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| 1 | Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases显示文摘Proteases, enzymes catalyzing the hydrolysis of peptide bonds, are present at high concentrations in the gastrointestinal tract. Besides their well-known role in the digestive process, they also function as signaling molecules through the activation of protease-activated receptors(PARs). Based on their chemical mechanism for catalysis, proteases can be classified into several classes: serine, cysteine, aspartic, metallo- and threonine proteases represent the mammalian protease families. In particular, the class of serine proteases will play a significant role in this review. In the last decades, proteases have been suggested to play a key role in the pathogenesis of visceral hypersensitivity, which is a major factor contributing to abdominal pain in patients with inflammatory bowel diseases and/or irritable bowel syndrome. So far, only a few preclinical animal studies have investigated the effect of protease inhibitors specifically on visceral sensitivity while their effect on inflammation is described in more detail. In our accompanying review we describe their effect on gastrointestinal permeability. On account of their promising results in the field of visceral hypersensitivity, further research is warranted. The aim of this review is to give an overview on the concept of visceral hypersensitivity as well as on the physiological and pathophysiological functions of proteases herein. | Hannah Ceuleers Hanne Van Spaendonk Nikita Hanning Jelena Heirbaut Anne-Marie Lambeir Jurgen Joossens Koen Augustyns Joris G De Man Ingrid De Meester Benedicte Y De Winter | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 2 | European evidence based consensus for endoscopy in inflammatory bowel disease显示文摘 | Vito Annese Marco Daperno Matthew D. Rutter Aurelien Amiot Peter Bossuyt James East Marc Ferrante Martin G?tz Konstantinos H. Katsanos Ralf Kie?lich Ingrid Ordás Alessandro Repici Bruno Rosa Shaji Sebastian Torsten Kucharzik Rami Eliakim | 2013 | Journal of Crohn’s and Colitis2013，，12： | 7 |
| 3 | Regulation of intestinal permeability: The role of proteases显示文摘The gastrointestinal barrier is-with approximately 400 m^2-the human body's largest surface separating the external environment from the internal milieu. This barrier serves a dual function: permitting the absorption of nutrients, water and electrolytes on the one hand, while limiting host contact with noxious luminal antigens on the other hand. To maintain this selective barrier, junction protein complexes seal the intercellular space between adjacent epithelial cells and regulate the paracellular transport. Increased intestinal permeability is associated with and suggested as a player in the pathophysiology of various gastrointestinal and extraintestinal diseases such as inflammatory bowel disease, celiac disease and type 1 diabetes. The gastrointestinal tract is exposed to high levels of endogenous and exogenous proteases, both in the lumen and in the mucosa. There is increasing evidence to suggest that a dysregulation of the protease/antiprotease balance in the gut contributes to epithelial damage and increased permeability. Excessive proteolysis leads to direct cleavage of intercellular junction proteins, or to opening of the junction proteins via activation of protease activated receptors. In addition, proteases regulate the activity and availability of cytokines and growth factors, which are also known modulators of intestinal permeability. This review aims at outlining the mechanisms by which proteases alter the intestinal permeability. More knowledge on the role of proteases in mucosal homeostasis and gastrointestinal barrier function will definitely contribute to the identification of new therapeutic targets for permeability-related diseases. | Hanne Van Spaendonk Hannah Ceuleers Leonie Witters Eveline Patteet Jurgen Joossens Koen Augustyns Anne-Marie Lambeir Ingrid De Meester Joris G De Man Benedicte Y De Winter | 2017 | World Journal of Gastroenterology2017，23，12： | 6 |
| 4 | Complement activation in the context of stem cells and tissue repair显示文摘The complement pathway is best known for its role in immune surveillance and inflammation. However,its ability of opsonizing and removing not only pathogens,but also necrotic and apoptotic cells,is a phylogenetically ancient means of initiating tissue repair. The means and mechanisms of complement-mediated tissue repair are discussed in this review. There is increasing evidence that complement activation contributes to tissue repair at several levels. These range from the chemo-attraction of stem and progenitor cells to areas of complement activation,to increased survival of various cell types in the presence of split products of complement,and to the production of trophic factors by cells activated by the anaphylatoxins C3 a and C5 a. This repair aspect of complement biology has not found sufficient appreciation until recently. The following will examine this aspect of complement biology with an emphasis on the anaphylatoxins C3 a and C5 a. | Ingrid U Schraufstatter Sophia K Khaldoyanidi Richard G DiScipio | 2015 | World Journal of Stem Cells2015，7，8： | 2 |
| 5 | Effect of Cyclosporine on Left Ventricular Remodeling After Reperfused Myocardial Infarction显示文摘 | Nathan Mewton Pierre Croisille Gerald Gahide Gilles Rioufol Eric Bonnefoy Ingrid Sanchez Thien Tri Cung Catherine Sportouch Denis Angoulvant Gérard Finet Xavier André-Fou?t Geneviève Derumeaux Christophe Piot Hélène Vernhet Didier Revel Michel Ovize | 2010 | Journal of the American College of Cardiology2010，，12： | 2 |
| 6 | Characteristics of an inducible cell-free antibacterial reaction in hemolymph of Samiacynthia pupae 显示文摘 | Boman H G Ingrid N F Kerstin P | 1974 | Infect Immun1974，10，： | 1 |
| 7 | Antioxidant assessment of an anthocyanin-enriched blackberry extract显示文摘 | INGRID E CHUN H DAVID G P | 2007 | Food Chemistry2007，101，： | 1 |
| 8 | Costs and Benefits for Farmers Participating in Innovative Marketing Channels for Quality Food Products显示文摘 | Verhaegen Ingrid Van H G | 2001 | Journal of Rural Studies2001，4，17： | 1 |
| 9 | Development of an immunoassay for the pyrcthroid insecticide esfenvalerate显示文摘 | SHAN G M DONALD W S INGRID W | 1999 | Journal of Agricultural and Food Chemistry1999，47，5： | 1 |
| 10 | Endocytosis and degradation of monoclonal antibodies targeting human B-cell malignancies显示文摘 | Farr A G Ingrid Borroz K | 1989 | Cancer Res1989，49，6： | 1 |
| 11 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 12 | Identification of anammox bacteria in a full--scale deammonification plant making use of anaerobic ammonia oxidation 显示文摘 | Innerebnera G Insama H Ingrid H | 2007 | Systematic and Applied Microbiology2007，30，5： | 1 |
| 13 | Development of an enzyme-linked immunosorbent assay for the detection of the pyrethroid insecticide fenpropathrin 显示文摘 | Donald W S Shirley J G | 1998 | J Agric and Food Chemistry1998，46，： | 1 |
| 14 | The rabbit as an ex- perimental and production animal: From genomics to pro- teomics 显示文摘 | Ingrid M Claire R G Domenico S | 2014 | Current Protein Peptide Sci2014，15，2： | 1 |
| 15 | Effects of tillage on runoff and erosion patterns显示文摘 | Ingrid T Gerard G Victor J | 2001 | Soil & Tillage research2001，61，1： | 1 |
| 16 | Introgression in interspecific hybrids of lily显示文摘 | VAN TUYl J M INGRID W G M MASS KI-BYUNG LIM | 2002 | Acta Hort ISHS2002，570，： | 1 |
| 17 | Pentaehlorophenol exposure in women with gynecological and endocrine dysfunction 显示文摘 | Ingrid G Anita F Bondo M | 1999 | Environ Res1999，80，： | 1 |
| 18 | 热性惊厥显示文摘热性惊厥是最常见的抽搐性疾病这是一种良性疾病、对认知无影响热性惊厥儿童有三分之一可复发,而发生癫痈的危险很小发生癫病的危险因素包括复杂热性惊厥、神经系统异常以及有癫痈家族史9%的儿童热性惊厥发作持续时间长; | Lynette G Sadleir Ingrid E Scheffer 杨群 | 2007 | 英国医学杂志中文版2007，10，5： | 1 |
| 19 | Humoral immune response against defined oxidized low-density lipoprotein antigens reflects structure and disease activity of carotid plaques显示文摘 | Isabel G Marie-Louise MG Ingrid S | 2005 | Arterioscler Thromb Vasc Biol2005，25，： | 1 |
| 20 | Antioxidant assessment of an an-thocyanin-enriched blackberry extract 显示文摘 | INGRID E HU C DAVID G P | 2007 | Food Chem2007，101，3： | 1 |
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