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| 1 | Complex role for the immune system in initiation and progression of pancreatic cancer显示文摘The immune system plays a complex role in the development and progression of pancreatic cancer. Inflammation can promote the formation of premalignant lesions and accelerate pancreatic cancer development. Conversely, pancreatic cancer is characterized by an immunosuppressive environment, which is thought to promote tumor progression and invasion. Here we review the current literature describing the role of the immune response in the progressive development of pancreatic cancer, with a focus on the mechanisms that drive recruitment and activation of immune cells at the tumor site, and our current understanding of the function of the immune cell types at the tumor. Recent clinical and preclinical data are reviewed, detailing the involvement of the immune response in pancreatitis and pancreatic cancer, including the role of specific cytokines and implications for disease outcome. Acute pancreatitis is characterized by a predominantly innate immune response, while chronic pancreatitis elicits an immune response that involves both innate and adaptive immune cells, and often results in profound sys-temic immune-suppression. Pancreatic adenocarcinoma is characterized by marked immune dysfunction driven by immunosuppressive cell types, tumor-promoting immune cells, and defective or absent inflammatory cells. Recent studies reveal that immune cells interact with cancer stem cells and tumor stromal cells, and these interactions have an impact on development and progression of pancreatic ductal adenocarcinoma(PDAC). Finally, current PDAC therapies are reviewed and the potential for harnessing the actions of the immune response to assist in targeting pancreatic cancer using immunotherapy is discussed. | Kristin S Inman Amanda A Francis Nicole R Murray | 2014 | World Journal of Gastroenterology2014，20，32： | 11 |
| 2 | Effects of all-trans-retinoic acid on melanocyte adhesion and motility 显示文摘 | Situ R Inman DR Fligiel SEG | 1993 | Dermatology1993，186，： | 1 |
| 3 | Problem-based learning and the medical school:another case of the emperor's new clothes?显示文摘 | BUTLER R INMAN D LOBB D | 2005 | Adv Physiol Educ2005，29，4： | 1 |
| 4 | The challenge of early diagnosis in ankylosing spondylitis显示文摘 | O'Shea F Salonen D Inman R | 2007 | Journal of Rheumatology2007，34，1： | 1 |
| 5 | Chained cross-training of assembly line workers显示文摘 | Inman R R Jordan W C Blumenfeld D E | 2004 | International Journal of Production Research2004，42，10： | 1 |
| 6 | Endothelin-receptor blockade mitigates the adverse effect of preretrieval warm ischemia on posttransplantation renal function in rats 显示文摘 | INMAN S R PLOTT W K POMILEE R A | 2003 | Transplantation2003，75，10： | 1 |
| 7 | 显示文摘 | Inman R D Gallegos K V Brause B D | 1984 | Am J Med1984，77，： | 1 |
| 8 | ASRS Sizing for Recreating Automotive Assembly Sequences 显示文摘 | Inman R R | 2003 | International Journal of Production Research2003，41，5： | 1 |
| 9 | Urachal anomalies:a lon- gitudinal study of uraehal remnants in children and adults显示文摘 | Ashley R A Inman B A Routh J C | 2007 | JUrol2007，178，4： | 1 |
| 10 | Voltammetry of titanium dioxide in molten calcium chloride at 900℃显示文摘 | DRING K DASHWOOD R INMAN D | 2005 | Journal of the Electrochemical Society2005，152，3： | 1 |
| 11 | A double-blinded, placebo-con trolled trial of low dose infliximab in ankylosing spondylitis显示文摘 | Inman R D Maksymowych W P | 2010 | J Rheumatol2010，37，6： | 1 |
| 12 | The effects of intranasal budesonide on allergen-induced production of interleukin-5 and eotaxin, airways, blood, and bone marrow eosinophilia, and eosinophil progenitor expansion in sensitized mice 显示文摘 | Shen H O'Byrne PM Ellis R Wattie J Tang C Inman MD | 2002 | Respir Crit Care Med2002，166，2： | 1 |
| 13 | Multi-walled carbon nanotube interactions with human epidermal keratinocytes 显示文摘 | Monteiro-Rivierea N A Nemanich R J Inman A O | 2005 | Toxicol Lett2005，155，： | 1 |
| 14 | Multi-walled carbon nanotube interactions with human epidermal keratinocytes显示文摘 | Monteiro-Riviere NA Nemanich R J Inman AO | 2005 | Toxicol Lett2005，155，： | 1 |
| 15 | Total JIT(T-JIT)and Its Impact on Supply Chain Competency and Organizational Performance显示文摘 | Green Jr K W Inman R A Birou L M | 2014 | International Journal of Production Economics2014，147，： | 1 |
| 16 | Modified goal chasing for products with non-zero/one bills of materials显示文摘 | Cakir A Inman R R | 1993 | International Journal of Production Research1993，31，1： | 1 |
| 17 | A simulation-based comparison of TOC and traditional accounting performance measures in a process industry 显示文摘 | SATISH MEHRA R ANTHONY INMAN GREGORY TUITE | 2005 | Journal of Manufacturing Technology Management2005，16，3： | 1 |
| 18 | The potential of land conservation agreements for protection of water resources显示文摘 | Smith L Inman A Cherrington R | 2012 | Environmental Science and Policy2012，24，： | 1 |
| 19 | Urachal car cinoma- clinicopathologic features and long term out- comes of an aggressive malignancy显示文摘 | Ashley R A Inman B A Sebo T J | 2006 | Cancer2006，107，4： | 1 |
| 20 | Multi-welled carbom nanotube interactions with human epidermal keratinocytes显示文摘 | MONTEIRO-RIVIERE N A NEMANICH R J INMAN A O | 2005 | Toxicology Letters2005，155，3： | 1 |
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