|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review显示文摘BACKGROUND Despite the advent of biological drugs, conventional therapy continues to be used in moderate to severe inflammatory bowel disease(MS-IBD). This study hypothesized that as a standard of treatment and the primary alternative to biologics, conventional therapy should present robust effectiveness results in IBD outcomes.AIM To investigate the effectiveness of conventional therapy for MS-IBD.METHODS A systematic review with no time limit was conducted in July 2017 through the Cochrane Collaboration, MEDLINE, and LILACS databases. The inclusion criteria encompassed meta-analyses, systematic reviews, randomized clinical trials, observational and case-control studies concerning conventional therapy in adult patients with MS-IBD, including Crohn's disease(CD) and ulcerative colitis(UC). Corticosteroids(prednisone, hydrocortisone, budesonide, prednisolone,dexamethasone), 5-aminosalicylic acid(5-ASA) derivatives(mesalazine and sulfasalazine) and immunosuppressants [azathioprine(AZA), methotrexate(MTX), mycophenolate, cyclosporine, tacrolimus, 6-mercaptopurine(6-MP)] were considered conventional therapy. The exclusion criteria were sample size below50; narrative reviews; specific subpopulations(e.g., pregnant women,comorbidities); studies on postoperative IBD; and languages other than English,Spanish, French or Portuguese. The primary outcome measures were clinical remission(induction or maintenance), clinical response and mucosal healing. As secondary outcomes, fecal calprotectin, hospitalization, death, and surgeries were analyzed. The quality of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation criteria.RESULTS The search strategy identified 1995 citations, of which 27 were considered eligible(7 meta-analyses, 20 individual studies). For induction of clinical remission, four meta-analyses were selected(AZA and 6-MP showed no advantage over placebo,MTX or 5-ASA in CD; MTX showed no statistically significant difference versus placebo, 6-MP, or 5-ASA in UC; tacrolimus was superior to placebo for UC in two meta-analyses). Only one meta-analysis evaluated clinical remission maintenance, showing no statistically significant difference between MTX and placebo, 5-ASA, or 6-MP in UC. AZA and 6-MP had no advantage over placebo in induction of clinical response in CD. Three meta-analyses showed the superiority of tacrolimus vs placebo for induction of clinical response in UC. The clinical response rates for cyclosporine were 41.7% in randomized controlled trials(RCTs) and 55.4% in non-RCTs for UC. For induction of mucosal healing,one meta-analysis showed a favorable rate with tacrolimus versus placebo for UC. For secondary outcomes, no meta-analyses specifically evaluated fecal calprotectin, hospitalization or death. Two meta-analyses were retrieved evaluating colectomy rates for tacrolimus and cyclosporine in UC. Most of the twenty individual studies retrieved contained a low or very low quality of evidence.CONCLUSION High-quality evidence assessing conventional therapy in MS-IBD treatment is scarce, especially for remission maintenance, mucosal healing and fecal calprotectin. | Adérson Omar Mourao Cintra Damiao Matheus Freitas Cardoso de Azevedo Alexandre de Sousa Carlos Marcela Yumi Wada Taciana Valéria Marcolino Silva Flávio de Castro Feitosa | 2019 | World Journal of Gastroenterology2019，25，9： | 13 |
| 2 | Duodenal stenting for malignant gastric outlet obstruction:Prospective study显示文摘AIM:To evaluate the results of duodenal stenting for palliation of gastroduodenal malignant obstruction by using a gastric outlet obstruction score (GOOS).METHODS:A prospective,non-randomized study was performed at a tertiary center between August 2005 and April 2010.Patients were eligible if they had malignant gastric outlet obstruction (GOO) and were not candidates for surgical treatment.Medical history and patient demographics were collected at baseline.Scheduled interviews were made on the day of the procedure and 15,30,90 and 180 d later or unscheduled as necessary.RESULTS:Fifteen patients (6 male,9 female;median age 61 years) with GOO who had undergone duodenal stenting were evaluated.Ten patients had metastasis at baseline (66.6%) and 14 were unable to accept oral intake (93.33%),including 7 patients who were using a feeding tube.Laboratory data showed biliary obstruction in eight cases (53.33%);all were submitted to biliary drainage.Two patients developed obstructive symptoms due to tumor ingrowth after 30 d and another due to tumor overgrowth after 180 d.Two cases of stent migration occurred.A good response to treatment was observed,with a mean time of approximately 1 d (19 h) until toleration of a liquid diet and slightly more than 2 d for both soft solids (51 h) and a solid food/normal diet (55 h).The mean time to first failure to maintain liquid intake (GOOS ≥ 1) was 93 d.During follow-up,the mean time to first failure to maintain the previously achieved GOOS of 2-3 (solid/semi-solid food),considered technical failure,was 71 d.On the basis of oral intake a GOOS is defined:0 for no oral intake;1 for liquids only;2 for soft solids only;3 for lowresidue or full diet.CONCLUSION:Enteral stenting to alleviate gastroduodenal malignant obstruction improves quality of life in patients with limited life expectancy,which can be evaluated by using a GOO scoring system. | Eduardo Guimaräes Hourneaux Moura Flávio Coelho Ferreira Spencer Cheng Diogo Turiani Hourneaux Moura Paulo Sakai Bruno Zilberstain | 2012 | World Journal of Gastroenterology2012，18，9： | 5 |
| 3 | Effect of rare-earth oxides on properties of silicon nitride obtained by normal sintering and sinter-HIP显示文摘This paper presented the microstructure,mechanical properties and oxidation behavior of silicon nitride obtained by both conventional sintering and sintering followed by hot isostatic pressing(HIP).Silicon nitride with additives such as 5 wt.% Al2O3 and 5 wt.% Ln2O3(Ln= La,La concentrate,Gd or La+Gd) were studied.The results revealed that Gd2O3 additions increased the formation of elongated grains of β-Si3N4,the fracture toughness and oxidation resistance.La2O3 additions led to higher densification and hardness values,while addition of La2O3 concentrate promoted the formation of materials with intermediate properties,compared to the other studied compositions.Hot isostatic pressing increased the hardness but decreased the fracture toughness of the material,mainly because it allowed residual pores to close and also reduced the average aspect ratio of β-Si3N4 grains. | Cecilia C.Guedes-Silva Flávio Machado de Souza Carvalho José Carlos Bressiani | 2012 | Journal of Rare Earths2012，30，11： | 4 |
| 4 | Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency显示文摘Background: Leptin has a strong relation to important traits in animal production, such as carcass composition,feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the hypothalamus.In this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake(DMI) and average daily gain(ADG) of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake(RFI) and select 20 animals for the high feed efficient(LRFI) and 20 for the low feed efficient(HRFI) groups. Blood samples were collected on d 56 and at slaughter(80 d) to determine circulating plasma leptin. Samples of Longissimus dorsi were taken at slaughter for leptin gene expression levels.Results: DMI and RFI were different between groups and LRFI animals showed less back fat and rump fat thickness,as well as less pelvic and kidney fat weight. Circulating leptin increased over time in all animals. Plasma leptin was greater in LRFI on 56 d and at slaughter(P = 0.0049). Gene expression of leptin were greater in LRFI animals(P = 0.0022) in accordance with the plasma levels. The animals of the LRFI group were leaner, ate less, and had more circulating leptin and its gene expression.Conclusion: These findings demonstrated that leptin plays its physiological role in young Nellore bulls, probably controlling food intake because feed efficient animals have more leptin and lower residual feed intake. | Lúcio Flávio Macedo Mota Cristina Moreira Bonafé Pamela Almeida Alexandre Miguel Henrique Santana Francisco JoséNovais Erika Toriyama Aldrin Vieira Pires Saulo da Luz Silva Paulo Roberto Leme JoséBento Sterman Ferraz Heidge Fukumasu | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 3 |
| 5 | 使用外源性蛋白酶提高免疫力显示文摘在动物饲料中使用蛋白酶通常是为了降低饲料成本。然而,通过最大限度地提高蛋白饲料的消化率,动物生产者可以降低日粮的粗蛋白水平,使用低成本的蛋白饲料,且不会影响动物的健康和生产性能。 | José Otávio B.Sorbara 杨革玲(译) 王晶晶(校) 靳文广(制表) | 2017 | 国外畜牧学(猪与禽)2017，0，5： | 3 |
| 6 | Screening of unknown atrial fibrillation through handheld device in the elderly显示文摘Objective To estimate the prevalence of unknown atrial fibrillation(AF)in the elderly population of the Veneto Region,Italy.Methods 1820 patients aged≥65 years with no history of AF and not anticoagulated were enrolled in primary-care settings.They underwent an opportunistic electrocardiogram screening with a handheld device(My Diagnostick)designed to specifically detect AF.The electrocardiogram recordings were reviewed by the researchers,who confirmed the presence of AF.Results The device detected an arrhythmia in 143 patients,which was confirmed as AF in 101/143(70.6%),with an overall prevalence of AF of 5.5%(101/1820).Prevalence of unknown AF resulted in 3.6%in patients aged 65–74 years,and 7.5%in patients age 75 or older,and increased according to CHA2 DS2-VASc score:3.5%in patients with a score of 1 or 2,5.6%in patients with a score of 3,7.0%in patients with a score of 4,and 7.2%in patients with a score≥5.The detection rate was significantly higher in patients with mild symptoms compared to asymptomatic counterparts(24.1%vs.4.0%,P<0.0001).At multivariate analysis,congestive heart failure and age≥75 years-old were independent predictors for screen-detected AF.Conclusions An opportunistic screening with handheld device revealed an unexpectedly high prevalence of unknown AF in elderly patients with mild symptoms.Prevalence increased with age and CHA2DS2-VASc score. | Francesco Rivezzi Riccardo Vio Claudio Bilato Leopoldo Pagliani Giampaolo Pasquetto Salvatore Saccà Roberto Verlato Federico Migliore Sabino Iliceto Vito Bossone Emanuele Bertaglia | 2020 | Journal of Geriatric Cardiology2020，17，8： | 3 |
| 7 | Calcium potentiates the effect of estradiol on PGF2α production in the bovine endometrium显示文摘Background: Estradiol(E2) is required for luteolysis in cows and its injection stimulates prostaglandin F2α(PGF2α)release. The main goal of our study was to investigate the ability of endometrial explants and cells treated with E2 and the calcium ionophore(CI) A23187 to synthesize PGF2α.Results: Treatment with E2 in vivo resulted in a 48.4% increase of PGF2α production by endometrial explants treated in vitro with A23187. Production of PGF2α was better stimulated with A23187 at concentrations of 10-6and10-5mol/L compared with other concentrations used. The concentration of PGF2α for untreated bovine endometrial cell cultures was 33.1 pg/m L, while for cultures treated with E2, A23187, or a combination of E2 and A23187, the PGF2α concentration was 32.5, 92.4 and 145.6 pg/m L, respectively.Conclusions: Treatment with A23187 tended to stimulate PGF2α production. In the presence of E2, A23187 significantly stimulated PGF2α synthesis. It appears that A23187 potentiates the effects of E2 with respect to synthesis of endometrial PGF2α in cattle. | Claudia Maria Bertan Membrive Pauline Martins da Cunha Flávio Vieira Meirelles Mario Binelli | 2015 | Journal of Animal Science and Biotechnology2015，6，2： | 2 |
| 8 | 含纳米流体热管性能计算模型的分析显示文摘将纳米流体应用在热管中进行热阻降低实验,可以得到理想的实验结果。然而,为了表征纳米流体在热管中的行为,目前所建立的热管和纳米流体的研究模型尚缺少深入讨论,特别是对于基础流体和纳米颗粒如碳纳米管或乙二醇的研究。因此,本研究先建立热管中纳米流体的流动方程,根据文献中热管的数据进行模拟。结果表明,实验测得的平均温度与预测结果有定性的一致性,误差在1.5%和23.9%之间。此外,实验得到的热管温度分布不能仅通过适当的热性能数值计算得到,这也表明沸腾现象比现有的应用模型更复杂。通过结合不同的性能模型,可以观察到纳米流体在此应用中存在最优的颗粒体积分数。 | Rodrigo Vidonscky PINTO Flávio Augusto Sanzovo FIORELLI | 2019 | Journal of Central South University2019，26，5： | 2 |
| 9 | Dexmedetomidine: Current Role in Anesthesia and Intensive Care显示文摘 | Joana Afonso Flávio Reis | 2012 | Brazilian Journal of Anesthesiology2012，，1： | 2 |
| 10 | Mathematical simulation of radial heat transfer in packed beds by pseudohomogeneous modeling显示文摘Uniform flow regime and constant effective thermal conductivity inside packed beds are commonly accepted in the evaluation of the fluid dynamics and heat transfer in such systems.However,several authors have confirmed the presence of an oscillatory velocity profile caused by the effective contribution of porosity profile in the fluid dynamic behavior of packed beds,which directly influences the heat transfer inside the beds.This paper describes the application of a pseudo-homogeneous mathematical model for describing heat transfer in packed beds with oscillatory profiles of velocity and porosity,using a radius-dependent model for effective thermal conductivity k r.Several temperature profiles were obtained in a packed bed system with thermal source located on the wall.The simulated temperature and effective thermal conductivity obtained from simulations were compared with experimental data and calculation from a model based on uniform k r fitting.The results indicate that the proposed mathematical modeling was capable of better representing the heat transfer in the packed bed. | Rodrigo Béttega Marcos Flávio Pinto Moreira Ronaldo Guimaraes Corrêa José Teixeira Freire | 2011 | Particuology2011，9，2： | 2 |
| 11 | Structural phase relations in perovskite-structured BiFeO_(3)-based multiferroic compounds显示文摘In this review,the state of the art in understanding the structural phase relations in perovskite-structured BiFeO_(3)-based polycrystalline solid solutions is presented and discussed.Issues about the close relation between the structural phase and overall physical properties of the reviewed systems are pointed out and discussed.It is shown that,by adjusting the structural symmetric arrangement,the ferroelectric and magnetic properties of BiFeO_(3)-based polycrystalline solid solutions can be tuned to find specific multifunctional applications.However,an intrinsic mechanism linking structural arrangement and physical properties cannot be identified,revealing that this subject still deserves further discussion and investigation. | Valdirlei Fernandes FREITAS Gustavo Sanguino DIAS Otávio Algusto PROTZEK Diogo Zampieri MONTANHER Igor Barbosa CATELLANI Daniel Matos SILVA Luiz Fernando CÓTICA Ivair Aparecido dos SANTOS | 2013 | Journal of Advanced Ceramics2013，2，2： | 2 |
| 12 | Role of dynamic computed tomography scans in patients with congenital craniovertebral junction malformations显示文摘AIM To evaluate the role of dynamic computed tomography(CT)scan imaging in diagnosing craniovertebral junction(CVJ)instability in patients with congenital CVJ malformations.METHODS Patients with symptomatic congenital CVJ malformations who underwent posterior fossa decompression and had a preoperative dynamic CT scan in flexion and extended position were included in this study.Measurements of the following craniometrical parameters were taken in flexed and extended neck position:Atlanto-dental interval(ADI),distance of the odontoid tip to the Chamberlain’s line,and the clivus-canal angle(CCA).Assessment of the facet joints congruence was also performed in both positions.Comparison of the values obtained in flexion and extension were compared using a paired Student’s t-test.RESULTS A total of ten patients with a mean age of 37.9 years were included.In flexion imaging,the mean ADI was1.76 mm,the mean CCA was 125.4°and the mean distance of the odontoid tip to the Chamberlain’s line was+9.62 mm.In extension,the mean ADI was1.46 mm(P=0.29),the mean CCA was 142.2°(P<0.01)and the mean distance of the odontoid tip to the Chamberlain’s line was+7.11 mm(P<0.05).Four patients(40%)had facetary subluxation demonstrated in dynamic imaging,two of them with mobile subluxation(both underwent CVJ fixation).The other two patients with a fixed subluxation were not initially fixed.One patient with atlantoaxial assimilation and C23 fusion without initial facet subluxation developed a latter CVJ instability diagnosed with a dynamic CT scan.Patients with basilar invagination had a lower CCA variation compared to the whole group.CONCLUSION Craniometrical parameters,as well as the visualization of the facets location,may change significantly according to the neck position.Dynamic imaging can provide additional useful information to the diagnosis of CVJ instability.Future studies addressing the relationship between craniometrical changes and neck position are necessary. | Otávio Turolo da Silva Enrico Ghizoni Helder Tedeschi Andrei Fernandes Joaquim | 2017 | World Journal of Orthopedics2017，8，3： | 2 |
| 13 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 14 | Synthesis Gas Production from Natural Gas on Supported Pt Catalysts显示文摘,联合部分氧化并且有 CO2 或蒸气的甲烷改过甲烷的汽车热的改过,与 Pt/Al2O3 Pt/ZrO2 和 Pt/CeO2 催化剂被执行,在 300 ¨ C 的一个温度范围 900 ??6 号元素碳的化学符号。也就是,汽车热的改过发生在二个同时的阶段甲烷的全部的燃烧并且与蒸气和 CO2 无变化的甲烷改过,与百分之百从 450 开始的 O2 变换 ??6 号元素碳的化学符号。为有 CO2 改过的联合, Pt/CeO2catalyst 在 800 点显示出最低起始的活动 ??6 号元素碳的化学符号,和在 40 h 在溪流上上的最高的稳定性。这催化剂也在 800 点与蒸气为反应介绍了最好的表演 ??6 号元素碳的化学符号。到在铈土上支持的催化剂的焦形成的更高的抵抗由于金属支持相互作用和在氧化物格子的氧的更高的活动性。给词调音:甲烷;冒热气改过;CO2 改过;部分氧化;汽车热的改过;铂催化剂;铈土; | Mariana M. V. M. Souza Octávio R. Macedo Neto Martin Schmal | 2006 | Journal of Natural Gas Chemistry2006，15，1： | 2 |
| 15 | Distinguishing between low-dimensional dynamics and randomness in measured time series显示文摘 | Provenzale A Srrfith L A Vio R Murante G | 1992 | Physica D: Nonlinear Phenomena1992，58，14： | 1 |
| 16 | Non-linear aeroelastic prediction for aircraft application显示文摘 | Henshaw M J C Badcock K J Vio G A | 2007 | Progress in Aerospace Sciences2007，43，： | 1 |
| 17 | Licensing endogenous cost-reduction in a differentiated Stackelberg model显示文摘 | Flávio Ferreira Oana R. Bode | 2013 | Communications in Nonlinear Science and Numerical Simulation2013，，2： | 1 |
| 18 | Diversity of biosurfactant producing microorganisms isolated from soils contaminated with diesel oil显示文摘 | Fa' tima Menezes Bentoa Fla' vio A de Oliveira Camargoa Benedict C Okekeb | 2005 | Microbiological Research2005，160，： | 1 |
| 19 | Emergy assessment of integrated production systems of grains, pig and fish in small farms in the South Brazil显示文摘 | Otávio Cavalett Júlio Ferraz de Queiroz Enrique Ortega | 2005 | Ecological Modelling2005，，3： | 1 |
| 20 | IGF - 1 decreases collagen degradation in diabetic NOD mesangial cells:implication for diabetic nephopathy 显示文摘 | Jaffa AA Vio C Velarde V | 1999 | J Diabetes1999，48，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员