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| 1 | Helicobacter pylori vac A genotype is a predominant determinant of immune response to Helicobacter pylori CagA显示文摘AIM To evaluate the frequency of Helicobacter pylori(H. pylori) Cag A antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori Cag A-immune response.METHODS Systematic data to H. pylori isolates, blood samples, gastric biopsies for histological and molecular analyses were available from 99 prospectively recruited subjects. Serological profile(anti-H. pylori, anti-Cag A) was correlated with H. pylori isolates(cag A, EPIYA, vac A s/m genotype), histology(Sydney classification) and mucosal interleukin-8(IL-8) m RNA and protein expression. Selected H. pylori strains were assessed for H. pylori Cag A protein expression and IL-8 induction in co-cultivation model with AGS cells.RESULTS Thirty point three percent of microbiologically confirmed H. pylori infected patients were seropositive for Cag A. Majority of H. pylori isolates were cag A gene positive(93.9%) with following vac A polymorphisms: 42.4% vac A s1m1, 23.2% s1m2 and 34.3% s2m2. Anti-Cag AIg G seropositivity was strongly associated with atrophic gastritis, increased mucosal inflammation according to the Sydney score, IL-8 and cag A m RNA expression. V a c A s a n d m p o l y m o r p h i s m s w e r e t h e m a j o r determinants for positive(vac A s1m1) or negative(vac A s2m2) anti-Cag A serological immune response, which also correlated with the in vitro inflammatory potential in AGS cells. In vitro co-cultivation of representative H. pylori strains with AGS cells confirmed functional Cag A translocation, which showed only partial correlation with Cag A seropositivity in patients, supporting vac A as major co-determinant of the immune response.CONCLUSION Serological immune response to H. pylori cag A + strain in H. pylori infected patients is strongly associated with vac A polymorphism, suggesting the crucial role of bacterial factors in immune and clinical phenotype of the infection. | Alexander Link Cosima Langner Wiebke Schirrmeister Wiebke Habendorf Jochen Weigt Marino Venerito Ina Tammer Dirk Schlüter Philipp Schlaermann Thomas F Meyer Thomas Wex Peter Malfertheiner | 2017 | World Journal of Gastroenterology2017，23，26： | 12 |
| 2 | Differential expression of Notch genes in human osteoblastic cells 显示文摘 | Michael S Ina F Leo G | 2002 | Int J Mol Med2002，9，3： | 1 |
| 3 | Formation and plasticity of GABAergic synapses:physiological mechanisms an d patho- physiological implications 显示文摘 | JEAN - MARC F INA B | 2003 | Pharmecol Therap2003，98，： | 1 |
| 4 | Annexin A2 in amniotic fluid: correlation with histological chorioamnionitis, preterm premature rup- ture of membranes, and subsequent preterm delivery 显示文摘 | Namba F Ina S Kitajima H | 2012 | J Obstet Gynaecol Res2012，38，1： | 1 |
| 5 | Cafeic acid phenethylester as a lipoxygenase inhibor with antioxidant properties显示文摘 | SUD INA G F M Irzoeva O K PUSKAREVA M A | 1993 | Febs Lett1993，，： | 1 |
| 6 | Extensive clinical ex- perience: Relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperan- drogenism 显示文摘 | Carm ina E Ro sato F J anniA | 2006 | J Clin Endocrino 1M etab2006，91，1： | 1 |
| 7 | Sugarcane yellow leaf virus:an emerging virus that has evolved by recombination between luteoviral and poleroviral ancestors 显示文摘 | MOONAN F MOL INA J MIRKOV T E | 2000 | Virology2000，269，： | 1 |
| 8 | Structure of continuously cast Ni-based superalloy Inconel 713C显示文摘 | ZUPANI?F BON?INA T KRI?MAN A TICHELAAR F D | | 0，，1： | 1 |
| 9 | Microstructural constituents of the Ni-based superalloy GMR235 in the as-cast condition显示文摘 | ZUPANI?F BON?INA T KRI?MAN A MARKOLI B SPAI?S | | 0，，09： | 1 |
| 10 | Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors显示文摘 | Sud'ina G F Pushkareva M A Shephard P | | 0，，： | 1 |
| 11 | First GOCE gravity field models derived by three different approaches显示文摘 | Roland P Sean B Federica M Christoph F Helmut G Wolf D S Eduand H Mirko R Jan M B Oleg A Mantin V Thomas F Reinhard M Ina K Fernando S and Carl C T | | 0，，11： | 1 |
| 12 | Involvement of Panton - Valentine leukocidin - producing Staphylococcus aureus in primary skin infections andpneumonia显示文摘 | I ina G Piemont Y Godail - Gamot F | 1999 | Clin Infect Dis1999，29，10： | 1 |
| 13 | Bronchial arteriography and em- bolotherapy for hemoptysis in patients with cystic fibrosis 显示文摘 | Tonkin Ina Ld Aram S Hanissian Thomas F Boulden Scott L Baum Morris L Gavant Robert E Gold PhillipGeorge Warren J Green | 1991 | Cardiovascular and interventional radiology1991，14，4： | 1 |
| 14 | Laser capture microdissection:molecular analysis of t issue显示文摘 | Bonner R F Emmertbu CK M R Colekrist INA | | 0，，5342： | 1 |
| 15 | Monitoring free serum IgE in severe asthma patients treated with omalizumab显示文摘 | Stephanie K Ina H Florian F | 2012 | Respiratory Medicine2012，106，： | 1 |
| 16 | UV N2 laser ablation of a Cu-Sn-Zn-Pb alloy: Microstructure and topography studied by focused ion beam 显示文摘 | ZUPANIC F BON(~INA T PIPI(~ D HEN(~-BARTOLI(~ V | 2008 | Journal of Alloys and Compounds2008，465，： | 1 |
| 17 | Caffeic Acid Phenethylester as A Lipoxygenasc Inhibitor with Antioxidant Properties显示文摘 | Sud'ina G F Mirzoeva O K Puskareva M A | 1993 | FEBS Lett1993，329，： | 1 |
| 18 | Efficient secretion of biologically active recombinant OB protein (Leptin) in Escherichia coli, purification from the periplasm and characterization 显示文摘 | YVES G INA F L ARTHUR C | 1998 | Protein Expres Purer1998，12，2： | 1 |
| 19 | Use of octogenarian livers safely expands the donor pool 显示文摘 | Jimenez Romero C Moreno Gonzalez E Col ina Ruiz F | 1999 | Transplanta- tion1999，68，4： | 1 |
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