|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Basic Helix-Loop-Helix Transcription Factor MYC1 Is Involved in the Regulation of the Flavonoid Biosynthesis Pathway in Grapevine显示文摘以前的结果显示在葡萄藤(Vitis vinifera ) ,由 MYB 抄写因素的 flavonoid 小径基因的规定与基本 helix-loop-helix 蛋白质(bHLHs ) 取决于他们的相互作用。现在的学习描述从葡萄藤的因素说出 VvMYC1 的 bHLH 的第一功能的描述。这个抄写因素种系发生地与 Arabidopsis bHLH 蛋白质,它参予 flavonoid 生合成和表皮的房间命运的控制有关。二混血儿的试金表明了的短暂倡导者和酵母 VvMYC1 身体上与劝诱 flavonoid 小径基因的倡导者的 MYB5a, MYB5b, MYBA1/A2,和 MYBPA1 交往,这在 anthocyanin 或 proanthocyanidin (PA ) 包含了合成。另外,短暂倡导者试金表明 VvMYC1 涉及它的自己的表示的反馈规定。抄本在果浆的皮肤和种子与 anthocyanins 和舞步的合成在果浆发展相互关联期间 VvMYC1 铺平,建议 VvMYC1 涉及在这些机关的 anthocyanins 和 PA 合成的规定。同样, VvMYC1 和 VvMYBA1 的短暂表示在葡萄藤暂停房间导致 anthocyanin 合成。这些结果建议 VvMYC1 是在葡萄藤控制 anthocyanin 和 PA 生合成的 transcriptional 串联的部分。 | Imene Hichri Simon C. Heppel Jeremy Pillet Celine Leon Stefan Czemmel Serge Delrot Virginie Lauvergeat Jochen Bogs | 2010 | Molecular Plant2010，3，3： | 46 |
| 2 | Overview of cytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBDs), including Crohn's disease and ulcerative colitis are complex disorders with undetermined etiology. Several hypotheses suggest that IBDs result from an abnormal immune response against endogenous flora and luminal antigens in genetically susceptible individuals. The dysfunction of the mucosal immune response is implicated in the pathogenesis of IBD. The balance between pro-inflammatory cytokines [tumor necrosis factor(TNF)-α, interleukin(IL)-1b, IL-8, and IL-17A], anti-inflammatory cytokines(IL-4 and IL-13), and immunoregulatory cytokines(IL-10 and transforming growth factors b) is disturbed. Moreover, evidence from animal and clinical studies demonstrate a positive correlation between an increased concentration of nitric oxide(NO) and the severity of the disease. Interestingly, proinflammatory cytokines are involved in the up-regulation of inducible oxide synthase(iN OS) expression in IBD. However, anti-inflammatory and immunoregulatory cytokines are responsible for the negative regulation of iN OS. A positive correlation between NO production and increased pro-inflammatory cytokine levels(TNF-α, IL-6, IL-17, IL-12, and interferon-γ) were reported in patients with IBD. This review focuses on the role of cytokines in intestinal inflammation and their relationship with NO in IBD. | Imene Soufli Ryma Toumi Hayet Rafa Chafia Touil-Boukoffa | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，3： | 30 |
| 3 | Phenolic and flavonoid contents, antioxidant and antimicrobial activities of leaf extracts from ten Algerian Ficus carica L. varieties显示文摘Objective: To determine the total phenolic and flavonoid contents, antioxidant and antimicrobial activities of methanolic leaf extracts of ten Algerian fig(Ficus carica L.)varieties(uniferous, biferous and caprifig tree).Methods: Phenolics were extracted by Soxhlet method and analyzed by the Folin–Ciocalteu colorimetric method. Flavonoids were determined by aluminum trichloride assay and the antioxidant capacity was determined by the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay. The antimicrobial activity was studied with the disc diffusion method and a macrodilution broth method was used to determine the minimal inhibitory concentrations and minimal lethal concentrations.Results: The mean extract yield was 14.10% ± 0.66%(n = 10). Leaf extract of biferous followed by uniferous varieties had the highest total phenolic contents [(52.296 ± 5.232)and(48.973 ± 2.015) mg gallic acid equivalent/g of dry plant extract respectively], flavonoids [(14.388 ± 0.333) and(14.136 ± 1.082) mg quercetin equivalent/g of dry plant extract] and antioxidant capacity [IC50(798.754 ± 108.590) and(825.004 ± 110.835) mg/m L]. Antioxidant capacity of fig leaves was significantly correlated with phenolic contents(r = 0.748). These extracts showed bactericidal activity and moderate antifungal activity, and the minimal inhibitory concentrations and minimal lethal concentrations were determined on Bacillus cereus and Staphylococcus aureus.Conclusions: All tested extracts contain phenolic compounds and exhibited an antioxidant activity and an antimicrobial effect against Gram-positive and Gram-negative bacteria. Further researches on identification and purification of phenolic compounds are required. | Souhila Mahmoudi Mustapha Khali Abderahim Benkhaled Karima Benamirouche Imen Baiti | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，3： | 17 |
| 4 | 富马酸替诺福韦二吡呋酯片在健康国人体内的药动学及生物等效性研究显示文摘目的:建立人血浆中替诺福韦浓度的LC-MS/MS测定法,并用于富马酸替诺福韦二吡呋酯片的药动学和生物等效性研究。方法:采用自身双交叉试验设计,20例男性健康受试者随机分成2组,分别空腹口服受试制剂或参比制剂300 mg,0~72 h间隔采集血样。以LC-MS/MS法测定血浆替诺福韦浓度,DAS2.1.1计算药动学参数。结果:建立的LC-MS/MS法在2~1 200 ng.mL-1范围内线性关系良好,最低定量限为2 ng·mL-1,批内及批间精密度RSD均小于15%。受试制剂与参比制剂的Tmax均为(0.5±0.2)h,Cmax分别为(604±207)和(573±189)ng.mL-1,t1/2分别为(17.1±2.9)和(17.4±4.0)h,AUC0~72 h分别为(2 490±604)和(2 297±499)h·ng·mL-1。结论:建立的LC-MS/MS法准确可靠,富马酸替诺福韦二吡呋酯片两种制剂生物等效。 | 宫旭 Imene Adouani 曾雪芳 杭太俊 宋敏 | 2013 | 中国新药杂志2013，22，6： | 8 |
| 5 | Antihydatic and immunomodulatory effects of Punica granatum peel aqueous extract in a murine model of echinococcosis显示文摘Objective:To investigate the effect of pomegranate peel aqueous extract(PGE) on the development of secondary experimental echinococcosis and on the viability of Echinococcux granulosus protoscoleces,and the immunomodulatory properties of PGE.Methods:Swiss mice were inoculated intraperitoneally with viable protoscoleces.Then,PGE was orally administered daily during cystic echinococcosis development.Cyst development and hepatic damage were macroscopically and histologically analyzed.The production of nitric oxide and TNF-α was assessed in plasma and the hepatic expression of iNOS.TNF-α,NF-κB and CD68 was examined.Moreover,protoscoleces were cultured and treated with different concentrations of PGE.Results:It was observed that in vitro treatment of protoscoleces caused a significant decrease in viability in a PGE-dose-dependent manner.In vivo,after treatment of cystic echinococcosis infected mice with PGE,a significant decrease in nitric oxide levels(P<0.000 1)and TNF-α levels(P<0.001) was observed.This decline was strongly related to the inhibition of cyst development(rate of hydatid cyst growth inhibition=63.08%) and a decrease in CD68 expression in both the pericystic layer of hepatic hydatid cysts and liver tissue(P<0.000 1).A significant diminution of iNOS,TNF-α and NF-κB expression was also observed in liver tissue of treated mice(P<0.000 1).Conclusions:Our results indicate an antihydatic scolicidal effect and immunomodulatory properties of PGE,suggesting its potential therapeutic role against Echinococcuss granulosus infection. | Moussa Labsi Lila Khelifi Dalila Mezioug Imene Soufli Chafia Touil-Boukoffa | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，3： | 5 |
| 6 | 阿尔及利亚中医药发展现状与分析显示文摘阿尔及利亚国民均可享受免费医疗制度,缺血性心脏病、脑卒中及AD等非传染性疾病发病率较高。针灸疗法已在阿尔及利亚获得民众认可,具有一定影响力。然而,受当地中医药人才培养不足、民众中医药知识匮乏、中医药尚未纳入医保等因素的限制,中医药在当地的临床应用和传播推广受到一定影响。建议从突破教育瓶颈、扩大人才队伍,开展针对性宣传、扩大中医药影响,推进中医药项目纳入医疗保险、促进政府立法保护等方面入手,提升扩大中医药传播力度和影响范围,推动中医药在阿尔及利亚的良性发展。 | 王靖怡 魏竞竞 Adouani Imene 李皓月 赫兰晔 赵静 许家杰 曹洪欣 | 2021 | 国际中医中药杂志2021，43，2： | 5 |
| 7 | Cytokine and apoptosis gene polymorphisms influence the outcome of hepatitis C virus infection显示文摘BACKGROUND:Hepatitis C virus (HCV) infection is thought to be chronic and the factors leading to viral clearance or persistence are poorly understood.This study was undertaken to investigate the possibility of a significant relationship between the spontaneous clearance or the persistence of hepatitis C virus (HCV) infection and cytokine and apoptosis gene polymorphisms in Tunisian patients on hemodialysis.METHODS:Polymorphisms of the genes IL-1 (-889 IL-1α,-511 and +3954 IL-1β,IL-1Ra),IL-18 (-137 and-607),IL-12 (-1188) and Apo1/Fas (-670) were determined by PCR-RFLP,PCR-SSP and PCR-VNTR in 100 healthy blood donors and 100 patients infected with HCV and undergoing hemodialysis.The patients were classified into two groups:G1 consisted of 76 active chronic hepatitis patients (positive for HCV RNA) and G2 consisted of 24 hemodialysed patients who spontaneously eliminated the virus (negative for HCV RNA).RESULTS:The frequency of genotype association [-137GC/-607CA] IL-18 was higher in G2 (41.7%) than in G1 (15.8%) (P=0.008;OR=0.26;95% CI,0.10-0.73).We also found a higher frequency of the AA genotype of the Apo1/Fas gene in G2 (41.6%) than in G1 (17.5%) (P=0.026;OR=3.49;95% CI,1.13-10.69).Adjustment for known covariate factors (age,gender and genotype) confirmed these univariate findings and revealed that the genotype association GC-CA of the (-137 and-607) IL-18 gene and the AA genotype of the Apo1/Fas gene were associated with the clearance of HCV (P=0.041 and 0.017,respectively).CONCLUSION:The two genotypes GC-CA of the (-137 and-607) IL-18 polymorphism and the AA genotype of the Apo1/Fas gene influence the outcome of HCV infection in Tunisian patients on hemodialysis. | Leila Ksiaa Cheikhrouhou Imen Sfar Hajer Aounallah-Skhiri Houda Aouadi Salwa Jendoubi-Ayed Taieb Ben Abdallah Khaled Ayed Yousr Lakhoua-Gorgi | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 4 |
| 8 | Robust Neural Control of Discrete Time Uncertain Nonlinear Systems Using Sliding Mode Backpropagation Training Algorithm显示文摘This work deals with robust inverse neural control strategy for a class of single-input single-output(SISO) discrete-time nonlinear system affected by parametric uncertainties. According to the control scheme, in the first step, a direct neural model(DNM)is used to learn the behavior of the system, then, an inverse neural model(INM) is synthesized using a specialized learning technique and cascaded to the uncertain system as a controller. In previous works, the neural models are trained classically by backpropagation(BP) algorithm. In this work, the sliding mode-backpropagation(SM-BP) algorithm, presenting some important properties such as robustness and speedy learning, is investigated. Moreover, four combinations using classical BP and SM-BP are tested to determine the best configuration for the robust control of uncertain nonlinear systems. Two simulation examples are treated to illustrate the effectiveness of the proposed control strategy. | Imen Zaidi Mohamed Chtourou Mohamed Djemel | 2019 | International Journal of Automation and computing2019，16，2： | 4 |
| 9 | Association of Fas/Apo1 gene promoter (-670 A/G) polymorphism in Tunisian patients with IBD显示文摘AIM: To detect a possible association between the polymorphism of the (-670 A/G) Fas/Apo1 gene promoter and susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) in the Tunisian population. METHODS: The (-670 A/G) Fas polymorphism was analyzed in 105 patients with CD, 59 patients with UC, and 100 controls using the polymerase chain reaction restriction fragment length polymorphism method. RESULTS: Significantly lower frequencies of the Fas -670 A allele and A/A homozygous individuals were observed in CD and UC patients when compared with controls. Analysis of (-670 A/G) Fas polymorphism with respect to sex in CD and UC showed a significant difference in A/A genotypes between female patients and controls (P corrected = 0.004 in CD patients and P corrected = 0.02 in UC patients, respectively). Analysis also showed a statistically significant association between genotype AA of the (-670 A/G) polymorphism and the ileum localization of the lesions (P corrected = 0.048) and between genotype GG and the colon localization (Pcorrected = 0.009). The analysis ofinflammatory bowel disease patients according to clinical behavior revealed no difference. CONCLUSION: Fas-670 polymorphism was associated with the development of CD and UC in the Tunisian population. | Walid Ben Aleya Imen Sfar Leila Mouelhi Houda Aouadi Mouna Makhlouf Salwa Ayed-Jendoubi Samira Matri Azza Filali Taoufik Najjar Taeib Ben Abdallah Khaled Ayed Yousr Gorgi | 2009 | World Journal of Gastroenterology2009，15，29： | 3 |
| 10 | Association of hepatitis C virus infection and diabetes in central Tunisia显示文摘AIM:To investigate hepatitis C virus(HCV) seroprevalence in Tunisian patients with diabetes mellitus and in a control group.METHODS:A cross-sectional study was conducted to determine the HCV seroprevalence in 1269 patients with diabetes(452 male,817 female) and 1315 nondiabetic patients,attending health centers in Sousse,Tunisia.HCV screening was performed in both groups using a fourth-generation enzyme immunoassay.RESULTS:In the diabetic group,17(1.3%) were found to be HCV-infected compared with eight(0.6%) in the control group,although the difference was not significant(P=0.057).Quantitative PCR was performed in 20 patients.Eleven patients were positive and showed HCV genotype 1b in all cases.CONCLUSION:Frequency of HCV antibodies was low in patients with diabetes and in the control group in central Tunisia,with no signifi cant difference between the groups. | Naoufel Kaabia Elhem Ben Jazia Ines Slim Imen Fodha Wissem Hachfi Rafika Gaha Mabrouk Khalifa Aoutef Hadj Kilani Halim Trabelsi Ahmed Abdelaziz Fethi Bahri Amel Letaief | 2009 | World Journal of Gastroenterology2009，15，22： | 2 |
| 11 | Comprehensive review of autoantibodies in patients with hyper-IgM syndrome显示文摘Hyper-immunoglobulin M syndrome is an X-linked primary immunodeficiency disease caused by mutations in the CD40 ligand gene.The CD40 ligand has been recently highlighted as playing a key role in the pathogenesis of primary biliary cholangitis.In the present study,we assessed an extensive set of serum autoantibodies in a series of well-defined patients with hyper-immunoglobulin M syndrome.Serum,liver-related and liver-not-related autoantibodies IgG,IgM and IgA were tested by ELISA and standard indirect immunofluorescence in HEp-2 cells in 13 Tunisian patients(8 males and 5 females,aged 1–12 years)with hyper-immunoglobulin M syndrome during 1995–2012 and,as controls,21 age-and gender-matched blood donors.The level of IgM antibody against MIT3 was significantly higher in patients than in controls(35.8 vs 10.7,P=0.002).Half of the hyperimmunoglobulin M syndrome patients were found to be anti-MIT3 IgM positive vs none of the controls(Po0.0001).Twenty-three percent of patients were found to be anti-sp100 antibody positive vs only 0.05%of controls.By immunofluorescence,92.3%of patients were MIT3 IgM positive vs none of the controls.In conclusion,the IgM class of anti-MIT3 antibodies was shown to be present by both ELISA and immunofluorescence in most of the patients with hyper-immunoglobulin M syndrome.The presence of the hallmark of primary biliary cholangitis,a disease where the CD40 ligand is a key player,in an immunodeficiency disease caused by mutations in the CD40 ligand gene is very intriguing and opens new scenarios in understanding the immune pathogenesis of primary biliary cholangitis. | Mohamed-Ridha Barbouche Qubo Chen Marco Carbone Imen Ben-Mustapha Zakera Shums Mehdi Trifa Federica Malinverno Francesca Bernuzzi Haiyan Zhang Nourhen Agrebi Gary L Norman Christopher Chang M Eric Gershwin Pietro Invernizzi | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 12 | Characterization of Tunisian marine sediments in Rades and Gabes harbors显示文摘The objective of this article is to study the geotechnical and environmental characteristics of sediments dredged from two Tunisian harbors:Rades and Gabes.The first harbor represents the main facility place in the national transport chain.The second one is selected as its sediments present a serious ecological constraint caused by the discharge of wastes into the marine environment.These sediments are either discarded at sea or landfilled despite their harmful effects on the environment.The article is divided into three main sections.The first one presents the material that was carried for Rades and Gabes harbors.The conservation conditions and the used experimental tests are detailed.Geotechnical characterization includes the determination of the grain size distribution,the water content,the Atterberg limits,the methylene blue value,the specific area,the bulk density,the specific unit weight,the organic and carbonate contents.Environmental characterization is assessed by the determination of metals concentrations in a leaching solution.The second section deals with the description and analysis of geotechnical properties of Rades and Gabes harbors' sediments.The results obtained show that Rades harbor sediments are slightly sandy clayey silts whereas Gabes harbor sediments are silty sands characterized by a highly plastic clay fraction.Both of the two sediments don't exhibit a high organic content.Finally,chemical,mineralogical and environmental properties are presented and then analysed.The experimental results obtained show that Rades and Gabes sediments could be used as a sand substitute in the formulation of a new construction material.Gabes harbor sediments are more polluted than Rades harbor sediments. | Imen BEL HADJ ALI Zoubeir LAFHAJ Mounir BOUASSIDA Imen SAID | 2014 | International Journal of Sediment Research2014，29，3： | 2 |
| 13 | Natural evolution of hepatitis C virus infection in hemodialysis Tunisian patients and CTLA-4 SNP's显示文摘AIM: To analyze the polymorphisms of CTLA-4 gene involved in the response against hepatitis C virus(HCV) infection.METHODS: We recruited 500 hemodialysed patients from several hemodialysis centers, all HCV-antibody positive, spread over different regions of Tunisia, as part of a national survey in 2008 conducted in the laboratory of immunology at the Charles Nicolle hospital Tunisia, classified into two groups G1(PCR+) and G2(PCR-) according to the presence or absence of viral RNA. Of these patients, 307 were followed prospectively on a viral molecular level over a period from 2002 to 2008, divided into two groups based on the persistence and viral clearance. PCR-RFLP was performed for the analysis of SNPs(+49) A/G and(+6230) G/A CTLA-4 for these 500 patients and 358 healthy controls.RESULTS: Analysis of clinical and virological charac-teristics of our cohort suggests a nosocomial infection in our hemodialysed patients with transfusion history as a primary risk factor and a predominance of genotype 1b. The haplotype analysis revealed an increase of frequencies of GG(+49)/(CT60) CTLA-4 in the entire patients group compared to controls(P = 0.0036 and OR = 1.42; 95%CI: 1.12-1.79, respectively). This haplotype is therefore associated with susceptibility to HCV infection. CONCLUSION: Our study suggests a possible role of CTLA-4 polymorphisms in the outcome of HCV infection in the Tunisian hemodialysed population. | Leila Ksiaa Cheikhrouhou Yousr Lakhoua-Gorgi Imen Sfar Salwa Jendoubi-Ayed Houda Aouadi Mouna Makhlouf Khaled Ayed Taieb Ben Abdallah | 2015 | World Journal of Gastroenterology2015，21，35： | 2 |
| 14 | Isolation and characterization of non-Frankia actinobacteria from root nodules of Alnus glutinosa , Casuarina glauca and Elaeagnus angustifolia显示文摘 | Faten Ghodhbane-Gtari Imene Essoussi | 2010 | Symbiosis2010，50，1： | 1 |
| 15 | Relationship between neutro- phil to lymphocyte ratio and slow coronary flow 显示文摘 | Do an M Akyel A (imen T | 2015 | Clin Appl Thromb Hemost2015，2，3： | 1 |
| 16 | Spectral beam splitting technolo- gy for increased conversion efficiency in solar concentra- ting systems-A review 显示文摘 | Imenes A G Mills D R | 2004 | Solar Energy Materials & Solar Cells2004，84，14： | 1 |
| 17 | Evolution of the fatty fraction during co-composting of olive oil industry wastes with animal manure: Maturity assessment of the end product显示文摘 | Ridha Hachicha Salma Hachicha Imen Trabelsi Steve Woodward Tahar Mechichi | 2009 | Chemosphere2009，，10： | 1 |
| 18 | Autologous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expre-ssion in the islets,alter T cell cytokine pattern and preserve regulatoryT cells in the periphery and induce sustained normoglycemia显示文摘 | Imene Boumaza Suganya Srinivasan | 2009 | Auto-immune2009，32，： | 1 |
| 19 | Methylmalonic acidemia and hyper- glycemia : An unusual association 显示文摘 | Imen M Hanene B Ichraf K | 2012 | Brain Dev2012，34，2： | 1 |
| 20 | A technique for purifying wastewater with polymeric fiocculant produced fiom wasteplastic显示文摘 | Imene B A Bayoudh S Baklouti M | 2007 | Desalination2007，204，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员