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| 1 | Immune response in COVID-19:addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2显示文摘To date,no vaccines or effective drugs have been approved to prevent or treat COVID-19 and the current standard care relies on supportive treatments.Therefore,based on the fast and global spread of the virus,urgent investigations are warranted in order to develop preventive and therapeutic drugs.In this regard,treatments addressing the immunopathology of SARS-CoV-2 infection have become a major focus.Notably,while a rapid and well-coordinated immune response represents the first line of defense against viral infection,excessive inflammatory innate response and impaired adaptive host immune defense may lead to tissue damage both at the site of virus entry and at systemic level.Several studies highlight relevant changes occurring both in innate and adaptive immune system in COVID-19 patients.In particular,the massive cytokine and chemokine release,the so-called“cytokine storm”,clearly reflects a widespread uncontrolled dysregulation of the host immune defense.Although the prospective of counteracting cytokine storm is compelling,a major limitation relies on the limited understanding of the immune signaling pathways triggered by SARS-CoV-2 infection.The identification of signaling pathways altered during viral infections may help to unravel the most relevant molecular cascades implicated in biological processes mediating viral infections and to unveil key molecular players that may be targeted.Thus,given the key role of the immune system in COVID-19,a deeper understanding of the mechanism behind the immune dysregulation might give us clues for the clinical management of the severe cases and for preventing the transition from mild to severe stages. | Michele Catanzaro Francesca Fagiani Marco Racchi Emanuela Corsini Stefano Govoni Cristina Lanni | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 11 |
| 2 | VEGF-E通过VEGF受体2特异性调控诱导正常和恶性组织中血管瘤样病变发生显示文摘病毒性VEGF-E(ov VEGF-E)属VEGF-A家族,在口疮病毒基因中被发现。与VEGF-A、B、C、D、胎盘生长因子(Pl GF)和蛇毒VEGF(sv VEGF)属同一家族成员。ov VEGF-E是VEGF家族中潜在的血管新生因子,其生物活性与VEGF-A相似,可促进血管内皮细胞分裂增殖。 | Fagiani E Lorentz P Bill R | 2016 | 中国口腔颌面外科杂志2016，14，3： | 9 |
| 3 | Nintedanib Is a Highly Effective Therapeutic for Neuroendocrine Carcinoma of the Pancreas (PNET) in the Rip1Tag2 Transgenic Mouse Model显示文摘 | Bill Ruben Fagiani Ernesta Zumsteg Adrian Antoniadis Helena Johansson David Haefliger Simon Albrecht Imke Hilberg Frank Christofori Gerhard | 2015 | Clinical Cancer Research2015，，21： | 1 |
| 4 | Angiopoietinsinangiogenesis显示文摘 | FAGIANIE CHRISTOFORIG | 2013 | CancerLetters2013，328，： | 1 |
| 5 | Angiopoietin-1 and 2 exert antagonistic functions in tumor angiogenesis,yet both in- duce lymphangiogenesis显示文摘 | Fagiani E Lorentz P Kopfsten I | 2011 | Cancer Res2011，71，1： | 1 |
| 6 | An giopoietin-1 and 2 exert antagonistic functions in tumor angiogenesis,yet both induce lymphangiogenesis显示文摘 | FAGIANI E LORENTZ P KOPFSTEM L | 2011 | Cancer Res2011，71，： | 1 |
| 7 | Cost and emissions impacts of plug-in hybrid vehicles on the Ohio power system 显示文摘 | Ramteen Sioshansi Riccardo Fagiani Vincenzo Marano | 2010 | Energy Policy2010，，38： | 1 |
| 8 | Angiopoietins in angiogenesis显示文摘 | Fagiani E Christofori G | 2013 | Cancer Lett2013，328，1： | 1 |
| 9 | Molecular regulations of circadian rhythm and implications for physiology and diseases显示文摘The term'circadian rhythms'describes endogenous oscillations with ca.24-h period associated with the earth’s daily rotation and light/dark cycle.Such rhythms reflect the existence of an intrinsic circadian clock that temporally orchestrates physiological processes to adapt the internal environment with the external cues. | Francesca Fagiani Daniele Di Marino Alice Romagnoli Cristina Travelli Davide Voltan Lorenzo Di Cesare Mannelli Marco Racchi Stefano Govoni Cristina Lanni | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 1 |
| 10 | Angiopoietins in angiogenesis 显示文摘 | Fagiani E Christofori G | 2013 | Cancer Lett2013，328，1： | 1 |
| 11 | Angiopoietin-1 and-2 exert antagonistic functions in tumor angiogenesis,yet both induce lymphangiogenesis显示文摘 | Fagiani E Lorentz P Kopfstein L | | 0，，17： | 1 |
| 12 | Angiopoietin-1 and -2 exert antagonistic functions in tumor angiogenesis, yet both induce lymphangiogenesis 显示文摘 | Fagiani E Lorentz P Kopfstein L | 2011 | Cancer Res2011，71，17： | 1 |
| 13 | Angiopoietin-1 and-2 exert antagonistic functions in tumor angiogenesis,yet both induce lymphangiogenesis显示文摘 | Fagiani E Lorentz P Kopfstein L | 2011 | Cancer Res2011，71，17： | 1 |
| 14 | Angiopoietins in angiogenesis显示文摘 | Fagiani E Christofori G | 2013 | Cancer Lett2013，328，1： | 1 |
| 15 | Angiopoietin-1 and -2 exert antagonistic functions in tumor angiogenesis, yet both induce lymphangiogenesis显示文摘 | Fagiani E Lorentz P Kopfstein L | 2011 | Cancer Res2011，71，17： | 1 |
| 16 | Angiopoietins in angiogenesis 显示文摘 | Fagiani E Christofori G | 2013 | Cancer Lett2013，328，1： | 1 |
| 17 | Angiopoietins in angiogencsis 显示文摘 | Fagiani E Christofori G | 2013 | Can- cer Left2013，328，1： | 1 |
| 18 | Angiopoietins in angiogenesis 显示文摘 | Fagiani E Christofori G | 2013 | Cancer Lett2013，328，1： | 1 |
| 19 | Molecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2显示文摘An elegant paper by Yuan et al.,recently published in Science,provides novel insights into the molecular features of neutralizing antibody responses to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Francesca Fagiani Michele Catanzaro Cristina Lanni | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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