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| 1 | Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/ eIF2a/ATF4/CHOP Signaling Pathway显示文摘Apoptosis induced by endoplasmic reticulum(ER)stress plays a crucial role in mediating brain damage after ischemic stroke.Recently,Hes1(hairy and enhancer of split 1)has been implicated in the regulation of ER stress,but whether it plays a functional role after ischemic stroke and the underlying mechanism remain unclear.In this study,using a mouse model of ischemic stroke via transient middle cerebral artery occlusion(tMCAO),we found that Hes1 was induced following brain injury,and that siRNA-mediated knockdown of Hes1 increased the cerebral infarction and worsened the neurological outcome,suggesting that Hes1 knockdown exacerbates ischemic stroke.In addition,mechanistically,Hes1 knockdown promoted apoptosis and activated the PERK/eIF2a/ATF4/CHOP signaling pathway after tMCAO.These results suggest that Hes1 knockdown promotes ER stress-induced apoptosis.Furthermore,inhibition of PERK with the specific inhibitor GSK2606414 markedly attenuated the Hes1 knockdown-induced apoptosis and the increased cerebral infarction as well as the worsened neurological outcome following tMCAO,implying that the protection of Hes1 against ischemic stroke is associated with the amelioration of ER stress via modulating the PERK/eIF2a/ATF4/CHOP signaling pathway.Taken together,these results unveil the detrimental role of Hes1 knockdown after ischemic stroke and further relate it to the regulation of ER stress-induced apoptosis,thus highlighting the importance of targeting ER stress in the treatment of ischemic stroke. | Yueyong Li Yingjun Zhang Huangde Fu Huadong Huang Qifeng Lu Houji Qin Yingning Wu Huatuo Huang Guizhen Mao Zhongheng Wei Pinhu Liao | 2020 | Neuroscience Bulletin2020，36，2： | 12 |
| 2 | A property-oriented design strategy for high performance copper alloys via machine learning显示文摘Traditional strategies for designing new materials with targeted property including methods such as trial and error,and experiences of domain experts,are time and cost consuming.In the present study,we propose a machine learning design system involving three features of machine learning modeling,compositional design and property prediction,which can accelerate the discovery of new materials.We demonstrate better efficiency of on a rapid compositional design of high-performance copper alloys with a targeted ultimate tensile strength of 600–950 MPa and an electrical conductivity of 50.0%international annealed copper standard.There exists a good consistency between the predicted and measured values for three alloys from literatures and two newly made alloys with designed compositions.Our results provide a new recipe to realize the property-oriented compositional design for highperformance complex alloys via machine learning. | Changsheng Wang Huadong Fu Lei Jiang Dezhen Xue Jianxin Xie | 2019 | npj Computational Materials2019，，1： | 12 |
| 3 | Conceptual study of lunar-based SAR for global change monitoring显示文摘As an active microwave remote sensing imaging sensor, Synthetic Aperture Radar(SAR) plays an important role in earth observation. Here we establish a SAR system based on the platform of the moon. This will aid large-scale, constant, and long-term dynamic Earth observations to better meet the needs of global change research and to complement the space borne and airborne earth observations. Lunar-based SAR systems have the characteristics of high resolution and wide swath width. The swath width could be thousands of kilometers in the stripe mode and it could cover 40% of earth's surface with 10 meters or even higher spatial resolution in the scanning mode. Using the simplified observation model, here we quantitatively analyze the spatial resolution and coverage area of lunar-based SAR and simulate the observation on the Qinghai-Tibet plateau and the Amazon plain. The results show that this system could provide near 100% daily coverage of the Qinghai-Tibet plateau, whereas 40% to 70% daily coverage of the Amazon plain. Lunar-based SAR could provide large-scale, long-term and stable time series data in order to support future research of global change. | GUO HuaDong DING YiXing LIU Guang ZHANG DaoWei FU WenXue ZHANG Lu | 2014 | Science China Earth Sciences2014，57，8： | 8 |
| 4 | Growth, photosynthesis and podophyllotoxin accumulation of Dysosma versipellis in response to a light gradient and conservation implications显示文摘Dysosma versipellis (Hance) M. Cheng ex Ying (Berberidaceae) is a rare and vulnerable, perennial herb endemic to China with pharmaceutical significance. Increasing habitat loss and over-exploitation of the plant has severely affected the plant's in situ conservation, necessitating ex situ conservation and commercial cultivation. The light regime is a critical environmental factor contributing to successful ex situ conservation via efficient production of biomass and secondary metabolites. We investigated the responses of 2-year-old D. versipellis plants to a light gradient in terms of leaf morphology, growth, biomass production, photo- synthesis and podophyllotoxin (PTOX) accumulation. D. versipellis responded to the light gradient in terms of plant height, leaf size, leaf photosynthesis and PTOX accumulation. Plants demonstrated optimal vegetative growth, photosynthetic capability, and PTOX production, under a light intensity equal to 30% full sunlight. Half full sunlight led to the lowest production of PTOX despite having no obviously different effects on growth. Full sunlight was able to cause leaf death in mid-summer (July), although these plantlets did not significantly differ in growth or biomass production before July and new leaves emerged in August. D. versipellis is therefore proposed to be a shade-tolerant plant, well adapted to variations in irradiance. Irradiance of 10%-50%, particularly ca. 30% full sunlight is strongly recommended for ex situ conservation and commercial cultivation. | ZHAO YunPeng GONG HuaDong LU WeiQiang JIANG WeiMei ZHOU XiaoLong FU ChengXin | 2011 | Chinese Science Bulletin2011，56，24： | 6 |
| 5 | Allocation Methodology of Multiple SVCs Considering Operation Scheme Changing显示文摘针对多静止同步补偿器(staticvarcompensator,SVC)对系统共同影响的问题,提出计及运行方式变化的多SVC布点方法。利用规范形分析,基于摄动方程2阶解析解信息建立拓展静态电压稳定边界的多SVC布点分析方法。首先根据静态电压稳定分析方法,确定系统危险运行方式(即距离系统电压崩溃最近的运行方式1;然后在该运行方式下,利用规范形方法对系统进行小扰动电压稳定分析,求出所有负荷节点的电压振荡曲线解析解;最后利用2阶解析解所给出的小扰动1阶振荡幅值和2阶振荡幅值信息,以多SVC布点多种方案对系统降低小扰动幅值的贡献为指标,给出多SVC布点结果。所提方法应用于IEEE30节点系统,试验结果表明,该方法相对于不考虑多点共同影响的多SVC布点方式,其静态电压稳定边界的拓展效果更好。 | XIONG Haoqing TANG Yong ZHANG Xiaohua MENG Yuanjing LIU Yuexin FU Hongjun SUN Huadong YI Jun XIONG Chuanping | 2012 | 中国电机工程学报2012，32，13： | 6 |
| 6 | Research on global change scientific satellites显示文摘Global change now poses a severe threat to the survival and development of mankind.Large-scale,real-time,highly accurate Earth observation from space has become a key technology used to observe global change.China is one of the most influential countries affecting and being affected by global change,yet it has no scientific satellite for global change research so far.Developing global change scientific satellites not only would meet an important demand of China,but also would be a valuable contribution to the world.By analyzing the mechanisms of space-based observation of variables sensitive to global change,this paper explores the concept of global change scientific satellites,and proposes a series of global change scientific satellites to establish a scientific observation system for global environmental change monitoring from space. | GUO HuaDong FU WenXue LI XinWu CHEN Pei LIU Guang LI Zhen WANG Cheng DONG Qing LEI LiPing BAI LinYan LIU QingJie | 2014 | Science China Earth Sciences2014，57，2： | 5 |
| 7 | Polymorphism of human cytomegalovirus(HCMV) UL144 gene in low passage clinical isolates显示文摘To explore the impact of gene polymorphism of human cytomegalovirus(HCMV)on virus virulence,the full-length UL144 gene and partial sequence of glycoprotein B(UL55)gene were sequenced and analyzed for 23clinical strains of HCMV isolated from urine samples of pediatric patients with congenital or postnatal HCMV infection.Among the 23 isolates,13(57%)were UL144genotype 1A,3(13%)were UL144 genotypes 2 and 7(30%)were UL144 genotype 3;geographic differences in genotype distribution were found for both UL144 and gB gene.No UL144 genotypes 1B and 1C were found in this study while these two genotypes were common in HCMV strains isolated in the US.Our results also demonstrated that for all clinical strains of gB genotypes I,III and UL144genotypes 1A,2,and 3 found in this study,mother-to-fetus vertical transmission was possible. | Xingxing Fu Liping Li Chaoyang Huang Xiaoman Li Huadong Wang Zhenyuan Xie Ze Chen | 2014 | Chinese Science Bulletin2014，59，25： | 3 |
| 8 | Progress on CASEarth Satellite Development显示文摘CASEarth satellite is the first space Earth science satellite produced by the Chinese Academy of Sciences.The satellite has three payloads:high-definition Thermal Infrared Spectrometer(TIS),highdefinition Glimmer Imager for Urbanization(GIU),and high-definition Multispectral Imager for Inshore(MII).These payloads are used to explore the urbanization level and residential layout,the coastal ecosystem,and new methods and approaches of environmental detection during night-time and even under conditions of polar aurora and provide scientific evidence for the refined depiction of human traces.The CASEarth satellite can provide space observation data for A Project on Big Earth Data Science Engineering as well as scientific and application studies inside and outside China. | GUO Huadong CHEN Hongyu CHEN Liangfu FU Bihong | 2020 | 空间科学学报2020，40，5： | 3 |
| 9 | An in planta haploid induction system in Brassica napus显示文摘Doubled haploid technology is widely used to accelerate plant breeding,but its use in the important oilseed crop Brassica napus L.is limited because B.napus haploids could only be obtained through in vitro anther or microspore cultures.Recently,maize(Zea mays)lines containing mutations in Domain of unknown function 679 membrane protein(DMP)were used as haploid inducer lines.This new haploid induction mechanism has been extended to several other plants,including the dicots Arabidopsis thaliana,tomato(Solanum lycopersicum),and tobacco(Nicotiana tabacum).Here,we knocked out four BnaDMP genes in the B.napus cultivar Westar using a clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9 vector with an enhanced green fluorescent protein expression cassette.Plants with DMP mutations in B.napus in the T_(0),T_(1),and T_(2) generations exhibited a haploid induction rate up to 2.53%.These results suggest that targeting BnaDMP could be useful for haploid induction in B.napus. | Yifan Li Dan Li Qing Xiao Huadong Wang Jing Wen Jinxing Tu Jinxiong Shen Tingdong Fu Bin Yi | 2022 | Journal of Integrative Plant Biology2022，64，6： | 2 |
| 10 | A Real-Time Multi-Vehicle Tracking Framework in Intelligent Vehicular Networks显示文摘In this paper,we provide a new approach for intelligent traffic transportation in the intelligent vehicular networks,which aims at collecting the vehicles’locations,trajectories and other key driving parameters for the time-critical autonomous driving’s requirement.The key of our method is a multi-vehicle tracking framework in the traffic monitoring scenario..Our proposed framework is composed of three modules:multi-vehicle detection,multi-vehicle association and miss-detected vehicle tracking.For the first module,we integrate self-attention mechanism into detector of using key point estimation for better detection effect.For the second module,we apply the multi-dimensional information for robustness promotion,including vehicle re-identification(Re-ID)features,historical trajectory information,and spatial position information For the third module,we re-track the miss-detected vehicles with occlusions in the first detection module.Besides,we utilize the asymmetric convolution and depth-wise separable convolution to reduce the model’s parameters for speed-up.Extensive experimental results show the effectiveness of our proposed multi-vehicle tracking framework. | Huiyuan Fu Jun Guan Feng Jing Chuanming Wang Huadong Ma | 2021 | China Communications2021，18，6： | 1 |
| 11 | Rapid design of secondary deformation-aging parameters for ultra-low Co content Cu-Ni-Co-Si-X alloy via Bayesian optimization machine learning显示文摘It is difficult to rapidly design the process parameters of copper alloys by using the traditional trial-and-error method and simultaneously improve the conflicting mechanical and electrical properties.The purpose of this work is to develop a new type of Cu-Ni-Co-Si alloy saving scarce and expensive Co element,in which the Co content is less than half of the lower limit in ASTM standard C70350 alloy,while the properties are as the same level as C70350 alloy.Here we adopted a strategy combining Bayesian optimization machine learning and experimental iteration and quickly designed the secondary deformation-aging parameters(cold rolling deformation 90%,aging temperature 450℃,and aging time 1.25 h)of the new copper alloy with only 32 experiments(27 basic sample data acquisition experiments and 5 iteration experiments),which broke through the barrier of low efficiency and high cost of trial-and-error design of deformation-aging parameters in precipitation strengthened copper alloy.The experimental hardness,tensile strength,and electrical conductivity of the new copper alloy are HV(285±4),(872±3)MPa,and(44.2±0.7)%IACS(international annealed copper standard),reaching the property level of the commercial lead frame C70350 alloy.This work provides a new idea for the rapid design of material process parameters and the simultaneous improvement of mechanical and electrical properties. | Hongtao Zhang Huadong Fu Yuheng Shen Jianxin Xie | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，6： | 1 |
| 12 | Recent progress in the machine learning-assisted rational design of alloys显示文摘Alloys designed with the traditional trial and error method have encountered several problems,such as long trial cycles and high costs.The rapid development of big data and artificial intelligence provides a new path for the efficient development of metallic materials,that is,machine learning-assisted design.In this paper,the basic strategy for the machine learning-assisted rational design of alloys was introduced.Research progress in the property-oriented reversal design of alloy composition,the screening design of alloy composition based on models established using element physical and chemical features or microstructure factors,and the optimal design of alloy composition and process parameters based on iterative feedback optimization was reviewed.Results showed the great advantages of machine learning,including high efficiency and low cost.Future development trends for the machine learning-assisted rational design of alloys were also discussed.Interpretable modeling,integrated modeling,high-throughput combination,multi-objective optimization,and innovative platform building were suggested as fields of great interest. | Huadong Fu Hongtao Zhang Changsheng Wang Wei Yong Jianxin Xie | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，4： | 1 |
| 13 | Co-guiding the dendrite-free plating of lithium on lithiophilic ZnO and fluoride modified 3D porous copper for stable Li metal anode显示文摘Lithium metal battery is considered to be the most promising energy storage technologies due to its ultra-high theoretical capacity and extremely low standard potential.However,the infinite volume change during uneven deposition/dissolution process and the growth of lithium dendrite resulting in severe capacity decay and high safety hazards,which hinders the application in next generation secondary batteries.In this paper,the three dimensional(3D)porous copper is prepared through an electrochemical etching CueZn alloy,and the pore walls are modified with lithiophilic layer of ZnO and fluorine.The as-prepared 3D Cu/ZnO/F can inhibit the growth of Li dendrite and mitigate the huge volume change of Li metal anode during cycling process,resulting in stable solid electrolyte interface(SEI)layer and electrode structure.The Li|3D Cu/ZnO/F cell can be stably cycled over 300 cycles with 98% of coulomb efficiency at 0.5 mA cm^(-2),1 mAh cm^(-2).The synergistic effects of both ZnO and fluorine on inducing the uniform deposition of lithium by providing bonding sites can inhibit the generation of lithium dendrites and thus improve the electrochemical performance of lithium metal batteries. | Xinshuang Chang Hang Liu Hang Yang Jie Di Wenhao Tang Huadong Fu Mingyang Li Ruiping Liu | 2020 | Journal of Materiomics2020，6，1： | 1 |
| 14 | Research on SAR data integrated processing methodology oriented on earth environment factor inversions显示文摘As an important advanced technique in the field of Earth observations,Synthetic Aperture Radar(SAR)plays a key role in the study of global environmental change,resources exploration,disaster mitigation,urban environments,and even lunar exploration.However,studies on imaging,image processing,and Earth factor inversions have often been conducted independently for a long time,which significantly limits the application effectiveness of SAR remote sensing due to the lack of an overall integrated design scheme and integrated information processing.Focusing on this SAR application issue,this paper proposes and describes a new SAR data processing methodology–SAR data integrated processing(DIP)oriented on Earth environment factor inversions.The simple definition,typical integrated modes and overall implementation ideas are introduced.Finally,focusing on building information extraction(man-made targets)and sea ice classification(natural targets)applications,three SAR DIP methods and experiments are conducted.Improved results are obtained under the guidance of the SAR DIP framework.Therefore,the SAR DIP theoretical framework and methodology represent a new SAR science application mode that has the capability to improve the SAR remote sensing quantitative application level and promote the development of new theories and methodologies. | Huadong Guo Jie Chen Xinwu Li Lu Zhang Wenjin Wu Huiying Liu Kai Wang Zhuo Li Xinwei Gu Qingrong Hu Xinmin Wang Jun Li Chunming Han Junjie Zhu Guozhuang Shen Guang Liu Wenxue Fu Zhongchang Sun Xiaoyang Wen | 2017 | International Journal of Digital Earth2017，10，7： | 0 |
| 15 | Specific-Scene Oriented Pedestrian Detection in Visual Sensor Network显示文摘Pedestrian detection is one of the most important problems in the visual sensor network. Considering that the visual sensors have limited cap ability, we propose a pedestrian detection method with low energy consumption. Our method contains two parts: one is an Enhanced Self-Organizing Background Subtraction (ESOBS) based foreground segmentation module to obtain active areas in the observed region from the visual sensors; the other is an appearance model based detection module to detect the pedestrians from the foreground areas. Moreover, we create our own large pedestrian dataset according to the specific scene in the visual sensor network. Numerous experiments are conducted in both indoor and outdoor specific scenes. The experimental results show that our method is effective. | Fu Huiyuan Ma Huadong Liu Liang | 2012 | China Communications2012，9，6： | 0 |
| 16 | From concept to action: a united, holistic and One Health approach to respond to the climate change crisis显示文摘It is unequivocal that human influence has warmed the planet,which is seriously affecting the planetary health including human health.Adapting climate change should not only be a slogan,but requires a united,holistic action and a paradigm shift from crisis response to an ambitious and integrated approach immediately.Recognizing the urgent needs to tackle the risk connection between climate change and One Health,the four key messages and recommendations that with the intent to guide further research and to promote international cooperation to achieve a more climate-resilient world are provided. | Renhe Zhang Xu Tang Jian Liu Martin Visbeck Huadong Guo Virginia Murray Catherine Mcgillycuddy Bing Ke Gretchen Kalonji Panmao Zhai Xiaoming Shi Jiahai Lu Xiaonong Zhou Haidong Kan Qunli Han Qian Ye Yong Luo Jianmin Chen Wenjia Cai Huiling Ouyang Riyanti Djalante Alexander Baklanov Lu Ren Guy Brasseur George Fu Gao Lei Zhou | 2022 | Infectious Diseases of Poverty2022，11，1： | 0 |
| 17 | Space technology:A powerful tool for safeguarding world heritage显示文摘WORLD HERITAGE AND SPACE TECHNOLOGY The Convention Concerning the Protection of the World Cultural and Natural Heritage(WHC),adopted by United Nations Educational,Scientific and Cultural Organization(UNESCO)on November 16,1972,aims to ensure the identification,protection,conservation,presentation,and transmission to future generations of the world’s cultural and natural heritage.The WHC works toward these goals by emphasizing the Outstanding Universal Value(OUV)of heritage sites and the unique contribution such places can make to conservation and human development agendas.1 As of the end of January 2023,theWHC has been signed by 194 state parties,covering 1,157 sites(including 900 cultural,218 natural,and 39 mixed properties),55 of which are considered to be in danger.These sites,totaling an area of more than 370 million hectares are designated as World Heritage(WH)sites(http://gffzzc5812fc6c44c4da6scuk596uk09uq69wo.ffgz.tsg.suse.edu.cn/en/list/).WH sites have played a significant role in the sustainable development of society globally and helped effectively maintain and preserve the cultural diversity and global biodiversity of the Earth. | Lei Luo Jie Liu Francesca Cigna Damian Evans Mario Hernandez Deodato Tapete Peter Shadie Athos Agapiou Abdelaziz Elfadaly Min Chen Lanwei Zhu Bihong Fu Ruixia Yang Shahina Tariq Mohamed Ouessar Rosa Lasaponara Xinyuan Wang Huadong Guo | 2023 | The Innovation2023，4，3： | 0 |
| 18 | Microstructure and properties evolution of in-situ fiber-reinforced Ag-Cu-Ni-Ce alloy during deformation and heat treatment显示文摘Silver-based alloys are significant light-load electrical contact materials(ECMs).The trade-off between mechanical properties and electrical conductivity is always an important issue for the development of silver-based ECMs.In this paper,we proposed an idea for the regulation of the mechanical properties and the electrical conductivity of Ag-11.40Cu-0.66Ni-0.05Ce(wt%)alloy using in-situ composite fiber-reinforcement.The alloy was processed using rolling,heat treatment,and heavy drawing,the strength and electrical conductivity were tested at different deformation stages,and the microstructures during deformation were observed using field emission scanning electron microscope(FESEM),transmission electron microscope(TEM)and electron backscatter diffraction(EBSD).The results show that the method proposed in this paper can achieve the preparation of in-situ composite fiber-reinforced Ag-Cu-Ni-Ce alloys.After the heavy deformation drawing,the room temperature Vickers hardness of the as-cast alloy increased from HV 81.6 to HV 169.3,and the electrical conductivity improved from 74.3%IACS(IACS,i.e.,international annealed copper standard)to 78.6%IACS.As the deformation increases,the alloy strength displays two different strengthening mechanisms,and the electrical conductivity has three stages of change.This research provides a new idea for the comprehensive performance control of high-performance silver-based ECMs. | Xingqun He Huadong Fu Jianxin Xie | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，11： | 0 |
| 19 | Comparison of immune responses and intestinal flora in epicutaneously sensitized BALB/c or C57BL/6 mouse models of food allergy显示文摘Cutaneous exposure to food allergens through a disrupted skin barrier is recognized as an important cause of food allergy,and the cutaneous sensitized mouse model has been established to investigate relevant allergic disorders.However,the role of different genetic backgrounds of mice on immune responses to food allergens upon epicutaneous sensitization is largely unknown.In this study,two strains of mice,i.e.,the BALB/c and C57BL/6 mice,were epicutaneously sensitized with ovalbumin on atopic dermatitis(AD)-like skin lesions,followed by intragastric challenge to induce IgE-mediated food allergy.Allergic outcomes were measured as clinical signs,specific antibodies and cytokines,and immune cell subpopulations,as well as changes in intestinal barrier function and gut microbiota.Results showed that both strains of mice exhibited typical food-allergic symptoms with a Th2-skewed response.The C57BL/6 mice,rather than the BALB/c mice,were fitter for establishing an epicutaneously sensitized model of food allergy since a stronger Th2-biased response and severer disruptions in the intestinal barrier and gut homeostasis were observed.This study provides knowledge for selecting an appropriate mouse model to study food-allergic responses associated with AD-like skin lesions and highlights the role of genetic variations in the immune mechanism underlying pathogenesis of food allergy. | Gang Yu Yuhao Jiang Shuifeng Zhang Pengpeng Liu Shunyu Wang Huadong Sheng Yanbo Wang Qiaozhi Zhang Linglin Fu | 2024 | Food Science and Human Wellness2024，13，2： | 0 |
| 20 | An end-to-end convolutional network for joint detecting and denoising adversarial perturbations in vehicle classification显示文摘Deep convolutional neural networks(DCNNs)have been widely deployed in real-world scenarios.However,DCNNs are easily tricked by adversarial examples,which present challenges for critical applications,such as vehicle classification.To address this problem,we propose a novel end-to-end convolutional network for joint detection and removal of adversarial perturbations by denoising(DDAP).It gets rid of adversarial perturbations using the DDAP denoiser based on adversarial examples discovered by the DDAP detector.The proposed method can be regarded as a pre-processing step—it does not require modifying the structure of the vehicle classification model and hardly affects the classification results on clean images.We consider four kinds of adversarial attack(FGSM,BIM,DeepFool,PGD)to verify DDAP’s capabilities when trained on BIT-Vehicle and other public datasets.It provides better defense than other state-of-the-art defensive methods. | Peng Liu Huiyuan Fu Huadong Ma | 2021 | Computational Visual Media2021，7，2： | 0 |
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