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	题名	作者	年代	出处	被引量
1	Contribution of NMDA receptors to dorsolateral prefrontal cortical networks in primates显示文摘Cognitive disorders such as schizophrenia and Alzheimer's disease are associated with dysfunction of the highly evolved dorsolateral prefrontal cortex(dl PFC), and with changes in glutamatergic N-methyl-D-aspartate receptors(NMDARs). Recent research on the primate dl PFC discovered that the pyramidal cell circuits that generate the persistent firing underlying spatial working memory communicate through synapses on spines containing NMDARs with NR2 B subunits(Glu N2B) in the post-synaptic density. This contrasts with synapses in the hippocampus and primary visual cortex, where Glu N2 B receptors are both synaptic and extrasynaptic. Blockade of Glu N2 B in the dl PFC markedly reduces the persistent firing of the Delay cells needed for neuronal representations of visual space. Cholinergic stimulation of nicotinic α7 receptors within the glutamate synapse is necessary for NMDAR actions. In contrast, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors have only subtle effects on the persistent firing of Delay cells, but contribute substantially to the firing of Cue and Response cells. Systemic administration of the NMDAR antagonist ketamine reduces the persistent firing of Delay cells, but increases the firing of some Response cells. The reduction in persistent firing produced by ketamine may explain why this drug can mimic or worsen the cognitive symptoms of schizophrenia. Similar actions in the medial PFC circuits representing the emotional aspects of pain may contribute to the rapid analgesic and anti-depressant actions of ketamine.	Min Wang Amy F T Arnsten	2015	Neuroscience Bulletin2015，31，2：	2
2	Stress signalling pathways that impair prefrontal cortex structure and function显示文摘	Arnsten AF	2009	Nature2009，10，：	1
3	Impact of methadone treatment on cardiac repolarization and conduction in opioid users显示文摘	MARTELL BA ARNSTEN JH KRANTZ MJ	2005	Am J Cardiol2005，95，7：	1
4	The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects:evidence for alpha-2 receptor subtypes显示文摘	Arnsten AF Cai JX Goldman-Rakic PS	1988	Neurosci1988，8，11：	1
5	Alpha-2 adrenergic agonists decrease distractibility in aged monkeys performing the delayed response task 显示文摘	Arnsten AF Contant TA	1992	Psychopharmacology (Berl)1992，108，12：	1
6	Impact of active drug use on antiretroviral therapy adherence and viral suppression in HIV- infected drug users显示文摘	Arnsten JH Demas PA Grant RW	2002	J Gen Intern Med2002，17，：	1
7	Impact of active drug use on antiretroviral therapy adherence and viral suppression in HIV- infected drug users显示文摘	Arnsten JH Demas PA Grant RW	2002	J Gen Intern Med2002，17，：	1
8	A prospective study ofadherence and viral load in a large multi-center cohort of HIV-in-fected women显示文摘	Howard AA Arnsten JH Lo Y	2002	AIDS2002，16，：	1
9	Decreased bone mineral density and increased fracture risk in aging men with or at risk for HIV infection显示文摘	Arnsten JH Freeman R Howard AA	2007	AIDS2007，21，5：	1
10	A prospective study of ad herence and viral load in a large multi-center cohort HIV-infected patients 显示文摘	Howard AA Arnsten JH Lo Y	2002	AIDS2002，30，1：	1
11	Antiretroviral thera- py adherence and viral suppression in HIV-infected drug users: comparison of self-report and electronic monitoring显示文摘	Arnsten JH Demas PA Farzadegan H	2001	Clin Infect Dis2001，33，8：	1
12	Current sexual activity and risky sexual behavior in older men with or at risk for HIV infection 显示文摘	CoopermanNA Arnsten JH Klein RS	2007	AIDS Educ Prey2007，19，：	1
13	Diagnosis and treatment of pulmonaryembolism in the elderly 显示文摘	Berman A R Arnsten JH	2003	C!in Geriatr Med2003，19，1：	1
14	Adrenergic targets for the treatment of cognitive deficits in schizophrenia 显示文摘	Arnsten AF	2004	Psychopharmacology (Berl)2004，174，1：	1
15	Effect of alcohol consumption on diabetes mellitusA systematic review显示文摘	Howard A A Arnsten J H Gourevitch M N	2004	Annals of Internal Medicine2004，140，3：	1
16	Neurobiology of executive functions: catecholamine influences on prefronial cortical function显示文摘	Arnsten A F Li B M	2005	Biol Psychiatry2005，57，13：	1
17	Individual, interpersonal, and structural correlates of effective HAART use among urban active injection drug users显示文摘	Knowhon A Arnsten J Eldred L	2006	J Acquir Immune Defie Syndr2006，41，4：	1
18	Through the looking glass: Differential nora- denergic modulation of prefrontal cortical function显示文摘	Arnsten AF	2000	Neu- ral Plast2000，7，12：	1
19	Practical and conceptual challenges inmeasuring antiretroviral adherence显示文摘	Berg KM Arnsten JH	2006	J Acquir Immune Def-ic Syndr2006，43，1：	1
20	Antiretroviral Therapy Adherence and Viral Suppression in HIV- Infected Drug Users:Comparison of Self-Report and Electronic Monitoring 显示文摘	Julia H Arnsten Penelope A Demas Homayoon Farzadegan	2001	Clinical Infectious Diseases2001，33，：	1

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