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| 1 | Usefulness of ω-3 fatty acid supplementation in addition to mesalazine in maintaining remission in pediatric Crohn's disease: A double-blind, randomized, placebo-controlled study显示文摘AIM: To assess the value of long-chain ω-3 fatty acids (FAs) supplementation in addition to amino-salicylic-acid (5-ASA) in pediatric patients with Crohn's disease (CD).METHODS: Thirty-eight patients (20 males and 18females, mean age 10.13 years, range 5-16 years)with CD in remission were randomized into two groups and treated for 12 mo. Group Ⅰ (18 patients) received 5-ASA (50 mg/kg/d)+ω-3 FAs as triglycerides in gastroresistant capsules, 3 g/d (eicosapentanoic acid, EPA, 400mg/g, docosahexaenoic acid, DHA, 200 mg/g). Group Ⅱ (20 patients) received 5-ASA (50 mg/kg/d)+olive oil placebo capsules. Patients were evaluated for fatty acid incorporation in red blood cell membranes by gas chromatography at baseline 6 and 12 mo after the treatment.RESUJLTS: The number of patients who relapsed at 1year was significantly lower in group Ⅰ than in group Ⅱ(P<0.001). Patients in group Ⅰ had a significant increase in the incorporation of EPA and DHA (P<0.001) and a decrease in the presence of arachidonic acids.CONCLUSION: Enteric-coated ω-3 FAs in addition to treatment with 5-ASA are effective in maintaining remission of pediatric CD. | C Romano S Cucchiara A Barabino V Annese C Sferlazzas SIGENP Italian Study Group of Pediatric Inflammatory Bowel Diseases | 2005 | World Journal of Gastroenterology2005，11，45： | 4 |
| 2 | Associations between cardiac arrhythmia,incident disability in activities of daily living and physical performance:the ILSA study显示文摘Background Cardiac arrhythmias are common conditions in older people.Unfortunately,there is limited literature on associations between cardiac arrhythmias and physical performance or disability.We therefore aimed to prospectively investigate associations between cardiac arrhythmias and changes in disability and physical performance during 8 years of follow-up,using data from the Italian Longitudinal Study on Aging(ILSA).Methods Cardiac arrhythmias diagnosis was posed through a screening phase,confirmed by a physician.The onset of disability in activities of daily living(ADL)and the changes in several physical performance tests during follow-up were considered as outcomes.Fully-adjusted and propensity-score Cox Proportional Hazard models and mixed models were used for exploring associations between cardiac arrhythmia and the outcomes of interest.Results The prevalence of cardiac arrhythmia at baseline was 23.3%.People reporting cardiac arrhythmia at the baseline were significantly older,more frequently male,smokers and reported a higher presence of all medical conditions investigated(hypertension,heart failure,angina,myocardial infarction,diabetes,stroke),but no difference in dementia,Parkinsonism,cognitive or mood disorder.Cardiac arrhythmia at baseline was significantly associated with the incidence of disability in ADL(HR=1.23;95%:CI:1.01–1.50;P=0.0478 in propensity score analyses;HR=1.28;95%CI:1.01–1.61;P=0.0401 in fully adjusted models).Cardiac arrhythmia at baseline was also associated with a significant worsening in balance test(P=0.0436).Conclusions The presence of cardiac arrhythmia at baseline was associated with a significant higher risk of disability and of worsening in some physical performance tests,particularly those relating to balance.Screening and frequently assessing physical performance in older people affected by cardiac arrhythmia can be important to prevent a loss of physical performance,with further,potential,complications of medical management. | Marianna Noale Nicola Veronese Lee Smith Andrea Ungar Stefano Fumagalli Stefania Maggi the Italian Longitudinal Study on Aging Working Group | 2020 | Journal of Geriatric Cardiology2020，17，3： | 3 |
| 3 | Effects of vinorelbine on quality of life and survival of elderly patients with advanced Non-small Cell Lung Cancer显示文摘 | Elderly Lung Cancer Vinorelbine Italian Study(ELVIS)Group | 1999 | J Natl Cancer Inst1999，91，4： | 1 |
| 4 | Endoscopic clue for the study and treatment of esophageal Varices: prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices显示文摘 | North Italian | 1988 | N Eng J Med1988，319，： | 1 |
| 5 | Non-invasive prenatal testing (NIPT) by maternal plasma DNA sequencing显示文摘 | Position Statement from the Italian College of Fetal Maternal Medicine | 2013 | J Prenat Med2013，7，2： | 1 |
| 6 | Dexamethasone alone or in combination with ondansetron for the prevention of delayed nausea and vom- iting induced by chemotherapy显示文摘 | The Italian Group for Antiemetic Research | 2000 | N Engl J Med2000，342，21： | 1 |
| 7 | Early-versus late-initiation of therapeutic hypothermia after cardiac arrest:preliminary observations from the experience of 17 Italian intensive care units显示文摘 | Italian Cooling Experience (ICE) Study Group | 2012 | Resuscitation2012，83，7： | 1 |
| 8 | A new prognostic system for hepatocellular carcinoma, a retrospective study of 435 patients 显示文摘 | The Cancer of the Liver Italian Program (CLIP) Investigators | 1998 | Hepatology1998，28，： | 1 |
| 9 | Recommendations for the use of cardiovascular tests in diagnosing dia-betic autonomic neuropathy显示文摘 | Diabetic Neuropathy Study Group of the Italian Society of Diabetology | 2011 | Nutr Metab Cardiovasc Dis2011，21，1： | 1 |
| 10 | A new prognostic system for hepatocellular carcinoma:a retrospective study of 435patients显示文摘 | The Cancer of the Liver Italian Program (CLIP) Investigators | | 0，，3： | 1 |
| 11 | Predict/on of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varicea;a prospective multicenter study显示文摘 | The North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices | 1988 | N Engl J Med1988，319，： | 1 |
| 12 | Effects of vinorelbine on quality of life and survival elderly patients with advanced non - small - cell lung cancer显示文摘 | The elderly lung cancer vinorelbine Italian study group (ELV1S) | 1999 | J Natl Cancer Inst1999，91，1： | 1 |
| 13 | Italian multicentre study on retinopathy of prematurity显示文摘 | Teh Italian ROP Study Group | 1997 | Eur J Pediatr1997，156，12： | 1 |
| 14 | Prospective validation of the CLIP score : A new prognostic system for patients with cirrhosis and hepatocellular carcinoma显示文摘 | The Cancer of the Liver Italian Program ( CLIP ) investigators | 2000 | Hepatology2000，31，4： | 1 |
| 15 | Effects of vinorelbine on quality of life and survival elderly patients with advancednon-small cell lung cancer显示文摘 | The elderly lung cancer vinorelbine Italian study group(ELVIS) | 1999 | J Natl Cancer Inst1999，91，1： | 1 |
| 16 | Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer 显示文摘 | The Elderly Lung Cancer Vinorelbine Italian Study Group | 1999 | J Natl Cancer Inst1999，91，1： | 1 |
| 17 | Effects of vinorelbine on quality of life and survival of elderly patients with advanced non- small cell lung cancer显示文摘 | The Elderly Lung Cancer Vinorelbine Italian Study Group | 1999 | J Natl Cancer Inst1999，85，： | 1 |
| 18 | The Italian Group for Antiemetic Research in Radiotherapy显示文摘 | Radiation-induced emesis:a prospective observational multicenter Italian trial | 1999 | Int J Radiat Oncol Biol Phys1999，44，3： | 1 |
| 19 | The effect ofantlpsycnotic medication on sexual function and serumprolactin levels in community treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR)study(NCT00239130显示文摘 | Hanssens L L Italian G Loze Jv | 2008 | Bmc Psychiatry2008，8，： | 1 |
| 20 | Epidemiological profile of 806 Italian children with hepatitis C virus infection over a 15-year period显示文摘 | Bortolotti F Iorio R Resti M Italian observatory for HCV infection and hepatitis clin children | 2007 | J Hepatol2007，46，5： | 1 |
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