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| 1 | Management and outcome of hepatocellular adenoma with massive bleeding at presentation显示文摘AIM To evaluate outcome of acute management and risk of rebleeding in patients with massive hemorrhage due to hepatocellular adenoma(HCA). METHODS This retrospective cohort study included all consecutive patients who presented to our hospital with massive hemorrhage(grade Ⅱ or Ⅲ) due to ruptured HCA and were admitted for observation and/or intervention between 1999-2016. The diagnosis of HCA was based on radiological findings from contrastenhanced magnetic resonance imaging(MRI) or pathological findings from biopsy or resection of the HCA. Hemorrhage was diagnosed based on findings from computed tomography or MRI. Medical records were reviewed for demographic features, clinical presentation, tumor features, initial and subsequent management, short-and long-term complications and patient and lesion follow-up. RESULTS All patients were female(n = 23). Treatment in the acute phase consisted of embolization(n = 9, 39.1%), conservative therapy(n = 13, 56.5%), andother intervention(n = 1, 4.3%). Median hemoglobin level decreased significantly more on days 0-3 in the intervention group than in the patients initially treated conservatively(0.9 mmol/L vs 2.4 mmol/L respectively, P = 0.006). In total, 4 patients suffered severe shortterm complications, which included hypovolemic shock, acute liver failure and abscess formation. After a median follow-up of 36 mo, tumor regression in nonsurgically treated patients occurred with a median reduction of 76 mm down to 25 mm. Four patients underwent secondary(elective) treatment(i.e., tumor resection) to address HCA size of > 5 cm and/or desire for future pregnancy. One case of rebleeding was documented(4.3%). None of the patients experienced long-term complication(mean follow-up time: 36 mo). CONCLUSION With a 4.3% risk of rebleeding, secondary(elective) treatment of HCA after massive hemorrhage may only be considered in patients with persistent HCA > 5 cm. | Anne J Klompenhouwer Robert A de Man Maarten GJ Thomeer Jan NM Ijzermans | 2017 | World Journal of Gastroenterology2017,23,25: | 5 |
| 2 | Machine perfusion in abdominal organ transplantation: Current use in the Netherlands显示文摘Scarcity of donor organs and the increment in patients awaiting a transplant increased the use of organs from expanded criteria donors or donation after circulatory death.Due to the suboptimal outcomes of these donor organs,there is an increased interest in better preservation methods,such as ex vivo machine perfusion or abdominal regional perfusion to improve outcomes.This state-ofthe-art review aims to discuss the available types of perfusion techniques,its potential benefits and the available evidence in kidney,liver and pancreas transplantation.Additionally,translational steps from animal models towards clinical studies will be described,as well as its application to clinical practice,with the focus on the Netherlands.Despite the lack of evidence from randomized controlled trials,currently available data suggest especially beneficial effects of normothermic regional perfusion on biliary complications and ischemic cholangiopathy after liver transplantation.For ex vivo machine perfusion in kidney transplantation,hypothermic machine perfusion has proven to be beneficial over static cold storage in a randomized controlled trial,while normothermic machine perfusion is currently under investigation.For ex vivo machine perfusion in liver transplantation,normothermic machine perfusion has proven to reduce discard rates and early allograft dysfunction.In response to clinical studies,hypothermic machine perfusion for deceased donor kidneys has already been implemented as standard of care in the Netherlands. | Elsaline Rijkse Jan NM IJzermans Robert C Minnee | 2020 | World Journal of Transplantation2020,10,1: | 2 |
| 3 | Prophylactic isradipine treatment after kidney transplantation:a prospective double-blind placebo-controlled randomized trial显示文摘 | van den Dorpel MA Zietse R Ijzermans JN | 1994 | Transpl Int1994,71,: | 2 |
| 4 | Nicotinic acid recep-tor subtypes and their ligands显示文摘 | Soudijn W van Wijngaarden I Ijzerman AP | 2007 | Med Res Rev2007,27,3: | 1 |
| 5 | Clinical rejection and persistent immune regulation in kidney transplant patients显示文摘 | Hendrikx TK Klepper M IJzermans J | 2009 | Transpl Immunol2009,21,: | 1 |
| 6 | Benign versus malignant hepatic nodules: MR imaging findings with pathologic correlation 显示文摘 | Hussain SM Zondervan PE IJzermans JN | 2002 | Radiographics2002,22,5: | 1 |
| 7 | Benign versus malignant hepatic nodules:MR imaging findings with pathologic correlation显示文摘 | Hussain SM Zondervan PE IJzermans JN | 2002 | Radiographics2002,22,5: | 1 |
| 8 | The influence ofthe reciprocal cable linkage in the advanced reciprocating gaitorthosis on paraplegic gait performance 显示文摘 | Ijzerman MJ Baardman G Hermens HJ | 1997 | Prosthetic Orthotint1997,21,1: | 1 |
| 9 | Systematic review of haemorrhage and rupture of hepatocellular adenomas显示文摘 | van Aalten SM de Man RA IJzermans JN | 2012 | Br J Surg2012,99,7: | 1 |
| 10 | Valsartan-induced improvement in insulin sensitivity is not paralleled by changes in microvascular function in individuals with impaired glucose metabolism显示文摘 | Nynke J. van der Zijl Erik H. Serné Gijs H. Goossens Chantalle C.M. Moors Richard G. IJzerman Ellen E. Blaak Michaela Diamant | 2011 | Journal of Hypertension2011,,10: | 1 |
| 11 | 手伸肌电刺激和伸肌屈肌交替电刺激对脑卒中患者偏瘫上肢的影响比较显示文摘 | 李正宇 Dekroon JR Ijzerman MJ Lankhorst GJ | 2008 | 神经损伤与功能重建2008,3,5: | 1 |
| 12 | The influ ence of the reciprocal cable linkage in the advanced recipro eating gait orthosis on paraplegic gait performanee显示文摘 | Ijzerman MJ Baardman G Hermens HJ | 1997 | Pros thet Orthot Int1997,21,1: | 1 |
| 13 | The influ ence of the reciprocal hip joint link in the Advanced Recipro cating Gait Orthosis on standing performance in paraplegia 显示文摘 | Baardman G IJzerman MJ Hermens HJ | 1997 | Prosthet Orthot Int1997,21,3: | 1 |
| 14 | Apoptosis induced by extracellular ATP in the mouse neuroblastoma cell line N1E-115: studies on involvement of P2 receptors and adenosine显示文摘 | Schrier SM Flosea BI Mulder GJ Nagelkerke JF Ijzerman AP | 2002 | Biochem Pharmacol2002,63,6: | 1 |
| 15 | Comparison of analytic hier- archy process and conjoint analysis methods in assessing treatment alternatives for stroke rehabilitation显示文摘 | Ijzerman M J van Til J A Bridges J F | 2012 | Patient2012,5,1: | 1 |
| 16 | Benign versus malignant hepatic nodules:MRimaging findings with pathologic correlation显示文摘 | Hussain SM Zondervan PE Ijzermans JN | 2002 | Radiographies2002,22,: | 1 |
| 17 | Management strategy after diagnosis of Abernethy malformation:a case report显示文摘 | Witjes CD Ijzermans JN Vonk Noordegraaf A | | 0,,01: | 1 |
| 18 | Temperature perceptions as a ground for social proximity显示文摘 | Hans IJzerman Gün R. Semin | 2010 | Journal of Experimental Social Psychology2010,,6: | 1 |
| 19 | KRAS and BRAF mutation status in circulating colorectal tumor cells and their correlation with primary and metastatic tumor tissue显示文摘 | Bianca Mostert Yuqiu Jiang Anieta M. Sieuwerts Haiying Wang Joan Bolt‐de Vries Katharina Biermann Jaco Kraan Zarina Lalmahomed Anne Galen Vanja Weerd Petra Spoel Raquel Ramírez‐Moreno Cornelis Verhoef Jan N.M. IJzermans Yixin Wang Jan‐Willem Gratama John | 2013 | Int. J. Cancer2013,,: | 1 |
| 20 | A novel che- mogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands : a potential strategy for receptor de-orphanization 显示文摘 | Van der Horst E Peironeely J E Ijzerman A P | 2010 | BMC Bioinformatics2010,11,4: | 1 |