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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study显示文摘High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures.Here,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in vivo.Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser.The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception.This transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical fibers.The use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae ovalis.This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. | Malcolm C Finlay Charles A Mosse Richard J Colchester Sacha Noimark Edward Z Zhang Sebastien Ourselin Paul C Beard Richard J Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 3 | RF thermal and new cold part design studies on a TTF-Ⅲ input coupler for Project-X显示文摘An RF power coupler is one of the key components in a superconducting (SC) linac. It provides RF power to the SC cavity and interconnects different temperature layers (1.8 K, 4.2 K, 70 K and 300 K). The TTF-Ⅲ coupler is one of the most promising candidates for the High Energy (HE) linac of Project X, but it cannot meet the average power requirements because of the relatively high temperature rise on the warm inner conductor, so some design modifications will be required. In this paper, we describe our simulation studies on the copper coating thickness on the warm inner conductor with RRR values of 10 and 100. Our purpose is to rebalance the dynamic and static loads, and finally lower the temperature rise along the warm inner conductor. In addition, to get stronger coupling, better power handling and less multipacting probability, one new cold part design was proposed using a 60 mm coaxial line; the corresponding multipacting simulation studies have also been investigated. | 裴士伦 Chris E Adolphsen 李增海 Nikolay A Solyak Ivan V Gonin | 2012 | Chinese Physics C2012，36，2： | 2 |
| 4 | Structure and Deformational Behavior of Poly(vinylidene fluoride) Hard Elastic Films显示文摘 | Ivan D Viii B Viktor L Galina E | 2007 | Acta chimica slovenica2007，54，： | 1 |
| 5 | Posttranscriptional Gene Silencing in Transgenic Sugarcane显示文摘 | Ivan L Ingelbrecht James E Irvine T Erik Mirkov | 1999 | Plant Physiol1999，119，4： | 1 |
| 6 | Co-occurrence of West Nile Fever and circovirus infection in a goose flock in Hungary 显示文摘 | Glavits R Ferenczi E Ivanics E | 2005 | Avian Pathol2005，34，5： | 1 |
| 7 | Correlations between fractional flow reserve and intravascular ultrasound in patients with an ambigu- ous left main coronary artery stenosis 显示文摘 | Jasti V Ivan E Yalarnanchili V | 2004 | Circulation2004，110，18： | 1 |
| 8 | Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the yon Hippel-Lindau protein 显示文摘 | Ohh M Park C W Ivan M Hoffman M A Kim T Y Huang L E | 2000 | Nat Cell Biol2000，2，： | 1 |
| 9 | Nonlinear friction characteristics between silica surfaces in high pH solution显示文摘 | Taran E Kanda Y Ivan Vakarelski U | 2007 | J Colloid Interf Sei2007，307，2： | 1 |
| 10 | Determination of total arsenic and toxicologically relevant arsenic speciesin fish by using electrothermal and hydride generation atomic absorption spectrometry显示文摘 | IVAN SERAFIMOVSKI IRINA B KARADJOVA TRAJ□e STAFILOV | 2006 | Microchemical Journal2006，，83： | 1 |
| 11 | Epizootic occurrence of haemorrhagic nephritis enteritis virus infection of geese显示文摘 | Palya V Ivanics E Glavits R | 2004 | Avain Pathol2004，33，： | 1 |
| 12 | A pituitary gene encodes a protein that produces differentiation of breast and prostate cancer cells 显示文摘 | Platica M Ivan E Holland JF | 2004 | Proc Natl Acad Sci U S A2004，101，6： | 1 |
| 13 | Remodeling of Carotid artery Is Associated with Increased Expression of Matrix MetalloProteinas- es in Mouse Blood Flow Cessation Model显示文摘 | Godin D Ivan E Johnson C et aI | 2000 | Circulation2000，102，23： | 1 |
| 14 | Correlations betweenfractional flow reserve and intravascular ultrasound in patientswith an ambigu- ous left main coronary artery stenosis 显示文摘 | Jasti V Ivan E Yalamanchili V | 2004 | Circulation2004，110，： | 1 |
| 15 | Photocount distribution of photons emitted from three sites of a human body显示文摘 | IVan Wijk R Van Wijk E Bajpai R P | 2006 | Journal of Pho- tochemistry and Photobiology B: Biology2006，84，1： | 1 |
| 16 | Correlations be- tween fractional flow reserve and intravascular ultrasound in patients with an ambiguous left main coronary artery stenosis 显示文摘 | JASTI V IVAN E YALAMANCHILI V | 2004 | Circulation2004，110，18： | 1 |
| 17 | Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle–mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response显示文摘 | Ivan Grskovic Anna Kutsch Christian Frie Gergely Groma Jacek Stermann Ursula Schl?tzer‐Schrehardt Anja Niehoff Stephen E Moss Sabrina Rosenbaum Ernst P?schl Markus Chmielewski Gunter Rappl Hinrich Abken John F Bateman Kathryn SE Cheah Mats Paulsson Bent B | 2012 | J Bone Miner Res2012，，11： | 1 |
| 18 | Cor- relations between fractional flow reserve and intravascularultrasound in patients with an ambiguous left main coronary artery显示文摘 | JASTI S V IVAN E YALAMANCHILI V | 2004 | Circulation2004，110，： | 1 |
| 19 | Correlations between fractional flow re- serve and intravascular ultrasound in patients with an ambiguous left main coro- nary artery stenosis 显示文摘 | Jasti V Ivan E Yalamanchili V | 2004 | Circulation2004，110，： | 1 |
| 20 | Evaluating the effectiveness of 2 educational interventions in family practice显示文摘 | Borgial Alexander E M Williams J Ivan Davis David A | 1999 | Canadian Medical Association Journal1999，161，8： | 1 |
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