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| 1 | Pattern Analysis of Lymph Node Metastasis and the Prognostic Importance of Number of Metastatic Nodes in Ampullary Adenocarcinoma显示文摘 | Lee Jae Hoon Lee Kyeong Geun Ha Tae Kyung Jun Young Jin Paik Seung Sam Park Hwon Kyum Lee Kwang Soo | 2011 | The American Surgeon2011，，3： | 1 |
| 2 | Analytical modeling and thermodynamic analysis of robust superhydrophobic surfaces with inverse-trapezoidal microstructures显示文摘 | Maesoon Im Hwon Im Lee Joo Hyung | 2010 | Langmuir2010，26，17： | 1 |
| 3 | In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocyte-like cells显示文摘 | Seung Hyun Hong Eun Ji Gang Ju Ah Jeong Chiyoung Ahn Soo Han Hwang Il Ho Yang Hwon Kyum Park Hoon Han Hoeon Kim | 2005 | Biochemical and Biophysical Research Communications2005，，4： | 1 |
| 4 | A Polydime-thyl- siloxane(PDMS)sponge for the selective absorption of oil from water显示文摘 | Choi Sung)in Kwon Taehong Im Hwon | 2011 | Acs Applied Materials & Interfaces2011，3，12： | 1 |
| 5 | Memory improvement in ibotenic acid induced model rats by extracts of Scutellaria baicalensis显示文摘 | Hwon Heo Yongsung Shin Woohee Cho | 2009 | Journal of Ethnopharmacology2009，，122： | 1 |
| 6 | Electrical and magnetic properties of NiCr2-xFexO4显示文摘 | Seung Hwon Lee Sang Jun Yoon Gi Ja Lee | 1999 | Materials Chemistry and Physics1999，61，： | 1 |
| 7 | A polydimethylsiloxane (PDMS) sponge for the selective absorption of oil from water显示文摘 | Choi S J Kwon T H Hwon I | 2011 | ACS Symposium Series2011，3，12： | 1 |
| 8 | Multi-layer nanogap array for high-performance SERS substrate显示文摘 | Myeong-Lok Seol Ju-Hyun Kim Taejoon Kang Hwon Im Sungho Kim Bongsoo Kim Yang-Kyu Choi | 2011 | Nanotechnology2011，，23： | 1 |
| 9 | Preclinical Long-term Magnetic Resonance Imaging Study of Silymarin Liver-protective Effects显示文摘Background and Aims:Efficacy evaluations with preclini-cal magnetic resonance imaging(MRI)are uncommon,but MRI in the preclinical phase of drug development provides information that is useful for longitudinal monitoring.The study aim was to monitor the protective effectiveness of silymarin with multiparameter MRI and biomarkers in a thioacetamide(TAA)-induced model of liver injury in rats.Correlation analysis was conducted to assess compare the monitoring of liver function by MRI and biomarkers.Meth-ods:TAA was injected three times a week for 8 weeks to generate a disease model(TAA group).In the TAA and sily-marin-treated(TAA-SY)groups,silymarin was administered three times weekly from week 4.MR images were acquired at 0,2,4,6,and 8 weeks in the control,TAA,and TAA-SY groups.Results:The area under the curve to maximum time(AUCtmax)and T_(2)*values of the TAA group decreased over the study period,but the serological markers of liver abnormality increased significantly more than those in the control group.In the TAA-SY group,MRI and serological biomarkers indicated attenuation of liver function as in the TAA group.However,pattern changes were observed from week 6 to comparable levels in the control group with si-lymarin treatment.Negative correlations between either AUCtmax or T_(2)*values and the serological biomarkers were observed.Conclusions:Silymarin had hepatoprotective effects on TAA-induced liver injury and demonstrated the usefulness of multiparametric MRI to evaluate efficacy in preclinical studies of liver drug development. | Yeon Ji Chae Hwon Heo Chul-Woong Woo Sang-Tae Kim Jae-Im Kwon Monica Young Choi Yu Sub Sung Kyung Won Kim Jeong Kon Kim Yoonseok Choi Dong-Cheol Woo | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 0 |
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