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| 1 | Management of critically ill patients with diabetes显示文摘Disorders of glucose homeostasis, such as stress-induced hypoglycemia and hyperglycemia, are common complications in patients in the intensive care unit. Patients with preexisting diabetes mellitus(DM) are more susceptible to hyperglycemia, as well as a higher risk from glucose overcorrection, that may results in severe hypoglycemia. In critically ill patients with DM, it is recommended to maintain a blood glucose range between 140-180 mg/d L. In neurological patients and surgical patients, tighter glycemic control(i.e., 110-140 mg/d) is recommended if hypoglycemia can be properly avoided. There is limited evidence that shows that critically ill diabetic patients with a glycosylated hemoglobin levels above 7% may benefit from looser glycemic control, in order to reduce the risk of hypoglycemia and significant glycemic variability. | Livier Josefina Silva-Perez Mario Alberto Benitez-Lopez Joseph Varon Salim Surani | 2017 | World Journal of Diabetes2017，8，3： | 10 |
| 2 | Pulmonary complications of hepatic diseases显示文摘Severe chronic liver disease(CLD) may result from portal hypertension, hepatocellular failure or the combination of both. Some of these patients may develop pulmonary complications independent from any pulmonary pathology that they may have. Among them the hepatopulmonary syndrome(HPS), portopulmonary hypertension(PPH) and hepatic hydrothorax(HH) are described in detail in this literature review. HPS is encountered in approximately 15% to 30% of the patients and its presence is associated with increase in mortality and also requires liver transplantation in many cases. PPH has been reported among 4%-8% of the patient with CLD who have undergone liver transplantation. The HH is another entity, which has the prevalence rate of 5% to 6% and is associated in the absence of cardiopulmonary disease. These clinical syndromes occur in similar pathophysiologic environments. Most treatment modalities work as temporizing measures. The ultimate treatment of choice is liver transplant. This clinical review provides basic concepts; pathophysiology and clinical presentation that will allow the clinician to better understand these potentially life-threatening complications. This article will review up-to-date information on the pathophysiology, clinical features and the treatment of the pulmonary complications among liver disease patients. | Salim R Surani Yamely Mendez Humayun Anjum Joseph Varon | 2016 | World Journal of Gastroenterology2016，22，26： | 3 |
| 3 | Management of hypertensive crises in the elderly显示文摘高血压的危机比 180/120 mmHg 高是血压的举起。这些能迫切或突现,取决于结束机关损坏的存在。高血压的危机的临床的演讲在老病人是相当可变的,并且临床医生们必须怀疑非特定的症状。在 pathophysiological 的过细的知识在他们改变的老病人需要的设法的高血压的危机,药理学选择,使用的药的 pharmacokinetics,他们的副作用,和他们和另外的药的相互作用。Clevidipine, nicardipine, labetalol, esmolol,和 fenoldopam 在比较喜欢的选择在之中由于他们的功效和 tolerability 老。除非没有可得到的另外的选择, Nitroprusside, hydralazine,和 nifedipine 应该被避免,由于复杂并发症和无法预言的回答的高风险。 | Abbas Alshami Carlos Romero America Avila Joseph Varon | 2018 | Journal of Geriatric Cardiology2018，15，7： | 3 |
| 4 | When a liver transplant recipient goes back to alcohol abuse: Should we be more selective?显示文摘Alcoholic liver disease(ALD) is one of the most common indications for liver transplantation(LT). However, it has always remained as a complicated topic from both medical and ethical grounds, as it is seen for many a 'self-inflicted disease'. Over the years, the survival rate of transplanted patients has significantly improved. The allocation system and the inclusion criteria for LT has also undergone some modifications. Early LT for acute alcoholic hepatitis has been subject to recent clinical studies with encouraging results in highly selected patients. We have learned from studies the importance of a multidisciplinary evaluation of candidates for LT. Complete abstinence should be attempted to overcome addiction issues and to allow spontaneous liver recovery. Risk factors for relapse include the presence of anxiety or depressive disorder, short duration of sobriety pre-LT and lack of social support. The identification of risk factors and the strengthen of social support system may decrease relapse among these patients. Family counseling of candidates is highly encouraged to prevent relapse to alcohol. Relapse has been associated with different histopathological changes, graft damage, graft loss and even decrease in survival among some studies. Therefore, each patient should be carefully selected and priority is to continue to lean on patients with high probability of success. The ethical issue remains as to the patient returning to drinking after the LT, hindering the way for other patients who could have received the same organ. | Monica Leon Joseph Varon Salim Surani | 2016 | World Journal of Gastroenterology2016，22，20： | 2 |
| 5 | The hemodynamic management of elderly patients with sepsis显示文摘Sepsis is among the most common reason for admission to intensive care units throughout the world. In the US and most Western nations sepsis is largely a disease of the elderly. Management of elderly patients with severe sepsis is challenging. Early recognition of this syndrome, together with the early administration of appropriate antibiotics and cautious fluid resuscitation is the cornerstone of therapy. Echocardiography together with non-invasive or invasive hemodynamic monitoring is recommended in patients who have responded poorly to fluids or have significant underlying cardiac disease. This paper reviews the hemodynamic changes that characterize sepsis, particularly as they apply to elderly patients and provides recommendations for the management of these patients. | Paul E. Marik Joseph Varon | 2007 | Journal of Geriatric Cardiology2007，4，2： | 2 |
| 6 | Correlation between metabolic syndrome and sleep apnea显示文摘The so-called 'metabolic syndrome'(MS),constitutes a cluster of metabolic and cardiovascular abnormalities,including fasting glucose,blood pressure,triglycerides,high density lipoprotein cholesterol(HDL-C),and waist circumference that arise from insulin resistance. Obstructive sleep apnea(OSA) syndrome is characterized by recurrent episodes of partial or complete obstruction of the upper airway,involving cessation or significant decreased airflow,with intermittent hypoxemia,frequent arousals from sleep and recurrent oxyhemoglobin desaturations that interfere with normal sleep patterns generating difficulty falling asleep,unrefreshing sleep and loud snoring. The relation between these two entities is known as 'Syndrome Z',and there is no question about the impact of these risk factors on health and disease. This clinical condition presents a growing epidemic Worldwide,affecting approximately 60% of the general population with both MS and OSA due to the constant increase of body mass index in humans. This article presents evidence-based data that focuses on the direct relationship between MS and OSA. | Alejandro Castaneda Edgar Jauregui-Maldonado Iqbal Ratnani Joseph Varon Salim Surani | 2018 | World Journal of Diabetes2018，9，4： | 2 |
| 7 | Diabetic ketoacidosis: Treatment in the intensive care unit or general medical/surgical ward?显示文摘Diabetic ketoacidosis(DKA) is defined as an acute metabolic disorder, which is characterized by an increased presence of circulating ketones, and the development of ketoacidosis in the presence of hyperglycemia. This syndrome occurs as a result of insulin deficiency. Patients can be dramatically ill, however, with aggressive treatment, most patients recover rapidly. Despite being a low-risk condition, the development of acidosis, is one of the admission criteria to the intensive care unit(ICU) for these patients, in order to provide close monitoring, and recognize complications that could result from the use of aggressive therapy, such as continuous infusions if insulin. In some institutions, DKA is treated in the emergency department and general medical/surgical wards to avoid ICU overcrowding. | Yamely Mendez Salim Surani Joseph Varon | 2017 | World Journal of Diabetes2017，8，2： | 2 |
| 8 | Diet-induced insulin resistance precedes other aspects of the metabolic syndrome 显示文摘 | Barnard RJ Roberts CK Varon SM | 1998 | J Appl Physiol1998，84，4： | 1 |
| 9 | Bench-to-bedside review:Rhabdomyolysis:an overview for clinicians显示文摘 | Huerta-Alardín AL Varon J Marik PE | 2005 | Crit Care2005，9，2： | 1 |
| 10 | Method for separation of Bdellovibrio from mixed bacterial population by filtration through millipore or by gradient differential centrifugation显示文摘 | Varon M Shilo M | 1970 | Rev Intern Oceanogr1970，1819，： | 1 |
| 11 | Diagnosis and management of labile blood pressure during acute cerebrovascular accidents and other hypertensive crises显示文摘 | Varon J | | 0，，08： | 1 |
| 12 | Hypertensive crises: challenges and management显示文摘 | MARIK P E VARON J | 2007 | Chest2007，131，6： | 1 |
| 13 | Diet induced insulin resistance precedes other aspects of the metabolic syndrome 显示文摘 | Barnard RJ Roberts CK Varon SM | 1998 | J Appl Physiol1998，84，4： | 1 |
| 14 | Nerve growth factor in CNS repair 显示文摘 | SILVIO VARON CONNER J M | 1994 | Journal of Neurotrauma1994，11，5： | 1 |
| 15 | Role of platelet-derived microparticles in angiogenesis and tumor progression显示文摘 | Varon D Shai E | 2009 | Discov Med2009，8，43： | 1 |
| 16 | The isolation of the mouse nerve growth factor protein in a high molecular weight form显示文摘 | Varon S Nomura J Shooter EM | 1967 | Biochemistry1967，6，7： | 1 |
| 17 | Platelet-derived microparticles promote invasiveness of prostate cancer cells cia upregulation of MMP-2 production显示文摘 | Dashevsky 0 Varon D Brill A | 2009 | IntJ Cancer2009，124，8： | 1 |
| 18 | Bench-to-bedside review : rhabdomyolysis- an overview for clinicians显示文摘 | Huerta-Alardin AL Varon J Marik PE | 2005 | Crit Care2005，9，2： | 1 |
| 19 | Dispersion of cell-to-cell uncoupling precedes low K^+ -induced ventricular fibrillation 显示文摘 | Tribulova N Manoach M Varon D | 2001 | Physiol Res2001，50，3： | 1 |
| 20 | Hypertensive crises:challenges and man- agement 显示文摘 | Marik PE Varon J | 2007 | Chest2007，131，6： | 1 |
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