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26篇 您的检索式：作者名="Ion David"

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	题名	作者	年代	出处	被引量
1	A view of cloud computing显示文摘	Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia	2010	Communications of the ACM2010，，4：	13
2	A view of cloud computing显示文摘	Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia	2010	Communications of the ACM2010，，4：	5
3	Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing.	Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann	2022	Bone Research2022，10，3：	2
4	Lasers for material processing显示文摘	Alexandru Nichici Ion David Eugen Cicala	1998	SPIE1998，3405，：	1
5	A view of cloud computing显示文摘	Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia	2010	Communications of the ACM2010，，4：	1
6	A view of cloud computing显示文摘	Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia	2010	Communications of the ACM2010，，4：	1
7	A view of cloud computing显示文摘	MICHAEL A ARMANDO F REAN Q ANTHONY D J RANDY K ANDY K GUNHO L DAVID P ARIEL R ION S MATEI Z	2010	Communications of the ACM2010，53，4：	1
8	Lasers for material processing 显示文摘	Alexandru Nichici Ion David Eugen Cicala	1998	SPIE1998，3405，：	1
9	A view of cloud computing显示文摘	Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia	2010	Communications of the ACM2010，，4：	1
10	A view of cloud computing显示文摘	Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia	2010	Communications of the ACM2010，，4：	1
11	Chord: A Scalable Peer-to-peer Lookup Service for Intemet Applications显示文摘	ION STOICA ROBERT MORRIS DAVID KARGER	2001	In Proc of the ACM SIGCOMM Conference2001，31，4：	1
12	A view of cloud computing显示文摘	Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia	2010	Communications of the ACM2010，，4：	1
13	A view of cloud computing显示文摘	Michael Armbrust Armando Fox Rean Griffith Anthony D. Joseph Randy Katz Andy Konwinski Gunho Lee David Patterson Ariel Rabkin Ion Stoica Matei Zaharia	2010	Communications of the ACM2010，，4：	1
14	Chord: A Scalable Peer-to-Peer Lookup Protocol for Intemet Applications显示文摘	ION S ROBERT M DAVID L N	2003	IEEE/ ACM Transations on Networking2003，11，1：	1
15	Chord:a scalable peer-to-peer lookup protocol for internet applications显示文摘	Ion Stoica Robert Morris David Liben-NowelL	2003	IEEE/ACM Transactions on Networking2003，11，2：	1
16	Chord: a scalable peer-to-peer lookup protocol for Inter- net applications 显示文摘	Ion Stoica Robert Morris David Liben Nowell	2003	IEEE/ACM Transactions on Networ- king2003，，：	1
17	,Chord:A Scalable Peer-To-Peer Lookup Service for Internet Applications显示文摘	Ion Stoica Robert Morris David Karger etc	2001	Proceedings of ACM Sigcomm2001，2001，：	1
18	Chord: a sealable Peer-to-Peer lookup protocol for internet applications 显示文摘	Ion Stoica Robert Morris David Liben-Nowell	2003	IEEE /ACM Transactions on Networking2003，11，1：	1
19	Chord显示文摘	Ion Stoica Robert Morris David Liben-Nowell David R. Karger M. Frans Kaashoek Frank Dabek Hari Balakrishnan	2003	IEEE/ACM Transactions on Networking (TON)2003，，1：	1
20	Optimal temperature control of intermittently heated buildings using Model Predictive Control: Part I – Building modeling显示文摘	Ion Hazyuk Christian Ghiaus David Penhouet	2011	Building and Environment2011，，：	1

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