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| 1 | 无创正压通气临床应用中的几点建议显示文摘近年来有创机械通气在我国发展很快 ,与其相比 ,无创通气则相对滞后 ,其重要原因之一可能是医生们对无创通气的疗效尚有疑虑。据了解无创通气应用方法不当、没有按正确的操作规程来实施 ,可能是疗效不理想或者患者不耐受的常见原因。中华医学会呼吸病学分会临床呼吸生理及ICU学组经过数次讨论 ,委托陈荣昌教授草拟了“无创正压通气临床应用中的几点建议”一文。本文之所以没有以“指南”的面目出现 ,是因为觉得临床实践尚有不足 ,希望读者在实践过程中不断总结出自己的宝贵经验 ,提出修改建议 ,使其更加完善。 | 中华医学会呼吸病学分会临床呼吸生理及ICU学组 | 2002 | 中华结核和呼吸杂志2002,25,3: | 495 |
| 2 | 感染相关的器官衰竭评分对多器官功能障碍综合征预后判断的意义显示文摘目的 采用感染相关的器官衰竭评分系统 (SOFA)描述多器官功能障碍综合征 (MODS)的临床特点。方法 回顾了 5家医院的加强医疗病房 (ICU) 1990至 1996年间收治的 36 6例MODS患者 ,并进行SOFA评分。结果 最高SOFA评分、SOFA评分差值以及入ICU时的SOFA评分与患者的住院病死率呈较好的相关关系 ,ROC曲线下的面积分别为 0 819,0 75 0和 0 6 16。没有器官衰竭的患者SOFA评分为 3 7± 1 2 ,病死率 2 1 7% ,6个器官衰竭的患者SOFA评分为 2 0 2± 1 4,病死率77 8%。呼吸系统达到最高评分的时间最短 (1 41d) ,循环系统所需时间最长 (4 89d)。Logistic回归模型显示 ,中枢神经系统评分对预后的影响最大 (OR 1 75 ) ,之后是肾脏 (OR 1 42 ) ,循环系统 (OR1 38) ,凝血 (OR 1 34)和呼吸系统 (OR 1 17)。肝脏对患者的预后没有影响 (OR 0 99)。结论 最高SOFA评分和SOFA评分差值可以较好地反映患者在ICU住院期间MODS的发生及预后情况。 | 杜斌 陈德昌 刘大为 席修明 陈惠德 杨乃众 杜新建 暨北京市危重病医学临床研究协作组ICU | 2001 | 中华医学杂志2001,81,2: | 78 |
| 3 | Effect of cis-9,trans-11-conjugated linoleic acid on cell cycle of gastric adenocarcinoma cell line(SGC-7901)显示文摘AIM: To determine the effect of cis-9, trans-1l-conjugated linoleic acid ( c9, tl 1-CLA) on the cell cycle of gastric cancer cells( SGC-7901 ) and its possible mechanism in inhibition cancer growth.METHODS: Using cell culture and immunocytochemicaltechniques, we examined the cell growth, DNA synthesis,expression of PCNA, cyclin A, B1, D1, pl6nink4a and p21clp/wafl ofSGC-7901 cells which were heated with various c9, tll-CLAconcentrations (25,50,100 and 200μnol@L-1)of c9, tll-CLA for 24and 48 h, with a negative control (0.1% ethane).RESULTS: The cell growth and DNA synthesis of SGC-7901cells were inhibited by c9, tll-CLA. SGC-7901 cells. Eightday after treatment with various concentrations of c9, tl1-CLA mentioned above, the inhibition rates were 5.92 % ,20.15 % ,75.61% and 82.44 % ,respectively and inhibitory effeotof c9, tll-CLA on DNA synthesis (except for 25 tmol/L,24h) showed significantly less 3H-TdR incorporation than thatin the negative controls (P < 0. 05 and P < 0. 01).Immunocytochemical staining demonstrated that SGC-7901cells preincubated in media supplemented with different c9,tl1-CLA concentrations at various times significantlydecreased the expressions of PCNA (the expression rateswere7.2-3.0 %,24 h and 9.1-0.9 % at 48 h, respectively),Cyclin A (l1.0-2.3 %, 24 h and 8.5-0.5 % ,48 h), B1 (4.8-1.8% at 24 h and 5.5-0.6 % at 48 h)and D1 (3.6-1.4 % at 24 hand 3.7 %-0 at 48 h) as compared with those in the negativecontrols(the expressions of PCNA, Cyclin A, B1 and D1were 6.5 % at 24h and 9.0 % at 48 h, 4.2% at 24h and5.1% at 48 h, 9.5 % at 24h and 6.0 % at 48 h,respectively)(P< 0.01), whereas the expressions of p16ink4a and p21clp/waf1,cyclin-dependent kinases inhibltors(CDKI), were increased.CONCLUSION: The cell growth and proliferation of SGC-7901cell is inhibited by c9, tll-CLA via blocking the cell cycle,with reduced expressions of cyclin A, B1 and D1 andenhanced expressions of CDKI( p16ink4a and p21cip/waf1). | Jia-Ren Liu Bai-Xiang Li Bing-Qing Chen Ying-ben Xue Yan-Mei Yang Yu-Mei Zheng,Department of Toxicological Health,Public Health College,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Xiao-Hui Han ICU of Cardiological Surgery,The Second Hospital,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Rui-Hai Liu,Food Science and Toxicology,Department of Food Science,Cornell University,Ithaca,NY 14853-7201,USA | 2002 | World Journal of Gastroenterology2002,8,2: | 26 |
| 4 | 云南省高浓度氯化钾注射液临床使用与管理专家共识(2020)显示文摘高警示药品的安全使用一直以来都是医疗机构药事管理重点关注的问题。高浓度氯化钾注射液属于A级高警示药品(即使用频率最高、风险最大),其安全使用风险存在于管理、储存、处方、调配、使用和监护等各个环节。因此,与普通药品相比,医疗机构需在各个环节采取更严格的核查措施并妥善管理,以避免用药错误的发生。为进一步规范云南省各级医疗机构高浓度氯化钾注射液的使用和管理、减少或消除其在使用各环节中用药错误发生的可能、保障患者用药安全,本编写组组织云南省各相关部门/学会,基于前期针对临床一线医、药、护的多轮调研结果以及德尔菲法专家意见,最终形成《云南省高浓度氯化钾注射液临床使用与管理专家共识(2020)》,旨在为规范该制剂的使用和管理提供有益参考。 | 云南省药事管理及临床药学质量控制中心 云南省急诊医学质量控制中心 云南省护理学会 云南省医院协会ICU专业委员会 云南省医院协会药事管理专业委员会 云南省药理学会临床药学专业委员会 云南省医师协会心脏重症专业委员会 《云南省高浓度氯化钾注射液临床使用与管理专家共识(2020)》编写组 罗应伟 张峻 钱传云 许汪斌 | 2021 | 中国药房2021,32,2: | 4 |
| 5 | 外科ICU患者血液管理专家共识(2021版)显示文摘外科ICU患者的共同特点是以重症外科疾病为基础,伴有感染、内环境不稳定及多器官功能衰竭等,需要进行器官功能支持等治疗。不少的外科ICU患者不同程度地存在贫血、血小板减少及凝血因子缺乏,需要进行血液成分的替代治疗[1-3]。对外科ICU患者进行血液管理(patient blood management,PBM)很有必要。为此,本共识组织临床输血等相关领域的专家,分析导致外科ICU患者贫血、血小板减少及凝血因子缺乏的原因,讨论相关的治疗方案,制定相应的PBM。 | 中国输血协会临床输血学专业委员会 外科ICU患者血液管理专家共识(2021版)编审委员会 胡丽华 周吉成 谢珏 | 2021 | 中华危重症医学杂志(电子版)2021,14,4: | 4 |
| 6 | 危重病医学与ICU显示文摘 | 广东省ICU专科建设与发展学术研讨会 | 2002 | 现代医院2002,3,: | 1 |
| 7 | Challenges and opportunities显示文摘 | Young GB: Continuous EEG monitoring in the ICU | 2009 | Can J Neurol Sci2009,362,: | 1 |
| 8 | NSAID-induced deleterious effects on the proximal and mid small bowel in seronegative spondyloarthropathy patients显示文摘AIM:To investigate the small bowel of seronegative spondyloarthropathy(SpA) patients in order to ascertain the presence of mucosal lesions.METHODS:Between January 2008 and June 2010,54 consecutive patients were enrolled and submitted to avideo capsule endoscopy(VCE) examination.Historyand demographic data were taken,as well as the history of non-steroidal anti-inflammatory drug(NSAID) consumption.After reading each VCE recording,a capsule endoscopy scoring index for small bowel mucosal inflammatory change(Lewis score) was calculated.Statistical analysis of the data was performed.RESULTS:The Lewis score for the whole cohort was 397.73.It was higher in the NSAID consumption subgroup(P = 0.036).The difference in Lewis score between NSAID users and non-users was reproduced for the first and second proximal tertiles of the small bowel,but not for its distal third(P values of 0.036,0.001 and 0.18,respectively).There was no statistical significant difference between the groups with regard to age or sex of the patients.CONCLUSION:The intestinal inflammatory involvement of SpA patients is more prominent in NSAID users for the proximal/mid small bowel,but not for its distal part. | Mihai Rimba■ Mǎdǎlina Marinescu Mihail Radu Voiosu Cristian Rǎsvan Bǎicu■ Simona Caraiola Adriana Nicolau Doina Ni■escu Georgeta Camelia Badea Magda Ileana Parvu | 2011 | World Journal of Gastroenterology2011,17,8: | 1 |
| 9 | 葡萄糖调节蛋白78促进肝硬化大鼠心肌细胞凋亡及其机制显示文摘目的:探讨葡萄糖调节蛋白78/免疫球蛋白重链结合蛋白(GRP78/BiP)是否促进肝硬化大鼠心肌细胞凋亡及其发生机制。方法:采用复合致病因素法建立肝硬化大鼠模型,在4周、6周和8周分别取材。实验1:取心脏称重并测量左室壁厚度,计算左室壁厚度与心脏重量比值及心脏指数。实验2:TUNEL法观察心肌细胞凋亡情况;免疫组化方法检测心肌组织中GRP78/BiP蛋白以及凋亡相关蛋白CCAAT增强子结合蛋白同源蛋白/生长停滞及DNA诱导蛋白153(CHOP/GADD153)、半胱氨酸天冬氨酸蛋白酶12(caspase-12)、核转录因子κB p65(NF-κB p65)、B细胞淋巴瘤/白血病蛋白2(Bcl-2)的表达。结果:随肝硬化病程进展,左室壁厚度与心脏重量比值以及心脏指数逐渐增加,8周组增加显著(P<0.05);心肌细胞凋亡指数、CHOP/GADD153和caspase-12阳性蛋白表达指数逐渐升高,8周组差异显著(P<0.05);NF-κB p65和Bcl-2阳性蛋白表达指数呈一致性变化,在4周组较其它组明显增高(P<0.05);GRP78/BiP蛋白阳性表达指数与心肌细胞凋亡指数、CHOP/GADD153、caspase-12蛋白阳性表达指数呈显著正相关,CHOP/GADD153与NF-κB p65、Bcl-2蛋白阳性表达指数呈显著负相关。结论:GRP78高表达在内质网应激介导的肝硬化心肌病发病中可能发挥重要作用。 | 张丽丽 庞慧 吕敏丽山西医科大学第二医院ICU 张慧英 贾建桃 王黎敏 刘燕 李旭炯 李宝红 张翠英 赵中夫 韩德五 JI Cheng | 2013 | 中国病理生理杂志2013,29,5: | 1 |
| 10 | 姜黄素抗兔动脉粥样硬化作用的研究显示文摘目的:研究姜黄素抗兔动脉粥样硬化(AS)的作用机制。方法:30只雄性日本大耳白家兔,其中给予高脂饲料喂食2个月,复制AS模型家兔20只,随机分成治疗和对照两组,各10只。均予基础饲料喂养,治疗组每天给予姜黄素(200mg/kg)灌胃,对照组每天给予生理盐水灌胃,共治疗1个月。治疗后处死家兔,观察两组主动脉粥样斑块面积比;取主动脉弓做病理切片;免疫组织化学检测主动脉壁主动脉基质金属蛋白酶9(MMP-9)和核转录因子-κB(NF-κB)的表达。结果:治疗组斑块面积/主动脉面积比低于对照组(P<0.05)。免疫组化显示,治疗组MMP-9、NF-κB阳性细胞表达率明显低于对照组,分别为[(16.5±8.0)%vs(38.5±13.6)%,P<0.05;(22.61±7.95)%vs(42.28±19.34)%,P<0.05]。结论:姜黄素可以显著降低动脉粥样硬化家兔主动脉壁MMP-9、NF-κB的表达,抑制动脉粥样硬化的形成。 | 赵志光 谢丽微 王宗敏 林梅瑟浙江省温州市中医院ICU | 2008 | 浙江中西医结合杂志2008,18,2: | 1 |
| 11 | Correlation between the AKI classification and outcome显示文摘 | Ostermann M Chang R Riyadh ICU Program Users Group | | 0,,: | 1 |
| 12 | Correlation between the AKI classification and outcome显示文摘 | Ostermann M Chang R Riyadh ICU Program Users Group | 2008 | Criti Care2008,12,6: | 1 |
| 13 | International expert statement on training standards for critical care ultrasonography 显示文摘 | Expert Round Table on Ultrasound in ICU | 2011 | Intensive Care Med2011,37,7: | 1 |
| 14 | Correla- tion between the AKI classification and outcome 显示文摘 | Osterman M Chang R Riyadh ICU Program Users Group | 2008 | Crit Care2008,12,: | 1 |
| 15 | Time oriented score system (TOSS):A method for direct and quantitative assessment of nursing workload for ICU patients显示文摘 | Italian Multicenter Group of ICU research(GIRTI) | | 0,,06: | 1 |
| 16 | Correla-tion between the AKI classification and outcome显示文摘 | Ostermann M Chang R Riyadh ICU Program Users Group | 2008 | Crit Care2008,12,6: | 1 |
| 17 | Correlation between the AKI classification and outcome显示文摘 | Ostermann M Chang R Riyadh ICU Program Users Group | 2008 | Crit Care2008,12,6: | 1 |
| 18 | Expression of CCR2 in collateral vessels induced by high fluid shear stress in rabbit hindlimb and its relationship with monocyte and macrophage显示文摘Objective To detect the expression of CC chemokine receptor 2(CCR2)in collateral vessels induced by high fluid shear stress in rabbit hindlimb and its relationship with monocyte and macrophage.Methods Ten rabbits were operated on left femoral artery ligation,on the right side,the femoral artery was ligated unilaterally | Dept ICU,3rd Affil Hosp,Centr South Univ | 2016 | China Medical Abstracts(Internal Medicine)2016,33,1: | 0 |