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| 1 | Coronary microvasculopathy in heart transplantation: Consequences and therapeutic implications显示文摘Despite the progress made in the prevention and treatment of rejection of the transplanted heart, cardiac allograft vasculopathy(CAV) remains the main cause of death in late survival transplanted patients. CAV consists of a progressive diffuse intimal hyperplasia and the proliferation of vascular smooth muscle cells, ending in wall thickening of epicardial vessels, intramyocardial arteries(50-20 μm), arterioles(20-10 μm), and capillaries(< 10 μm). The etiology of CAV remains unclear; both immunologic and non-immunologic mechanisms contribute to endothelial damage with a sustained inflammatory response. The immunological factors involved are Human Leukocyte Antigen compatibility between donor and recipient, alloreactive T cells and the humoral immune system. The non-immunological factors are older donor age, ischemia-reperfusion time, hyperlipidemia and CMV infections. Diagnostic techniques that are able to assess microvascular function are lacking. Intravascular ultrasound and fractional flow reserve, when performed during coronary angiography, are able to detect epicardial coronary artery disease but are not sensitive enough to assess microvascular changes. Some authors have proposed an index of microcircula-tory resistance during maximal hyperemia, which is calculated by dividing pressure by flow(distal pressure multiplied by the hyperemic mean transit time). Non-invasive methods to assess coronary physiology are stress echocardiography, coronary flow reserve by transthoracic Doppler echocardiography, single photon emission computed tomography, and perfusion cardiac magnetic resonance. In this review, we intend to analyze the mechanisms, consequences and therapeutic implications of microvascular dysfunction, including an extended citation of relevant literature data. | Alessandra Vecchiati Sara Tellatin Annalisa Angelini Sabino Iliceto Francesco Tona | 2014 | World Journal of Transplantation2014，4，2： | 3 |
| 2 | Screening of unknown atrial fibrillation through handheld device in the elderly显示文摘Objective To estimate the prevalence of unknown atrial fibrillation(AF)in the elderly population of the Veneto Region,Italy.Methods 1820 patients aged≥65 years with no history of AF and not anticoagulated were enrolled in primary-care settings.They underwent an opportunistic electrocardiogram screening with a handheld device(My Diagnostick)designed to specifically detect AF.The electrocardiogram recordings were reviewed by the researchers,who confirmed the presence of AF.Results The device detected an arrhythmia in 143 patients,which was confirmed as AF in 101/143(70.6%),with an overall prevalence of AF of 5.5%(101/1820).Prevalence of unknown AF resulted in 3.6%in patients aged 65–74 years,and 7.5%in patients age 75 or older,and increased according to CHA2 DS2-VASc score:3.5%in patients with a score of 1 or 2,5.6%in patients with a score of 3,7.0%in patients with a score of 4,and 7.2%in patients with a score≥5.The detection rate was significantly higher in patients with mild symptoms compared to asymptomatic counterparts(24.1%vs.4.0%,P<0.0001).At multivariate analysis,congestive heart failure and age≥75 years-old were independent predictors for screen-detected AF.Conclusions An opportunistic screening with handheld device revealed an unexpectedly high prevalence of unknown AF in elderly patients with mild symptoms.Prevalence increased with age and CHA2DS2-VASc score. | Francesco Rivezzi Riccardo Vio Claudio Bilato Leopoldo Pagliani Giampaolo Pasquetto Salvatore Saccà Roberto Verlato Federico Migliore Sabino Iliceto Vito Bossone Emanuele Bertaglia | 2020 | Journal of Geriatric Cardiology2020，17，8： | 3 |
| 3 | Dynamic equivalents of asynchronous motor loads in system stability studies显示文摘 | Iliceto Francesco Capasso Alfonso | 1974 | IEEE Trans on Power Apparatus and Systems1974，93，5： | 1 |
| 4 | Myocardial edema underlies dynamic T-wave inversion (Wellens’ ECG pattern) in patients with reversible left ventricular dysfunction显示文摘 | Federico Migliore Alessandro Zorzi Martina Perazzolo Marra Cristina Basso Francesco Corbetti Manuel De Lazzari Giuseppe Tarantini Paolo Buja Carmelo Lacognata Gaetano Thiene Domenico Corrado Sabino Iliceto | 2011 | Heart Rhythm2011，，： | 1 |
| 5 | Clinical implications of anti-heart autoantibodies in myocarditis and dilated cardiomyopathy显示文摘 | Alida L. P. Caforio Francesco Tona Stefania Bottaro Annalisa Vinci Greta Dequal Luciano Daliento Gaetano Thiene Sabino Iliceto | 2008 | Autoimmunity2008，，1： | 1 |
| 6 | Clinical implications of anti-heart autoantibodies in myocarditis and dilated cardiomyopathy显示文摘 | Alida L. P. Caforio Francesco Tona Stefania Bottaro Annalisa Vinci Greta Dequal Luciano Daliento Gaetano Thiene Sabino Iliceto | 2008 | Autoimmunity2008，，1： | 1 |
| 7 | Noninvasive ventilation in the event of acute respiratory failure in patients with idiopathic pulmonary fibrosis显示文摘 | Andrea Vianello Giovanna Arcaro Laura Battistella Emanuela Pipitone Stefania Vio Alessandra Concas Luciana Paladini Federico Gallan Maria Rita Marchi Francesco Tona Sabino Iliceto | 2014 | Journal of Critical Care2014，，： | 1 |
| 8 | Cellular and subcellular coherent dynamics,biological functional properties,and system-environment interaction显示文摘In this view point paper,we briefly summarize some of the clinical,biochemical and biophysical results obtained in our research on Relaxation Response.We also qualitatively describe the theoretical biophysical model that could link them.Our work points to a unified view of the human biological system activity,joining the dynamics ruling the interactions and correlations of the microscopic components to the knowledge of their specific individual properties in the effort of going beyond a purely atomistic approach. | CARLO DAL LIN SABINO ILICETO FRANCESCO TONA GIUSEPPE VITIELLO | 2022 | BIOCELL2022，46，8： | 0 |
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