 5 |
| 3 | Electrochemical and XPS investigations of cobalt in KOH solutions 显示文摘 | Ismail K M Badawy W A | 2000 | J Appl Electrochem2000，30，11： | 2 |
| 4 | K-means-type algorithm显示文摘 | Selim S Z Ismail M A | 1994 | IEEE Trans Pattern Anal Mach Intell1994，6，1： | 2 |
| 5 | Advanced physical-chemical treatment experiences on young municipal landfill leachate 显示文摘 | Izzet Q Mahmut A Ismail K | 2003 | Waste Management2003，，23： | 1 |
| 6 | A survey of trust and reputation systems for online service provision显示文摘 | Josang A Ismail R Boyd C | 2007 | Preprint of Article Published in Decision Support Systems2007，43，2： | 1 |
| 7 | On the numerical solutions of Fredholm-Volterra integral equation显示文摘 | Abdou M A Mohamed K I Ismail A S | 2003 | Applied Mathematics and Computation2003，146，： | 1 |
| 8 | Fabrication of carbon membranes for gas separateion-a review显示文摘 | Saufi S M Ismail A F | 2004 | Carbon2004，42，： | 1 |
| 9 | GC-ECD and GC-MS Analysis of Profenofos Residues and Its Biochemical Effect in Tomatoes Products显示文摘 | ISMAIL S M M ALI H M HABIBA R A | 1993 | Journal of Agricultural of Food Chemistry1993，41，4： | 1 |
| 10 | Recent advances of inorganic fillers in mixed matrix membrane for gas separa- tion显示文摘 | Goh P S Ismail A F Sanip S M etal | 2011 | Separation and Purification Technology2011，81，3： | 1 |
| 11 | Effect of crack opening on the local diffusion of chloride in cracked mortar samples显示文摘 | ISMAIL M TOUMI A FRANCOIS R | 2008 | Cement and Concrete Research2008，38，89： | 1 |
| 12 | Purification and a dehydrin involved in chilling tolerance during seedling emergence of cowpea 显示文摘 | Ismail A M Hall A E Close T partial characterization of Sequence and their Biology J | 1999 | Plant Physiology1999，120，1： | 1 |
| 13 | Effect of crack opening on the local diffusion of chloride in cracked mortar samples 显示文摘 | Ismail M Toumi A Francois R | 2008 | Cement and Concrete Research2008，38，89： | 1 |
| 14 | The effect of storage temperature on histamine production and the freshness of yellowfin tuna(Tbunnus albacares)显示文摘 | Nejib G Moza A A Ismail M A | 2005 | Food Research International2005，38，2： | 1 |
| 15 | Germination ecophysiology in population of Zygophyllum qatarenses Hadidi from contrasting habitats显示文摘 | ISMAIL A M A | | 0，，02： | 1 |
| 16 | Natural fibre high- density polyethylene and lead oxide composites for radi- ation shielding 显示文摘 | Abdo A E Ali M A M Ismail M R | 2003 | Radiation Physics and Chemistry2003，66，3： | 1 |
| 17 | A comparative study on the structure and performance of porous polyvinylidene fluoride and polysulfone hollow fiber membranes for CO 2 absorption显示文摘 | ISMAIL A F MANSOURIZADEH A | 2010 | Journal of Membrane Science2010，365，1： | 1 |
| 18 | Comparison of dexmedetomi- dine and dexamethasone for prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy显示文摘 | Bakri MH Ismail EA Ihrahim A | 2015 | Korean J Anesthesiol2015，68，3： | 1 |
| 19 | An optimized method for measurement of gamma - H2AX in blood mononuclear and cultured cells 显示文摘 | Muslimovic A Ismail IH Gao Y | 2008 | Nature Protocols2008，3，7： | 1 |
| 20 | 5-axis milling of spherical surfaces显示文摘 | WARKENTIN A BEDI S ISMAIL F | 1995 | International Journal of Machine Tools and Manufacture1995，36，2： | 1 |
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