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| 1 | Factors related to quality of life in patients with cirrhosis and ascites: Relevance of serum sodium concentration and leg edema显示文摘 | Elsa Solà Hugh Watson Isabel Graupera Fanny Turón Rogelio Barreto Ezequiel Rodríguez Marco Pavesi Vicente Arroyo Mónica Guevara Pere Ginès | 2012 | Journal of Hepatology2012，，6： | 3 |
| 2 | Thioredoxin reductase-1knock down does not result in thioredoxin-1oxidation显示文摘 | Watson WH Heilman JM Hughes LL | 2008 | Biochem Biophys Res Commun2008，368，3： | 1 |
| 3 | Present and Future Directions in Data Warehousing 显示文摘 | Hugh J Watson | 1998 | The Database for Advanced in Information System1998，29，： | 1 |
| 4 | Effects and safety of natriuretic peptides as treatment of cirrhotic ascites:A systematic review and meta-analysis显示文摘BACKGROUND Natriuretic peptides are involved in the cascade of pathophysiological events occurring in liver cirrhosis,counterbalancing vasoconstriction and anti-natriuretic factors.The effects of natriuretic peptides as treatment of cirrhotic ascites have been investigated only in small studies,and definitive results are lacking.AIM To examine the effects and safety of natriuretic peptides in cirrhosis patients with ascites.METHODS We searched MEDLINE,Web of Science,Scopus,Cochrane Library and Embase for all available studies applying intravenous administration of any natriuretic peptide to patients suffering from cirrhotic ascites.Inclusion was not limited by treatment duration or dose,or by follow-up duration.Both randomised controlled trials and non-randomised studies were eligible for inclusion.The primary outcome was change in renal sodium excretion.Secondary outcomes included safety measures and changes in renal water excretion,plasma aldosterone concentration,and plasma renin activity.RESULTS Twenty-two studies were included.Atrial natriuretic peptide(ANP)was the only intensively studied treatment.Sodium excretion increased in response to continuous ANP infusion and was more pronounced when infusion rates of>30 ng/kg/min were administered compared with≤30 ng/kg/min(P<0.01).Moreover,natriuresis was significantly higher in study subgroups with mild/moderate ascites compared with moderate/severe and refractory ascites(P<0.01).ANP infusions increased renal water excretion,although without reaching a statistically significant dose-response gradient.Plasma aldosterone concentration and plasma renin activity were significantly lower at baseline in study subgroups achieving a negative sodium balance in response to an ANP administration compared with treatment non-responders(P<0.01).Blood pressure decreases occurred less frequently when ANP doses≤30 ng/kg/min were applied.The quality of evidence for a natriuretic response to ANP was low,mainly due to small sample sizes and considerable between-study heterogeneity.Data were sparse for the other natriuretic peptides;B-type natriuretic peptide and urodilatin.CONCLUSION Intravenous ANP infusions increase sodium excretion in patients with cirrhotic ascites.Continuous infusion rates>30 ng/kg/min are the most effective.However,safety increases with infusion rates≤30 ng/kg/min. | Rasmus Hvidbjerg Gantzel Mikkel Breinholt Kjær Peter Jepsen Niels Kristian Aagaard Hugh Watson Lise Lotte Gluud Henning Grønbæk | 2022 | World Journal of Hepatology2022，14，4： | 1 |
| 5 | Randomized trial of tacrolimus versus cyclosporin microemulsion in renal transplantation显示文摘 | Trompeter R Filler G Webb NJ Watson AR Milford DV Tyden G Grenda R Janda J Hughes D Ehrich JH Klare B Zacchello G Bjorn Brekke I McGraw M Perner F Ghio L Balzar E Friman S Gusmano R Stolpe J | 2002 | Pediatr Nephrol2002，17，3： | 1 |
| 6 | An empirical investigation of the factors affecting data warehousing success 显示文摘 | WIXOM BARBARA H WATSON HUGH J | 2001 | MIS Quarterly2001，25，1： | 1 |
| 7 | Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during ear/y placental develop- ment显示文摘 | WATSON E D HUGHES M SIMMONS D G | 2011 | DevDyn2011，240，11： | 1 |
| 8 | Apoptosis and Glomerulonephritis显示文摘 | Watson S Cailhier J F Hughes J | | 0，，： | 1 |
| 9 | Measurement of twitch transdiaphragmatic, esophageal, and endotracheal tube pressure with bilateral anterolateral magnetic phrenic nerve stimulation in patients in the intensive care unit 显示文摘 | Watson AC Hughes PD Louise Harris M | 2001 | Crit Care Med2001，29，7： | 1 |
| 10 | Parenting practices are associated with fruit and vegetable consumption in preschool children 显示文摘 | O' CONNOR TM HUGHES SO WATSON KB | 2010 | Public Health Nutr2010，13，1： | 1 |
| 11 | Effects of a selective vasopressin V 2 receptor antagonist, satavaptan, on ascites recurrence after paracentesis in patients with cirrhosis显示文摘 | Florence Wong Pere Gines Hugh Watson Yves Horsmans Paolo Angeli Paul Gow Pascal Minini Mauro Bernardi | 2010 | Journal of Hepatology2010，，2： | 1 |
| 12 | Factors relat- ed to quality of life in patients with cirrhosis and ascites : Relevance of ser- um sodium concentration and leg edema 显示文摘 | Elsa Sola Hugh Watson Isabel Graupera | 2012 | Journal of Hepatology2012，57，6： | 1 |
| 13 | Effects of a selective vasopressin V 2 receptor antagonist, satavaptan, on ascites recurrence after paracentesis in patients with cirrhosis显示文摘 | Florence Wong Pere Gines Hugh Watson Yves Horsmans Paolo Angeli Paul Gow Pascal Minini Mauro Bernardi | 2010 | Journal of Hepatology2010，，2： | 1 |
| 14 | Apoptosis and glomerulonephritis显示文摘 | Watson S Cailhier JF Hughes J | 2006 | Curr Dir Autoimmun2006，9，： | 1 |
| 15 | Apoptosis and Glomerulonephritis 显示文摘 | Watson S Cailhier JF Hughes J | 2006 | Curr Dir Autoimmun2006，9，： | 1 |
| 16 | Health professionals' and dietetics practitioners' perceived effectiveness of fruit and vegetable parenting practices across six countries 显示文摘 | O'Connor T Watson K Hughes S | 2010 | J Am Diet Assoc2010，110，7： | 1 |
| 17 | The phototropin family of photoreceptors显示文摘 | Briggs W R Beck C F Cashmore A R Christie J M Hughes J Jarillo J A Kagawa T Kanegae H Liscum E Nagatani A Okada K Salomon M Rüdiger W Sakai T Takano M Wada M Watson J C | 2001 | Plant Cell2001，13，： | 1 |
| 18 | Current Practices in Data Warehousing显示文摘 | HUGH J WATSON D A ANNINO | 2001 | Information Systems Management2001，18，1： | 1 |
| 19 | Esophageal adenocarcinoma cells do not traffic Fas ligand to the cell surface: Evidence against the 'Counterattack' hypothesis 显示文摘 | Watson GA Queiroz de Oliveira P Hughes SJ | 2004 | Surg Res2004，121，2： | 1 |
| 20 | An empirical investigation of the factors affecting data ware-housing显示文摘 | Barbara H Wixom Hugh J Watson | | 0，，01： | 1 |
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