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| 1 | Characterization of goat whey proteins and their bioactivity and toxicity assay显示文摘Goat whey is an industry-discarded dairy by-product that has interesting nutritional value and a nutrient composition with important functional potential,where proteins have a high biological value and play an important role in the organism’s physiology.Therefore,the aim of this study was to identify,quantify,concentrate and investigate the capacity of goat whey proteins to perform different biological activities and to evaluate their acute toxicity.Concentrated proteins were quantified and identified by Bradford,Kjehdal and SDS-PAGE methods.Antibacterial activity was performed against Listeria monocytogenes,Salmonella spp.,Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli microorganisms and showed MIC ranging from 15 to 120μg mL-1,with the highest inhibition for L.monocytogenes growth.Antiproliferative activity was performed against human malignant melanoma cells and their proliferation inhibition was up to 66.8%within 72 h of exposure.The highest antioxidant capacity was obtained at concentration 2 mg that showed 29.69%of inhibition of DPPH radical oxidation.The acute toxicity test was performed using Artemia franciscana larvae in which whey proteins were able to preserve larval survival throughout exposure.Thus,we can conclude that goat’s whey has proteins that can play a positive effect on health,with antimicrobial activity and without toxicity.The present study highlights the great potential of goat’s whey to be developed as a safe biopreservative or as a functional ingredient in the food industry. | Maria Isabel Ferreira Campos Paula Perazzo de Souza Barbosa Laura Junqueira Camargo Luciano Da Silva Pinto Bianca Mataribu Catarina Serr˜ao Luis Fernando Marques-Santos Jos´e Hon´orio Lopes Julia Mariano Caju de Oliveira Carlos Alberto de Almeida Gadelha Tatiane Santi-Gadelha | 2022 | Food Bioscience2022，46，2： | 2 |
| 2 | Nonalcoholic fatty liver disease in asymptomatic Brazilian adolescents显示文摘AIM:To evaluate the prevalence and clinical characteristics of Nonalcoholic fatty liver disease(NAFLD) among asymptomatic Brazilian adolescents. METHODS:Transversal observational study included asymptomatic adolescents with central obesity from private and public schools in Salvador-Bahia,northeastern Brazil.The children answered a questionnaire that included age,gender,race,and medical history,and were submitted to a complete physical exam and abdominal ultrasound.Biochemical exams included:ALT,AST,GGT,C reactive protein(CRP),fasting glucose,insulin,cholesterol and triglycerides.Criteria for NAFLD included:the presence of steatosis in ultrasound and/or high level of ALT,negative or occasional historic of intake of alcohol(≤140 g/wk),negative investigation for hepatitis A,B,C,auto-immune hepatitis,Wilson disease and hemochromatosis.RESULTS:From October,2005 to October,2006,the study included 1801 subjects between 11 and 18 years of age and a mean age of 13.7±2.0 years.One hundred ninety-nine had central obesity.The prevalence of NAFLD was 2.3%,most of whom were male and white.Insulin resistance(IR)was observed in 22.9% of them and had positive correlations with ALT and GGT(P<0.05).Elevated CRP was observed in 6.9% of the cases;however,it was not associated with WC,IR or liver enzymes. CONCLUSION:The prevalence of NAFLD in Brazilian adolescents was low.The ethnicity may have influence this frequency in the population studied,which had a large proportion of African descendents. | Raquel Rocha Helma Pinchemel Cotrim Almir Galvo Vieira Bitencourt Daniel Batista Valente Barbosa Adméia Souza Santos Alessandro de Moura Almeida Bruno Cunha Isabel Guimares | 2009 | World Journal of Gastroenterology2009，15，4： | 2 |
| 3 | Survey of infectious and parasitic diseases in stray cats at the Lisbon Metropolitan Area, Portugal显示文摘 | Ana Duarte Isabel Castro Isabel M. Pereira da Fonseca Virgilio Almeida Luis M. Madeira de Carvalho José Meireles Maria I. Fazendeiro Luis Tavares Yolanda Vaz | 2009 | Journal of Feline Medicine and Surgery2009，，6： | 1 |
| 4 | Processing and storage effects on anthocyanin composition and antioxidant activity of jams produced with C amarosa strawberry显示文摘 | Luís F. Amaro M. Teresa Soares Carina Pinho Isabel F. Almeida Olívia Pinho Isabel M. P. L. V. O. Ferreira | 2013 | Int J Food Sci Technol2013，，10： | 1 |
| 5 | Atypical posterior reversible encephalopathy syndrome: a flare of systemic lupus erythe- matosus显示文摘 | Cecilia Monteiro Isabel Almeida Daniel Dias etal | 2012 | The Journal of rheumatology2012，1，39： | 1 |
| 6 | Heavy metal toxicity in Rhizobitun leguminosarum biovar viciae isolated from soils subjected to different sources of heavy-metal contamination:Effects on protein expression显示文摘 | Sofia Isabel Almeida Pereira | 2006 | Applied Soil Ecology2006，33，： | 1 |
| 7 | Autosomal dominant polycystic kidney disease: evidence for the existence of a third locus in a Portuguese family显示文摘 | Salomé Almeida Edgar Almeida Dorien Peters José Reim?o Pinto Isabel Távora Jo?o Lavinha Martjn Breuning Mateus Martins Prata | 1995 | Human Genetics1995，，1： | 1 |
| 8 | Man- ganese alters rat brain amino acids levels 显示文摘 | Dinamene Santos M Camila Batoreu Isabel Almeida | 2012 | Biol Trace Elem Res2012，150，13： | 1 |
| 9 | Seasonal and spatial variability of free-living bacterial community composition along an estuarine gradient (Ria de Aveiro, Portugal)显示文摘 | Isabel S. Henriques Artur Alves Marta Tac?o Adelaide Almeida ?ngela Cunha António Correia | 2006 | Estuarine Coastal and Shelf Science2006，，1： | 1 |
| 10 | Biochemical and ultrastructural changes in leaves of potato plants grown under supplementary UV-B radiation显示文摘 | Isabel Santos Fernanda Fidalgo José M Almeida | 2004 | Plant Sci2004，167，： | 1 |
| 11 | Growth of Chlorella vulgaris on sugarcane vinasse:The effect of anaerobic digestion pretreatment显示文摘 | Sheyla Santa Isabel Marques Iracema Andrade Nascimento Paulo Fernando de Almeida | 2013 | Appl Biochem Biotechnol2013，171，8： | 1 |
| 12 | Neuropsychological features of progranulin-associated frontotemporal dementia: a nested case-control study显示文摘The distinction between sporadic and genetic behavioural-variant frontotemporal dementia(bvFTD)regarding some neuropsychological(NP)features remains challenging.Specifically,progranulin(GRN)-associated bvFTD frequently presents with early episodic memory impairment and some degree of parietal dysfunction which are supporters of Alzheimer’s disease(AD)diagnosis.In this context,we aimed to characterize the NP profile of GRN-bvFTD as compared to sporadic-bvFTD and AD in patients with mild dementia(Mini-Mental State Examination score≥17 and Clinical Dementia Rating Scale score≤1.We identified 21 patients at Centro Hospitalar e Universitário de Coimbra,Portugal with GRN mutations belonging to fifteen different families.As our focus was bvFTD variants,FTD-related aphasic forms(3 patients)were excluded.The remaining 18 GRN-bvFTD were further matched with 18 sporadic-bvFTD and 18 AD patients according to disease staging,age and education.All patients completed the Mini-Mental State Examination,Montreal Cognitive Assessment(MoCA)and a comprehensive NP assessment battery.Results were converted into z-scores.Differences between groups in individual NP measures and NP domains were assessed through non-parametric tests(Kruskal-Wallis test analysis)and eta squared(ŋ2)was calculated as a measure of effect size.Group comparisons show that GRN patients have worse performances on verbal retrieval processes(P=0.039,ŋ2=0.110)and visuoconstructive abilities(P=0.039,ŋ2=0.190)than sporadic bvFTD forms.When compared to AD,GRN patients present a higher impairment in frontal(P=0.001,ŋ2=0.211)and parietal(P=0.041,ŋ2=0.129)measures and a better performance in memory tasks(P=0.020,ŋ2=0.120).Sporadic-bvFTD forms are worse than AD in frontal measures(P=0.032,ŋ2=0.200),being better in both memory(P=0.010,ŋ2=0.131)and visuospatial skills(P=0.023,ŋ2=0.231).Considering these results,we conclude that GRN-bvFTD patients present a NP profile that associates the typical patterns of FTD and AD deficits.This is particularly expressive in visuoconstructive abilities,which was the more discriminative feature between groups,followed by episodic verbal memory.This study was approved by the Institutional Ethics Committee of Centro Hospitalar e Universitário de Coimbra,Portugal(CE-029/2019)on June 24,2019. | Marisa Lima Miguel Tábuas-Pereira Diana Duro João Durães Daniela Vieira Inês Baldeiras Maria Rosário Almeida Isabel Santana | 2021 | Neural Regeneration Research2021，16，5： | 0 |
| 13 | Relation between Life Events and Intimacy and Relational Satisfaction in Men from 40 Years of Age显示文摘 | Madalena Luz de Almeida Isabel Leal | 2018 | Journal of Health Science2018，6，4： | 0 |
| 14 | Impact of Particle Size, Thermal Processing, Fat Inclusion and Moisture Addition on Pellet Quality and Protein Solubility of Broiler Feeds显示文摘 | Keysuke Muramatsu Alex Maiorka Isabel Cristina Mores Vaccari Renata Nuernberg Reis Fabiano Dahlke Adelar Almeida Pinto Uislei Antonio Dias Orlando Marcelo Bueno Momca Imagawa | 2013 | Journal of Agricultural Science and Technology(A)2013，3，12： | 0 |
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