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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Hepatitis C virus lymphotropism and peculiar immunological phenotype:Effects on natural history and antiviral therapy显示文摘Hepatitis C virus(HCV) has been recognized to be both a hepato-and lymphotropic virus.HCV lymphotropism represents an essential lap in the pathogenesis of virusrelated autoimmune and lymphoproliferative disorders,ranging from clonal expansion of B-cells with organ-and non-organ-specific autoantibody production up to overt non-Hodgkin's lymphoma along a continuous step-by-step model of B-cell lymphomagenesis,where the intermediated mixed cryoglobulinemia could be considered as a stage of suppressible antigen-driven lymphoproliferation.HCV infection of lymphoid cells could set up privileged reservoirs able to interfere with the host viral clearance eff iciency and may be implicated in viral recurrence after apparently successful antiviral therapy.The HCV long-lasting extrahepatic replicative state generates an abnormal systemic immunological response,easily detectable by searching simple laboratory and clinical parameters,mainly represented by vasculitis-like skin features and hypocomplementemia.The presence or absence of this hypersensitivity pattern seems to correlate with the antiviral response and could be identif ied as a novel immunological cofactor.Further research is required to fully verify the real impact on therapeutic choice/regimen. | Paolo Conca Giovanni Tarantino | 2009 | World Journal of Gastroenterology2009，15，19： | 5 |
| 3 | Hepatic steatosis in overweight/obese females: New screening method for those at risk显示文摘AIM: To identify which parameters could help to distinguish the 'metabolically benign obesity', which is not accompanied by insulin resistance (IR) and early atherosclerosis.METHODS: Eighty two of 124 overweight/obese females formed the study population, which was divided into two groups (52 and 30 subjects, respectively) with and without IR according to a HO meostatic Metabolic Assessment (HOMA) cut-off of 2, and were studied in a cross-sectional manner. The main outcome measures were waist circumference, serum uric acid, high-density lipoprotein-cholesterol and triglycerides, alanine amino-transferase, blood pressure and the two imaging para-meters, hepatic steatosis and longitudinal diameter of the spleen, which were measured in relation to the presence/absence of IR. RESULTS: A variable grade of visceral obesity was observed in all subjects with the exception of three.Obesity of a severe grade was represented more in the group of IR individuals (P = 0.01). Hepatic steatosis, revealed at ultrasound, was more pronounced in IR than in non-IR subjects (P = 0.005). The two groups also demonstrated a clear difference in longitudinal spleen diameter and blood pressure, with raised and signif icant values in the IR group. Metabolic syndrome was frequent in the IR group, and was not modified when adjusted for menopause (P = 0.001). At linear regression, the β values of waist circumference and body mass index predicting HOMA were 0.295, P = 0.007 and 0.41, P = 0.0001, respectively. Measures of spleen longitudinal diameter were well predicted by body mass index (BMI) values, β = 0.35, P = 0.01, and by HOMA, β = 0.41, P = 0.0001. Blood pressure was predicted by HOMA values, β = 0.39, P = 0.0001). HOMA and hepatic steatosis were highly associated (rho = 0.34, P = 0.002). Interestingly, IR patients were almost twice as likely to have hepatic steatosis as non-IR patients. Among the MS criteria, blood pressure was very accurate in identifying the presence of IR (AUROC for systolic blood pressure 0.66, cut-off 125 mm of Hg, sensibility 64%, specif icity 75%; AUROC for diastolic blood pressure 0.70, cut-off 85 mm of Hg, sensibility 54.5%, specif icity 75%). CONCLUSION: As health care costs are skyrocketing, reliable and mainly inexpensive tools are advisable to better defi ne subjects who really need to lose weight. | Giovanni Tarantino Genoveffa Pizza Annamaria Colao Fabrizio Pasanisi Paolo Conca Patrizia Colicchio Carmine Finelli Franco Contaldo Carolina Di Somma Silvia Savastano | 2009 | World Journal of Gastroenterology2009，15，45： | 4 |
| 4 | CEA and CA19.9 as Early Predictors of Progression in Advanced/Metastatic Colorectal Cancer Patients Receiving Oxaliplatin-Based Chemotherapy and Bevacizumab显示文摘 | Roberto Petrioli Antonella Licchetta Giandomenico Roviello Alessandra Pascucci Edoardo Francini Gianluca Bargagli Raffaele Conca Salvatora Tindara Miano Giuseppe Marzocca Guido Francini Multidisciplinary Oncology Group on Gastrointestinal Tumors | 2012 | Cancer Investigation2012，，1： | 2 |
| 5 | Time-dependent changes in rat brain neuroactive steroid concentrations and GABAA receptor function after acute stress显示文摘 | Barbaccia ML Roscetti G Trabucchi M Mostallino MC Concas A Purdy RH | 1996 | Neuroendocrinology1996，63，2： | 1 |
| 6 | Effect of chronicrepetitive transcranial magnetic stimulation on regionalcerebral blood flow and regional cerebral glucose uptake indrug treatment-resistant depressives显示文摘 | Conca A Peschina W Konig P | 2002 | Neuropsychobiolgy2002，45，1： | 1 |
| 7 | Echocardiographic parameters of mechanical syn chrony in healthy individuals 显示文摘 | CONCA C FALETRA FF MIYAZAKI C | 2009 | Am Coil Cardiol2009，103，1： | 1 |
| 8 | EVALUATION OF HEAVY METAL REMEDIATION USING MINERAL APATITE显示文摘 | Xiaobing Chen Judith V. Wright James L. Conca Loni M. Peurrung | 1997 | Water Air and Soil Pollution (-)1997，，1： | 1 |
| 9 | Echocardiographic parameters of mechanical synchrony in healthy individuals显示文摘 | Conca C Faletra FF Miyazaki C | 2009 | Am J Cardiol2009，103，1： | 1 |
| 10 | Deep brain stimulation:a review on current research显示文摘 | Conca A Di Pauli J Hinterhuber H | | 0，，01： | 1 |
| 11 | PDGFRA immunostaining can help in the diagnosis of gastrointestinal stromal tumors 显示文摘 | Miselli F Millefanti C Conca E | 2008 | Am J Surg Pathol2008，32，5： | 1 |
| 12 | Effects of pH on heavy metal sorption on mineral apatite 显示文摘 | CHEN Xiao-bing WRIGHT J V CONCA J L | 1997 | En- viron Sci Technol1997，31，3： | 1 |
| 13 | Docetaxel and epirubicin compared with docetaxel and prednisone in advanced castrate-resistant prostate cancer:a randomised phase Ⅱ study显示文摘 | Petrioli R Pascucci A Conca R | 2011 | Br J Cancer2011，104，4： | 1 |
| 14 | A simplified ABS numerical model: comparison with HIL and full scale experimental tests 显示文摘 | Cheli F Concas A Giangiulio E | 2008 | Computers and Structures2008，86，1314： | 1 |
| 15 | Transeranial magnetic stimulation induces 'pseudoabsence seizure' 显示文摘 | Conca A Konig P Hausmann A | 2000 | Acta Psychiatr Scand2000，101，3： | 1 |
| 16 | Evaluation of heavy metal remediation using mineral apatite显示文摘 | Chen X B Wright J V Conca J L | 1997 | Water Air and Soil Pollution1997，98，： | 1 |
| 17 | The use of mosses as environmental metal pollution indicators 显示文摘 | Aceto M Abollino O Conca R | 2003 | Chemosphere2003，50，： | 1 |
| 18 | Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors显示文摘 | Machein MR Conca W | 1998 | Am J Pathol1998，153，： | 1 |
| 19 | Investigation of the precursors of γ-Fe2 O3 in Fe2 O3/SiO2 nanocomposites obtained through sol-gel显示文摘 | Cannas C Concas G Falqui A | 2001 | Journal of NonCrystalline Solids2001，286，： | 1 |
| 20 | PDGFRA immuno- staining can help in the diagnosis of gastrointestinal stmmal tumors显示文摘 | Miselli F Millefanti C Conca E | 2008 | Am J Surg Pathol2008，32，5： | 1 |
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