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| 1 | 男性迟发性性腺功能减退症的检查、治疗和监测:国际男科学会(ISA)、国际老年男性研究会(ISSAM)、欧洲泌尿外科学会(EAU)、欧洲泌尿外科学院(EAA)和美国男科学会(ASA)联合推荐显示文摘简介
人口学资料明确显示:老年人口占总人口的百分率正逐年增加。当前,有关老年男性雄激素缺乏的问题逐渐成为令人感兴趣、但又充满争议的世界性话题。已经有横向和纵向的研究资料表明,随着年龄增大,成年男子的雄激素水平逐渐降低, | Wang C Nieschlage E Swerdloff R Behre HM Hellstrom WJ Gooren LJ Kaufman JM Legros JJ Lunenfeld B Morales A Morley JE Schulman C Thompson IM Weidner W Wu FCW 伍学焱(翻译) | 2011 | 国际生殖健康/计划生育杂志2011，30，1： | 8 |
| 2 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 3 | CD24 expression predicts distant metastasis in extrahepatic bile duct cancer显示文摘AIM: To evaluate the prognostic significance of CD24 expression in patients undergoing adjuvant chemoradiotherapy for extrahepatic bile duct (EHBD) cancer. METHODS: Eighty-four patients with EHBD cancer who underwent curative resection followed by adjuvant chemoradiotherapy were enrolled in this study. Postoperative radiotherapy was delivered to the tumor bed and regional lymph nodes up to a median of 40 Gy (range: 40-56 Gy). All patients also received fluoropyrimidine chemotherapy for radiosensitization during radiotherapy. CD24 expression was assessed with immunohistochemical staining on tissue microarray. Clinicopathologic factors as well as CD24 expression were evaluated in multivariate analysis for clinical outcomes including loco-regional recurrence, distant metastasisfree and overall survival. RESULTS: CD24 was expressed in 36 patients (42.9%). CD24 expression was associated with distant metastasis, but not with loco-regional recurrence nor with overall survival. The 5-year distant metastasis-free survival rates were 55.1% and 29.0% in patients with negative and positive expression, respectively (P=0.0100). On multivariate analysis incorporating N stage, histologic differentiation and CD24 expression, N stage was the only significant factor predicting distant metastasis-free survival (P=0.0089), while CD24 expression had borderline significance (P=0.0733). In subgroup analysis, CD24 expression was significantly associated with 5-year distant metastasis-free survival in node-positive patients (38.4% with negative expression vs 0% with positive expression, P=0.0110), but not in nodenegative patients (62.0% with negative expression vs 64.0% with positive expression,P=0.8599). CONCLUSION: CD24 expression was a significant predictor of distant metastasis for patients undergoing curative resection followed by adjuvant chemoradiotherapy especially for node-positive EHBD cancer. | Kyubo Kim Hye Sook Min Eui Kyu Chie Jin-Young Jang Sun Whe Kim Sae-Won Han Do-Youn Oh Seock-Ah Im Tae-You Kim Yung-Jue Bang Ja-June Jang Sung W Ha | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 4 | A comparative on properties of multi -walled carbon nanotubes(MWCNTs) modified with acids and oxyfluorination 显示文摘 | KIM S D KIM J W IM J S | 2007 | Journal of Fluorine Chemsitry2007，128，： | 1 |
| 5 | CT anatomy of the lingular segmental bronchi显示文摘 | LEE K S IM J G BAE W K | 1991 | J Computer Assisted Tomography1991，15，： | 1 |
| 6 | Potentially unstable intertrochanteric fractures 显示文摘 | Im G I Shin Y W Song Y J | 2005 | J Orthop Trauma2005，19，1： | 1 |
| 7 | 查看详情显示文摘 | Maeng Y J Yoon B S Suh M H Im W B Lee S H | | 0，，： | 1 |
| 8 | Enhancement of red spectral emission intensity of Y3Al5O12:Ce3+phosphor via Pr Co-doping and Tb substitution for the application to white LEDs显示文摘 | JANG H S IM W B LEE D C | 2007 | J Lumin2007，126，2： | 1 |
| 9 | Microbial interactions associated with secondary cucumber fermentation显示文摘 | Franco W Perez-Diaz IM | 2013 | Journal of Applied Microbiology2013，114，1： | 1 |
| 10 | Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer显示文摘 | HANS W OH D Y IM S A | 2009 | Br J Cancer2009，100，2： | 1 |
| 11 | Photoluminescence characteristics of energy transfer between Bi3+ and Eu3+ in LnVO4:Eu,Bi (Ln=Y,La,Gd)显示文摘 | Park W J Jung M K Im S J | 2008 | Colloids Surf A2008，，313314： | 1 |
| 12 | Anti-tumor effects of human peripheral gammadelta T cells in a mouse tumor model显示文摘 | Zheng B J Chan K W Im S | 2001 | Int J Cancer2001，92，： | 1 |
| 13 | Tuberculosis of the central airways:CT findings of active and fibrotic disease显示文摘 | Moon W K Im J G Yeon K M | 1997 | AIR Am J Roentgenol1997，169，3： | 1 |
| 14 | Nitrogen and hydrogen adsorption of activated carbon fibers modified by fluorination 显示文摘 | JUNG M-J KIM J W IM J S PARK S-J LEE Y-S | 2009 | Journal of Industrial and Engineering Chemistry2009，15，3： | 1 |
| 15 | Haematologicalparameters and respiratory function in diploid andtriploid Far Eastern catfish, Silurus asotus显示文摘 | Seol D W Im S Y Hur W J | 2008 | genesgenomics2008，30，3： | 1 |
| 16 | Potentially unstable intertrochanteric fractures显示文摘 | Im G I Shin Y W Song Y J | 2005 | J Orthop Trauma2005，19，1： | 1 |
| 17 | Ion permeation through the a-hemolysin channel: theoretical studies based on Brownian dynamics and Poisson-Nernst-Plank electrodiffusion theory 显示文摘 | Noskov S Y Im W Roux B | 2004 | Biophsical Journal2004，87，： | 1 |
| 18 | Activity of tedizolid phosphate(TR-701 ) in murine models of infection with penicillin-resistantand penicillin-sensitive Streptococcus pneumoniae 显示文摘 | CHOI S IM W BARTIZAL K | 2012 | Antimi-crob Agents Chemother2012，56，9： | 1 |
| 19 | Selective inhibition of tumor cell growth by a recombinant singlechain antibodytoxin specific for the C-erbB-2 receptor 显示文摘 | 13,Wels W Harwerth IM Mueller M | 1992 | Cancer1992，52，： | 1 |
| 20 | Phase Ⅱ study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer显示文摘 | Han S W Oh D Y Im S A | 2009 | British Journal of Cancer2009，100，2： | 1 |
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