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| 1 | Current and novel approaches in the pharmacological treatment of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most lethal malignant tumours worldwide.The mortality-to-incidence ratio is up to 91.6%in many countries,representing the third leading cause of cancer-related deaths.Systemic drugs,including the multikinase inhibitors sorafenib and lenvatinib,are first-line drugs used in HCC treatment.Unfortunately,these therapies are ineffective in most cases due to late diagnosis and the development of tumour resistance.Thus,novel pharmacological alternatives are urgently needed.For instance,immune checkpoint inhibitors have provided new approaches targeting cells of the immune system.Furthermore,monoclonal antibodies against programmed cell death-1 have shown benefits in HCC patients.In addition,drug combinations,including first-line treatment and immunotherapy,as well as drug repurposing,are promising novel therapeutic alternatives.Here,we review the current and novel pharmacological approaches to fight HCC.Preclinical studies,as well as approved and ongoing clinical trials for liver cancer treatment,are discussed.The pharmacological opportunities analysed here should lead to significant improvement in HCC therapy. | Fernanda Villarruel-Melquiades María Eugenia Mendoza-Garrido Claudia M García-Cuellar Yesennia Sánchez-Pérez Julio Isael Pérez-Carreón Javier Camacho | 2023 | World Journal of Gastroenterology2023，29，17： | 2 |
| 2 | Reverse obliquity fractures of the intertrochanteric region of the femur显示文摘 | Georgo J Haidukewych TA Drew Isael | 2007 | The Journal of Bone & Joint Surgery(America Volume)2007，83，5： | 1 |
| 3 | Minimal Atrophy of the Entorhinal Cortex and Hippocampus: Progression of Cognitive Impairment显示文摘 | Varon Daniel Loewenstein David A Potter Elizabeth Greig Maria T Agron Joscelyn Shen Qian Zhao Weizhao Celeste Ramirez Maria Santos Isael Barker Warren Potter Huntington Duara Ranjan | 2011 | EN2011，，4： | 1 |
| 4 | Reverse obliquity fractures of the intertrochanteric region of the femur 显示文摘 | Georgo J Haidukewych TA Drew Isael | 2007 | The Journal of Bone & Joint Surgery(America Volume)2007，83，5： | 1 |
| 5 | Laparoscopic Fowler-Stephens orchiopexy for the high abdominal testis显示文摘 | Isael F Shawn B | 1999 | J Urol1999，162，： | 1 |
| 6 | Aqueous extracts from Tenebrio molitor larval and pupal stages inhibit early hepatocarcinogenesis in vivo显示文摘Hepatocellular carcinoma(HCC),which is the most frequent primary liver malignancy,is ranked as the sixth most common cancer and the third leading cause of cancer-related deaths worldwide,with its incidence expected to continue rising.One of the reasons is that most patients are diagnosed at an advanced stage when therapeutic options are ineffective.The development of HCC is attributed to a chronic exposition to either one or a combination of low amounts of different hepatotoxins,such as in hepatitis virus infection,alcohol consumption,aflatoxin from contaminated foods,metabolic factors,and exposure to chemical carcinogens from tobacco smoke(Fomer et al.,2018). | Armando ZEPEDA-BASTIDA Juan OCAMPO-LOPEZ Brisa Rodope ALARCON-SANCHEZU Osiris German IDELFONSO-GARCIA Sandra ROSAS-MADRIGAL Diana Ivette APARJCIO-BAUTISTA Julio Isael PEREZ-CARREON Saul VILLA-TREVINO Jaime ARELLANES-ROBLEDO | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，12： | 0 |
| 7 | Erratum to:Aqueous extracts from Tenebrio molitor larval and pupal stages inhibit early hepatocarcinogenesis in vivo显示文摘Following an Assessment by the Autonomous University of Hidalgo State and the National Institute of Genomic Medicine,this erratum corrects the authorship of this article by adding Dulce Maria MORENO-GARCiA as the first author.The published article(Zepeda-Bastida et al.,2021)has now been updated with the corrected authorship,author contributions,and acknowledgments,which may be seen in this erratum. | Dulce María Moreno-García Armando Zepeda-Bastida Juan Ocampo-López Brisa Rodope Alarcón-Sánchez Osiris Germán Idelfonso-García Sandra Rosas-Madrigal Diana Ivette Aparicio-Bautista Julio Isael Pérez-Carreón Saúl Villa-Treviño Jaime Arellanes-Robledo | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，4： | 0 |
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