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| 1 | Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis显示文摘Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world. Given that the burden of chronic liver disease is expected to rise owing to increasing rates of alcoholism, hepatitis B and C prevalence and obesity-related fatty liver disease, it is expected that the incidence of HCC will also increase in the foreseeable future. This article summarizes the international epidemiology, the risk factors and the pathogenesis of HCC, including the roles of viral hepatitis, toxins, such as alcohol and aflatoxin, and insulin resistance. | Asmaa Ibrahim Gomaa Shahid A Khan Mireille B Toledano Imam Waked Simon D Taylor- Robinson | 2008 | World Journal of Gastroenterology2008，14，27： | 78 |
| 2 | Diagnosis of hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is one of the commonest cancers worldwide, particularly in parts of the developing world, and is increasing in incidence. This article reviews the current modalities employed for the diagnosis of HCC, including serum markers, radiological techniques and histological evaluation, and summarises international guidelines for the diagnostic approach to HCC. | Asmaa I Gomaa Shahid A Khan Edward LS Leen Imam Waked Simon D Taylor-Robinson | 2009 | World Journal of Gastroenterology2009，15，11： | 44 |
| 3 | Recent advances in multidisciplinary management of hepatocellular carcinoma显示文摘The incidence of hepatocellular carcinoma(HCC) is increasing, and it is currently the second leading cause of cancer-related death worldwide. Potentially curative treatment options for HCC include resection, transplantation, and percutaneous ablation, whereas palliative treatments include trans-arterial chemoembolization(TACE), radioembolization, and systemic treatments. Due to the diversity of available treatment options and patients' presentations, a multidisciplinaryteam should decide clinical management of HCC, according to tumor characteristics and stage of liver disease. Potentially curative treatments are suitable for very-early- and early-stage HCC. However, the vast majority of HCC patients are diagnosed in later stages, where the tumor characteristics or progress of liver disease prevent curative interventions. For patients with intermediate-stage HCC, TACE and radioembolization improve survival and are being evaluated in addition to potentially curative therapies or with systemic targeted therapy. There is currently no effective systemic chemotherapy, immunologic, or hormonal therapy for HCC, and sorafenib is the only approved moleculartargeted treatment for advanced HCC. Other targeted agents are under investigation; trials comparing new agents in combination with sorafenib are ongoing. Combinations of systemic targeted therapies with local treatments are being evaluated for further improvements in HCC patient outcomes. This article provides an updated and comprehensive overview of the current standards and trends in the treatment of HCC. | Asmaa I Gomaa Imam Waked | 2015 | World Journal of Hepatology2015，7，4： | 15 |
| 4 | 倾斜旋转型三维隔震装置的力学模型和竖向性能试验研究显示文摘基于铅芯橡胶隔震支座的变形及耗能力学性能特点,设计开发出一种新型的倾斜旋转型三维隔震装置,给出了三维隔震装置的组成构造和力学性能设计方法,提出了三维隔震装置的变形机理,推导了三维隔震装置的刚度和阻尼的理论计算公式。设计了倾斜旋转型三维支座的模型支座系统,并完成了竖向压缩力学性能试验。试验结果表明该倾斜旋转型三维隔震装置构造合理、传力机制明确,在竖向变形状态下具有良好的阻尼耗能性能;试验得到的支座刚度和理论计算刚度一致性较好。 | 刘文光 余宏宝 IMAM MOUSTAFA I. 何文福 | 2017 | 振动与冲击2017，36，9： | 15 |
| 5 | Platelet-albumin-bilirubin score - a predictor of outcome of acute variceal bleeding in patients with cirrhosis显示文摘BACKGROUND The albumin-bilirubin(ALBI)score was validated as a prognostic indicator in patients with liver disease and hepatocellular carcinoma.Incorporating platelet count in the platelet-albumin-bilirubin(PALBI)score improved validity in predicting outcome of patients undergoing resection and ablation.AIM To evaluate the PALBI score in predicting outcome of acute variceal bleeding in patients with cirrhosis.METHODS The data of 1517 patients with cirrhosis presenting with variceal bleeding were analyzed.Child Turcotte Pugh(CTP)class,Model of End-stage Liver Disease(MELD),ALBI and PALBI scores were calculated on admission,and were correlated to the outcome of variceal bleeding.Areas under the receivingoperator characteristic curve(AUROC)were calculated for survival and rebleeding.RESULTS Mean age was 52.6 years;1176 were male(77.5%),69 CTP-A(4.5%),434 CTP-B(29.2%),1014 CTP-C(66.8%);306 PALBI-1(20.2%),285 PALBI-2(18.8%),and 926 PALBI-3(61.1%).Three hundred and thirty-two patients died during hospitalization(21.9%).Bleeding-related mortality occurred in 11%of CTP-B,28%of CTP-C,in 21.8%of PALBI-2 and 34.4%of PALBI-3 patients.The AUROC for predicting survival of acute variceal bleeding was 0.668,0.689,0.803 and 0.871 for CTP,MELD,ALBI and PALBI scores,respectively.For predicting rebleeding the AUROC was 0.681,0.74,0.766 and 0.794 for CTP,MELD,ALBI and PALBI scores,respectively.CONCLUSION PALBI score on admission is a good prognostic indicator for patients with acute variceal bleeding and predicts early mortality and rebleeding. | Omar Elshaarawy Naglaa Allam Eman Abdelsameea Asmaa Gomaa Imam Waked | 2020 | World Journal of Hepatology2020，12，3： | 13 |
| 6 | Spatial distribution and source identification of heavy metal pollution in roadside surface soil:a study of Dhaka Aricha highway,Bangladesh显示文摘Introduction:In this study,metal pollution and their sources in surface soils were evaluated by pollution indices and multivariate statistical techniques in association with a geographical information system(GIS).Methods:Surface soil samples were collected in dry season from different locations of Dhaka Aricha highway and analyzed by energy dispersive X-ray fluorescence(EDXRF).Results:Thirteen different metals were found in the tested samples.Pollution indices are determined by enrichment factor in an order of Zr>Sn>P>Mn>Zn>Rb>Fe>Ba>Sr>Ti>K>Ca>Al.The resulting geoaccumulation index(Igeo)value shows the following order:Sn>Zr>P>Mn>Zn>Rb>Fe>Ba>Ti>Sr>K>Ca>Al.Contamination factors(CFs)of the metals range from 1.422 to 3.979(Fe);0.213 to 1.089(Al);0.489 to 3.484(Ca);1.496 to 2.372(K);1.287 to 3.870(Ti);2.200 to 14.588(Mn);5.938 to 56.750(Zr);0.980 to 3.500(Sr);2.321 to 4.857(Rb);2.737 to 6.526(Zn);16.667 to 27.333(Sn);3.157 to 16.286(P);and 0.741 to 3.328(Ba).Pollution load index calculated from the CFs indicates that soils are strongly contaminated by Zr and Sn.Principal component analysis(PCA)of parameters exhibits three major components.R-mode cluster analysis reveals three distinct groups in both site and metal basis clustering that shows a similar pattern with the PCA.Conclusions:These results might be helpful for future monitoring of further increase of heavy metal concentrations in surface soils along highways. | Fahad Ahmed A.N.M.Fakhruddin M.D.Toufick Imam Nasima Khan Tanzir Ahmed Khan Md.Mahfuzur Rahman Abu Tareq Mohammad Abdullah | 2016 | Ecological Processes2016，5，1： | 11 |
| 7 | Validation of modified albumin-bilirubin-TNM score as a prognostic model to evaluate patients with hepatocellular carcinoma显示文摘BACKGROUND An ideal staging system for hepatocellular carcinoma(HCC)should rely on the hepatic reserve function and tumor burden.With the improvement in diagnostic and treatment strategies for HCC,in addition to recent treatment of viral hepatitis,finding a suitable assessment tool for hepatic reserve has become mandatory.AIM To validate a recently proposed modified albumin-bilirubin-TNM(mALBI-T)grade as a prognostic model for patients with HCC in Egypt.METHODS For patients diagnosed with HCC,Child-Turcotte-Pugh(CTP)score,Barcelona Clinic Liver Cancer(BCLC)stage,albumin-bilirubin(ALBI),plateltetalbumin– bilirubin(PALBI),ALBI-based BCLC,ALBI-T and mALBI-T grades were estimated.Patients were followed from time of diagnosis to date of death or date of data collection if they remained alive.Overall survival and received treatments were determined.Survival data were analyzed.RESULTS A total of 1910 patients were included(mean age,57 years;1575 males).At presentation,50.6%had CTP A,36.1%had CTP B and 13.4%had CTP C;12%had ALBI grade 1,62.3%had ALBI grade 2 and 24.7%had ALBI grade 3.Overall median survival was 13 mo;survival was better in patients with ALBI 1 than in those with ALBI 2 and 3(28.6 vs 14 and 5.8 mo,respectively,P<0.001).Patients with ALBI-T grades 0 and 1 had better survival than those with ALBI-T grades 2,3,4 and 5(P<0.001).The modified ALBI-T showed better stratification and significant improvement in prediction of survival.CONCLUSION ALBI-T grade is a superior prognostic tool that selects patients with HCC who have better liver reservoir and tumor stage.mALBI-T is a better prognostic model in patients with HCC. | Omar Elshaarawy Alzhraa Alkhatib Mostafa Elhelbawy Asmaa Gomaa Naglaa Allam Ayman Alsebaey Eman Rewisha Imam Waked | 2019 | World Journal of Hepatology2019，11，6： | 7 |
| 8 | Body mass index and colon cancer screening:The road ahead显示文摘Screening for colorectal cancer(CRC) has been associated with a decreased incidence and mortality from CRC.However,patient adherence to screening is less than desirable and resources are limited even indeveloped countries.Better identification of individuals at a higher risk could result in improved screening efforts.Over the past few years,formulas have been developed to predict the likelihood of developing advanced colonic neoplasia in susceptible individuals but have yet to be utilized in mass screening practices.These models use a number of clinical factors that have been associated with colonic neoplasia including the body mass index(BMI).Advances in our understanding of the mechanisms by which obesity contributes to colonic neoplasia as well as clinical studies on this subject have proven the association between BMI and colonic neoplasia.However,there are still controversies on this subject as some studies have arrived at different conclusions on the influence of BMI by gender.Future studies should aim at resolving these discrepancies in order to improve the efficiency of screening strategies. | Kanwarpreet Tandon Mohamad Imam Bahaa Eldeen Senousy Ismail Fernando Castro | 2015 | World Journal of Gastroenterology2015，21，5： | 4 |
| 9 | Subversion of cellular autophagy during virus infection:Insights from hepatitis B and hepatitis C viruses显示文摘Autophagy is a self-eating process,in which the damaged or excessed cell organelles and misfolded protein aggregates are removed from the cellular microenvironment.Autophagy is generally thought of as a pro-survival mechanism which is not only important for balancing energy supply at times of nutrient deprivation but also in the removal of various stress stimuli to ensure homeostasis.In addition to the target materials of“self”origin,autophagy can also eliminate intracellular pathogens and acts as a defense mechanism to curb infections.In addition,autophagy is linked to the host cell's innate immune response.However,viruses have evolved various strategies to manipulate and overtake host cell machinery to establish productive replication and maintain infectious process.In fact,replication of many viruses has been found to be autophagy-dependent and suppression of autophagy can potentially affect the viral replication.Thus,autophagy can either serve as an anti-viral defense mechanism or a pro-viral process that supports viral replication.Hepatitis B virus(HBV)and hepatitis C virus(HCV)are known to co-opt cellular autophagy process as a pro-viral tool.Both viruses also induce mitophagy,which contributes to the establishment of chronic hepatitis.This review focuses on the roles of autophagy and mitophagy in the chronic liver disease pathogenesis associated with HBV and HCV infections. | Mohsin Khan Hasan Imam Aleem Siddiqui | 2018 | Liver Research2018，2，3： | 4 |
| 10 | Prevalence and risk factors associated with malaria infection among pregnant women in a semi-urban community of north-western Nigeria显示文摘Background:Malaria during pregnancy remains a serious public health problem,with substantial risks for the mother,her foetus and the newborn.The aim of this study was to determine the prevalence of malaria and possible risk factors for malaria infection among pregnant women in a semi-urban area in north-western Nigeria.Pregnant women are among the most susceptible to malaria infection.Knowledge of their malaria infection status is an important yardstick to measure the effectiveness of any malaria control programme.Methods:We conducted a cross sectional study in the semi-urban area of Argungu,Kebbi State Nigeria.Two hundred and fifty five pregnant women were included in the study after informed verbal consent was obtained.For each participant,the socio-demographic profile,stage of pregnancy and attitude to the use of insecticide-treated nets(ITNs)were investigated using a questionnaire.Peripheral blood samples were collected and thick blood smears were prepared and stained with Giemsa stains to check for malaria parasitaemia.The associations between age,education level and use of ITNs with occurrence of malaria infection during pregnancy were analysed using the chi-square test.Results:One hundred and six(41.6%)out of 255 pregnant women were infected with malaria parasites,with a mean parasite density of 800 parasitesμl−1.It was found that prevalence and parasite density decreased as age increased.The chi-square test indicated that a lack of education and non-usage of ITNs were significantly associated with malaria infection.Conclusion:Malaria is still a major public health issue among pregnant women mainly due to illiteracy and non-compliance to using ITNs.Increasing awareness about malaria preventive measures and early attendance of antenatal care services will help to reduce malaria and,consequently,its associated morbidities and mortalities. | Sani Abdullahi Fana Mohammed Danladi Abubakar Bunza Sule Aliyu Anka Asiya Umar Imam Shehu Usman Nataala | 2015 | Infectious Diseases of Poverty2015，4，1： | 4 |
| 11 | Bioactive Materials:A Comprehensive Review on Interactions with Biological Microenvironment Based on the Immune Response显示文摘Application of“bioactive materials”,as a modified version of biomaterials,can optimize the response of the biological system due to their surface reactivity and formation of strong interactions with the adjacent tissue upon implantation.However,choosing an appropriate bioactive material that suits to the application and provides the desired mechanical,physical,chemical and biological functionality,as well as understanding the aspects of biological reaction to the biomaterial,in particular immune response,it plays a key role in successful integration of the implant.In this review,we will discuss different bioactive materials including bioactive ceramics,polymers and composites and their applications in drug delivery and scaffold preparation in order to provide an adequate introduction to the recent studies.Considering the necessity of regulation of implant fate for higher biocompatibility,the comprehensive overview to the immune response will be reviewed with the focus on representing the cell-biomaterial interactions and more importantly,the inflammatory responses.Ultimately,we will also discuss about different approaches namely as immunomodulation to elicit the desired physiochemical properties and mimicking native cellular response using bioactive compounds,functionalizing the implant surface with active molecules and alteration of the surface morphology.With better understanding of bioactive materials and their interactions with body,more novel biomaterials representing desired properties can be designed. | Shirin Nour Nafiseh Baheiraei Rana Imam Navid Rabiee Mohammad Khodaei Akram Alizadeh Seyed Mohammad Moazzeni | 2019 | Journal of Bionic Engineering2019，16，4： | 4 |
| 12 | Normal liver stiffness: a study in living donors with normal liver histology显示文摘AIM: To define the normal range of liver stiffness(LS) values using transient elastography in living-related liver transplantation candidate donors with normal liver histology. METHODS: LS was measured using Fibroscan in 50(16 women, 34 men) healthy potential donors(mean age 28.4 ± 5.9 years) who were being evaluated for liver donation for their relatives at the National Liver Institute, Menoufeya University, Egypt. All potential donors had normal liver tests and were negative for hepatitis B or C virus infection. Abdominal ultrasounds showed normal findings. None of the subjects had diabetes, hypertension, renal impairment, heart disease, or body mass index > 30 kg/m2. All subjects had normal liver histology upon liver biopsy. They all donated the right lobe of their liver with successful outcomes.RESULTS: The mean LS was 4.3 ± 1.2 k Pa(range: 1.8-7.1 k Pa). The 5th and 95 th percentiles of normal LS were 2.6 k Pa and 6.8 k Pa, respectively, with a median of 4 k Pa; the interquartile range was 0.6 ± 0.4. LS measurements were not significantly different between men and women(4.4 ± 1.1 k Pa vs 3.9 ± 1.3 k Pa) and did not correlate with age. However, stiffness values were significantly lower in subjects with a body mass index < 26 kg/m2 compared to those with an index ≥ 26 kg/m2(4.0 ± 1.1 k Pa vs 4.6 ± 1.2 k Pa; P <0.05). There were no differences in hospital stay or postoperative bilirubin, albumin,alanine and aspartate transaminases, or creatinine levels(at discharge) between donors with livers stiffness ≤ 4 k Pa and those with stiffness > 4 k Pa. CONCLUSION: Healthy donors with normal liver histology have a median LS of 4 k Pa. Stiffness values are elevated relative to increase in body mass index. | Ayman Alsebaey Naglaa Allam Khalid Alswat Imam Waked | 2015 | World Journal of Hepatology2015，7，8： | 3 |
| 13 | Ascites and alpha-fetoprotein improve prognostic performance of Barcelona Clinic Liver Cancer staging显示文摘AIM: To assess how ascites and alpha-fetoprotein(AFP) added to the Barcelona Clinic Liver Cancer(BCLC) staging predict hepatocellular carcinoma survival.METHODS: The presence of underlying cirrhosis, ascites and encephalopathy, Child-Turcotte-Pugh(CTP) score, the number of nodules, and the maximum diameter of the largest nodule were determined at diagnosis for 1060 patients with hepatocellular carcinoma at a tertiary referral center for liver disease in Egypt. Demographic information, etiology of liver disease, and biochemical data(including serum bilirubin, albumin, international normalized ratio, alanine and aspartate aminotransferases, and AFP) were evaluated. Staging of the tumor was determined at the time of diagnosis using the BCLC staging system; 496 patients were stage A and 564 patients were stage B. Patients with mild ascites on initial ultrasound, computed tomography, or clinical examination, and who had a CTP score ≤ 9 were included in this analysis. All patients received therapy according to the recommended treatment based on the BCLC stage, and were monitored from the time of diagnosis to the date of death or date of data collection. The effect of the presence of ascites and AFP level on survival was analyzed.RESULTS:At the time the data were censored,123/496(24.8%)and 218/564(38.6%)patients with BCLC stages A and B,respectively,had died.Overall mean survival of the BCLC A and B patients during a three-year follow-up period was 31 mo[95%confidence interval(95%CI):29.7-32.3]and 22.7mo(95%CI:20.7-24.8),respectively.The presenceof ascites,multiple focal lesions,large tumor size,AFP level and CTP score were independent predictors of survival for the included patients on multivariate analysis(P<0.001).Among stage A patients,18%had ascites,33%had AFP≥200 ng/m L,and 8%had both.Their median survival in the presence of ascites was shorter if AFP was≥200 ng/m L(19 mo vs 24 mo),and in the absence of ascites,patients with AFP≥200 ng/m L had a shorter survival(28mo vs 39 mo).For stage B patients,survival for the corresponding groups was 12,18,19 and 22 mo.The one-,two-,and three-year survival rates for stage A patients without ascites and AFP<200 ng/m L were94%,77%,and 71%,respectively,and for patients with ascites and AFP≥200 ng/m L were 83%,24%,and 22%,respectively(P<0.001).Adding ascites and AFP≥200 ng/m L improved the discriminatory ability for predicting prognosis(area under the curve,0.618vs 0.579 for BCLC,P<0.001).CONCLUSION:Adding AFP and ascites to the BCLC staging classification can improve prognosis prediction for early and intermediate stages of hepatocellular carcinoma. | Asmaa I Gomaa Alzhraa Al-Khatib Wael Abdel-Razek Mohammed Saad Hashim Imam Waked | 2015 | World Journal of Gastroenterology2015，21，18： | 3 |
| 14 | 稀土元素La在MnCoGe体系中的掺杂效应显示文摘MnCoGe是MM′X型马氏体相变材料体系中最具代表性的研究对象之一.由于其结构相变温度高于自身的磁有序温度,研究者采用了各种调控方法来降低结构相变温度以实现磁共结构耦合.但是,针对稀土元素在这类体系中的掺杂效应较少被报道.因此,本文研究了Mn_(1-x)La_(x)CoGe (x=0, 0.01, 0.02, 0.03, 0.05)系列化合物的结构与磁性. La的加入引起主相中Mn和Ge元素的成分缺失,使得马氏体转变温度逐渐降低,实现了磁共结构耦合.然而,由于La导致元素成分缺失的能力有限,进一步增加掺杂量导致析出更多的第二相但却没有引起相变温度的持续降低.在微观组织中观察到主相被针状第二相分隔成小'畴',这可能是高La含量样品中存在大量残余奥氏体相的原因. | 张红国 石晋豪 Hidayah Andi Imam 吴正 乔文静 岳明 | 2021 | 中国科学:物理学、力学、天文学2021，51，6： | 2 |
| 15 | Fatal case of newborn Lassa fever virus infection mimicking late onset neonatal sepsis: a case report from northern Nigeria显示文摘Background:Lassa fever is a zoonotic viral infection endemic to the West Africa countries.It is highly fatal during pregnancy and as such reports of neonatal onset Lassa fever infections are rare in scientific literature.We report a fatal case of Lassa fever in a 26-day-old neonate mimicking the diagnosis of late-onset neonatal sepsis.Case presentation:The patient is a 26-day-old neonate who was admitted with a day history of fever,poor feeding,pre-auricular lymphadenopathy and sudden parental death.He was initially evaluated for late onset neonatal sepsis.He later developed abnormal bleeding and multiple convulsions while on admission,prompting the need to evaluate for Lassa fever using reverse transcription polymerase chain reaction(RT-PCR).He died 31 h into admission and RT-PCR result was positive for Lassa fever.Conclusions:Neonatal Lassa fever infection is highly fatal and can mimic neonatal sepsis.High index of suspicion is needed particularly for atypical presentations of neonatal sepsis in Lassa fever endemic areas. | Taofik Oluwaseun Ogunkunle Surajudeen Oyeleke Bello Chinwe Immaculata Anderson Rashida Musa Rasaq Olaosebikan Abdulazeez Imam | 2020 | Infectious Diseases of Poverty2020，9，4： | 2 |
| 16 | Genetic Diversity Analysis of Rice Germplasm in Tripura State of Northeast India Using Drought and Blast Linked Markers显示文摘We genotyped 74 rice germplasms including Tripura's local landraces, improved varieties, cultivars and breeding lines and other rice varieties using molecular markers for genetic diversity, drought QTLs, and blast resistance genes. The number of alleles per locus ranged from 2 to 5 with an average of 2.9. The polymorphic information content value per locus ranged from 0.059(RM537) to 0.755(RM252) with an average of 0.475. Cluster analysis based on 30 simple sequence repeat markers revealed 5 clusters and also indicated the presence of variability within the rice accessions. The drought QTL q DTY2.1 was found in 56.0% of germplasms and q DTY1.1 was detected in only 6.8% of the germplasms. Out of seven rice blast resistance genes screened, only two rice varieties, RCPL-1-82 and Buh Vubuk(Lubuk), were positive for four blast resistance genes while only Releng possessed two blast resistance genes. Among 74 rice germplasms, only three accessions, Releng, RCPL1-82 and Buh Vubuk(Lubuk), possessed both drought-related QTLs and blast resistance genes. Overall, the 74 indigenous rice genotypes showed low level of genetic diversity, which is in contrast to high level of genetic diversity among rice varieties in northeast India, where highlights the good farming practice, conservation of germplasms and the limitation of molecular markers employed in this study. The presence of both drought related QTLs and blast resistance genes in some of the germplasms can be useful in future breeding programmes. | Alpana ANUPAM Jahangir IMAM Syed Mohammad QUATADAH Anantha SIDDAIAH Shankar Prasad DAS Mukund VARIAR Nimai Prasad MANDAL | 2017 | Rice science2017，24，1： | 2 |
| 17 | Active vibration control of flexible beams using shape memory actuators显示文摘 | Baz A Imam K McCoy J | 2005 | Journal of Sound and Vibration2005，140，3： | 1 |
| 18 | Oxidative stress and reactive nitrogen species generation during renal ischemia显示文摘 | Walker LM York JL Imam SZ | | 0，，1： | 1 |
| 19 | The transthracic impedance cardiogram is a potential haemodynamic sensor for an automated external defibrillator显示文摘 | Johnson PW Imam Z Dempsey G | 1998 | Eur Heart J1998，19，12： | 1 |
| 20 | Simulation of flow in rectangular clarifiers显示文摘 | MCCORQUODALE J A | 1983 | Journal of Environmental Engineering1983，109，3： | 1 |
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