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| 1 | Randomized controlled trial: Moxibustion and acupuncture for the treatment of Crohn's disease显示文摘AIM: To evaluate the clinical efficacy and safety of acupuncture and moxibustion for the treatment of active Crohn's disease(CD).METHODS: Ninety-two patients were equally and randomly divided into the treatment group and received herb-partitioned moxibustion combined with acupuncture, and the control group received wheat bran-partitioned moxibustion combined with superficial acupuncture. The patients received three treatment sessions per week for 12 wk and were followed up for 24 wk. The main outcome was evaluated using the CD Activity Index(CDAI) score, and the secondary outcomes were evaluated using laboratory indicators such as hemoglobin(HGB), C-reactive protein(CRP), erythrocyte sedimentation rate, quality-of-life, endoscopic ratings, and intestinal histology scores.RESULTS: The CDAI scores of both the treatment and control groups were significantly reduced after treatment compared with those measured before treatment. However, the degree of improvement in the treatment group was significantly greater than that of the control group. The improvement in symptoms in patients of the treatment group was sustained at follow-up, whereas that of the control group was not. The overall efficacy of the treatment was significantly greater than that of the control. Both groups demonstrated significant improvements in quality-of-life ratings after treatment, but the improvement was significantly greater in the treatment group than in the control group. In addition, the patients in the treatment group showed significantly increased HGB and significantly decreasedCRP levels and histopathological scores at the end of treatment, whereas the control group did not exhibit significant changes.CONCLUSION: Moxibustion with acupuncture provided significant therapeutic benefits in patients with active CD beyond the placebo effect and is therefore an effective and safe treatment for active CD. | Chun-Hui Bao Ji-Meng Zhao Hui-Rong Liu Yuan Lu Yi-Fang Zhu Yin Shi Zhi-Jun Weng Hui Feng Xin Guan Jing Li Wei-Feng Chen Lu-Yi Wu Xiao-Ming Jin Chuan-Zi Dou Huan-Gan Wu | 2014 | World Journal of Gastroenterology2014，20，31： | 19 |
| 2 | H2A.Z Represses Gene Expression by Modulating Promoter Nucleosome Structure and Enhancer Histone Modifications in Arabidopsis显示文摘 | Xiaozhuan Dai Youhuang Bai Lihua Zhao Xianying DOU Yanhui Liu Lulu Wang Yi Li Weimin Li Yanan Hui Xinyu Huang Zonghua Wang Yuan Qin | 2017 | Molecular Plant2017，10，10： | 14 |
| 3 | Effect of Quercetin on Atherosclerosis Based on Expressions of ABCA1, LXR-α and PCSK9 in ApoE-/- Mice显示文摘Objective:To investigate the effect of quercetin on ATP binding cassette transporter A1(ABCA1),liver X receptor(LXR),and proprotein convertase subtilisin/kexin type 9(PCSK9)expressions in apoE-knockout(ApoE-/-)mice.Methods:The high-fat diet-induced atherosclerosis(AS)in ApoE-/-mice was established.Thirtysix mice were divided into 3 groups using random number table method:model group(n=12),quercetin group(n=12),and atorvastatin group(n=12),with C57BL/6J mice of the same strain and age as the control group(n=12).Quercetin group and atorvastatin group were administrated with quercetin and atorvastatin by oral gavage,with doses of 12.5 and 4 mg/(kg・d),respectively.Animals in the control and model groups were given an equal volume of distilled water by oral gavage once per day for a total of 12 weeks.Western blot and immunohistochemical methods were employed to determine the aortic ABCA1,LXR-a and PCSK9 protein expressi on.En zyme linked imm uno sorbent assay method was used to detect the expressi on of serum total cholesterol(TC),triglyceride(TG),high density lipoprotein-cholesterol(HDL-C),low density lipoproteincholesterol(LDL-C),tumor necrosis factor-a(TNF-a),interleukin-6(IL-6),and IL-10,combined with tissue pathological exami nation.Results:ApoE-/-mice fed with a high-fat diet had no table atherosclerosis lesions,with reduced ABCA1,LXR-a and IL-10 levels(all P<0.01),elevated PCSK9,TNF-a and IL-6 expression,and increased TC and LDL-C con tents(all P<0.01).After querceti n in terventi on,the areas of AS plaques and the expressions of PCSK9,TNF-a and IL-6 were significantly reduced(all P<0.01),while the expressions of ABCA1 and LXR-a were increased significantly(all P<0.01).Conclusion:Quercetin effectively interfered with AS development by regulating the expressions of ABCA1,LXR-a and PCSK9 in ApoE,mice. | LI Shan-shan CAO Hui SHEN Ding-zhu CHEN Chuan XING San-li DOU Fang-fang JIA Qing-ling | 2020 | Chinese Journal of Integrative Medicine2020，26，2： | 13 |
| 4 | Absorption mechanism of carbon-nanotube paper- titanium dioxide as a multifunctional barrier material for lithium-sulfur batteries显示文摘Lithium-sulfur batteries attract much interest as energy storage devices for their low cost, high specific capacity, and energy density. However, the insulating properties of sulfur and high solubility of lithium polysulfides decrease the utilization of active materials by the battery resulting in poor cycling performance. Herein, we design a multifunctional carbon-nanotube paper/titanium-dioxide barrier which effectively reduces active material loss and suppresses the diffusion of lithium polysulfides to the anode, thereby improving the cycling stability of lithium-sulfur batteries. Using this barrier, an activated carbon/sulfur cathode with 70% sulfur content delivers stable cycling performance and high Coulombic efficiency (-99%) over 250 cycles at a current rate of 0.5 C. The improved electrochemical performance is attributed to the synergistic effects of the carbon nanotube paper and titanium dioxide, involving the physical barrier, chemical adsorption from the binding formation of Ti-S and S-O, and other interactions unique to the titanium dioxide and sulfur species. | Guiyin Xu Jiaren Yuan Xinyong Tao Bing Ding Hui Dou Xiaohong Yan Yang xiao Xiaogang Zhang | 2015 | Nano Research2015，8，9： | 7 |
| 5 | Pseudocapacitive materials for electrochemical capacitors:from rational synthesis to capacitance optimization显示文摘Among various energy-storage devices,electrochemical capacitors(ECs) are prominent power provision but show relatively low energy density.One way to increase the energy density of ECs is to move from carbon-based electric double-layer capacitors to pseudocapacitors,which manifest much higher capacitance.However,compared with carbon materials,the pseudocapacitive electrodes sufer from high resistance for electron and/or ion transfer,signiicantly restricting their capacity,rate capability and cyclability.Rational design of electrode materials ofers opportunities to optimize their electrochemical performance,leading to devices with high energy density while maintaining high power density.his paper reviews the diferent approaches of electrodes striving to advance the energy and power density of ECs. | Jie Wang Shengyang Dong Bing Ding Ya Wang Xiaodong Hao Hui Dou Yongyao Xia Xiaogang Zhang | 2017 | National Science Review2017，4，1： | 7 |
| 6 | A New Cyclic Peptide from Schnabelia tetradonta显示文摘A new cyclic octapeptide (schnabepeptide B) was isolated from the aerial part ofSchnabelia tetradonta (Sun) C. Y. Wu et C. Chen (Lamiaceae). Its structure was elucidated ascyclo-(NH-Trp-Gly1-Leu1-Gly2-Pro1-Pro2-Leu2-Pro3-CO) on the basis of extensive 2D NMR andMS spectra. | Hui DOU, Yan ZHOU, Shu lin PENG, Li Sheng DING Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041 | 2003 | Chinese Chemical Letters2003，14，9： | 7 |
| 7 | Formation control with obstacle avoidance of second-order multi-agent systems under directed communication topology显示文摘This paper addresses the obstacle avoidance problem of formation control for the multi-agent systems modeled by double integrator dynamics under a directed interconnection topology. The control task is finished by a leader-follower formation scheme combined with an artificial potential field(APF) method.The leader-follower scheme is carried out by taking the desired trajectory with the desired velocity as virtual leader, while the APF method is carried out by dealing with the obstacles as the high potential points. When the obstacle avoidance tasks are finished, the artificial potential forces degrade the formation performance, so their undesired effects are treated as disturbances, which is analyzed by the robust H∞performance. Based on Lyapunov stability theory, it is proved that the proposed formation approach can realize the control objective. The result is also extended to the switching multi-agent formation. The effectiveness of the proposed formation scheme is further confirmed by simulation studies. | Guoxing WEN CLPhilip CHEN Hui DOU Hongli YANG Chunfang LIU | 2019 | Science China(Information Sciences)2019，62，9： | 7 |
| 8 | 2020 roadmap on pore materials for energy and environmental applications显示文摘Porous materials have attracted great attention in energy and environment applications,such as metal organic frameworks(MOFs),metal aerogels,carbon aerogels,porous metal oxides.These materials could be also hybridized with other materials into functional composites with superior properties.The high specific area of porous materials offer them the advantage as hosts to conduct catalytic and electrochemical reactions.On one hand,catalytic reactions include photocatalytic,p ho toe lectrocatalytic and electrocatalytic reactions over some gases.On the other hand,they can be used as electrodes in various batteries,such as alkaline metal ion batteries and electrochemical capacitors.So far,both catalysis and batteries are extremely attractive topics.There are also many obstacles to overcome in the exploration of these porous materials.The research related to porous materials for energy and environment applications is at extremely active stage,and this has motivated us to contribute with a roadmap on ’porous materials for energy and environment applications’. | Zengxi Wei Bing Ding Hui Dou Jorge Gascon Xiang-Jian Kong Yujie Xiong Bin Cai Ruiyang Zhang Ying Zhou Mingce Long Jie Miao Yuhai Dou Ding Yuan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 5 |
| 9 | Two new compounds from Zingiber officinale显示文摘新周期的 diarylheptanoid, 1,5-epoxy-3-hydroxy-1-(3-methoxy-4,5-dihydroxyphenyl )-7-(4-hydroxyphenyl)-heptane (1 ) ,以及新单音的萜烯, 10-O- β - d-glucopyranosyl-hydroxy cineole (2 ) 从姜 officinale 的根茎被孤立。混合物的结构 1 和 2 被建立基于他们的光谱数据。另外,这些混合物的抗氧化剂活动也被测量。 | Yu Zhao Qiao Feng Tao Rong Ping Zhang Chang Xin Zhou Hui Dou Shu Yun Shi Ye Cheng Xiao Lian Li Sun Su Zeng Ke Xin Huang Xiao Dong Zhang Xiao Kun Li | 2007 | Chinese Chemical Letters2007，18，10： | 4 |
| 10 | Efficacy of Shoushen granule on adenosine triphosphate binding cassette transporter A1, proprotein convertase subtilisin/kexin type 9 and toll-like receptor 4/nuclear factor kappa-B signaling pathway in ApoE-knockout mice显示文摘OBJECTIVE: To evaluate the efficacy of Shoushen granule, prepared with four Chinese medicinals, on the targeted regulation of adenosine triphosphate binding cassette transporter A1(ABCA1) through proprotein convertase subtilisin/kexin type 9(PCSK9) and toll-like receptor 4(TLR4)/nuclear factor kappa-B(NF-κB) signaling pathway to affect atherosclerosis(AS) in ApoE-knockout(ApoE-/-) mice.METHODS: ApoE-/-mice fed with a high-fat diet were used for AS modeling and divided into Model,Shoushen, and Atorvastatin groups. C57 BL/6 J mice at the same age and background strain were included in the Control group. Western blot and immunohistochemistry were used to measure ABCA1, PCSK9, TLR4, and NF-κB protein expression in mouse aortas. Enzyme-linked immuno sorbent assay was used to measure mouse serum tumor necrosis factor-α(TNF-α), interleukin-10(IL-10), monocyte chemoattractant protein 1(MCP-1), and intercellular cell adhesion molecule-1(ICAM-1) expression. Serum lipid profiles and histopathology were also assessed. Shoushen granule were composed of Heshouwu(Radix Polygoni Multiflori) 15 g, Gouqizi(Fructus Lycii) 15 g, Sheng shanzha(Raw Fructus Crataegus Pinnatifidae) 10 g, and Sanqi(Radix Notoginseng) 3 g.RESULTS: ApoE-/-mice fed with a high-fat diet had notable AS lesions, with reduced ABCA1 and IL-10 levels, elevated PCSK9, TLR4, NF-κB, TNF-α, MCP-1,and ICAM-1 expression, and increased total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) contents. With drug interventions, the areas of AS plaques were significantly reduced,the ABCA1 and IL-10 levels were increase, while the PCSK9, TLR4, NF-κB, TC, and LDL-C contents,and the TNF-α, MCP-1, and ICAM-1 expression were reduced.CONCLUSION: Shoushen granule effectively interfered with AS development by antagonizing the expression of key factors of the PCSK9 and TLR4/NF-κB signaling pathway to upregulate ABCA1 expression. | Li Shanshan Cao Hui Shen Dingzhu Chen Chuan Xing Sanli Dou Fangfang Jia Qingling | 2019 | Journal of Traditional Chinese Medicine2019，39，4： | 4 |
| 11 | Conophylline Promotes the Proliferation of Immortalized Mesenchymal Stem Cells Derived from Fetal Porcine Pancreas (iPMSCs)显示文摘Conophylline, is a bis (indole) alkaloid consisting of two pentacyclic aspidosperma skeletons, isolated from Tabernaemontana divaricata, which has been found to induce β-cell differentiation in rat pancreatic acinar carcinoma cells and in cultured rat pancreatic tissue. However, the precise role of conophylline in the growth and survival of immortalized pancreatic mesenchymal stem cells (iPMSCs) derived from fetal porcine pancreas were not understood at present. To determine whether this molecule is involved in controlling the proliferation of iPMSCs, we examined the effects of conophylline on iPMSCs. We found that conophylline can robustly stimulate iPMSCs proliferation, even promote their potential differentiation into islet-like clusters analyzed by cell counting, morphology, RT-PCR and real-time PCR, Western blotting, glucose-stimulated insulin release and insulin content analysis. The effects of conophylline were inhibited by LY294002, which is the inhibitor of the PI3K pathway. These results suggest that conophylline plays a key role in the regulation of cell mass proliferation, maintenance of the undifferentiated state of iPMSCs and also promotes iPMSCs differentiated into insulin-producing cells. | ZHANG Hui-ru LI Dan CAO Hui Lü Xiao CHU Yuan-kui BAI Yao-fu JIN Ya-ping PENG Sha DOU Zhong-ying HUA Jin-lian | 2013 | Journal of Integrative Agriculture2013，12，4： | 3 |
| 12 | Effect of Rotational Speed on the Stability of Two Rotating Side-by-side Circular Cylinders at Low Reynolds Number显示文摘Flow around two rotating side-by-side circular cylinders of equal diameter D is numerically studied at the Reynolds number 40≤ Re ≤200 and various rotation rate θ_i. The incoming flow is assumed to be two-dimensional laminar flow. The governing equations are the incompressible Navier-Stokes equations and solved by the finite volume method(FVM). The ratio of the center-to-center spacing to the cylinder diameter is T/D=2. The objective of the present work is to investigate the effect of rotational speed and Reynolds number on the stability of the flow.The simulation results are compared with the experimental data and a good agreement is achieved. The stability of the flow is analyzed by using the energy gradient theory, which produces the energy gradient function K to identify the region where the flow is the most prone to be destabilized and the degree of the destabilization. Numerical results reveal that K is the most significant at the separated shear layers of the cylinder pair. With Re increases,the length of the wake is shorter and the vortex shedding generally exhibits a symmetrical distribution forθ_i<θ_(crit), It is also shown that the unsteady vortex shedding can be suppressed by rotating the cylinders in the counter-rotating mode. | DOU Huashu ZHANG Shuo YANG Hui SETOGUCHI Toshiaki KINOUE Yoichi | 2018 | Journal of Thermal Science2018，27，2： | 3 |
| 13 | Bushen Jiangzhi formula reduces atherosclerosis in apoE-/-mice through autophagy显示文摘OBJECTIVE:To study the effect of Bushen Jiangzhi formula(BSJZF)on atherosclerosis(AS)in apolipoprotein E knockout(apoE^-/-)mice and the underlying mechanism.METHODS:We used a high fat diet to induce AS in apoE^-/- mice.The mice were randomly divided into four groups:model,BSJZF,atorvastatin,and 3-methyladenine groups.Syngeneic C57BL/6 mice of the same age were used for the control group.Autophagosomes in the aorta were examined by transmission electron microscopy.Morphology,lipid accumulation,and collagen deposition in the aorta were examined by hematoxylin and eosin,Oil Red O,and Masson's staining,respectively.Serum levels of tumor necrosis factor alpha(TNF-α),interferon gamma(IFN-γ),and interleukin 10(IL-10)were measured by enzyme-linked immunoassays.Protein expression of microtubule-associated protein light chain 3(LC3),Beclin 1,and p62 in the aorta were examined by Western blot analyses.RESULTS:ApoE^-/- mice fed a high fat diet exhibited AS symptoms including less autophagosomes in the aorta,higher serum levels of TNF-α,IFN-γ,and p62,and lower serum levels of IL-10,LC3,and Beclin 1.Treatment with BSJZF significantly reduced the area of the aortic plaque,decreased expression of TNF-α,IFN-γ,and p62,and increased expression of IL-10,LC3,and Beclin 1.CONCLUSION:Our findings suggest that BSJZF promotes autophagy and reduces inflammation by regulating the expression of autophagy-related proteins LC3,Beclin 1,and p62,thereby effectively treating AS. | Cao Hui Jia Qingling Shen Dingzhu Yan Li Chen Chuan Xing Sanli Dou Fangfang | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 3 |
| 14 | Bioinformatics analysis of microarray data to explore the key genes involved in HSF4 mutation-induced cataract显示文摘AIM: To reveal the mechanisms of heat-shock transcription factor 4(HSF4) mutation-induced cataract. METHODS: GSE22362, including 3 HSF4-null lens and 3 wild-type lens, was obtained from Gene Expression Omnibus database. After data preprocessing, the differentially expressed genes(DEGs) were identified using the limma package. Based on Database for Annotation, Visualization and Integrated Discovery(DAVID) tool, functional and pathway enrichment analyses were performed for the DEGs. Followed by protein-protein interaction(PPI) network was constructed using STRING database and Cytoscape software. Furthermore, the validated microRNA(miRNA)-DEG pairs were obtained from miRWalk2.0 database, and then miRNA-DEG regulatory network was visualized by Cytoscape software. RESULTS: A total of 176 DEGs were identified in HSF4-null lens compared with wild-type lens. In the PPI network,FBJ osteosarcoma oncogene(FOS), early growth response1(EGR1) and heme oxygenase(decycling) 1(HMOX1) had higher degrees and could interact with each other. Besides,mmu-miR-15 a-5 p and mmu-miR-26 a-5 p were among the top 10 miRNAs in the miRNA-DEG regulatory network.Additionally, mmu-miR-26 a-5 p could target EGR1 in the regulatory network. CONCLUSION: FOS, EGR1, HMOX1, mmu-miR-26 a-5 p and mmu-miR-15 a-5 p might function in the pathogenesis of HSF4 mutation-induced cataract. | Rui Tian Yang Xu Wen-Wen Dou Hui Zhang | 2018 | International Journal of Ophthalmology(English edition)2018，11，6： | 3 |
| 15 | Three new diarylheptanoids and their antioxidant property显示文摘三新 diarylheptanoids,即,钠(5S,2E )-1,7-bis(4-hydroxyphenyl)-1-hydroxy-2-hepten-5-sulfonate (1 ) ,钠(5R,2E )-1,7-bis(4-hydroxyphenyl)-1-hydroxy-2-hepten-5-sulfonate (2 ) 和 3,5-diacetoxy-1-(3-methoxy-4,5-dihydroxyphenyl )-7-(4-hydroxy-3-methoxyphenyl)heptane (3 ) 从姜 officinale 的根茎被孤立。新混合物的结构根据分光镜的方法被阐明。3 的抗氧化剂活动在包含 DPPH 自由激进分子和超级氧化物阴离子激进分子的 vitro 模型旁边是 assayed。 | Chang Xin Zhou Xiang Yi Zhang Xiao Wu Dong Qiao Feng Tao Hui Dou Rong Ping Zhang Ke Xin Huang Xiao Kun Li Chang Xiang Chen Su Zeng Yu Zhao | 2007 | Chinese Chemical Letters2007，18，10： | 2 |
| 16 | A Method for Alpine Wetland Delineation and Features of Border: Zoigê Plateau, China显示文摘Accurate wetland delineation is the basis of wetland definition and mapping, and is of great importance for wetland management and research. The Zoigê Plateau on the Qinghai-Tibet Plateau was used as a research site for research on alpine wetland delineation. Several studies have analyzed the spatiotemporal pattern and dynamics of these alpine wetlands, but none have addressed the issues of wetland boundaries. The objective of this work was to discriminate the upper boundaries of alpine wetlands by coupling ecological methods and satellite observations. The combination of Landsat 8 images and supervised classification was an effective method for rapid identification of alpine wetlands in the Zoigê Plateau. Wet meadow was relatively stable compared with hydric soils and wetland hydrology and could be used as a primary indicator for discriminating the upper boundaries of alpine wetlands. A slope of less than 4.5° could be used as the threshold value for wetland delineation. The normalized difference vegetation index(NDVI) in 434 field sites showed that a threshold value of 0.3 could distinguish grasslands from emergent marsh and wet meadow in September. The median normalized difference water index(NDWI) of emergent marsh remained more stable than that of wet meadow and grasslands during the period from September until July of the following year. The index of mean density in wet meadow zones was higher than the emergent and upland zones. Over twice the number of species occurred in the wet meadow zone compared with the emergent zone, and close to the value of upland zone. Alpine wetlands in the three reserves in 2014 covered 1175.19 km2 with a classification accuracy of 75.6%. The combination of ecological methods and remote sensing technology will play an important role in wetland delineation at medium and small scales. The correct differentiation between wet meadow and grasslands is the key to improving the accuracy of future wetland delineation. | ZHENG Yaomin NIU Zhenguo GONG Peng LI Mengna HU Lile WANG Lei YANG Yuxiang GU Hai-jun MU Jinrong DOU Gejia XUE Hui WANG Lin LI Hua DOU Gejie DANG Zhicairang | 2017 | Chinese Geographical Science2017，27，5： | 2 |
| 17 | A modified laser-induced choroidal neovascularization animal model with intravitreal oxidized low-density lipoprotein显示文摘AIM: To investigate whether intravitreal injection of oxidized low-density lipoprotein(OxLDL) can promote laserinduced choroidal neovascularization(CNV) formation in mice and the mechanism involved, thereby to develop a better animal model.METHODS: C57BL6/J mice were randomized into three groups. Immediately after CNV induction with 532 nm laser photocoagulation, 1.0 μL of OxLDL [100 μg/m L in phosphate-buffered saline(PBS)] was intravitreally injected, whereas PBS and the same volume low-density lipoprotein(LDL;100 μg/m L in PBS) were injected into the vitreous as controls. Angiogenic and inflammatory cytokines were measured by quantitative real-time polymerase chain reaction(q RT-PCR) and Western blotting(WB) after 5 d, and CNV severity was analyzed by choroid flat mount and immunofluorescence staining after 1wk. In vitro, retinal pigment epithelial(RPE) cell line(ARPE19) were treated with OxLDL(LDL as control) for 8 h. Angiogenic and inflammatory cytokine levels were measured. A specific inhibitor of lectin-like oxidized low-density lipoprotein receptor 1(LOX1) was used to evaluate the role of LOX1 in this process.RESULTS: At 7 d after intravitreal injection of 1 μL(100 μg/mL) OxLDL, T15-labeled OxLDL was mainly deposited around the CNV area, and the F4/80-labeled macrophages, the CD31-labeled vascular endothelial cells number and CNV area were increased. Meanwhile, WB and qR T-PCR results showed that vascular endothelial growth factor(VEGF), CC chemokine receptor 2(CCR2), interleukin-6(IL-6), IL-1β, and matrix metalloproteinase 9(MMP9) expressions were increased, which was supported by in vitro experiments in RPE cells. LOX1 inhibitors significantly reduced expressions of inflammatory factors IL-1β and VEGF. CONCLUSION: A modified laser-induced CNV animal model is established with intravitreal injection of 1 μL(100 μg/mL) of OxLDL at 7 d, which at least partially through LOX1. This animal model can be used as a simple model for studying the role of OxLDL in age-related macular degeneration. | Tong Wu Kuan-Rong Dang Ya-Fen Wang Bao-Zhen Lyu Wen-Qin Xu Guo-Rui Dou Jian Zhou Yan-Nian Hui Hong-Jun Du | 2020 | International Journal of Ophthalmology(English edition)2020，13，8： | 2 |
| 18 | Management Algorithm for Prevention of Mother-to-child Transmission of Hepatitis B Virus(2022)显示文摘The World Health Organization(WHO)has set the goal of eliminating hepatitis as a threat to public health by 2030.Blocking mother-to-child transmission(MTCT)of hepatitis B virus(HBV)is not only the key to eliminating viral hepatitis,but also a hot issue in the field of hepatitis B prevention and treatment.To standardize the clinical management of preventing MTCT of HBV and achieve zero HBV infection among infants,the Chinese Foundation for Hepatitis Prevention and Control organized experts to compile a management algorithm for prevention of MTCT of HBV based on the latest research progress and guidelines,including 10 steps of pregnancy management and postpartum follow-up,among which screening,antiviral treatment,and infant immunization are its core components. | Zhihua Liu Zhongdan Chen Fuqiang Cui Yang Ding Yunfei Gao Guorong Han Jidong Jia Jie Li Zengde Li Yingxia Liu Qing Mao Ailing Wang Wei Wang Lai Wei Jianhong Xia Qing Xie Xizhong Yang Xueru Yin Hua Zhang Liaoyun Zhang Wenhong Zhang Hui Zhuang Xiaoguang Dou Jinlin Hou | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 2 |
| 19 | Thinking on Functional Mechanism of Acupuncture for Inflammatory Bowel Diseases Based on Metabolomics显示文摘Acupuncture has a good therapeutic effect in treatment of inflammatory bowel diseases(IBD), but its functional mechanism has not been systematically explained. Metabolomics is the scientific study of dynamic chemical processes involving metabolites as well as metabolic response of living organisms. Metabolomics, a research method with integrity and dynamics, corresponds to the overall regulatory effect of acupuncture and is in line with the overall concept of traditional Chinese medicine(TCM) and the concept of homeostasis. In the recent years, metabolomics has been extensively applied to the clinical and experimental study of IBD, and its potential applied value has been unanimously acknowledged by the researchers. In this article, the application status of metabolomics in acupuncture is summarized, and the research ideas to study the mechanism of acupuncture in the regulation and control of IBD by metabolomics are preliminarily explored. | Dou Chuan-zi Feng Hui Zheng Xiao Liu Xiao-xu Zhu Xi-fa Liu Shi-min Wu Lu-yi Yang Ling Lu Yuan Zhang Wei-wei Liu Hui-rong Huang Guo-qi | 2014 | Journal of Acupuncture and Tuina Science2014，12，2： | 2 |
| 20 | CUL4B facilitates HBV replication by promoting HBx stabilization显示文摘Objective:Hepatitis B virus(HBV)infection is a major public health problem worldwide.However,the regulatory mechanisms underlying HBV replication remain unclear.Cullin 4 B-RING ubiquitin E3 ligase(CRL4 B)is involved in regulating diverse physiological and pathophysiological processes.In our study,we aimed to explain the role of CUL4 B in HBV infection.Methods:Cul4 b transgenic mice or conditional knockout mice,as well as liver cell lines with CUL4 B overexpression or knockdown,were used to assess the role of CUL4 B in HBV replication.Immunoprecipitation assays and immunofluorescence staining were performed to study the interaction between CUL4 B and HBx.Cycloheximide chase assays and in vivo ubiquitination assays were performed to evaluate the half-life and the ubiquitination status of HBx.Results:The hydrodynamics-based hepatitis B model in Cul4 b transgenic or conditional knockout mice indicated that CUL4 B promoted HBV replication(P<0.05).Moreover,the overexpression or knockdown system in human liver cell lines validated that CUL4 B increased HBV replication in an HBx-dependent manner.Importantly,immunoprecipitation assays and immunofluorescence staining showed an interaction between CUL4 B and HBx.Furthermore,CUL4 B upregulated HBx protein levels by inhibiting HBx ubiquitination and proteasomal degradation(P<0.05).Finally,a positive correlation between CUL4 B expression and HBV pg RNA level was observed in liver tissues from HBV-positive patients and HBV transgenic mice.Conclusions:CUL4 B enhances HBV replication by interacting with HBx and disrupting its ubiquitin-dependent proteasomal degradation.CUL4 B may therefore be a potential target for anti-HBV therapy. | Haixia Shan Bo Wang Xiaodong Zhang Hui Song Xi Li Yongxin Zou Baichun Jiang Huili Hu Hao Dou Changshun Shao Lifen Gao Chunhong Ma Xiaoyun Yang Xiaohong Liang Yaoqin Gong | 2022 | Cancer Biology & Medicine2022，19，1： | 2 |
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