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| 1 | 利用土壤入渗速率和土壤抗剪力确定土壤侵蚀等级显示文摘土壤入渗速率决定着地表径流,土壤抗剪力制约着土壤的可蚀性能,因此,两者对水土流失作用有着直接的影响,可以用来确定土壤侵蚀的等级。 | 潘剑君 Berg.,IE | 1995 | 水土保持学报1995，9，2： | 24 |
| 2 | Significance of hepatitis virus infection in the oncogenicinitiation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common causes of cancer-related death worldwide. Chronic infection of hepatitis B virus(HBV) and/or hepatitis C virus(HCV) is a major risk factor in the development of the HCC, independently from excessive alcohol abuse and metabolic disease. Since the biology of HBV and HCV is different, their oncogenic effect may go through different mechanisms, direct and/or indirect. Viral hepatitis infection is associated with cellular inflammation, oxidative stress, DNA damage, that may lead to subsequent hepatic injuries such as chronic hepatitis, fibrosis, cirrhosis, and finally HCC. Direct oncogenic properties of these viruses are related with their genotypic characteristics and the ability of viral proteins to interact with host proteins, thus altering the molecular pathways balance of the cells. In addition, the integration of HBV DNA, especially the gene S and X, in a particular site of the host genome can disrupt chromosomal stability and may activate various oncogenic mechanisms, including those in hematopoietic cells. Recently, several studies also had demonstrated that viral hepatitis could trigger the population of hepatic cancer stem cells. This review summarize available pre-clinical and clinical data in literature regarding oncogenic properties of HBV and HCV in the early initiation of HCC. | Caecilia HC Sukowati Korri E El-Khobar Susan I Ie Beatrice Anfuso David H Muljono Claudio Tiribelli | 2016 | World Journal of Gastroenterology2016，22，4： | 18 |
| 3 | Predictive value of ^(18)F-fluorodeoxyglucose PET/CT for transarterial chemolipiodolization of hepatocellular carcinoma显示文摘Myeong Jun Song,Si Hyun Bae,Chung-Hwa Park,Jeong Won Jang,Jong Young Choi,Seung Kew Yoon,Department of Internal Medicine,College of Medicine,The Catholic University of Korea,Seoul 137-040,South Korea Ie Ryung Yoo,Department of Nuclear,Medicine College of Medicine,The Catholic University of Korea,Seoul 137-040,South Korea Ho Jong Chun,Byung Gil Choi,Hae Giu Lee,Department of Radiology,College of Medicine,The Catholic University of Korea,Seoul 137-040,South | Myeong Jun Song Si Hyun Bae Ie Ryung Yoo Chung-Hwa Park Jeong Won Jang Ho Jong Chun Byung Gil Choi Hae Giu Lee Jong Young Choi Seung Kew Yoon | 2012 | World Journal of Gastroenterology2012，18，25： | 8 |
| 4 | Recent Advances and Perspectives in Transition Metal-Catalyzed 1,4-Functionalizations of Unactivated 1,3-Enynes for the Synthesis of Allenes显示文摘Classic methods for the synthesis of allenes usually introduce only one functional group into products.In this review,we highlight the recent advances and perspectives in the synthesis of allenes by transition metal-catalyzed 1,4-functionalization of unactivated 1,3-enynes. | Liang Fu Steffen GreВies Pinhong Chen Guosheng Liu | 2020 | Chinese Journal of Chemistry2020，38，1： | 7 |
| 5 | 微量元素用于临床实践中的问题显示文摘在生物圈内有100多种元素,但目前知道有十四种是人体所必需的。本文论述了这十四种元素的生物化学功能、主要缺乏症状、中毒摄入量、中毒时的症状,澳大利亚的平均膳食摄入量、澳大利亚和美国的每日推荐的膳食摄入量、食物来源及含量,还论述了引起人类微量元素缺乏的病因及人体微量元素的正常值。 | Dreosti IE 赵永同 郝海兵 | 1991 | 国外医学(卫生学分册)1991，18，1： | 6 |
| 6 | Virological response to adefovir monotherapy and the risk of adefovir resistance显示文摘AIM:To evaluate virological response to adefovir(ADV) monotherapy and emergence of ADV-resistant mutations in lamivudine(LAM)-resistant chronic hepatitis B patients.METHODS:Seventy-seven patients with documented LAM resistance who were treated with 10 mg/d ADV for>96 wk were analyzed for ADV resistance.RESULTS:At week 48 and 96,eight(10%)and 14(18%)of 77 LAM-resistant patients developed the ADV-resistant strain(rtA181V/T and/or rtN236T mutations),respectively.Hepatitis B virus(HBV)DNA levels during therapy were significantly higher in patients who developed ADV resistance than in those who did not.Incidence of ADV resistance at week 96 was 11%,8%and 6%among patients with complete virological response(HBV DNA level<60 IU/mL);0%,5%and 19%among patients with partial virological response(HBV DNA level≥60 to 2000 IU/mL);and 32%,34% and 33%among patients with inadequate virological response(HBV DNA levels>2000 IU/mL)at week 12,week 24 and week 48,respectively.HBV DNA levels >2000 IU/mL at week 24 showed best performance characteristics in predicting ADV resistance.CONCLUSION:Development of ADV resistance mutations was associated with HBV DNA levels,which could identify patients with LAM resistance who are likely to respond to ADV monotherapy. | Dong Hyun Sinn Geum-Youn Gwak Moon Seok Choi Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Joon Hyeok Lee Hyang Ie Lee | 2011 | World Journal of Gastroenterology2011，17，30： | 5 |
| 7 | A new potential risk factor in patients with erectile dysfunction and premature ejaculation: folate deficiency显示文摘我们调查了酸(FA ) 与可勃起的机能障碍(编辑) 或早泄(PE ) 在病人铺平的浆液 folic。Fasting 浆液样品与编辑从 42 个病人被获得, 36 与 PE,有 PE 的 25 个编辑病人,和 30 个健康的人;吝啬的 intravaginal 射精潜伏时间(IELT ) 在 4 星期基线时期期间被测量。性荷尔蒙的层次(刺激滤泡的荷尔蒙, luteinizing 荷尔蒙,全部的睾丸激素) , homocysteine (Hcys ) ,和 FA 用 chemiluminescent 免疫分析被测量。PE 病人和正常控制人的性函数用早泄(CIPE ) 的中国索引被评估。可勃起的 Function-5 (IIEF-5 ) 问询表的缩短的国际索引被用来为编辑病人并且为正常控制计量可勃起的质量。浆液 FA 集中在编辑是更低的(7.61 ±3.97 ng ml −1), PE (9.37 ±3.40 ng ml −1), 和 ED/PE (8.84 ±4.28 个 ng ml −1) 病人比在健康的人(12.23 ±5.76 ng ml −1, P <0.05 ) 。在性荷尔蒙层次的重要差别都没与性机能障碍和健康控制在病人之间被发现(P >0.05 ) 。在浆液 FA 集中和 CIPE 分数之间有积极关联(r = 0.530, P <0.01 ) , IIEF-5 得分(r = 0.589, P <0.01 ) ,并且 IELT (r = 0.445, P <0.01 ) ;与 Hcys 集中的否定关联(r =− 0.487, P <0.01 ) 在所有参加者被发现。这些调查结果显示出在浆液 FA 层次和性机能障碍之间的一种强壮的关系,可能由于氮的氧化物, Hcys,和 5-hydroxytryptamine 的新陈代谢上的 FA 的效果。 | Wen-Jie Yan Nan Yu Tai-Lang Yin Yu-]ie Zou Jing Yang | 2014 | Asian Journal of Andrology2014，16，6： | 5 |
| 8 | Clinical course during the first 10 years of ulcerative colitis: results from a population-based inception cohort (IBSEN Study)显示文摘 | Inger Camilla Solberg Idar Lygren J?rgen Jahnsen Erling Aadland Ole H?ie Milada Cvancarova Tomm Bernklev Magne Henriksen Jostein Sauar Morten H. Vatn Bj?rn Moum And the IBSEN Study Group | 2009 | Scandinavian Journal of Gastroenterology2009，，4： | 3 |
| 9 | Prognostic value of 18-fluorodeoxyglucose positron emission tomography-computed tomography in resectable colorectal cancer显示文摘AIM:To assess the prognostic value of preoperative 18 fluorodeoxyglucose positron emission tomography(FDG-PET)/computed tomography(CT) in patients with resectable colorectal cancer.METHODS:One hundred sixty-three patients with resectable colorectal cancer who underwent FDG-PET/CT before surgery were included.Patient data including pathologic stage at presentation,histology,treatment,disease-free survival and the maximum standardized uptake value(SUVmax) of the primary tumor on FDG-PET/CT were retrospectively analyzed.Median follow up duration was 756(range,419-1355).The primary end point was disease-free survival.RESULTS:Twenty-five of 163 patients(15.3%) had recurrences.The median SUVmax values of the recurrence and no-recurrence groups were 8.9(range,5-24) and 8.2(range,0-23,P = 0.998).Receiver operating characteristic(ROC) curve analysis showed no significant association between SUVmax and recurrence(area under the curve = 0.5,P = 0.998,95% CI:0.389-0.611).Because a statistically significant value was not found,SUVmax was dichotomized at its median of 8.6.The disease-free survival curve was analyzed using the median SUVmax(8.6) as the cut off.Univariate and multivariate analysis did not provide evidence that disease-free survival rates for the subgroups defined by the median SUVmax were significantly different(P = 0.52,P = 0.25).CONCLUSION:Our study suggests that the high FDG uptake of primary mass in resectable colorectal cancer doesn't have a significant relationship with tumor recurrence and disease-free survival. | Jang Eun Lee Sang Woo Kim Jin Su Kim Kyu Yong Choi Won Kyung Kang Seong Taek Oh Ie Ryung Yoo Sung Hoon Kim | 2012 | World Journal of Gastroenterology2012，18，36： | 3 |
| 10 | 实验性高胆固醇血症兔离体主动脉功能变化的研究显示文摘目的 :探讨高胆固醇血症对血管功能的影响。方法 :2 0只新西兰雄性兔随机分为 2组 :正常饮食组 (nor-mal cholesterol,NC) 10只及高胆固醇饮食组 (hypercholesterol,HC) 10只。 4周后取出每只兔的降主动脉 ,5 mm宽动脉环放置于含有 2 5 ml Kreb液的组织 -器官水浴系统中。分别测量游离血管对乙酰胆碱 (10 - 1 0~ 10 - 5 m ol/L)的舒张反应及对去甲肾上腺素 (10 - 1 0~ 10 - 5 m ol/ L)的收缩反应。结果 :2组兔血胆固醇有显著差异 ,其中 NC组(30 .1± 11.2 ) mg/ dl,HC组 (987.3± 110 .0 ) mg/ dl(P <0 .0 1) ;HC组血管对乙酰胆碱舒张反应与 NC组比较明显减弱 ,HC组最大为 (5 8.5 0± 6 .17) % ,NC组最大为 (10 3.2± 6 .9) % (P <0 .0 1) ;HC组血管对去甲肾上腺素反应增强 ,最大收缩力 HC组为 (4 .15± 0 .5 6 ) g,NC组为 (2 .9± 0 .3) g(P <0 .0 5 )。 2组动脉病理学检查无动脉硬化的改变。结论 :高胆固醇血症降低血管内皮依赖性舒张反应 ,增加血管对去甲肾上腺素的收缩反应。高胆固醇血症时血管内皮功能改变早于动脉粥样硬化的结构改变。 | 王景全 于雅媛 白小涓 Julien IE Hoffman | 2000 | 中国医科大学学报2000，29，6： | 2 |
| 11 | 中链脂肪酸及其α-单脂肪酸甘油酯的抗菌研究——单一作用和协同作用显示文摘对葡萄球菌属、棒状杆菌属、芽孢杆菌属、李斯特菌属和链球菌属的几种革兰氏阳性菌株进行中链脂肪酸及其α-单脂肪酸甘油酯的抗菌活性评价。α-单脂肪酸甘油酯比脂肪酸更具活性,其中α-单月桂酸甘油酯是最具活性的化合物。以化脓性链球菌为试验菌,观察作用效果。首先,阻断α-单月桂酸甘油酯甘油部分的羟基,得到一种具有显著抗菌活性的化合物(MIC,3.9μg/mL)。其次,考察α-单月桂酸甘油酯与α-单葵酸甘油酯两种成分混合物时,α-单月桂酸甘油酯与α-单葵酸甘油酯之间以及α-单月桂酸甘油酯与活性差的月桂酸之间的协同关系。其中一种成分优于另一种成分2倍的混合物比单独的某种成分更为活跃。此外,组成成分比例为1:1也是不利的。当α-单肉豆寇酸甘油酯的量等于或少于α-单月桂酸甘油酯时,α-单月桂酸甘油酯与单肉豆寇酸甘油酯对金黄色葡萄球菌209存在协同作用。 | Batovska D I Todorova I T Tsvetkova Ie | 2020 | 福建畜牧兽医2020，42，1： | 2 |
| 12 | Formation mechanisms,potentials and exploration practices of large lithologic gas reservoirs in and around an intracratonic rift:Taking the Sinian-Cambrian of Sichuan Basin as an example显示文摘By examining structures,sediments,reservoirs and accumulation assemblages in the Deyang-Anyue rift and its surrounding area,four new understandings are obtained.First,during the initiation period of Deyang-Anyue rift,multiple groups of faults developed in the rift due to the effect of tensile force,bringing about multiple mound and shoal belts controlled by horsts in the second member of the Sinian Dengying Formation;in the development stage of the rift,the boundary faults of the rift controlled the development of mound and shoal belts at the platform margin in the fourth member of Dengying Formation;during the shrinkage period of the rift,platform margin grain shoals of the Cambrian Canglangpu Formation developed in the rift margin.Second,four sets of large-scale mound and shoal reservoirs in the second member of Dengying Formation,the fourth member of Dengying Formation,Canglangpu Formation and Longwangmiao Formation overlap with several sets of source rocks such as Qiongzhusi Formation source rocks and Dengying Formation argillaceous limestone or dolomite developed inside and outside the rift,forming good source-reservoir-cap rock combinations;the sealing of tight rock layers in the lateral and updip direction results in the formation model of large lithologic gas reservoirs of oil pool before gas,continuous charging and independent preservation of each gas reservoir.Third,six favorable exploration zones of large-scale lithologic gas reservoirs have been sorted out through comprehensive evaluation,namely,mound and shoal complex controlled by horsts in the northern part of the rift in the second member of Dengying Formation,isolated karst mound and shoal complex of the fourth member of Dengying Formation in the south of the rift,the superimposed area of multi-stage platform margin mounds and shoals of the second and fourth members of Dengying Formation and Canglangpu Formation in the north slope area,the platform margin mounds and shoals of the second and fourth members of Dengying Formation in the west side of the rift,the platform margin mound and shoal bodies of the fourth member of Dengying Formation in the south slope area,etc.Fourth,Well Pengtan-1 drilled on the mound and shoal complex controlled by horsts of the second member of Dengying Formation in the rift and Well Jiaotan-1 drilled on the platform margin mound and shoal complex of the North Slope have obtained high-yield gas flows in multiple target layers,marking the discovery of a new gas province with reserves of(2-3)×10^(12) m^(3).This has proved the huge exploration potential of large lithologic gas reservoir group related to intracratonic rift. | WEI Guoqi YANG Wei XIE Wuren SU NanX IE Zengye ZENG Fuying MA Shiyu JIN Hui WANG Zhihong ZHU Qiuying HAO Cuiguo WANG Xiaodan | 2022 | Petroleum Exploration and Development2022，49，3： | 2 |
| 13 | 每日一次与按需使用乌地那非对治疗2型糖尿病患者勃起功能障碍的有效性和安全性比较显示文摘通过一项为期12周的多中心、随机、开放、平行组试验,比较每日一次与按需使用乌地那非对治疗2型糖尿病患者勃起功能障碍的有效性和安全性。按需服用乌地那非200mg能够改善勃起功能障碍的161名患者,被随机分为200mg按需治疗组(n=80)和50mg每日一次组仰=81),两组分别接受相应治疗8周,8周后停药并随访4周,这些患者均通过性活动日志中Q2(插入成功率)和Q3(性交中保持勃起至完成性交的成功率)进行评估。主要的疗效指标是国际勃起功能问卷.勃起功能分级(IIEF.EFD)评分的变化。次要的疗效指标包括性活动日志02、Q3,国际勃起功能问卷的Q3、Q4及其他部分,全球评估问卷,以及正常率(EFD_〉26)的变化。我们也对血管内皮细胞标志物进行了检测。经过8周的治疗,两组的IIEF.EFD评分都得到改善fP〈O.0001),且两组之间没有显著的统计学差异。但这种改善并没有维持到无治疗随访期之后。次要的疗效指标也有类似的结果。在血管内皮标志物方面,两组之间无显著差异。患者对每日一次乌地那非具有更好的耐受性,且两组之间药物不良反应以及不良事件方面无显著性差异。其中脸红和头痛是最常见的不良反应。这两种方案都能改善糖尿病患者的勃起功能障碍,且均有良好的患者耐受性。乌地那非每日给药对糖尿病患者勃起功能障碍的治疗作用值得进一步研究。 | Soon Hyun Park Sung Woo Park Bong Yun Cha Ie Byung Park Kyung Wan Min Yeon Ah Sung Tae Hwa Kim Jae Min Lee Kang Seo Park | 2015 | Asian Journal of Andrology2015，17，1： | 2 |
| 14 | Pancreatic pseudocyst filled with semisolid lipids mimicking solid mass on endoscopic ultrasound显示文摘Pancreatic pseudocysts,which account for 70%-90% of pancreatic cystic lesions,characteristically are non-epithelially lined cystic cavities that are contiguous with the pancreas. Pancreatic pseudocysts can be caused by acute,chronic or traumatic pancreatitis and should be differentiated from other pancreatic diseases with cystic appearances,especially cystic neoplasms. We report a unique case of a pancreatic pseudocyst filled with semisolid lipids,which appeared by endoscopic ultrasound as a solid mass,and was therefore resected. | Sang-Woo Cha Sae Hee Kim Hyang Ie Lee Yun Jung Lee Hyeon Woong Yang Sung Hee Jung Anna Kim Min Koo Lee Hyun Young Han Dong Wook Kang | 2010 | World Journal of Gastroenterology2010，16，8： | 2 |
| 15 | DNA fragmentation in dicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat显示文摘 | Hill IE MacManus JP Rasquinha I | 1995 | Brain Res1995，676，2： | 2 |
| 16 | Fallopian tube precursors of ovarian low‐ and high‐grade serous neoplasms显示文摘 | Russell Vang Ie‐Ming Shih Robert J Kurman | 2012 | Histopathology2012，，1： | 2 |
| 17 | Colorectal carcinoma and brain metastasis:distribution,treatment,and survival显示文摘 | Hammoud MA McCutcheon IE Elsouki R | | 0，，： | 2 |
| 18 | A review of the nutritional effects of algae in marine fish larvae显示文摘 | Reitan K I Rainuzzo J R o ie G | 1997 | Aquaculture1997，155，： | 2 |
| 19 | Plasma homocyatoine as a risk Factor gov vascular diaseas显示文摘 | Graham IM Daly IE Refsum HM | 1997 | JAMA1997，277，： | 1 |
| 20 | Analysis of HLA-G in maternal plasma, follicular fluid, and preimplantation embryos reveal an asymmetric pattern of expression显示文摘 | Shaikly VR Morrison IE Taranissi M | 2008 | J Immunol2008，180，6： | 1 |
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