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| 1 | Role of bile acid sequestrants in the treatment of type 2 diabetes显示文摘Cholestyramine is a first-generation bile acid sequestrant(BAS) and antihyperlipidemic agent that currentl y has limited use because of its relatively weak effect on lowering low density-lipoprotein(LDL)-chol es terol(C) and poor tolerability.The current first choice drugs for hyper-LDL-cholesterolemia are 3-hy droxy-3-me t hyl-glutaryl coenzyme A reductase inhibitors(statins) because of their strong LDL-C lowering effects and efficacy in prevention of card io vascular disease.Howe ver,after lowering the target levels of LDL-C in very high risk patients,combination therapy with statins and other antihyper lipidemic drugs may become more important for treatment of hyper-LDL-cholesterolemia.Second-generation BASs such as coles evelam and colestimide have a glucose-lowering effect and improved tolerance,which has led to re-evaluation of their utility in combination with statins or antidiabetic agents. | Kohzo Takebayashi Yoshimasa Aso Toshihiko Inukai | 2010 | World Journal of Diabetes2010，1，5： | 4 |
| 2 | Root Development and Nutrient Uptake显示文摘 | H. Wang Y. Inukai A. Yamauchi | 2006 | Critical Reviews in Plant Sciences2006，，3： | 2 |
| 3 | Effect of proton pump inhibitors on glycemic control in patients with diabetes显示文摘Gastrin is a linear peptide hormone which is secreted mostly in the stomach pyloric antrum G cells. Although the main role of this hormone is the promotion of the secretion of gastric acid from the stomach parietal cells, gastrin can also behave as a growth factor and stimulate gastric cell proliferation. It is also reported that gastrin promotes β cell neogenesis in the pancreatic ductal complex, modest pancreatic β cell replication, and improvement of glucose tolerance in animal models, in which the remodeling of pancreatic tissues is promoted. These findings suggest the possibility that gastrin has the potential to promote an increase of β cell mass in pancreas, and therefore that gastrin may improve glucose tolerance. Proton pump inhibitors(PPIs) are wildly used clinically for the therapy of gastro-esophageal reflex disease, gastritis due to excess stomach acid, and gastric ulcers. PPIs indirectly elevate serum gastrin levels via a negative feedback effect. Recent evidence has revealed the beneficial effect of PPIs on glycemic control especially in patients with type 2 diabetes mellitus(T2DM), probably via the elevation of the levels of serum gastrin, although the detailed mechanism remains unclear. In addition, the beneficial effects of a combination therapy of gastrin or a PPI with a glucagon-like peptide-1 receptor agonist on glycemic control in animal models have been demonstrated. Although PPIs may be possible candidates for a new approach in the therapy of diabetes, a prospective, longterm, randomized, double-blind, placebo-controlled study is needed to establish the effect of PPIs on glycemic control in a large number of patients with T2 DM. | Kohzo Takebayashi Toshihiko Inukai | 2015 | World Journal of Diabetes2015，6，10： | 2 |
| 4 | Glimepiride enhances intrinsic peroxisome proliferator-activated receptor gamma activity in 3T3-Ll adipocytes显示文摘 | Inukai K Watanabe M Nakashim Y | 2005 | Biochem Biophys Res Commun2005，328，2： | 1 |
| 5 | Anatomical variants in the floor of the thirdventricle; implications for endoscopic third ventriculostomy 显示文摘 | Morota N Watabe T Inukai T | 2000 | J Neurol Neurosurg Psychiatry2000，69，4： | 1 |
| 6 | Clinical evaluation of gasless endoscopic thyroid surgery显示文摘 | Inukai M U sui Y | 2005 | Surg Today2005，35，3： | 1 |
| 7 | Small low-density lipoprotein and small low-density lipoproteirdtotal low-density lipoprotein are closely associated with intima-media thickness of the carotid artery in Type 2 diabetic patients 显示文摘 | INUKAI T YAMAMOTO R SUETSUGU M | 2005 | J Diabetes Complications2005，19，5： | 1 |
| 8 | Endoplasmic reticulum stress inducers, but not imatinib, sensitize Philadelphia chromosome-positive leukemia cells to TRAIL-mediated apoptosis显示文摘 | Xiaochun Zhang Takeshi Inukai Koshi Akahane Kinuko Hirose Itaru Kuroda Hiroko Honna Kumiko Goi Keiko Kagami Tetsuzo Tauchi Hideo Yagita Kanji Sugita | 2011 | Leukemia Research2011，，7： | 1 |
| 9 | Insulin resistance and changes in the blood coagulation-fibrinolysis system after a glucose clamp technique in patients with type 2 diabetes mellitus显示文摘 | Takanashi K Inukai T | 2000 | J Med2000，31，： | 1 |
| 10 | SLUG,a ces-1-related zinc finger transcription factor gene with antiapoptotic activity,is a downstream target of the E2A-HLF oncoprotein显示文摘 | Inukai T Inoue A Kurosawa H | 1999 | Mol Cell1999，4，： | 1 |
| 11 | Where do gibberellin biosynthesis and gibberellin signaling occur in rice plants显示文摘 | Keneko M ltoh H Inukai Y | | 0，，： | 1 |
| 12 | TNF-related apoptosis-indu-cing ligand (TRAIL) frequently induces apoptosis in Philadelphiachromosome-positive leukemia cells 显示文摘 | Uno K Inukai T Kayagaki N | 2003 | Blood2003，101，9： | 1 |
| 13 | Novel microRNAs dif*ferentially expressed during aging in the mouse brain 显示文摘 | Inukai S de Lencastre A Turner M | 2012 | PLoSOne2012，7，40： | 1 |
| 14 | ANGPTL3 is increase in both insulin-deficient and resistant diabetic states显示文摘 | Inukai K Nakashima Y WatanabeM | 2004 | Biochem Biopkys Res Commun2004，317，4： | 1 |
| 15 | Association of cardio- ankle vascular index with brain natriuretic peptide levels in hypertension 显示文摘 | Masugata H Senda S Inukai M | 2012 | J Atheroscler Thromb2012，19，3： | 1 |
| 16 | Efficacy of glimepiride in Japanese type 2 diabetic subjects显示文摘 | Inukai K | 2005 | Diabetes Res Clin Pract2005，68，3： | 1 |
| 17 | Resistance of infant leukemia with MLL rearrangement to tumor necrosis factor-related apoptosis-inducing ligand: a possible mechanism for poor sensitivity to antitumor immunity显示文摘 | Inukai T Zhang X Goto M | 2006 | Leukemia2006，20，12： | 1 |
| 18 | 显示文摘 | Tankanashi K Inukai T | 2000 | J Med2000，31，12： | 1 |
| 19 | Development of pre-isogenic lines for rice blast-resistance by marker-aided selection from a recombinant inbred population显示文摘 | T. Inukai R. S. Zeigler S. Sarkarung M. Bronson L. V. Dung T. Kinoshita R. J. Nelson | 1996 | Theoretical and Applied Genetics1996，，4： | 1 |
| 20 | Rescue of rat anterior horn neurons after spinal cord injury by retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene 显示文摘 | Nakajima H Uchida K Kobayashi S Inukai T Horiuchi Y Yayama T | 2007 | Neurotrauma2007，24，4： | 1 |
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