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| 1 | Epidermal self-powered sweat sensors for glucose and lactate monitoring显示文摘Sweat could be a carrier of informative biomarkers for health status identification;therefore,wearable sweat sensors have attracted significant attention for research.An external power source is an important component of wearable sensors,however,the current power supplies,i.e.,batteries,limit further shrinking down the size of these devices and thus limit their application areas and scenarios.Herein,we report a stretchable self-powered biosensor with epidermal electronic format that enables the in situ detec-tion of lactate and glucose concentration in sweat.Enzymatic biofuel cells serve as self-powered sensing modules allowing the sweat sensor to exhibit a determination coefficient(R2)of 0.98 with a sensitivity of 2.48 mV/mM for lactate detection,and R2 of 0.96 with a sensitivity of 0.11 mV/μM for glucose detection.The microfluidic channels developed in an ultra-thin soft flexible polydimethylsiloxane layer not only enable the effective collection of sweat,but also provide excellent mechanical properties with stable performance output even under 30%stretching.The presented soft sweat sensors can be integrated at nearly any location of the body for the continuous monitoring of lactate and glucose changes during normal daily activities such as exercise.Our results provide a promising approach to develop next-generation sweat sensors for real-time and in situ sweat analysis. | Xingcan Huang Jiyu Li Yiming Liu Tszhung Wong Jingyou Su Kuanming Yao Jingkun Zhou Ya Huang Hu Li Dengfeng Li Mengge Wu Enming Song Shijiao Han Xinge Yu | 2022 | Bio-Design and Manufacturing2022，5，1： | 3 |
| 2 | Microstructure control of organic semiconductors via UV-ozone for high-sensitivity NO2 detection显示文摘Developing high sensitive organic semiconductors(OSCs)in organic thin-film transistors(OTFTs)is the key for OTFT based gas sensors.Herein,we report a simple processing route of highly sensitive OSCs for high performance OTFT based nitrogen dioxide(NO2)sensors,where the active OSC layer is based on ultraviolet-ozone(UVO)treated poly(3-hexylthiophene-2,5-diyl)(P3HT).Compared to conventional P3HT based OTFT sensors,the reported device exhibits a remarkable improvement of the gas response from 350%to 30000%.The studies in morphologies,chemical compositions and microstructures of the UVOtreated films reveal that a large number of carrier traps generated in the P3HT films is the decisive reason for the enhancement of sensing performance.Moreover,the optimized device shows great potential of practical applications on the stand points of sensitivity,selectivity,reusability and the ability of recovery,as well as limit of detection of~7.3 ppb.This simple method provides an innovative understanding for the role of the carrier traps in sensing performance and demonstrates a bright future for developing high performance OTFT gas sensors. | HOU SiHui FAN HuiDong WU MengGe YU XinGe YU JunSheng | 2021 | Science China(Technological Sciences)2021，64，5： | 2 |
| 3 | Garment embedded sweat-activated batteries in wearable electronics for continuous sweat monitoring显示文摘Thin,soft,and skin-integrated electronic system has great advantages for realizing continuous human healthcare monitoring.Here,we report an ultra-thin,flexible,and garment-based microelectronics powered by sweat-activated batteries(SABs)and applications of powering biosensors and microelectronic systems for real time sweat monitoring.The SAB cell is ultra-thin(1.25 mm)with excellent biocompatibility.The SAB has good electricity output with high capacity(14.33 mAh)and maximum power density(3.17 mW cm^(−2))after being activated by the sweat volume of 0.045 mL cm^(−2),which could continuously power 120 light emitting diodes over 3 h.The outputs could maintain stable after repeatable bending.Wireless microelectronics system could be continuously powered by the SABs for 3 h to monitor sweat and physiological information,including sweat Na+concentration,pH,and skin impedance.The reported integrated system provides a potential for solving the power issues of flexible wearable electronics and realizing personalized medicine. | Xingcan Huang Yiming Liu Jingkun Zhou Sina Khazaee Nejad Tsz Hung Wong Ya Huang Hu Li Chun Ki Yiu Wooyoung Park Jian Li Jingyou Su Ling Zhao Kuanming Yao Mengge Wu Zhan Gao Dengfeng Li Jiyu Li Rui Shi Xinge Yu | 2022 | npj Flexible Electronics2022，6，1： | 1 |
| 4 | Miniaturization of mechanical actuators in skin-integrated electronics for haptic interfaces显示文摘Skin-integrated electronics,also known as electronic skin(e-skin);are rapidly developing and are gradually being adopted in biomedical fields as well as in our daily lives.E-skin capable of providing sensitive and high-resolution tactile sensations and haptic feedback to the human body would open a new e-skin paradigm for closed-loop human-machine interfaces.Here,we report a class of materials and mechanical designs for the miniaturization of mechanical actuators and strategies for their integration into thin,soft e-skin for haptic interfaces.The mechanical actuators exhibit small dimensions of 5 mm diameter and 1.45 mm thickness and work in an electromagnetically driven vibrotactile mode with resonance frequency overlapping the most sensitive frequency of human skin.Nine mini actuators can be integrated simultaneously in a small area of 2 cm×2 cm to form a 3×3 haptic feedback array,which is small and compact enough to mount on a thumb tip.Furthermore,the thin,soft haptic interface exhibits good mechanical properties that work properly during stretching,bending,and twisting and therefore can conformally fit onto various parts of the human body to afford programmable tactile enhancement and Braille recognition with an accuracy rate over 85%. | Dengfeng Li Jiahui He Zhen Song Kuanming Yao Mengge Wu Haoran Fu Yiming Liu Zhan Gao Jingkun Zhou Lei Wei Zhengyou Zhang Yuan Dai Zhaoqian Xie Xinge Yu | 2021 | Microsystems & Nanoengineering2021，7，5： | 1 |
| 5 | Responsive P(NIPAM-co-AA)particle-functionalized magnetic micro- spheres显示文摘 | Wang Yiheng Xia Mengge Wu Yongtao | 2014 | Australian Journal of Chemistry2014，67，1： | 1 |
| 6 | Noncovalent binding interactions of polyacrylamide and clay in nanocom- posite hydrogels显示文摘 | Wu Yongtao Xia Mengge Fan Qinqin | 2011 | Journal of Polymer Science Part B:Polymer Physics?2011，49，4： | 1 |
| 7 | Muscle-inspired soft robots based on bilateral dielectric elastomer actuators显示文摘Muscle groups perform their functions in the human body via bilateral muscle actuation,which brings bionic inspiration to artificial robot design.Building soft robotic systems with artificial muscles and multiple control dimensions could be an effective means to develop highly controllable soft robots.Here,we report a bilateral actuator with a bilateral deformation function similar to that of a muscle group that can be used for soft robots.To construct this bilateral actuator,a low-cost VHB 4910 dielectric elastomer was selected as the artificial muscle,and polymer films manufactured with specific shapes served as the actuator frame.By end-to-end connecting these bilateral actuators,a gear-shaped 3D soft robot with diverse motion capabilities could be developed,benefiting from adjustable actuation combinations.Lying on the ground with all feet on the ground,a crawling soft robot with dexterous movement along multiple directions was realized.Moreover,the directional steering was instantaneous and efficient.With two feet standing on the ground,it also acted as a rolling soft robot that can achieve bidirectional rolling motion and climbing motion on a 2°slope.Finally,inspired by the orbicularis oris muscle in the mouth,a mouthlike soft robot that could bite and grab objects 5.3 times of its body weight was demonstrated.The bidirectional function of a single actuator and the various combination modes among multiple actuators together allow the soft robots to exhibit diverse functionalities and flexibility,which provides a very valuable reference for the design of highly controllable soft robots. | Yale Yang Dengfeng Li Yanhua Sun Mengge Wu Jingyou Su Ying Li Xinge Yu Lu Li Junsheng Yu | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 8 | Thin,soft,skin-integrated electronics for real-time and wireless detectionof uricacid in sweat显示文摘Wearable sweat sensors are gaining significant attention due to their unparalleled potential for noninvasive health monitoring.Sweat,as a kind of body fluid,contains informative physiological indicators that are related to personalized health status.Advances in wearable sweat sampling and routing technologies,flexible,and stretchable materials,and wireless digital technologies have led to the development of integrated sweat sensors that are comfortable,flexible,light,and intelligent.Herein,we report a flexible and integrated wearable device via incorporating a microfluidic system and a sensing chip with skin-integrated electronic format toward in-situ monitoring of uric acid(UA)in sweat that associates with gout,cardiovascular,and renal diseases.The microfluidic system validly realizes the real-time capture perspiration from human skin.The obtained detection range is 5-200μM and the detection limit is 1.79μM,which offers an importance diagnostic method for clinical relevant lab test.The soft and flexible features of the constructed device allows it to be mounted onto nearly anywhere on the body.We tested the sweat UA in diverse subjects and various body locations during exercise,and similar trends were also observed by using a commercial UA assay kit. | Yue Hu Lan Wang Jian Lia Yawen Yang Guangyao Zhao Yiming Liu Xingcan Huang Pengcheng Wu Binbin Zhang Yanli Jia Mengge Wu Shengxin Jia Qiang Zhang Guoqiang Xu Rui Shi Dengfeng Li Yingchun Li Zhengchun Peng Xinge Yu | 2023 | International Journal of Smart and Nano Materials2023，14，4： | 0 |
| 9 | Stretchable,skin-conformable neuromorphic system for tactile sensory recognizing and encoding显示文摘Expanding wearable technologies to artificial tactile perception will be of significance for intelligent human-machine interface,as neuromorphic sensing devices are promising candidates due to their low energy consumption and highly effective operating properties.Skin-compatible and conformable features are required for the purpose of realizing wearable artificial tactile perception.Here,we report an intrinsically stretchable,skin-integrated neuromorphic system with triboelectric nanogenerators as tactile sensing and organic electrochemical transistors as information processing.The integrated system provides desired sensing,synaptic,and mechanical characteristics,such as sensitive response(~0.04 kPa^(-1))to low-pressure,short-and long-term synaptic plasticity,great switching endurance(>10000 pulses),symmetric weight update,together with high stretchability of 100%strain.With neural encoding,demonstrations are capable of recognizing,extracting,and encoding features of tactile information.This work provides a feasible approach to wearable,skin-conformable neuromorphic sensing system with great application prospects in intelligent robotics and replacement prosthetics. | Mengge Wu Qiuna Zhuang Kuanming Yao Jian Li Guangyao Zhao Jingkun Zhou Dengfeng Li Rui Shi Guoqiang Xu Yingchun Li Zijian Zheng Zhihui Yang Junsheng Yu Xinge Yu | 2023 | InfoMat2023，5，12： | 0 |
| 10 | Origami-inspired folding assembly of dielectric elastomers for programmable soft robots显示文摘Origami has become an optimal methodological choice for creating complex three-dimensional(3D)structures and soft robots.The simple and low-cost origami-inspired folding assembly provides a new method for developing 3D soft robots,which is ideal for future intelligent robotic systems.Here,we present a series of materials,structural designs,and fabrication methods for developing independent,electrically controlled origami 3D soft robots for walking and soft manipulators.The 3D soft robots are based on soft actuators,which are multilayer structures with a dielectric elastomer(DE)film as the deformation layer and a laser-cut PET film as the supporting flexible frame.The triangular and rectangular design of the soft actuators allows them to be easily assembled into crawling soft robots and pyramidal-and square-shaped 3D structures.The crawling robot exhibits very stable crawling behaviors and can carry loads while walking.Inspired by origami folding,the pyramidal and square-shaped 3D soft robots exhibit programmable out-of-plane deformations and easy switching between two-dimensional(2D)and 3D structures.The electrically controllable origami deformation allows the 3D soft robots to be used as soft manipulators for grasping and precisely locking 3D objects.This work proves that origami-inspired fold-based assembly of DE actuators is a good reference for the development of soft actuators and future intelligent multifunctional soft robots. | Yanhua Sun Dengfeng Li Mengge Wu Yale Yang Jingyou Su Tszhung Wong Kangming Xu Ying Li Lu Li Xinge Yu Junsheng Yu | 2022 | Microsystems & Nanoengineering2022，8，2： | 0 |
| 11 | Contractility detection of isolated mouse papillary muscle using myotronic Myostation-Intact device显示文摘Background:To understand the relationship between myocardial contractility and ex-ternal stimuli,detecting ex vivo myocardial contractility is necessary.Methods:We elaborated a method for contractility detection of isolated C57 mouse papillary muscle using Myostation-Intact system under different frequencies,volt-ages,and calcium concentrations.Results:The results indicated that the basal contractility of the papillary muscle was 0.27±0.03 mN at 10 V,500-ms pulse duration,and 1 Hz.From 0.1 to 1.0 Hz,con-tractility decreased with an increase in frequency(0.45±0.11-0.10±0.02 mN).The voltage-initiated muscle contractility varied from 3 to 6 V,and the contractility gradu-ally increased as the voltage increased from 6 to 10 V(0.14±0.02-0.28±0.03 mN).Moreover,the muscle contractility increased when the calcium concentration was increased from 1.5 to 3 mM(0.45±0.17-1.11±0.05 mN);however,the contractility stopped increasing even when the concentration was increased to 7.5 mM(1.02±0.23 mN).Conclusions:Our method guaranteed the survivability of papillary muscle ex vivo and provided instructions for Myostation-Intact users for isolated muscle contractility investigations. | Hong Lian Zhuyun Qin Mengge Wu Peipei Zuo Lina Bai Minjie Lu Lulu Li Haitao Zhang | 2022 | Animal Models and Experimental Medicine2022，5，5： | 0 |
| 12 | Thin,soft,3D printing enabled crosstalk minimized triboelectric nanogenerator arrays for tactile sensing显示文摘With the requirements of self-powering sensors in flexible electronics,wearable triboelectric nanogenerators(TENGs)have attracted great attention due to their advantages of excellent electrical outputs and low-cost processing routes.The crosstalk effect between adjacent sensing units in TENGs significantly limits the pixel density of sensor arrays.Here,we present a skin-integrated,flexible TENG sensor array with 100 sensing units in an overall size of 7.5 cm×7.5 cm that can be processed in a simple,low-cost,and scalable way enabled by 3D printing.All the sensing units show good sensitivity of 0.11 V/kPa with a wide range of pressure detection from 10 to 65 kPa,which allows to accurately distinguish various tactile formats from gentle touching(as low as 2 kPa)to hard pressuring.The 3D printing patterned substrate allows to cast triboelectric layers of polydimethylsiloxane in an independent sensing manner for each unit,which greatly suppresses the cross talk arising from adjacent sensing units,where the maximum crosstalk output is only 10.8%.The excellent uniformity and reproducibility of the sensor array offer precise pressure mapping for complicated pattern loadings,which demonstrates its potential in tactile sensing and human-machine interfaces. | Jian Li Yiming Liu Mengge Wu Kuanming Yao Zhan Gao Yuyu Gao Xingcan Huang Tsz Hung Wong Jingkun Zhou Dengfeng Li Hu Li Jiyu Li Ya Huang Rui Shi Junsheng Yu Xinge Yu | 2023 | Fundamental Research2023，3，1： | 0 |
| 13 | Identification and characterization of human hematopoietic mesoderm显示文摘The embryonic mesoderm comprises heterogeneous cell subpopulations with distinct lineage biases.It is unclear whether a bias for the human hematopoietic lineage emerges at this early developmental stage.In this study,we integrated single-cell transcriptomic analyses of human mesoderm cells from embryonic stem cells and embryos,enabling us to identify and define the molecular features of human hematopoietic mesoderm(HM)cells biased towards hematopoietic lineages.We discovered that BMP4 plays an essential role in HM specification and can serve as a marker for HM cells.Mechanistically,BMP4 acts as a downstream target of HDAC1,which modulates the expression of BMP4 by deacetylating its enhancer.Inhibition of HDAC significantly enhances HM specification and promotes subsequent hematopoietic cell differentiation.In conclusion,our study identifies human HM cells and describes new mechanisms for human hematopoietic development. | Yuqi Wen Jingjing Zhao Runqing Zhang Fan Liu Xiaoyuan Chen Dan Wu Mengge Wang Cuicui Liu Pei Su Panpan Meng Yiyue Zhang Xin Gao Lu Wang Hongtao Wang Jiaxi Zhou | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
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