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1429篇 您的检索式:作者名="Hurwitz"
    题名 作者 年代 出处 被引量
1饮水等三大环境危险因素与肝癌--泰兴市肝癌病例对照研究显示文摘目的通过泰兴肝癌环境病例对照研究,搞清肝癌环境危险因素,进一步证实饮水等与肝癌的关系,从而采取预防措施。方法选择以人群为基础的病例对照调查方法,通过问卷、采血,测定对两种病毒的感染、黄曲霉毒素(AFB1)摄入后白蛋白加合物和机体内基因检测,并进行统计分析,以判断当地肝癌主要危险因素。结果HBsAg比数比(OR)=5.68(95%可信限CI3.80-8.51),丙型肝炎OR=4.19(95%CI1.72-10.22),两种肝炎均为肝癌危险因素,但以乙型肝炎为主。居民摄入霉变食物OR=2.25(95%CI1.39-3.64)。1/2病例和1/3对照有饮生水习惯,经常饮生水者OR=4.60(95%CI1.30-16.30)。肝癌家族史OR=2.99(95%CI1.78-5.01)。吸烟和饮酒未达到危险水平。多吃蔬菜和水果有保护作用OR=0.58(95%CI0.38-0.89)。摄取霉变食物或AFB1加合物,饮生水与HBsAg有联合作用。肝癌与存在基因MTHFR anyT,并同时具有三大环境因素者(摄取霉变食物,饮生水与HBsAg)有明显的联合作用,OR由22跃升到72倍。IFNA17亦与HB-sAg和AFB1加合物有联合作用。结论泰兴肝癌与三大环境因素(HBsAg、摄取霉变食物,饮生水)有密切关系。两种基因的多态,尤其MTHFR anyT值得关注。管水、改粮和防肝炎仍然是预防肝癌的重要措施。俞顺章 穆丽娜 蔡琳 陈传炜 卫国荣 周学富 丁保国 常军 曹巍 Eric Hurwitz Janet Sinsheimer Barbara Visscher 姜庆五 张作风 2008复旦学报(医学版)2008,35,1:19
2监控所有智能电表的重要性显示文摘本文介绍了电表的基本原理,以及精度对电表的重要性。介绍了一种可以避免窃电的解决方法。Jed Hurwitz 2016电子产品世界2016,23,1:5
3Pyruvate kinase M2 regulates homologous recombination- mediated DNA double-strand break repair显示文摘到 genotoxic 治疗的抵抗是治疗失败和肿瘤复发的一个主要原因。激活 DNA 损坏反应(DDR ) 并且允许癌症房间逃离 genotoxic 治疗的致命的效果的内在的机制仍然保持不清楚。这里,我们揭开通过的意外机制 pyruvate kinase M2 (PKM2 ) ,在癌症房间的高度表示的 PK isoform 和癌症的一个主人管理者新陈代谢的 reprogramming,与 DDR 集成直接支持 DNA 双海滨裂缝(DSB ) 修理。响应电离放射和氧化应力,在导致它的原子累积的 T328 的 ATM phosphorylates PKM2。pT328-PKM2 被要求并且对足够支持通过到在 DNA 的 DSB 和切除术的增加 CtIPs 招募的 T126 上的交往 CtBP 蛋白质(CtIP ) 的 phosphorylation 的调停的 DNA DSB 修理结束的相应再结合(HR ) 。ATM-PKM2-CtIP 轴的混乱敏化癌症房间到许多损坏 DNA 代理人和 PARP1 抑制。而且,增加了原子 pT328-PKM2 水平在 glioblastoma 病人与显著地更坏的幸存被联系。联合,这些数据倡导者是的指向 PKM2 策略的使用不仅破坏癌症新陈代谢而且禁止抵抗的重要机制到 genotoxic 治疗的一个工具。Steven T. Sizemore Manchao Zhang Ju Hwan Cho Gina M. Sizemore Brian Hurwitz Balveen Kaur Norman L. Lehman Michael C. Ostrowski Pierre A. Robe Weili Miao Yinsheng Wang Arnab Chakravarti Fen Xia 2018Cell Research2018,28,11:5
4Pyrolytic conversion of methyland vinylsilane polymers to Si-C ceramics 显示文摘HURWITZ F I KACIK T A BU X Y 1995J Mater Sci1995,30,:2
5Everolimus in colorectal cancer显示文摘Ivy Altomare Herbert Hurwitz 2013Expert Opinion on Pharmacotherapy2013,,4:2
6Ambivalence over emotional expression in patients with gastrointestinal cancer and their caregivers: Associations with patient pain and quality of life显示文摘Laura S. Porter Francis J. Keefe Isaac Lipkus Herbert Hurwitz 2005Pain2005,,3:2
7Immunotherapy with Autologous, Human Dendritic Cells Transfected with Carcinoembryonic Antigen mRNA显示文摘Michael A. Morse Smita K. Nair Paul J. Mosca Amy C. Hobeika Timothy M. Clay Yuping Deng David Boczkowski Alan Proia Donna Neidzwiecki Pierre-A. Clavien# Herbert I. Hurwitz Jeffrey Schlom Eli Gilboa H. Kim Lyerly 2003Cancer Investigation2003,,3:2
8Bevacizumab plus irinotecan,fluorouracil,and leucovorin for metastatic colorectal cancer显示文摘Hurwitz H Fehrenbacher L Novotny W 0,,:2
9Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer 显示文摘Hurwitz H Fehrenbacher L Novotny W 2004N Engl J Med2004,350,23:1
10Bevacizumab plus irinotecan,fluorouracil,and leucovorin for metastatic colorectal cancer显示文摘Hurwitz H Fehrenbacher L Novotny W 2004N Engl J Med2004,350,23:1
11The Problem of Nonresponse in Sample Surveys显示文摘Hansen M H Hurwitz W N 1946Journal of the American Statistical Association1946,,41:1
12Occult vitamin D deficiency in postmenopausal US women with acute hip fracture显示文摘LeBoff M Kohlmeier L Hurwitz S 1999JAMA1999,281,16:1
13Phase Ⅱ , randomized trial comparing bevacizumab plus fluorouracil (FU) /leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer 显示文摘Kabbinavar F Hurwitz H Fehrenbacher L 2003J Clin Oncol2003,21,1:1
14Cfinone vaginal gel is equally effective and better tolera- ted than intramuscular progesterone for luteal phase support in in vitro fertilization-embryo transfer cycles: a prospective randomized study 显示文摘Elena Yanushpolsky MD Shelley Hurwitz PHD Loasise Greenberg MED 2010Fertility and Sterility2010,94,7:1
15Migraine proph- ylaxis:a comparison of propranolol and amitriptyline显示文摘Ziegler DK Hurwitz A Hassanein RS 1987Arch Neurol1987,44,5:1
16Complete immunosuppressive withdrawal as a uniform approach to post-transplant lymphoproliferative disease in pediatric liver transplantation 显示文摘Hurwitz M Desai DM Cox KL 2004Pediatr Transplant2004,8,3:1
17Targeted inhibition of VEGF receptor 2: anupdate on ramuciramab 显示文摘Clarke JM Hurwitz HI 2013Expert Opin Biol Ther2013,13,8:1
18Yolk sac sign: sonographic appearance of the fetal yolk sac in missed abortin 显示文摘HURWITZ S R 1986J Ultrasound Med1986,5,8:1
19Nucleotide sequence and expression of human chromosome 21 - encoded superoxide dismutase Mrna显示文摘 Dafni N Lieman - Hurwitz J 1983ProNatl Acad Sci U S A1983,80,18:1
20What's a good doctor and how can you make one?显示文摘 2002BMJ2002,325,:1
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