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| 1 | Hepatitis B virus pre-S2 start codon mutations in Indonesian liver disease patients显示文摘AIM: To identify the prevalence of pre-S2 start codon mutations and to assess their association with liver disease progression. METHODS: The mutations were identified by direct sequencing from 73 asymptomatic carriers, 66 chronic hepatitis (CH), 66 liver cirrhosis (LC) and 63 hepatocellular carcinoma (HCC) patients. Statistical significances were determined using Fisher's exact test, χ 2 test, and t -test analyses whenever appropriate. Pre-S mutation as a risk factor for advanced liver disease was estimated by unconditional logistic regression model adjusted with age, sex, and hepatitis B e antigen (HBeAg). P < 0.05 was considered significant. RESULTS: Mutation of the hepatitis B virus (HBV) pre-S2 start codon was found in 59 samples from 268 subjects (22.0%), with higher prevalence in patients with cirrhosis 27/66 (40.9%) followed by HCC 18/63 (28.6%), chronic hepatitis 12/66 (18.2%) and asymptomatic carriers 2/73 (2.7%) (P < 0.001). Logistic regression analysis showed that pre-S2 start codon mutation was an independent factor for progressive liver disease. Other mutations, at T130, Q132, and A138, were also associated with LC and HCC, although this was not statistically significant when adjusted for age, sex, and HBeAg. The prevalence of pre-S2 start codon mutation was higher in HBV/B than in HBV/C (23.0% vs 19.1%), whilst the prevalence of T130, Q132, and A138 mutation was higher in HBV/C than in HBV/B. The prevalence of pre-S2 start codon mutation was higher in LC (38.9%) and HCC (40.0%) than CH (5.6%) in HBeAg(+) group, but it was similar between CH, LC and HCC in HBeAg(-) group. CONCLUSION: Pre-S2 start codon mutation was higher in Indonesian patients compared to other Asian countries, and its prevalence was associated with advanced liver disease, particularly in HBeAg(+) patients. | Andi Utama Marlinang Diarta Siburian Ismail Fanany Mariana Destila Bayu Intan Rama Dhenni Tri Shinta Kurniasih Syafruddin AR Lelosutan Wenny Astuti Achwan Nasrul Zubir Arnelis Benyamin Lukito Irawan Yusuf Laurentius Adrianus Lesmana Ali Sulaiman | 2012 | World Journal of Gastroenterology2012，18，38： | 3 |
| 2 | Effect of hand hygiene intervention on the absenteeism of pre-school children in Klang Valley,Malaysia:a quasi-experimental study显示文摘Background Absenteeism amongst pre-school children is often due to illnesses such as hand,foot,and mouth disease,acute gastroenteritis,cold and flu,which are easily spread amongst them.This is because of weak immunity and lack of knowledge on proper hand hygiene.This quasi-experimental study assessed the efficacy of an intervention consisting of a hand hygiene education programme,along with digital tools in bringing about a change in behaviour and health conditions amongst pre-school children in Klang Valley,Malaysia.Methods A total of 377 school children,male and female,aged 5–6 years old,participated and were assigned to either the intervention or a control group.During the 2 months intervention period,children in the test group were trained on proper hand hygiene practices and techniques with the aid of the interactive android-based tablets.The numbers of absent days of all the children were recorded for 2 months before the intervention and during the intervention.Results In the test group,there was a 25%increase in the total number of absent days from the pre-intervention period to the intervention period,a much lesser increment observed as compared to that of control group in which the increase was much higher at 89%.Results showed a significant difference(P<0·05)between the absenteeism rates for the test and control group during the intervention period.Conclusion These results suggest that proper education and intervention increase hand hygiene compliance,which may help decrease school absenteeism due to illness;however,a longer study duration may be necessary to evaluate the benefit further. | Nurul Azmawati Mohamed Mohd Dzulkhairi Mohd Rani Tengku Zetty Maztura Tengku Jamaluddin Zarini Ismail Shalinawati Ramli Habibah Faroque Farisha Nur Abd Samad Abdul Rashid Ariffien Aisyah Ar Redha Che Amir FaridIlina Isahak | 2020 | World Journal of Pediatrics2020，16，4： | 2 |
| 3 | Prevalence of oral mu- cosal lesions in patients with type 2 diabetes attending hospital universitisains Malaysia显示文摘 | Al-Maweri SA Ismail NM Ismail AR | 2013 | Malays J Med Sci2013，20，4： | 1 |
| 4 | Parametric study on ice formation inside a spherical capsule显示文摘 | Ismail K AR Henriiquez J R da Silva T M A | 2003 | International Journal of Thermal Science2003，42，9： | 1 |
| 5 | Effect of spimlina intervention on oxidative stress, antioxidant status, and lipid profile in chronic obstructive pulnnmary disease patients显示文摘 | Ismail M Hossain MF Tanu AR | 2015 | Biomed Res lnt2015，2015，48： | 1 |
| 6 | Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human U87 malignant glioma cells by aloe emodin 显示文摘 | Ismail S Haris K Abdul Ghani AR | 2013 | Journal of Asian natural products research2013，9，15： | 1 |
| 7 | Response surface optimisation for the extraction of phenolics and flavonoids from a pink guava puree industrial by-product显示文摘 | KONG KW ISMAIL AR TAN ST | 2010 | Int J Food Sci Technol2010，45，8： | 1 |
| 8 | Relation of Osteoprotegerin,Visfatin and Ghrelin to Metabolic Syndrome in Type 2 Diabetic Patients显示文摘 | Ahmed MB Ismail MI Meki AR | 2015 | Int J Health Sci(Qassim)2015，9，2： | 1 |
| 9 | Wegener' s granulomatosis masquerading as upper lid chalazion显示文摘 | Ismail AR Theaker JM Manners RM | 2007 | Eye2007，21，6： | 1 |
| 10 | Breakage of an intramed-ullary rod after bone union in congenital pseudoarthrosis of the tibia:a re-port of two cases显示文摘 | Sulaiman AR Simbak N Wan Ismail WF | 2011 | J Orthop Surg(Hong Kong)2011，19，2： | 1 |
| 11 | Ballooning of the conjunctiva during phacoemulsification 显示文摘 | Ismail AR Eleftheriadis H Vakalis A | 2001 | J Cataract Refract Surg2001，27，6： | 1 |
| 12 | Effect of spirulina intervention on oxidative stress, antioxidant status, and lipid profile in chronic obstructive pulmonary disease patients 显示文摘 | Ismail M Hossain MF Tanu AR | 2015 | Biomed Res Int2015，2015，48： | 1 |
| 13 | Transplantation of human dental pulp stem cells:enhance bone consolidation in mandibu-lardistraction osteogenesis显示文摘 | Alkaisi A Ismail AR Mutum SS | | 0，，10： | 1 |
| 14 | Attenuation deforms time-intensity curves during contrast echocardiography:implications for assessment of mean transit rates显示文摘 | Jayaweera AR Ismail S Kaul S | 1994 | J Am Soc Echocardiogr1994，7，6： | 1 |
| 15 | Compressive optic neuropathy in fungal hypertrophic cranial pachymeningitis显示文摘 | Ismail AR Clifford L Meacock WR | 2007 | Eye (Lond)2007，21，4： | 1 |
| 16 | Comparison between PCM filled glass windows and absorbing gas filled windows 显示文摘 | Ismail Kama! AR Salinas Carlos T Henriquez Jorge R | 2008 | Energy and Buildings2008，40，5： | 1 |
| 17 | Associated factors of tooth wear among Malaysian 16-year-olds:a case-control study in Kota Bharu,Kelantan显示文摘 | Saerah NB Mastura N bin Ismail AR | 2012 | Community Dent Health2012，29，1： | 1 |
| 18 | The interaction between ear and sex differences and stimulus rate显示文摘 | Ismail H Thomton AR | 2003 | Hear Res2003，179，12： | 1 |
| 19 | Relation of osteoprotegerin, visfa- tin and ghrelin to metabolic syndrome in type 2 diabetic patients 显示文摘 | Ahmed MB Ismail MI Meki AR | 2015 | lnt J Health Sci(Qassim)2015，9，2： | 1 |
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