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| 1 | ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy显示文摘响应滋养的应力,房间开始能导致改编或死亡的一个 autophagy 节目。位于从饥饿发信号到 autophagy 的开始下面的机制充分没被理解。在当前的学习,我们证明 PARP-1 的缺席或 inactivation 强烈推迟导致饥饿的 autophagy。我们发现了那 DNA 损坏是由 γ 测量了的导致饥饿的 autophagy 的一个早事件; -H2AX 累积和彗星试金,与在两个参数显示减小的 PARP-1 猛烈房间。在饥饿期间,导致 ROS 的 DNA 损坏激活 PARP-1,导致 ATP 弄空(在滋养的剥夺以后的一个早事件) 。PARP-1 的缺席弄钝 AMPK 激活并且阻止了 mTOR 活动的完全的损失,导致在 autophagy 的延期。PARP-1 弄空在饥饿的房间赞成 apoptosis,建议在滋养的剥夺以后的 autophagy 和 PARP-1 激活的一个支持幸存的角色。在 PARP-1 变异的老鼠的出生不满一月的婴儿使遭到了到尖锐饥饿的 vivo 结果表演,也显示缺乏的肝 autophagy,暗示为在导致饥饿的 autophagy 的 PARP-1 的一个生理的角色。因此,表明小径的 PARP 是 autophagy 承诺追随者饥饿的起始的步骤的一个关键管理者。 | Jose Manuel Rodriguez-Vargas Maria Jose Ruiz-Magana Carmen Ruiz-Ruiz Jara Majuelos-Melguizo Andreina Peralta-Lea Maria Isabel Rodriguez Jose Antonio Munoz-Gaimez Mariano Ruiz de Almodovar Eva Siles Abelardo Lopez Rivas Marja Jaattela F Javier Oliver | 2012 | Cell Research2012，22，7： | 8 |
| 2 | Flexible distributed feedback lasers based on nanoimprinted cellulose diacetate with efficient multiple wavelength lasing显示文摘Here we present the assembly of novel transparent all-polymer distributed feedback(DFB)lasers.Flexible and highly transparent cellulose diacetate(CdA)was employed as substrate on which gratings with different periods were engraved by thermal nanoimprinting with high fidelity.Highly luminescent conjugated polymers(CP),poly(9,9-dioctylfluorene)(PFO),poly(9,9-dioctylfluorene-alt-benzothiadiazole)(F8BT),and a blend of F8BT and poly(3-hexylthiophene)-poly(9,9-dioctylfluorene-altbenzothiadiazole)(P3HT:F8BT)were deposited by spin coating onto the nanostructured plastic surfaces,giving rise to perpendicular single-mode lasing emission in the blue,green,and red wavelength ranges,respectively.These lasers show linewidths below 1 nm and low thresholds(≈6μJcm^(−2) for blue and red lasing emission),comparable to other state-of-the-art lasers obtained from similar optical gain materials on rigid substrates.The followed strategy is scalable and versatile,enabling the development of large area nanoimprinted DFB lasers(>1cm^(2))on plastic,which is highly relevant for applications in various markets. | José R.Castro Smirnov Ahmad Sousaraei Manuel R.Osorio Santiago Casado Jaime J.Hernández Longfei Wu Qi Zhang Ruidong Xia Daniel Granados Reinhold Wannemacher Isabel Rodriguez Juan Cabanillas-Gonzalez | 2019 | npj Flexible Electronics2019，3，1： | 2 |
| 3 | αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model显示文摘Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular organisms.Their regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with age.During aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016). | Paloma Martinez-Redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol Isabel Guillen-Vicente Elena Rodriguez-Inigo Juan Manuel Lopez-Alcorocho Marta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte | 2020 | Protein & Cell2020，11，3： | 2 |
| 4 | Metabolomic insights intothe intricate gut microbial - host interac- tion in the development of obesity and type 2 diabetes 显示文摘 | Palau - Rodriguez M Tulipani S Isabel Queipo - Ortuno M | 2015 | Fron- tiers in Microbiology2015，6，： | 1 |
| 5 | The effect of entrepreneurship education programmes on satisfaction with innovation behaviour and performance 显示文摘 | Natalia Martin Cruz Rodriguez Escudero Aria Isabel Hernangomez Barahona Juan Fernando Saboia Leitao | 2009 | Journal of European Industrial Training2009，，33： | 1 |
| 6 | Identification of goose, mule duck, chicken, turkey and swine in Foie Gras by species - specific polymerase chain reaction显示文摘 | Miguel A Rodriguez Teresa Garcia Isabel Gonzalez | 2003 | J Agric Food Chem2003，51，： | 1 |
| 7 | Medical abortion and manual vacuum aspiration for legal abortion protect women's health and reduce costs to the health system:findings from Colombia显示文摘 | Maria Isabel Rodriguez Willis Simancas Mendoza Camilo GuerraPalacio | 2015 | Reproductive Health Matters2015，44，22： | 1 |
| 8 | Evolution of Bacillus thuringiensis Cry toxins insecticidal activity显示文摘 | Alejandra Bravo Isabel Gómez Helena Porta Blanca Ines García‐Gómez Claudia Rodriguez‐Almazan Liliana Pardo Mario Soberón | 2012 | Microbial Biotechnology2012，，1： | 1 |
| 9 | Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD显示文摘 | Jordi de Batlle Jaume Sauleda Eva Balcells Federico P. Gómez Michelle Méndez Esther Rodriguez Esther Barreiro Jaume J. Ferrer Isabelle Romieu Joaquim Gea Josep M. Antó Judith Garcia-Aymerich | 2012 | The Journal of Nutritional Biochemistry2012，，7： | 1 |
| 10 | Identification of goose, mule duck, chicken, turkey and swine in Foie Gras by species-specific polymerase chain reaction 显示文摘 | Miguel A Rodriguez Teresa Garcia Isabel Gonzalez | 2003 | J Agric Food Chem2003，51，： | 1 |
| 11 | Pyrolysis of scrape tyres显示文摘 | Isabel de Marco Rodriguez Laresgoiti Mf Cabrero ma | 2001 | Fuel Processing Technology2001，，72： | 1 |
| 12 | TaqMan real-time PCR for the detection and quantitation ofpork in meat mixtures显示文摘 | Miguel A Rodriguez Teresa Garcia Isabel Gonzdlez | 2005 | Meat Science2005，70，： | 1 |
| 13 | Production of melatonin by Saccharomyces strains under growth and fermentation conditions显示文摘 | María Isabel Rodriguez‐Naranjo María Jesús Torija Albert Mas Emma Cantos‐Villar María del Carmen Garcia‐Parrilla | 2012 | Journal of Pineal Research2012，，3： | 1 |
| 14 | Desmoglein-2 and Desmocollin-2 Mutations in Dutch Arrhythmogenic Right Ventricular Dysplasia/Cardiomypathy Patients: Results From a Multicenter Study显示文摘 | Zahurul A. Bhuiyan Jan D.H. Jongbloed Jasper van der Smagt Paola M. Lombardi Ans C.P. Wiesfeld Marcel Nelen Meyke Schouten Roselie Jongbloed Moniek G.P.J. Cox Marleen van Wolferen Luz M. Rodriguez Isabelle C. van Gelder Hennie Bikker Albert J.H. Suurmeije | 2009 | Circulation: Cardiovascular Genetics2009，，5： | 1 |
| 15 | Phenotypic characterization of idiosyncratic drug‐induced liver injury: The influence of age and sex显示文摘 | M. Isabel Lucena Raúl J. Andrade Neil Kaplowitz Miren García‐Cortes M. Carmen Fernández Manuel Romero‐Gomez Miguel Bruguera Hacibe Hallal Mercedes Robles‐Diaz Jose F. Rodriguez‐González Jose Maria Navarro Javier Salmeron Pedro Martinez‐Odriozola Ramón Pér | 2009 | Hepatology2009，，： | 1 |
| 16 | A novel nanostruc-turedpoly(lactic-co-glycolic-acid)-multi-walled carbon nanotube composite for blood-contacting applications:Thrombogenicity studies显示文摘 | Li Buay koh Isabel Rodriguez Subbu S | 2009 | Acta Biomaterialia2009，5，9： | 1 |
| 17 | PCR identificatiml of beef,sheep,goat,and pork in raw and heat- treated meat mixtures显示文摘 | Miguel A Rodriguez Teresa Garcia Isabel Gonz(dez | 2004 | J Food Prot2004，67，1： | 1 |
| 18 | Quantitation of mule duck in goose fbie gras using taqman real-time polymerase chain reaction显示文摘 | Miguel A Rodriguez Teresa Gareia Isabel GonzOlez | 2004 | J Agric Food Chem2004，52，6： | 1 |
| 19 | Identification of goose, mule duck, chicken, turkey, and swine in foie gras by species-specific polymerase chain reaction显示文摘 | ] Miguel A Rodriguez Teresa Garcia Isabel Gonztlez | 2003 | J Agric Food Chem2003，51，6： | 1 |
| 20 | Effectiveness and safety of first-generation protease inhibitors in clinical practice:Hepatitis C virus patients with advanced fibrosis显示文摘AIM:To evaluates the effectiveness and safety of the first generation,NS3/4A protease inhibitors(PIs) in clinical practice against chronic C virus,especially in patients with advanced fibrosis. METHODS:Prospective study and non-experimental analysis of a multicentre cohort of 38 Spanish hospitals that includes patients with chronic hepatitis C genotype 1,treatment-na?ve(TN) or treatment-experienced(TE),who underwent triple therapy with the first generation NS3/4A protease inhibitors,boceprevir(BOC) and telaprevir(TVR),in combination with pegylated interferon and ribavirin. The patients were treatment in routine practice settings. Data on the study population and on adverse clinical and virologic effects were compiled during the treatment period and during follow up.RESULTS:One thousand and fifty seven patients were included,405(38%) were treated with BOC and 652(62%) with TVR. Of this total,30%(n = 319) were TN and the remaining were TE:28%(n = 298) relapsers,12%(n = 123) partial responders(PR),25%(n = 260) null-responders(NR) and for 5%(n = 57) with prior response unknown. The rate of sustained virologic response(SVR) by intention-to-treatment(ITT) was greater in those treated with TVR(65%) than in those treated with BOC(52%)(P < 0.0001),whereas by modified intention-to-treatment(m ITT) no were found significant differences. By degree of fibrosis,56% of patients were F4 and the highest SVR rates were recorded in the non-F4 patients,both TN and TE. In the analysis by groups,the TN patients treated with TVR by ITT showed a higher SVR(P = 0.005). However,by m ITT there were no significant differences between BOC and TVR. In the multivariate analysis by m ITT,the significant SVR factors were relapsers,IL28 B CC and non-F4; the type of treatment(BOC or TVR) was not significant. The lowest SVR values were presented by the F4-NR patients,treated with BOC(46%) or with TVR(45%). 28% of the patients interrupted the treatment,mainly by non-viral response(51%):this outcome was more frequent in the TE than in the TN patients(57% vs 40%,P = 0.01). With respect to severe haematological disorders,neutropaenia was more likely to affect the patients treated with BOC(33% vs 20%,P ≤ 0.0001),and thrombocytopaenia and anaemia,the F4 patients(P = 0.000,P = 0.025,respectively). CONCLUSION:In a real clinical practice setting with a high proportion of patients with advanced fibrosis,effectiveness of first-generation PIs was high except for NR patients,with similar SVR rates being achieved by BOC and TVR. | Javier Salmeron Carmen Vinaixa Ruben Berenguer Juan Manuel Pascasio Juan Jose Sanchez Ruano Miguel angel Serra Ana Gila Moises Diago Manuel Romero-Gomez Jose Maria Navarro Milagros Testillano Conrado Fernandez Dolores Espinosa Isabel Carmona Jose Antonio Pons Francisco Jorquera Francisco Javier Rodriguez Ramon Perez Jose Luis Montero Rafael Granados Miguel Fernandez Ana Belen Martin Paloma Munoz de Rueda Rosa Quiles | 2015 | World Journal of Gastroenterology2015，21，30： | 0 |
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