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| 1 | Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer显示文摘Objective:Long-term survivors(LS)of non-small cell lung cancer(NSCLC)without driver alterations,displaying an overall survival(OS)of more than 3 years,comprise around 10%of cases in several series treated with chemotherapy.There are classical prognosis factors for these cases[stage,Eastern Cooperative Oncology Group(ECOG),etc.],but more data are required in the literature.In this multi-center study,we focused on LS of advanced NSCLC with OS above 36 months to perform a clinical-pathological and molecular characterization.Methods:In the first step,we conducted a clinical-pathological characterization of the patients.Afterwards,we carried out a genetic analysis by comparing LS to a sample of short-term survivors(SS)(with an OS less than 9 months).We initially used whole-genome RNA-seq to identify differentiating profiles of LS and SS,and later confirmed these with reverse transcription-polymerase chain reaction(RT-PCR)for the rest of the samples.Results:A total of 94 patients were included,who were mainly men,former smokers,having adenocarcinoma(AC)-type NSCLC with an ECOG of 0-1.We obtained an initial differential transcriptome expression,displaying 5 over-and 33 under-expressed genes involved in different pathways:namely,the secretin receptor,surfactant protein,trefoil factor 1(T FF1),serpin,Ca-channels,and Tolllike receptor(TLRs)families.Finally,RT-PCR analysis of 40(20 LS/20 SS)samples confirmed that four genes(surfactant proteins and SFTP)were significantly down-regulated in SS compared to LS by using an analysis of covariance(ANCOVA)model:SFTPA1(P=0.023),SFTPA2(P=0.027),SFTPB{P=0.02),and SFT PC(P=0.047).Conclusions:We present a sequential genetic analysis of a sample of NSCLCLS with no driver alterations,obtaining a differential RNA-seq/RT-PCR profile showing an abnormal expression of SF genes. | Juan Moreno-Rubio Santiago Ponce Rosa Alvarez Maria Eugenia Olmedo Sandra Falagan Xabier Mielgo Fatima Navarro Patricia Cruz Luis Cabezon-Gutierrez Carlos Aguado Gonzalo Colmenarejo Marta Munoz-Fernandez de Leglaria Ana Belen Enguita Maria Cebollero Amparo Benito Isabel Alemany Carolina del Castillo Ricardo Ramos Ana Ramirez de Molina Enrique Casado Maria Sereno | 2020 | Cancer Biology & Medicine2020，17，2： | 4 |
| 2 | 完全肿瘤细胞减灭术加全盆腔切除加腹腔热灌注化疗在腹膜癌合并盆腔肿瘤中的应用显示文摘目的:肿瘤细胞减灭术(cytoreductive surgery,CRS)+全盆腔切除术(total pelvic exenteraction,TPE)+腹腔热灌注化疗(hyperthermic intraperitoneal chemotherapy,HIPEC)整合治疗策略,是目前唯一可能治愈腹膜癌合并晚期盆腔肿瘤的疗法。本研究探讨CRS+TPE+HIPEC适应证、手术方式和技巧,尤其是避免功能性造瘘的重建方法。方法:数据来源于本中心前瞻性数据库,选取2006年9月至2021年1月,共1 172例腹膜癌患者,累计接受CRS+HIPEC治疗1 314例次,其中14例接受TPE且无造瘘功能重建,纳入研究对象。结果:14例患者均通过腹膜切除术实现了腹部肿瘤细胞减灭程度(completeness of cytoreduction,CC)评分0(CC 0)切除,通过TPE实现了盆腔R0切除,且无任何形式造瘘。无消化道吻合口病发症,术后尿漏5例,其中3例无需有创修补,1例行肾造瘘术,1例二次手术修补。无术后90天内死亡。结论:CRS+HIPEC手术中,TPE非绝对禁忌。在高度专业化的腹膜癌中心,肿瘤病理学家和专业手术团队联合,可提高CRS+TPE+HIPEC整合治疗策略的安全性和有效性,促进术后恢复,提高患者生活质量。CRS+TPE+HIPEC整合治疗策略的应用仍有待进一步深入研究。 | Pedro Barrios Oriol Crusellas Montse Martin Isabel Ramos 姬忠贺(翻译) 李雁(审校) | 2022 | 中国肿瘤临床2022，49，24： | 1 |
| 3 | A simplified model of software project dynamics显示文摘 | Mercedes Ruiz Isabel Ramos Miguel Toro | 2001 | Journal of Systems and Software2001，59，3： | 1 |
| 4 | Abdominal tuberculosis: Imaging features显示文摘 | José M. Pereira Antonio J. Madureira Alberto Vieira Isabel Ramos | 2005 | European Journal of Radiology2005，，2： | 1 |
| 5 | Dysregulation of Protein Kinase A Signaling in the Aged Prefrontal Cortex显示文摘 | Brian P. Ramos Shari G. Birnbaum Isabelle Lindenmayer Samuel S. Newton Ronald S. Duman Amy F.T. Arnsten | 2003 | Neuron2003，，4： | 1 |
| 6 | Epicatechin Gallate Induces Cell Death via p53 Activation and Stimulation of p38 and JNK in Human Colon Cancer SW480 Cells显示文摘 | Isabel Cordero-Herrera MaríaAngeles Martín Laura Bravo Luis Goya Sonia Ramos | 2013 | Nutrition and Cancer2013，，5： | 1 |
| 7 | In vitro chemo-protective effect of bioactive peptide lunasin against oxidative stress in human Hep G2 cells显示文摘 | Samuel Fernandez-Tome Sonia Ramos Isabel CorderoHerrera | 2014 | Food Research International2014，62，： | 1 |
| 8 | Information systems and organizational memory: A literature review 显示文摘 | Victor Freitas de Azeredo Barros Isabel Ramos Gilberto Perez | 2015 | Journal of Information Systems and Technology Management2015，，12： | 1 |
| 9 | Prevalence of Symptomatic and Asymptomatic Peripheral Arterial Disease and the Value of the Ankle-brachial Index to Stratify Cardiovascular Risk显示文摘 | R. Ramos M. Quesada P. Solanas I. Subirana J. Sala J. Vila R. Masiá C. Cerezo R. Elosua M. Grau F. Cordón D. Juvinyà M. Fitó M. Isabel Covas A. Clarà M. ángel Mu?oz J. Marrugat | 2009 | European Journal of Vascular & Endovascular Surgery2009，，3： | 1 |
| 10 | Trends in Drug Resistance Prevalence in HIV-1–infected Children in Madrid: 1993 to 2010 Analysis显示文摘 | Miguel de Mulder Gonzalo Yebra Adriana Navas Leticia Martin Maria Isabel de Jose Maria Luisa Navarro Santiago Jimenez de Ory Ignacio Gonzalez-Granado Maria Jose Mellado Jose Tomas Ramos Africa Holguin | 2012 | The Pediatric Infectious Disease Journal2012，，11： | 1 |
| 11 | Coupling GIS with Hydrologic and Hydraulic Flood Modelling显示文摘 | Francisco Nunes Correia Filipe Castro Rego Maria Da Gra?a Saraiva Isabel Ramos | 1998 | Water Resources Management1998，，3： | 1 |
| 12 | Coupling GIS with Hydrologic and Hydraulic Flood Modelling显示文摘 | Francisco Nunes Correia Filipe Castro Rego Maria Da Gra?a Saraiva Isabel Ramos | 1998 | Water Resources Management1998，，3： | 1 |
| 13 | A Dynamic Integrated Framework for Software Process Improvement显示文摘 | Mercedes Ruiz Isabel Ramos Miguel Toro | 2002 | Software Quality Journal2002，，2： | 1 |
| 14 | Community‑based screening of Chagas disease among Latin American migrants in a non‑endemic country: an observational study显示文摘Background:Chagas disease is a parasitic disease endemic to Latin America,but it has become a disease of global concern due to migration fows.Asymptomatic carriers may host the parasite for years,without knowing they are infected.The aim of this study is to assess prevalence of Chagas disease and evaluate the participants’level of knowl‑edge between Latin American migrants attending a community-based screening campaign.Methods:Three community-based campaigns were performed in Alicante(Spain)in 2016,2017 and 2018,including educational chats and blood tests for Trypanosoma cruzi serology.Participants completed a questionnaire assessing knowledge about the mechanisms of transmission,disease presentation,diagnosis,and treatment.People seroposi‑tive for T.cruzi underwent diagnostic confrmation by two diferent tests.Results were analyzed by multivariable logistic regression and expressed as adjusted odds ratios(aORs),adjusting for age,sex,and time in Spain.Results:A total of 596 participants were included in the study;17%were aged under 18 years.Prevalence in adults was 11%[54/496;95%confdence interval(CI):8.3–14.5%]versus 0%among children.All but one case were in Bolivians.Diagnosis was independently associated with having been born in Bolivia(aOR:102,95%CI:13–781)and a primary school-level education(aOR:2.40,95%CI:1.14–5.06).Of 54 people diagnosed with Chagas disease(most of whom were asymptomatic),42(77.7%)returned to the clinic at least once,and 24(44.4%)received treatment.Multivariable analysis showed that coming from Argentina(aOR:13,95%CI:1.61–1188)or Bolivia(aOR:1.90,95%CI:1.19–3.39)and having received information about Chagas disease in Spain(aOR:4.63,95%CI:2.54–8.97)were associ‑ated with a good level of knowledge on the disease.Having primary level studies(aOR:0.59,95%CI:0.34–0.98)and coming from Ecuador(aOR:4.63,95%CI:2.52–847)were independently associated with a lower level of knowledge.Conclusions:Community-based interventions are a good strategy for diagnosing neglected diseases such as Chagas disease in non-endemic countries and for identifying and treating infected,asymptomatic individuals. | Violeta Ramos‑Sesma Miriam Navarro Jara Llenas‑García Concepción Gil‑Anguita Diego Torrus‑Tendero Philip Wikman‑Jorgensen María García‑López Concepción Amador‑Prous María‑Paz Ventero‑Martín Pedro Guevara‑Hernández Ana Garijo‑Saiz Ares Sanchez‑Sanchez Cristina Bernal‑Alcaraz Ana‑Isabel Pujades‑Tarraga Roser Muñoz‑Perez María Flores‑Chávez José‑Manuel Ramos‑Rincón | 2021 | Infectious Diseases of Poverty2021，10，5： | 0 |
| 15 | What do we know about pseudodementia?显示文摘Depression and dementia can lead to generalised cognitive and memory dysfunction.Thus,differentiating these disorders is important and challenging.Pseudodementia is a term used clinically to describe symptoms that resemble dementia but are caused by other conditions(most frequently depression),rather than being recognised as an official diagnosis.Pseudodementia is characterised by a cognitive impairment that mimics dementia but which does not have its origin in neurological degeneration,deriving instead from functional psychiatric conditions.This condition is more commonly observed in older adults(particularly those over the age of 50 or 60 years),and its risk factors overlap with those for depression.Pseudodementia is essentially characterised by deficits in memory,executive function and speech and,therefore,can easily be confused with dementia,although there are aspects that allow its differentiation.Diagnosing pseudodementia can be difficult,especially as there is significant overlap between its symptoms and those of other conditions.However,it is important to recognise characteristic aspects of this disorder,as its correct identification is essential for proper treatment. | SaloméMouta Isabel Fonseca Vaz Miguel Pires Sara Ramos Diana Figueiredo | 2023 | General Psychiatry2023，36，4： | 0 |
| 16 | Skin problems in children under five years old at a rural hospital in Southern Ethiopia显示文摘Objective: To examine the prevalence of cutaneous disorders in children under 5 years old who attended a rural hospital in Southern Ethiopia.Methods: A prospective cross-sectional study was conducted from January 26 to February 20, 2015 in children under 5 years old who attended Gambo Rural Hospital in West Arsi of the Oromia Region, Ethiopia.Results: A total of 324 children were included(59.6% male) whose median age was 16.4months. In total, 147 children [45.4%; 95% confidence interval(CI): 40.0%–50.8%]under 5 years had a skin problem, of which 101(68.7%) consulted for that reason. The other 46(31.3%) consulted for a general health problem and the dermatological condition was a secondary finding during the physical exploration. In 93 children(28.7%; 95% CI:20%–33.8%), it was the main disease, and in 54 children(16.5%; 95% CI: 13.0%–21.1%)it was concomitant with other diseases. The most common dermatological disease was scabies(n = 44, 13.6%; 95% CI: 10.3%–17.7%). Impetigo was diagnosed in 32 children(9.9%; 95% CI: 7.1%–13.3%), of which 23(71.9%) had complicated impetigo. Nineteen children(5.9%; 95% CI: 3.8%–9.0%) had eczema, 10(3.1%) had eczema associated to other conditions. The following most frequent skin problems were tinea(n = 9; 2.8%),infected wound and ulcer(n = 7; 2.2%), and burns(n = 6; 1.9%).Conclusions: Skin problems, mainly scabies, impetigo, and eczema were common in young children attended at a rural hospital in Southern Ethiopia. Children under 5 years should be examined thoroughly to rule out skin diseases, especially scabies. | José Manuel Ramos Paula Moles-Poveda Dalu Tessema Mubarack Kedir Gamadi Safayo Abraham Tesfasmariam Francisco Reyes Isabel Belinchon | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，7： | 0 |
| 17 | Interferon-free treatments in patients with hepatitis C genotype 1-4 infections in a real-world setting显示文摘AIM To investigated the real-world effectiveness and safety of various regimens of interferon-free treatments in patients infected with hepatitis C virus(HCV).METHODS We performed an observational study to analyze different antiviral treatments administered to 462 HCV-infected patients, of which 56.7% had liver cirrhosis. HCV RNA after 4 wk of treatment and at 12 wk after treatment sustained virologic response(SVR) as well as serious adverse events(SAEs) was analyzed first for the whole cohort and then separately in patients who met or did not meet the inclusion criteria of a clinical trial(CT-met and CT-unmet, respectively).RESULTS The most frequently prescribed treatment was simeprevir/sofosbuvir(36.4%), followed by sofosbuvir/ledipasvir(24.9%) and ombitasvir/paritaprevir/ritonavir(r)/dasabuvir(19.9%). Ribavirin(RBV) was administered in 198 patients(42.9%). SVRs occurred in 437/462 patients(94.6%). The SVRs ranged between 93.3% and 100% for genotypes 1-4. SVRs were achieved in 96.2% patients in the CTmet group vs 91.9% patients in the CT-unmet group(P = 0.049). Undetectable HCV RNA at week 4 occurred in 72.9% of the patients. In the univariate analysis, the factors associated with SVRs were lower liver stiffness, absence of cirrhosis, higher platelet count, higher albumin levels, no RBV dose reduction, undetectable HCV RNA at week 4 and CT-met group. In the multivariate analysis, only albumin was an independent predictor of treatment failure(P = 0.04). Eleven patients(2.4%) developed SAEs; 5.2% and 0.7% of the patients in the CT-unmet and CT-met groups, respectively(P = 0.003).CONCLUSION A high proportion of patients with HCV infection achieved SVRs. For patients who did not meet the CT criteria, treatment regimens must be optimized. | Huascar Ramos Pedro Linares Ester Badia Isabel Martín Judith Gómez Carolina Almohalla Francisco Jorquera Sara Calvo Isidro García Pilar Conde Begona álvarez Guillermo Karpman Sara Lorenzo Visitación Gozalo Mónica Vásquez Diana Joao Marina de Benito Lourdes Ruiz Felipe Jiménez Federico Sáez-Royuela 无 | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，2： | 0 |
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