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| 1 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 2 | A measurement of the cosmological constant using elliptical galaxies as strong gravitational lenses 显示文摘 | Im M Griffths R E Ratnatunga K U | 1997 | Astrophys J1997，475，： | 2 |
| 3 | Monoeyte transmigration induced by modification of low density lipoprotein in eocultures of human aortic wall cells is due to induction of monoeyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein显示文摘 | Imes SS Hama SY | 1991 | J Clin Invest1991，88，： | 1 |
| 4 | Mechanisms of normal and tumor-derived angiogenesis显示文摘 | Papetti M Herman IM | 2002 | Am J Physiol Cell Physiol2002，282，94： | 1 |
| 5 | Elevated levels of C - reac - tiveproteinatdisch angeinpatients with unstable angin apredicue currectin stability显示文摘 | Luigi M Biascci IM Liuzzo G | 1999 | Circulation1999，99，7： | 1 |
| 6 | Interleukin-1 induces transcription of keratin K6 in human epidermal keratinocytes显示文摘 | Komine M Rao LS Freedberg IM | 2001 | J Invest Dermatol2001，116，2： | 1 |
| 7 | Changes in plasma matrix metaUoproteinase-9 levels in patients with acute ischemie stroke 显示文摘 | Cojocarui IM Cojocaru M Sapira V | 2012 | Rom J Intern Med2012，50，2： | 1 |
| 8 | Concurrent splenic lymphangiomatosis and Proteus syndrome显示文摘 | Emran RS Anwar IM Trudel M | 2013 | SaudiMedJ2013，34，9： | 1 |
| 9 | 查看详情显示文摘 | Maeng Y J Yoon B S Suh M H Im W B Lee S H | | 0，，： | 1 |
| 10 | QSAR modeling and transmission electron microscopy stereology of altered mitochondrial ultrastructure of white blood cells in patients diagnosed as schizophrenic and treated with antipsychotic drugs显示文摘 | Inuwa IM Peet M Williams MA | | 0，，： | 1 |
| 11 | Pulmonary manifestations of systemic autoimmune diseases显示文摘 | Cojocaru M Cojocaru IM Silosi I | 2011 | Maedica (Buchar)2011，6，： | 1 |
| 12 | Binge drinking and its relation to metabolic syndrome in korean adult men 显示文摘 | Im H J Park S M Choi J H | 2014 | Korean J Fam Med2014，35，4： | 1 |
| 13 | Disruption of renal tubular mitochondrial quality control by myo-inositol oxygenase in diabetic kidney disease显示文摘 | Zhan M Usman IM Sun L Kanwar YS | 2014 | Journal of the American Society of Nephrology:JASN2014，，： | 1 |
| 14 | Surface plasmon enhanced photoconductance and single electron effects in mesoporous titania nanofibers loaded with gold nanoparticles显示文摘 | SON M IM J WANG K | 2010 | Appl Phys Lett2010，96，02： | 1 |
| 15 | 1 Burnou t and Engagement in University Students a Cross - national Study显示文摘 | Schau feliW B M arti IM P into A M eta | 2002 | Journal of Cross - Cultural Psychology2002，33，5： | 1 |
| 16 | Increased breast cancer risk in in vitro fertilisation treated women with a multiple preg- nancy= A new hypothesis based on historical in vitro fertilisation treatment data显示文摘 | Krul IM Groeneveld E Spaan M | 2015 | Eur J Cancer2015，51，1： | 1 |
| 17 | Critical in vivo roles for classical estrogen receptors in rapid estrogen actions on intracellular signaling in mouse brain显示文摘 | Abrahám IM Todman MG Korach KS | 2004 | Endocrinology2004，145，7： | 1 |
| 18 | Photoluminescence characteristics of energy transfer between Bi3+ and Eu3+ in LnVO4:Eu,Bi (Ln=Y,La,Gd)显示文摘 | Park W J Jung M K Im S J | 2008 | Colloids Surf A2008，，313314： | 1 |
| 19 | Tuberculosis of the central airways:CT findings of active and fibrotic disease显示文摘 | Moon W K Im J G Yeon K M | 1997 | AIR Am J Roentgenol1997，169，3： | 1 |
| 20 | Testing for unit roots in heterogeneous panels显示文摘 | Im K S Pesaran M H Y Shin | 2003 | Journal of Econometrics2003，115，： | 1 |
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