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| 1 | Diabetes mellitus and metformin in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the leading cause of cancer-related death worldwide. Diabetes mellitus, a risk factor for cancer, is also globally endemic. The clinical link between these two diseases has been the subject of investigation for a century, and diabetes mellitus has been established as a risk factor for HCC. Accordingly, metformin, a first-line oral anti-diabetic, was first proposed as a candidate anti-cancer agent in 2005 in a cohort study in Scotland. Several subsequent large cohort studies and randomized controlled trials have not demonstrated significant efficacy for metformin in suppressing HCC incidence and mortality in diabetic patients; however, two recent randomized controlled trials have reported positive data for the tumor-preventive potential of metformin in non-diabetic subjects. The search for biological links between cancer and diabetes has revealed intracellular pathways that are shared by cancer and diabetes. The signal transduction mechanisms by which metformin suppresses carcinogenesis in cell lines or xenograft tissues and improves chemoresistance in cancer stem cells have also been elucidated. This review addresses the clinical and biological links between HCC and diabetes mellitus and the anti-cancer activity of metformin in clinical studies and basic experiments. | Koji Fujita Hisakazu Iwama Hisaaki Miyoshi Joji Tani Kyoko Oura Tomoko Tadokoro Teppei Sakamoto Takako Nomura Asahiro Morishita Hirohito Yoneyama Tsutomu Masaki | 2016 | World Journal of Gastroenterology2016，22，27： | 7 |
| 2 | Biological features and biomarkers in hepatocellular carcinoma显示文摘Similar to other cancers, a multistep process of carcinogenesis is observed in hepatocellular carcinoma(HCC). Although the mechanisms underlying the development of HCC have been investigated in terms of oncology, virology, and stem cell biology, the whole picture of hepatocarcinogenesis remains to be elucidated. Recent progress in molecular biology has provided clues to the underlying cause of various diseases. In particular, sequencing technologies, such as whole genome and exome sequencing analyses, have made an impact on genomic research on a variety of cancers including HCC. Comprehensive genomic analyses have detected numerous abnormal genetic alterations, such as mutations and copy number alterations. Based on these findings, signaling pathways and cancer-related genes involved in hepatocarcinogenesis could be analyzed in detail. Simultaneously, a number of novel biomarkers, both from tissue and blood samples, have been recently reported. These biomarkers have been successfully applied to early diagnosis and prognostic prediction of patients with HCC. In this review, we focus on the recent developments in molecular cancer research on HCC and explain the biological features and novel biomarkers. | Tetsuhiro Chiba Eiichiro Suzuki Tomoko Saito Sadahisa Ogasawara Yoshihiko Ooka Akinobu Tawada Atsushi Iwama Osamu Yokosuka | 2015 | World Journal of Hepatology2015，7，16： | 5 |
| 3 | 使用ATP酶敏感钾离子通道开放剂——尼可地尔静脉给药用于冠状动脉腔内血管成形术介入治疗的药学证据显示文摘1前言动物实验研究表明,反复短暂的冠脉闭塞导致心脏抗心肌缺血的发作,这种现象被称为缺血性预处理。一些研究表明,这种预处理的效果是由于ATP敏感性钾通道的激活(KATP通道)。人类涉及经皮冠状动脉成形术(PTCA)的临床研究发现KATP通道的关闭与格列本脲防止预处理的效果通常出现在反复球囊扩张期间血管成形术模型中,表明ATP敏感性钾通道在预处理中发挥了核心作用。 | Hitoshi Matsuo Sachiro Watanabe Tomonori Segawa Shinji Yasuda Takeshi Hirose Makoto Iwama Shinichiro Tanaka Takahiko Yamaki Yukihiko Matsuno Masaaki Tomita Shinya Minatoguchi Hisayoshi Fujiwara 魏丽莎 | 2015 | 首都食品与医药2015，0，8： | 3 |
| 4 | Effect of the anti-diabetic drug metformin in hepatocellular carcinomain vitro and in vivo显示文摘 | Hisaaki Miyoshi Kiyohito Kato Hisakazu Iwama Emiko Maeda Teppei Sakamoto Koji Fujita Yuka Toyota Joji Tani Takako Nomura Shima Mimura Mitsuyoshi Kobayashi Asahiro Morishita Hideki Kobara Hirohito Mori Hirohito Yoneyama Akihiro Deguchi Takashi Himoto Kazut | 2014 | International Journal of Oncology2014，，1： | 3 |
| 5 | 初产妇和经产妇妊娠期间的诊室和家庭血压显示文摘妊娠高血压可导致分娩时产生严重的并发症,如脑卒中、早产或低出生体质量。初产妇被认为是妊娠高血压的一个危险因素。产次与妊娠期间家庭血压相关性仍不明确。方法:入选初产妇和经产妇共575名,评估妊娠高血压和先兆子痫的发病率。收集在一家日本产科医院接受产前检查的530名正常血压孕妇的家庭和诊室血压值。诊室血压为产前检查2次测量的血压平均值,参与者妊娠期间每日清晨在家自测血压。 | Ishikuro M Obara T Metoki H Ohkubo T Yamamoto M Akutsu K Sakurai K Iwama N Katagiri M Yagihashi K Yaegashi N Mori S Suzuki M Kuriyama S Imai Y 罗冬梅 叶鹏 | 2013 | 中华高血压杂志2013，21，6： | 2 |
| 6 | Gastric submucosa-invasive carcinoma associated with EpsteinBarr virus and endoscopic submucosal dissection: A case report显示文摘BACKGROUND Epstein-Barr virus(EBV)-associated carcinoma is a gastric cancer subtype with a morphology characterized by gastric carcinoma with lymphoid stroma(GCLS).Clinicopathological studies have indicated a better prognosis for GCLS than for common gastric carcinomas.Some previous cases of early gastric cancer associated with EBV had been diagnosed by endoscopic resection.CASE SUMMARY We present two GCLS cases subjected to endoscopic submucosal dissection(ESD)for a definitive diagnosis.A protruded gastric lesion was identified by routine endoscopic examination,but forceps biopsy showed no atypical cells before ESD.The resected specimen showed a poorly differentiated adenocarcinoma with lymphoid cells involving the mucosa and submucosa.The final diagnosis was submucosa-invasive poorly differentiated gastric adenocarcinoma.Accordingly,additional gastrectomy was recommended to obtain a complete cure.One patient underwent additional distal gastrectomy with lymph node dissection,but the other was refused because of cardiovascular complications.Both patients remained in remission for more than half a year.EBV positivity was determined by EBV-encoded RNA in situ hybridization.We also conducted a literature review of cases of early gastric cancer associated with EBV that had been diagnosed by ESD.CONCLUSION Submucosa-invasive GCLS could be dissected using ESD,and EBV positivity should be subsequently assessed to determine whether or not any additional curative surgery is required.Further prospective investigations on the prevalence of lymph node metastasis in EBV-associated carcinoma should be performed to expand the indications for endoscopic resection. | Yu Kobayashi Takehito Kunogi Hiroki Tanabe Yuki Murakami Takuya Iwama Takahiro Sasaki Keitaro Takahashi Katsuyoshi Ando Yoshiki Nomura Nobuhiro Ueno Shin Kashima Kentaro Moriichi Hidehiro Takei Mikihiro Fujiya Toshikatsu Okumura | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 2 |
| 7 | Salinity effects on oxygen consumption,gill Na+,K+-ATPase and ion regulation in juvenile coho salmon显示文摘 | | 1998 | Joural of Fish Biology1998，53，5： | 1 |
| 8 | The use of frozen autogenous bone flaps in delayed cranioplasty revisited显示文摘 | Iwama T Yamada J Imai S | 2003 | Neurosurgery2003，52，3： | 1 |
| 9 | Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1显示文摘 | Iwama A Oguro H Negishi M | 2004 | Immunity2004，21，6： | 1 |
| 10 | Effect of shosaikoto,a japanese ane Chinese herbalmedicinal mixture on the mitogenic activity of lipopolysaccharide,a new pharmacological testing method显示文摘 | Hrioko Iwama Sakae Amagaya Yukio Ogihara | 1987 | J Ethnohparmacol1987，211，： | 1 |
| 11 | Antioxidative collagen-derived peptides in human-placenta extract 显示文摘 | TOGASHI S I TAKAHASHI N IWAMA M | 2002 | Placenta2002，23，6： | 1 |
| 12 | The significance of chemoradiation therapy for TNM cStage esophageal squamous cell carcinoma显示文摘 | Iwama M Fujiwara Y Sato K | 2011 | Gan To Kagaku Ryoho2011，38，12： | 1 |
| 13 | Effect of shosaikoto a Japanese and chinese traditional herbal medical minture,on the initogenic activity of lipopolysaccharide: a new pharmacological testing methed 显示文摘 | Iwama H Amagaya S Ogihara Y | 1987 | J Ethnopharamcology1987，21，： | 1 |
| 14 | A (2-c/ N-) approximation algorithm for the stable marriage problem显示文摘 | Iwama K Miyazaki S Yamauchi N | 2008 | Algorithmica2008，51，3： | 1 |
| 15 | Telomeric length and telomemse activity vary with age in peripheral blood cells obtained from normal individuals显示文摘 | Iwama H Ohyashiki K Ohyashiki JH | 1998 | Hum-Genet1998，102，4： | 1 |
| 16 | Clinical implications of telomerase activity levels in acute leukemia显示文摘 | Iwama H Hayashi S | 1997 | Clin Cancer Res1997，3，4： | 1 |
| 17 | Average-case competitive analysis for ski-rental problems显示文摘 | Fujiwara H Iwama K | 2002 | Lecture Notes in Computer Science Springer2002，2518，： | 1 |
| 18 | Epigenome in hematopoietic malignancies显示文摘 | Iwama A | 2011 | Rinsho Ketsueki2011，52，10： | 1 |
| 19 | Chondromyxoid fibroma of the ethmoid sinus显示文摘 | M. Hashimoto J. Izumi I. Sakuma T. Iwama J. Watarai | 1998 | Neuroradiology1998，，9： | 1 |
| 20 | The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo显示文摘 | Kato K Gong J Iwama H | 2012 | Mol Cancer Ther2012，11，3： | 1 |
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