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| 1 | Energy metabolism and the skeleton:Reciprocal interplay显示文摘The relation between bone remodelling and energy expenditure is an intriguing,and yet unexplained,challenge of the past ten years. In fact,it was only in the last few years that the skeleton was found to function,not only in its obvious roles of body support and protection,but also as an important part of the endocrine system. In particular,bone produces different hormones,like osteocalcin(OC),which influences energy expenditure in humans. The undercarboxylated form of OC has a reduced affinity for hydroxyapatite; hence it enters the systemic circulation more easily and exerts its metabolic functions for the proliferation of pancreatic β-cells,insulin secretion,sensitivity,and glucose tolerance. Leptin,a hormone synthesized by adipocytes,also has an effect on both bone remodelling and energy expenditure; in fact it inhibits appetite through hypothalamic influence and,in bone,stimulates osteoblastic differentiation and inhibits apoptosis. Leptin and serotonin exert opposite influences on bone mass accrual,but several features suggest that they might operate in the same pathway through a sympathetic tone. Serotonin,in fact,acts via two opposite pathways in controlling bone remodelling: central and peripheral. Serotonin product by the gastrointestinal tract(95%) augments bone formation by osteoblast,whereas brain-derived serotonin influences low bone mineral density and its decrease leads to an increase in boneresorption parameters. Finally,amylin(AMY) acts as a hormone that alters physiological responses related to feeding,and plays a role as a growth factor in bone. In vitro AMY stimulates the proliferation of osteoblasts,and osteoclast differentiation. Here we summarize the evidence that links energy expenditure and bone remodelling,with particular regard to humans. | Patrizia D'Amelio Anna Panico Elena Spertino Giovanni Carlo Isaia | 2012 | World Journal of Orthopedics2012，3，11： | 2 |
| 2 | The uric acid metabolism pathway as a therapeutic target in hyperuricemia related to metabolic syndrome显示文摘 | André a Name Colado Sim? o Marcell Alysson Batisti Lozovoy Isaias Dichi | 2012 | Expert Opinion on Therapeutic Targets2012，，12： | 2 |
| 3 | Aflatoxin B1-induced hepatocellular carcinoma in developing countries:Geographical distribution, mechanism of action and prevention (Review)显示文摘 | Abdu Hamid Isaias Tesfamariam Yucheng Zhang Zhen Zhang | 2013 | Oncology Letters2013，，4： | 2 |
| 4 | Bone metabolism in type 2 diabetes mellitus显示文摘 | Isaia GC Ardissone P Di Stefano M | 1999 | Acta Diabeto1999，36，12： | 1 |
| 5 | First assessment of effects of global change on threatened spiders: Potential impacts on Dolomedes plantarius (Clerck) and its conservation plans显示文摘 | Boris Leroy Mauro Paschetta Alain Canard Michel Bakkenes Marco Isaia Frédéric Ysnel | 2013 | Biological Conservation2013，，： | 1 |
| 6 | Night-time use of rotigotine in advanced Parkinson's disease显示文摘 | Canesi M Mariani CB Isaias IU | 2010 | Funct Neurol2010，25，： | 1 |
| 7 | Posttraumatic and postsurgical neuropathie pain responsive to treatment with capsaicin 8% topical patch 显示文摘 | Zis P Apsokardos A Isaia C | 2014 | Pain Physician2014，17，2： | 1 |
| 8 | Young age as aprognostic factor in cervical cancer:results of a population-based study 显示文摘 | Brewster WR D isaia PJ Monk BJ | 1999 | Am J obsterGynecol1999，，180： | 1 |
| 9 | Osteoporosis:still a complication of primary Billary cirrosis显示文摘 | Solerio E Isaia G Innarella R | | 0，，： | 1 |
| 10 | The use of raloxifene in osteoporo- sis treatment 显示文摘 | D'Amelio P Isaia GC | 2013 | Expert Opin Pharmacother2013，14，： | 1 |
| 11 | Duodenal levodopa infusion for advanced Parkinson's disease: 12-month treatment outcome显示文摘 | Antonini A Isaias IU Canesi M | 2007 | Mov Disord2007，22，8： | 1 |
| 12 | Influence of the use of rice husk ash on the electrical resistivity of con- crete: A technical and economic feasibility study 显示文摘 | Gastaldini A L G Isaia G C Hoppe T F | 2009 | Con- struct Build Mater2009，23，11： | 1 |
| 13 | Reduced-energy cranberry juice increases folic acid and adiponectin and reduces homocysteine and oxidative stress in patients with the metabolic syndrome显示文摘 | Tathiana Name Colado Sim?o Marcell Alysson Batisti Lozovoy Andréa Name Colado Sim?o Sayonara Rangel Oliveira Danielle Venturini Helena Kaminami Morimoto Lúcia Helena Silva Miglioranza Isaias Dichi | 2013 | British Journal of Nutrition2013，，10： | 1 |
| 14 | Mixed-1,10-phenanthroline-Cu(Ⅱ) Complexes:Synthesis, Cytotoxic Activity Versus Hematological and Solid Tumor Cells and Complex Formation Equilibria with Glutathione显示文摘 | Pivetta T Isaia F Verani G | 2012 | J Inorg Biochem2012，114，： | 1 |
| 15 | Insomnia among hospitalized elderly patients: Prevalence, clinical characteristics and risk factors显示文摘 | Isaia G Corsinovi L Bo M | 2011 | Arch Gerontol Geriatr2011，52，2： | 1 |
| 16 | Mexican Bark Paper: Evidence of His- tory of Tree Species Used显示文摘 | Citlallil6pez Binnqtiist Alejandre Quintanar- IsaIas Ma- rie Vander Meeren | 2012 | Economic Botany2012，66，2： | 1 |
| 17 | Insomnia among hospitalized elderly patients: prevalence, clinical characteristics and risk factors 显示文摘 | Isaia G Corsinovi L Bo M | 2011 | Arch Gerontol Geriatr2011，52，2： | 1 |
| 18 | Bone metabolism in type 2 diabetes mellitus显示文摘 | Isaia GC Ardissone P Di SM | 1999 | Acta Diabetol1999，36，12： | 1 |
| 19 | Impact of ges- tational diabetes mellitus screening strategies on perinatal outcomes : a simulation study 显示文摘 | Maican F Isaias P Maria IS | 2013 | Diab Res Clin Pract2013，99，3： | 1 |
| 20 | Bone metabolism in type 2 diabetes mellitus显示文摘 | Isaia GC Ardisone P Di Stefano M | 1999 | Acta Diabetes1999，36，12： | 1 |
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