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| 1 | Characterization of goat whey proteins and their bioactivity and toxicity assay显示文摘Goat whey is an industry-discarded dairy by-product that has interesting nutritional value and a nutrient composition with important functional potential,where proteins have a high biological value and play an important role in the organism’s physiology.Therefore,the aim of this study was to identify,quantify,concentrate and investigate the capacity of goat whey proteins to perform different biological activities and to evaluate their acute toxicity.Concentrated proteins were quantified and identified by Bradford,Kjehdal and SDS-PAGE methods.Antibacterial activity was performed against Listeria monocytogenes,Salmonella spp.,Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli microorganisms and showed MIC ranging from 15 to 120μg mL-1,with the highest inhibition for L.monocytogenes growth.Antiproliferative activity was performed against human malignant melanoma cells and their proliferation inhibition was up to 66.8%within 72 h of exposure.The highest antioxidant capacity was obtained at concentration 2 mg that showed 29.69%of inhibition of DPPH radical oxidation.The acute toxicity test was performed using Artemia franciscana larvae in which whey proteins were able to preserve larval survival throughout exposure.Thus,we can conclude that goat’s whey has proteins that can play a positive effect on health,with antimicrobial activity and without toxicity.The present study highlights the great potential of goat’s whey to be developed as a safe biopreservative or as a functional ingredient in the food industry. | Maria Isabel Ferreira Campos Paula Perazzo de Souza Barbosa Laura Junqueira Camargo Luciano Da Silva Pinto Bianca Mataribu Catarina Serr˜ao Luis Fernando Marques-Santos Jos´e Hon´orio Lopes Julia Mariano Caju de Oliveira Carlos Alberto de Almeida Gadelha Tatiane Santi-Gadelha | 2022 | Food Bioscience2022，46，2： | 2 |
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| 5 | Importance of postgel reactions in determining the polymer network structure and properties:poly (N-vinylimidazole) hydrogels显示文摘 | Isabel E Pacios Ines F Pierola | 2006 | Macromolecules2006，39，： | 1 |
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| 8 | IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis显示文摘 | Malamut Georgia El Machhour Raja Montcuquet Nicolas Martin-Lannerée Séverine Dusanter-Fourt Isabelle Verkarre Virginie Mention Jean-Jacques Rahmi Gabriel Kiyono Hiroshi Butz Eric A Brousse Nicole Cellier Christophe Cerf-Bensussan Nadine Meres | 2010 | Journal of Clinical Investigation2010，，6： | 1 |
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| 11 | University-industry collaboration and innovation in emer- gent and mature industries in new industrialized countries 显示文摘 | ISABEL MARIA BODAS FREITAS ROSANE ARGOU MARQUESC EVANDO MIRRA DE PAULA E SILVA | 2013 | Research Policy2013，，42： | 1 |
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| 14 | Importance of postgel reactions in determining the polymer network structure and properties:poly (N-vinylimidazole) hydrogels显示文摘 | Isabel E Pacios Ines F Pierola | 2006 | Macromolecules2006，39，： | 1 |
| 15 | Development and validation of a fast high-performance liquid chromatography method for the determination of microcncapsulated pyrethroid pesticides显示文摘 | ISABEL P R GIL-ALEGRE M E ANA ISABEL T S | 2006 | Analytica Chirnica Acta2006，557，12： | 1 |
| 16 | A novel ther- moreversible gelling product made by enzymatic modifica- tion of starch显示文摘 | Marc J E C Isabelle C Euverink G W | 2005 | Starch2005，57，： | 1 |
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| 19 | Theoretical studies of manganese and iron superoxide dismutases:superoxide binding and superoxide oxidation显示文摘 | ISABEL A A JOSE A R Diane E C | 2005 | J Phys Chem B2005，109，24： | 1 |
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