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| 1 | Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori显示文摘AIM: To investigate the bactericidal and anti-adhesive properties of 25 plants against Helicobacter pylori (H pylori).METHODS: Twenty-five plants were boiled in water to produce aqueous extracts that simulate the effect of cooking. The bactericidal activity of the extracts was assessed by a standard kill-curve with seven strains of H pylori. The anti-adhesive property was assessed by the inhibition of binding of four strains of FITC-labeled H pylori to stomach sections. RESULTS: Of all the plants tested, eight plants, including Bengal quince, nightshade, garlic, dill, black pepper, coriander, fenugreek and black tea, were found to have no bactericidal effect on any of the isolates. Columbo weed, long pepper, parsley, tarragon, nutmeg, yellow-berried nightshade, threadstem carpetweed, sage and cinnamon had bactericidal activities against H pylori, but total inhibition of growth was not achieved in this study. Among the plants that killed H pylori, turmeric was the most efficient, followed by cumin, ginger, chilli, borage, black caraway, oregano and liquorice. Moreover, extracts of turmeric; borage and parsley were able to inhibit the adhesion of H pylori strains to the stomach sections.CONCLUSION: Several plants that were tested in our study had bactericidal and/or anti-adhesive effects on H pylori. Ingestion of the plants with anti-adhesive properties could therefore provide a potent alternative therapy for H pylori infection, which overcomes the problem of resistance associated with current antibiotic treatment. | Rachel O'Mahony Huda Al-Khtheeri Deepaka Weerasekera Neluka Fernando Dino Vaira John Holton Christelle Basset | 2005 | World Journal of Gastroenterology2005，11，47： | 29 |
| 2 | Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease显示文摘Autophagy is an evolutionarily conserved intracellular degradative function that is important for liver homeostasis.Accumulating evidence suggests that autophagy is deregulated during the progression and development of alcoholic and non-alcoholic liver diseases.Impaired autophagy prevents the clearance of excessive lipid droplets(LDs),damaged mitochondria,and toxic protein aggregates,which can be generated during the progression of various liver diseases,thus contributing to the development of steatosis,injury,steatohepatitis,fibrosis,and tumors.In this review,we look at the status of hepatic autophagy during the pathogenesis of alcoholic and non-alcoholic liver diseases.We also examine the mechanisms of defects in autophagy,and the hepato-protective roles of autophagy in non-alcoholic fatty liver disease(NAFLD)and alcoholic liver disease(ALD),focusing mainly on steatosis and liver injury.Finally,we discuss the therapeutic potential of autophagy modulating agents for the treatment of these two common liver diseases. | Bilon Khambu Shengmin Yan Nazmul Huda Gang Liu Xiao-Ming Yin | 2018 | Liver Research2018，2，3： | 13 |
| 3 | Quantitative Comparison of Calcium Hydroxide Removal by EndoActivator, Ultrasonic and ProTaper File Agitation Techniques: An in vitro Study显示文摘Calcium hydroxide (CH) dressing residues can compromise endodontic sealing. This study aimed to evaluate the amount of remaining CH in root canals after mechanical removal by four groups of irrigation techniques including needle irrigation only, ProTaper file, EndoActivator, and ultrasonic file. Fifteen extracted single-rooted teeth were collected and used for all four groups. The samples were firstly prepared by ProTaper rotary instruments, and then sectioned longitudinally through the long axis of the root canals, followed by final reassembling by wires. CH was kept in the canals for 7 days setting. The removal procedure began with 5 mL of 2.5% sodium hypochlorite (NaOCl) followed by 1 mL of 17% ethylenediaminetetraacetic acid and a final irrigation with 5 mL of 2.5% NaOCl solution for all groups. No additional agitation of the irrigant was performed in group 1, while agitation for 20 s between irrigants was done with F2 ProTaper rotary file in group 2, EndoActivator with tip size 25/.04 in group 3 and by an ultrasonic file 25/.02 in group 4. The total activation time was 60 s. The roots were then disassembled and captured by digital camera. The ratio of CH coated surface area to the surface area of the whole canal as well as each third of the canal was calculated. The data were statistically analyzed by one-way ANOVA using post hoc Tukey test. Results showed that none of the four techniques could remove all CH. No significant difference was found between EndoActivator and ultrasonic techniques. However, they both removed significantly more CH than ProTaper and needle irrigation (P=0.0001). In conclusion, the sonic and ultrasonic agitation techniques were more effective in removing intracanal medicaments than the ProTaper rotary file and needle irrigation in all thirds of the canal. | Huda Yasir Khaleel Ahmed Jawad Al-Ashaw 杨焰 逄爱慧 马净植 | 2013 | Journal of Huazhong University of Science and Technology(Medical Sciences)2013，33，1： | 4 |
| 4 | 反相高效液相色谱法同时测定片剂中的加替沙星与盐酸氨溴索(英文)显示文摘A reversed-phase high performance liquid chromatography (HPLC) method was developed, validated, and used for the quantitative determination of gatifloxacin (GA) and ambroxol hydrochloride (AM), from its tablet dosage form. Chromatographic separation was performed on a HiQ Sil C18 column (250 mm×4.6 mm, 5 μm), with a mobile phase comprising of a mixture of 0.01 mol/L potassium dihydrogen orthophosphate buffer and acetonitrile (70∶30, v/v), and pH adjusted to 3 with orthophosphoric acid, at a flow rate of 1 mL/min, with detection at 247 nm. Separation was completed in less than 10 min. As per International Conference on Harmonisation (ICH) guidelines the method was validated for linearity, accuracy, precision, limit of quantitation, limit of detection, and robustness. Linearity of GA was found to be in the range of 10-60 μg/mL and that for AM was found to be 5-30 μg/mL. The correlation coefficients were 0.999 6 and 0.999 3 for GA and AM respectively. The results of the tablet analysis (n=5) were found to be 99.94% with ±0.25% standard deviation (SD) and 99.98% with±0.36% SD for GA and AM respectively. Percent recovery of GA was found to be 99.92%-100.02% and that of AM was 99.86%-100.16%. The assay experiment shows that the method is free from interference of excipients. This demonstrates that the developed HPLC method is simple, linear, precise, and accurate, and can be conveniently adopted for the routine quality control analysis of the tablet. | SHAHED Mirza NANDA Rabindra DEHGHAN Muhammad Hassan NASREEN Huda FEROZ Shaikh | 2008 | 色谱2008，26，3： | 3 |
| 5 | Hepatic senescence, the good and the bad显示文摘Gradual alterations of cell’s physiology and functions due to age or exposure to various stresses lead to the conversion of normal cells to senescent cells.Once becoming senescent,the cell stops dividing permanently but remains metabolically active.Cellular senescence does not have a single marker but is characterized mainly by a combination of multiple markers,such as,morphological changes,expression of cell cycle inhibitors,senescence associatedβ-galactosidase activity,and changes in nuclear membrane.When cells in an organ become senescent,the entire organism can be affected.This may occur through the senescence-associated secretory phenotype(SASP).SASP may exert beneficial or harmful effects on the microenvironment of tissues.Research on senescence has become a very exciting field in cell biology since the link between age-related diseases,including cancer,and senescence has been established.The loss of regenerative and homeostatic capacity of the liver over the age is somehow connected to cellular senescence.The major contributors of senescence properties in the liver are hepatocytes and cholangiocytes.Senescent cells in the liver have been implicated in the etiology of chronic liver diseases including cirrhosis and hepatocellular carcinoma and in the interference of liver regeneration.This review summarizes recently reported findings in the understanding of the molecular mechanisms of senescence and its relationship with liver diseases. | Nazmul Huda Gang Liu Honghai Hong Shengmin Yan Bilon Khambu Xiao-Ming Yin | 2019 | World Journal of Gastroenterology2019，25，34： | 3 |
| 6 | Glutathione (GSH) improves sperm quality and testicular morphology in streptozotocin-induced diabetic mice显示文摘Diabetes mellitus(DM)is known to cause reproductive impairment.In men,it has been linked to altered sperm quality and testicular damage.Oxidative stress(OS)plays a pivotal role in the development of DM complications.Glutathione(GSH)is a part of a nonenzymatic antioxidant defense system that protects lipid,protein,and nucleic acids from oxidative damage.However,the protective effects of exogenous GSH on the male reproductive system have not been comprehensively examined.This study determined the impact of GSH supplementation in ameliorating the adverse effect of type 1 DM on sperm quality and the seminiferous tubules of diabetic C57BL/6NTac mice.GSH at the doses of 15 mg kg^(-1)and 30 mg kg^(-1)was given intraperitoneally to mice weekly for 6 consecutive weeks.The mice were then weighed,euthanized,and had their reproductive organs excised.The diabetic(D Group)showed significant impairment of sperm quality and testicular histology compared with the nondiabetic(ND Group).Diameters of the seminiferous lumen in diabetic mice treated with 15 mg kg^(-1) GSH(DGSH15)were decreased compared with the D Group.Sperm motility was also significantly increased in the DGSH15 Group.Improvement in testicular morphology might be an early indication of the protective roles played by the exogenous GSH in protecting sperm quality from effects of untreated type 1 DM or diabetic complications.Further investigation using different doses and different routes of GSH is necessary to confirm this suggestion. | Fathiah Abdullah Mohamed Noor Khan Nor-Ashikin Renu Agarwal Yuhaniza Shafinie Kamsani Mastura Abd Malek Nor Salmah Bakar Aqila-Akmal Mohammad Kamal Mimi-Sophia Sarbandi Nor-Shahida Abdul Rahman Nurul Huda Musa | 2021 | Asian Journal of Andrology2021，23，3： | 3 |
| 7 | Economics of the plant species used in homestead agroforestry on an offshore Sandwip Island of Chittagong District, Bangladesh显示文摘This study was performed in five villages of Sandwip Upazila, Chittagong district with a view to identify the tree resources, utilization pattern and economic return of major fruit and timber tree species. Information collected from a total of 60 households ranging from marginal, small, medium and large categories. Number of plant species increased with the increase of homestead area. A total of 33 plant species were recorded from the homegarden, of which 19 were fruit and 14 were timber tree species. Considerable number of vegetables was also planted under the shade of the homestead trees. The investment analysis showed that average benefit-cost ratios were greater than one, net present values were positive and internal rate of returns were more than 10%. Long term investment on horticulture and timber tree species is highly profitable if species like Artocarpus heterophyllus, Cocos nucifera, Tectona grandis and Swietenia macrophylla are planted. | R. U. Momen S. M. S. Huda M. K. Hossain B. M. Khan | 2006 | Journal of Forestry Research2006，17，4： | 3 |
| 8 | Effects of sludge on germination and initial growth performance of Leucaena leucocephala seedlings in the nursery显示文摘研究被执行决定污泥的不同类型的影响(市政,工业;居住) 在地萌芽上,生长;L 的生节。在托儿所的 leucocephala 幼苗。在种子播种前,污泥的不同联合与滋养的缺乏的自然森林土被合并。领域萌芽,生节地位;幼苗的物理生长参数(射击;根长度,活力索引,领子直径,叶数字,新鲜;弄干射击的重量;根;全部的干燥生物资源增长) 在三以后被记录;六月种子播种。地萌芽,生节地位;生长参数在与控制相比与污泥修改的土壤显著地被改变。小瘤的最高的数字从与居住污泥(1:1 ) 修改的土壤被记录;最高新鲜;干燥小瘤重量也在三从一样的联合被发现;六个月旧的幼苗。在生长参数的情况下,最高的生长从土壤被记录;与控制相比的居住污泥(1:1 ) 联合。从学习,与居住污泥(1:1 ) 修改的土壤提供更好的地萌芽,这能被推荐,生长;L 的小瘤形成。在降级的土壤的 leucocephala。 | G. M. A. Iqbal S. M. S. Huda M. Sujauddin M. K. Hossain | 2007 | Journal of Forestry Research2007，18，3： | 3 |
| 9 | Heavy metals accumulation in suburban roadside plants of a tropical area(Jengka,Malaysia)显示文摘Introduction:This study aims to examine the uptake and translocation of Cd,Cu,Fe,and Pb in different parts of three roadside plant species grown in the semi-urban of Jengka,Pahang,Malaysia.Methods:Heavy metal concentrations were determined from various parts of Athyrium esculentum(AE),Chromolaena odorata(CO),and Lantana camara(LC).The bioconcentration factor(BCF)and translocation ratio of heavy metals from soils to plants were estimated.Results:Fe showed the highest metal concentration determined(<850 mg kg^(−1)),while Cd showed the lowest metal concentration observed(<0.12 mg kg^(−1))in all plants.Heavy metal concentration in the roadside plants was higher than metal determined in the same species from an uncontaminated site.Principal component analysis(PCA)suggests anthropogenic and natural sources of heavy metal.Plant roots slightly enriched by Cd and Pb(BCF<1),while the leaves absorbed and accumulated Cu and Fe(BCF>1).The translocation ratio of four metals suggests that absorption of the three plants had the rank:root>stem>leaves.Conclusion:The metals in the root zone transported weakly to the stem but more strongly mobilized to leaves when available in the stems.A comprehensive study of heavy metal concentration in a variety of roadside plants in the tropical area should be done in the future ensuring the precise source and translocation mechanisms. | Fazrul Razman Sulaiman Huda Asilah Hamzah | 2018 | Ecological Processes2018，7，1： | 2 |
| 10 | Paediatric conj oint bicondylar Hoffa fracture with patellar tend on injury: An unusual pattern of injury显示文摘Epiphyseal injuries of distal femur are rare with an incidence of 1%—6% among all physeal injuries. Prompt diagnosis and appropriate surgical treatment is crucial to achieve satisfactory functional outcomes. A conjoint bicondylar coronal split (Hoffa) fracture with complete transaction of ipsilateral patellar tendon has been reported in a 12 year old child. The injury was managed by open reduction and internal fixation and bone to ten don repair. This case emphasizes the need of accurate intraepiphyseal fixation for the management of these fractures in skeletally immature patients. | Julfiqar Najmul Huda Ajay Pant | 2019 | Chinese Journal of Traumatology2019，22，4： | 2 |
| 11 | 施加磷肥和钾肥对苗圃内印度黄檀木生长和结瘤的影响(英文)显示文摘本文探测了无机肥(磷和钾)对苗圃内培养的印度黄檀生长和结瘤的影响。播种前,磷和钾肥以不同比例混合后与营养匮乏的自然林土壤混合,然后混合土再补以粪肥(混合土:粪肥=3:1)。出苗后60天时记录植株结瘤状况(结瘤数、形状、鲜重、干重和颜色)和植株生长参数(枝条和根长及鲜重和干重、直径)。与对照相比,补充肥料的土壤显著地改变了植株生长和结瘤状况(P<0.05)。植株结瘤的数目、鲜重和干重均在磷钾施肥量为 160kg/hm2时达到最大值,分别为62, 0.05g和0.07g。不同比例的补肥处理改变了结瘤形状和颜色,同时显著地影响了枝条和根长、直径、鲜重和干重等生长参数。研究揭示:苗圃内生长的黄檀,在贫瘠的自然林土壤中施以160kg/hm2磷钾肥并混以粪肥(混合土:粪肥=3:1)可使植株生长和结瘤的形成达最佳。 | S. M. S. Huda M. Sujauddin S. Shafinat M. S. Uddin | 2007 | Journal of Forestry Research2007，18，4： | 2 |
| 12 | Radiation exposure and image quality in chest CT examinations显示文摘 | Ravenel JG Scalzetti EM Huda W Garrisi W | 2001 | AJR2001，177，： | 1 |
| 13 | Prevalence, antibiotic re- sistance and genetic diversity of Listeria monocytogenes isola- ted from ducks, their rearing and processing environments in Penang, Malaysia 显示文摘 | Adzitey F Ali GR Huda NA | 2013 | Food Control2013，32，2： | 1 |
| 14 | How do radiographic techniques affect image quality and patient doses in CT?显示文摘 | Huda W Ravenel JG Scalzetti EM | 2002 | Semin Ultrasound CT MR2002，23，5： | 1 |
| 15 | Molecular and Neuroanatomical Properties of the Endogenous Opioid System:Implications for Treatment of Opiate Addiction显示文摘 | Huda A Fan M Darragh PD | 1997 | Semi neurosci1997，9，： | 1 |
| 16 | Do you know where I can find the new center which is called 'cognitive styles and language learning strategy link' 显示文摘 | Zahra Naimie d Sae- dah Siraj Reihaneh Shagholi Huda A1 Hejaili | 2010 | Procedia So- cial and Behavioral Sciences2010，，2： | 1 |
| 17 | Technique factors and image quality as functions of patient weight at abdominal CT 显示文摘 | Huda W Scalzetti EM Levin G | 2000 | Radiology2000，217，2： | 1 |
| 18 | Development of carbon precursor from bamboo tar 显示文摘 | W M Qiao Y Song M Huda | 2005 | letters to the Editor/Carbon2005，43，30023039： | 1 |
| 19 | Effect of radiographic techniques (kVp and mAs) on image quality and patient doses in digital subtraction angiography显示文摘 | Gkanatsios NA Huda W Peters KR | 2002 | Med Phys2002，29，8： | 1 |
| 20 | Interpretation of the gamma interferon test for diagnosis of subclinical paratuberculosis in cattle显示文摘 | Jungersen G Huda A Hansen J J | 2002 | Clin Dingn Lab Immunol2002，9，2： | 1 |
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