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| 1 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 2 | Orexin A attenuates the sleep-promoting effect of adenosine in the lateral hypothalamus of rats显示文摘Orexin neurons within the lateral hypothalamus play a crucial role in the promotion and maintenance of arousal. Studies have strongly suggested that orexin neurons are an important target in endogenous adenosine-regulated sleep homeostasis. Orexin A induces a robust increase in the firing activity of orexin neurons, while adenosine has an inhibitory effect. Whether the excitatory action of orexins in the lateral hypothalamus actually promotes wakefulness and reverses the sleep-producing effect of adenosine in vivo is less clear. In this study,electroencephalographic and electromyographic recordings were used to investigate the effects of orexin A and adenosine on sleep and wakefulness in rats. We found that microinjection of orexin A into the lateral hypothalamus increased wakefulness with a concomitant reduction of sleep during the first 3 h of post-injection recording, and this was completely blocked by a selective antagonist for orexin receptor 1,SB 334867. The enhancement of wakefulness also occurred after application of the excitatory neurotransmitter glutamate in the first 3 h post-injection. However, in the presence of the NMDA receptor antagonist APV, orexin A did not induce any change of sleep and wakefulness in the first 3 h.Further, exogenous application of adenosine into the lateral hypothalamus induced a marked increase of sleep in the first 3-h post-injection. No significant change in sleep and wakefulness was detected after adenosine application followed by orexin A administration into the same brain area. These findings suggest that the sleep-promoting action of adenosine can be reversed by orexin A applied to the 丨ate「a丨 hypothalamus, perhaps by exciting giutamatergic input to orexin neurons via the action0 f orexin receptor | Yanping Cun Lin Tang Jie Yan Chao He Yang Li Zhian Hu Jianxia Xia | 2014 | Neuroscience Bulletin2014，30，5： | 8 |
| 3 | Preliminary assessment of heavy metal contamination in surface water and sediments from Honghu Lake, East Central China显示文摘表面水和沉积里的重金属集中在湖北省从洪胡·莱克收集了,中国被分析,并且生态的风险根据沉积质量指南被评估。结果证明表面水里的重金属的平均集中是被评价:作为 > Zn > Cu > Cr > Pb > Ni > Cd > Hg。与在另外的河和背景价值里报导的结果比较,洪胡·莱克被弄脏由作为, Cr, Pb, Cu 和 Ni。大多数金属可能主要从在湖附近的化肥,工业自河和国内废水。重金属集中比在另外的区域在入口区域是相对更高的。当重要积极关联在 Zn, Cd 和 Pb 之间是在场的时,否定关联在很重的金属和 pH 之间被观察。在沉积核心,当时, Cu, Zn, Cr 和 Ni 显示出一个减少的趋势在场的 Cd 一个增加的趋势。减少作为,在由于在 1998 的洪水事件的 1990 年代力量的 Cu, Zn, Cr 和 Ni。生态的风险评价的分析基于沉积质量指南建议在从洪胡·莱克的大多数沉积的重金属有中等毒性,与 Cr being 最高的优先级污染物质[出版摘要] | Ying HU Shihua QI Chenxi WU Yanping KE Jing CHEN Wei CHEN Xiangyi GONG | 2012 | Frontiers of Earth Science2012，6，1： | 7 |
| 4 | Groundwater contributions in water-salt balances of the lakes in the Badain Jaran Desert,China显示文摘Groundwater-fed lakes are essential for the ecology in arid and semiarid regions.As a typical arid region,the Badain Jaran Desert (BJD) is famous in the world for the presence of a large number of groundwater-fed saline lakes among the mega dunes.Based on the up to date geological surveys and observations,this study analyzed the groundwater contributions in water-salt balances of the lakes in the desert.We found different types of springs,including the sublacustrine springs that indicate an upward flow of groundwater under the lakebed.A simplified water balance model was developed to analyze the seasonal variations of water level in the Sumu Barun Jaran Lake,which revealed an approximately steady groundwater discharge in the lake and explained why the amplitude of seasonal changes in lake level is less than 0.5 m.In addition,a salt balance model was developed to evaluate the salt accumulations in the groundwater-fed lakes.The relative salt accumulation time is 800–7,000 years in typical saline lakes,which were estimated from the concentration of Cl-,indicating a long history evolution for the lakes in the BJD.Further researches are recommended to provide comprehensive investigations on the interactions between the lakes and groundwater in the BJD. | GONG Yanping WANG Xusheng HU B Xiao ZHOU Yangxiao HAO Chunbo WAN Li | 2016 | Journal of Arid Land2016，8，5： | 7 |
| 5 | High spatial and temporal resolution synthetic aperture phase microscopy显示文摘A new optical microscopy technique,termed high spatial and temporal resolution synthetic aperture phase microscopy(HISTR-SAPM),is proposed to improve the lateral resolution of wide-field coherent imaging.Under plane wave illumination,the resolution is increased by twofold to around 260 nm,while achieving millisecond-level temporal resolution.In HISTR-SAPM,digital micromirror devices are used to actively change the sample illumination beam angle at high speed with high stability.An off-axis interferometer is used to measure the sample scattered complex fields,which are then processed to reconstruct high-resolution phase images.Using HISTR-SAPM,we are able to map the height profiles of subwavelength photonic structures and resolve the period structures that have 198 nm linewidth and 132 nm gap(i.e.,a full pitch of 330 nm).As the reconstruction averages out laser speckle noise while maintaining high temporal resolution,HISTR-SAPM further enables imaging and quantification of nanoscale dynamics of live cells,such as red blood cell membrane fluctuations and subcellular structure dynamics within nucleated cells.We envision that HISTR-SAPM will broadly benefit research in material science and biology. | Cheng Zheng Di Jin Yanping He Hongtao Lin Juejun Hu Zahid Yaqoo Peter T.C.So Renjie Zhou | 2020 | Advanced Photonics2020，2，6： | 5 |
| 6 | Characterization of the most abundant Lactobacillus species in chicken gastrointestinal tract and potential use as probiotics for genetic engineering显示文摘在不同的胃肠的道的 Lactobacilli 种类的计数和散开(官方补给) broilers 的区域被量的即时 polymerasechain 反应,和六 L 的 probiotic 特征调查。从 broiler 的官方补给的道孤立的 reuteri 种类也被调查为遗传工程获得潜在的目标。Lactobacilli 在盲肠在庄稼和最低庄稼有最高的差异。与更低的官方补给的道相比,更多的 Lactobacilli 在上面的官方补给的道被发现。乳杆菌 reuteri, L。johnsonii, L。acidophilus, L。crispatus, L。salivarius,和 L。aviarius 在整个鸡的官方补给的道是占优势的乳杆菌种类和礼品。乳杆菌 reuteri 是最丰富的乳杆菌种类。乳杆菌 reuteri XC1 有将是为遗传工程的一个潜在、理想的目标的好 probiotic 特征。 | Lei Wang Mingjian Fang Yanping Hu Yuxin Yang Mingming Yang Yulin Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 4 |
| 7 | PhaseⅡstudy of induction chemotherapy followed by concurrent chemoradiotherapy with raltitrexed and cisplatin in locally advanced nasopharyngeal carcinoma显示文摘Objective:For locally advanced nasopharyngeal carcinoma(LA-NPC)patients,high incidences of distant metastases and severe treatment related toxicities are the main obstacles needed to be overcome.Raltitrexed,a specific thymidylate synthase inhibitor with a convenient administration schedule,has an acceptable and manageable toxicity,and possesses radio-sensitizing properties.To investigate the efficacy and safety of raltitrexed and cisplatin induction chemotherapy and concurrent chemoradiotherapy(IC+CCRT)in patients with LA-NPC,a phaseⅡclinical study was conducted.Methods:Sixty eligible patients with LA-NPC were enrolled into this study.A raltitrexed-cisplatin combination was used as part of an IC+CCRT regimen.Raltitrexed-cisplatin IC was given once every 3 weeks(q3 w)for two cycles,followed by raltitrexed-cisplatin based CCRT q3 w for two cycles.Intensity-modulated radiotherapy(IMRT)was given for all enrolled patients.Results:All patients were included in survival analysis according to the intent-to-treat principle.The objective response rate(ORR)3 months after treatment was 98%.The 2-year overall survival(OS)rate was 92%.The median relapse-free survival(RFS)time was 30.5[95%confidence interval(95%CI),28.4-32.3]months.The 2-year RFS rate was 85%.The 2-year local failure-free survival(LFFS)rate was 97%and the 2-year distant metastasis-free survival(DMFS)rate was 88%.Acute toxicities were mostly grade 2 and 3 reactions in bone marrow suppression,gastrointestinal side effect and oropharyngeal mucositis.Only two patients occurred grade 4 acute toxicities,one was bone marrow suppression and the other was dermatitis radiation.Conclusions:The combination of raltitrexed and cisplatin has a comparable efficacy to those in standard firstline therapy. | Yuan Wu Xueyan Wei Zilong Yuan Hongbin Xu Yanping Li Ying Li Liu Hu Guang Han Yu Qian Desheng Hu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 4 |
| 8 | Synergistic engineering of CRISPR-Cas nucleases enables robust mammalian genome editing显示文摘The naturally occurring prokaryotic CRISPR-Cas systems provide valuable resources for the development of new genome-editing tools.However,the majority of prokaryotic Cas nucleases exhibit poor editing efficiency in mammalian cells,which significantly limits their utility.Here,we have developed a method termed Improving Editing Activity by Synergistic Engineering(MIDAS).This method exerts a synergistic effect to improve mammalian genome-editing efficiency of a wide range of CRISPR-Cas systems by enhancing the interactions of Cas nuclease with the protospacer adjacent motif(PAM)and the single-stranded DNA(ssDNA)substrate in the catalytic pocket simultaneously.MIDAS robustly and significantly increased the gene-editing efficiency of Cas12i,Cas12b,and CasX in human cells.Notably,a Cas12i variant,Cas12iMax,exhibited robust activity with a very broad PAM range(NTNN,NNTN,NAAN,and NCAN)and higher efficiency than the current widely used Cas nucleases.A high-fidelity version of Cas12iMax(Cas12iHiFi)has been further engineered to minimize off-target effects.Our work provides an expandable and efficacious method for engineering Cas nucleases for robust mammalian genome editing. | Yangcan Chen Yanping Hu Xinge Wang Shengqiu Luo Ning Yang Yi Chen Zhikun Li Qi Zhou Wei Li | 2022 | The Innovation2022，3，4： | 3 |
| 9 | THEORY AND APPLICATION OF πBRIDGE HYDRAULIC RESISTANCE NETWORKS显示文摘1INTRODUCTIONTherearetwokindsofhydraulicnetworks,i.e.4armsbridgehydraulicresistancenetworkandhalfbridgehydraulicresistancene... | Yanping, Hu Jianhua, Wei Yingfu, Guo Genmao, Wu Deshun, Liu | 1999 | 中国有色金属学会会刊:英文版1999，9，1： | 3 |
| 10 | Identification of ssDNA aptamers specific to clinical isolates of Streptococcus mutans strains with different cariogenicity显示文摘链球菌 mutans,一个克积极的容许的厌氧的细菌,被认为是为牙齿的龋的一个主要 etiological 因素。在 thisstudy,从龋活跃、没有龋的个人的牙齿的瓷釉表面的匾为 S 被获得并且栽培。mutans 隔离。形态学检查,生物化学的描述,和聚合酶链反应被执行到识别。mutans。S 的 cariogenicity。从临床的标本孤立的 mutans 种类被测试细菌的 acidogenicity, aciduricity,细胞外的 polysaccharideproduction,和粘附能力评估。最后,减少性的 SELEX (由 exponentialenrichment 的 ligands 的系统的进化) 指向整个未经触动的房间的技术与 highcariogenicity 为对种类特定的 ssDNA aptamers 习惯于屏幕。在九轮减少性的 SELEX 以后,足够的水池丰富是由放射性的 isotopeanalysis 出现被完成。充实的水池随机被克隆并且定序,由联机的 MEME 和 RNA 结构软件 analysisof 列在后面序列。从流动 cytometry 的结果显示了那 aptamers H1, H16, H4, L1, L10,和 H19 能 discriminatehighly cariogenic S。mutans 紧张从糟糕, cariogenic 拉紧。在这些之中, Aptamer H19 与 cariogenic S 有最强壮的有约束力的能力。有 69.45 的一个分离常数的 mutans 紧张 ? 畣慬? 敭档湡獩獭漠 ??? 湡 ? 桴 ? 潰整瑮慩? 敮 ? 桴牥灡略楴? 瑳慲整楧獥潦 ? 桴 ? 牴慥浴湥 ? 景琠楨?湩敦瑣潩 | Wei Cui Jiaojiao Liu Donghua Su Danyang Hu Shuai Hou Tongnan Hu Jiyong Yang Yanping Luo Qing Xi Bingfeng Chu Chenglong Wang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 3 |
| 11 | Neurological function following intra-neural injection of fluorescent neuronal tracers in rats显示文摘Fluorescent neuronal tracers should not be toxic to the nervous system when used in long-term labeling.Previous studies have addressed tracer toxicity,but whether tracers injected into an intact nerve result in functional impairment remains to be elucidated.In the present study,we examined the functions of motor,sensory and autonomic nerves following the application of 5% Fluoro-Gold,4% True Blue and 10% Fluoro-Ruby (5μL) to rat tibial nerves via pressure injection.A set of evaluation methods including walking track analysis,plantar test and laser Doppler perfusion imaging was used to determine the action of the fluorescent neuronal tracers.Additionally,nerve pathology and ratio of muscle wet weight were also observed.Results showed that injection of Fluoro-Gold significantly resulted in loss of motor nerve function,lower plantar sensibility,increasing blood flow volume and higher neurogenic vasodilatation.Myelinated nerve fiber degeneration,unclear boundaries in nerve fibers and high retrograde labeling efficacy were observed in the Fluoro-Gold group.The True Blue group also showed obvious neurogenic vasodilatation,but less severe loss of motor function and degeneration,and fewer labeled motor neurons were found compared with the Fluoro-Gold group.No anomalies of motor and sensory nerve function and no myelinated nerve fiber degeneration were observed in the Fluoro-Ruby group.Experimental findings indicate that Fluoro-Gold tracing could lead to significant functional impairment of motor,sensory and autonomic nerves,while functional impairment was less severe following True Blue tracing.Fluoro-Ruby injection appears to have no effect on neurological function. | Wen Hu Dan Liu Yanping Zhang Zhongyi Shen Tianwen Gu Xiaosong Gu Jianhui Gu | 2013 | Neural Regeneration Research2013，8，14： | 3 |
| 12 | Surface disorder engineering in ZnCdS for cocatalyst free visible light driven hydrogen production显示文摘Metal chalcogenide solid solution,especially ZnCdS,has been intensively investigated in photocatalytic H_(2) generation due to their cost-effective synthetic procedure and adjustable band structures.In this work,we report on the defect engineering of ZnCdS with surface disorder layer by simple room temperature Li-ethylenediamine(Li-EDA)treatment.Experimental results confirm the formation of unusual Zn and S dual vacancies,where rich S vacancies(Vs)served as electron trapping sites,meanwhile Zn vacancies(Vzn)served as hole trapping sites.The refined structure significantly facilitates the photo charge carrier transfer and improves photocatalytic properties of ZnCdS.The disordered ZnCdS shows a highest photocatalytic H_(2) production rate of 33.6 mmol·g^(-1)·h^(-1) under visible light with superior photocatalytic stabilities,which is 7.3 times higher than pristine ZnCdS and 7 times of Pt(1 wt.%)loaded ZnCdS. | Enna Ha Shuhong Ruan Danyang Li Yuanmin Zhu Yanping Chen Jiangyuan Qiu Zhaohui Chen Tingting Xu Jingyun Su Luyang Wang Junqing Hu | 2022 | Nano Research2022，15，2： | 3 |
| 13 | Synthesis,characterization and cell imaging properties of rare earth compounds based on hydroxamate ligand显示文摘Six binuclear rare earth compounds were synthesized through the ligand of 4-Bromo-N-hydroxy-Nmethyl-benzamide(sH_2 bha). Compounds 1-3 are isomorphous, and compound 1 is crystallized in the monoclinic system with the P2_1/c space group. Compounds 4 and 5 are isomorphous, and compound 4 is crystallized in the triclinic system with the P-1 space group. Compound 6 is crystallized in the triclinic system with the P-1 space group. The compounds were characterized by thermogravimetric analysis(TGA) and IR spectroscopy. The fluorescence spectrum in the visible area shows characteristic peaks of Eu, Tb, and Dy compounds. The efficiency of Eu compound on the viability of PC3 cells was assessed using CCK8 assays. From the CCK8 results, ionic concentration may have a great effect on PC3 cells' proliferation. Eu compound shows red fluorescence in the cytoplasm of PC3 cell. As for Eu compound, it might have potential application in cell imaging technology. | Linyan Yang Yanping Zhang Liwei Hu Yunhe Zong Ruili Zhao Tianming Jin Wen Gu | 2018 | Journal of Rare Earths2018，36，4： | 3 |
| 14 | Effects of critical geometric parameters on the optical performance of a conical cavity receiver显示文摘The optical performance of a receiver has a great influence on the efficiency and stability of a solar thermal power system.Most of the literature focuses on the optical performance of receivers with different geometric shapes,but less research is conducted on the effects of critical geometric parameters.In this paper,the commercial software TracePro was used to investigate the effects of some factors on a conical cavity receiver,such as the conical angle,the number of loops of the helical tube,and the distance between the focal point of the collector and the aperture.These factors affect the optical efficiency,the maximum heat flux density,and the light distribution in the conical cavity.The optical performance of the conical receiver was studied and analyzed using the Monte Carlo ray tracing method.To make a reliable simulation,the helical tube was attached to the inner wall of the cavity in the proposed model.The results showed that the amount of light rays reaching the helical tube increases with the increasing of the conical angle,while the optical efficiency decreases and the maximum heat flux density increases.The increase in the number of loops contributed to an increase in the optical efficiency and a uniform light distribution.The conical cavity receiver had an optimal optical performance when the focal point of the collector was near the aperture. | Hu XIAO Yanping ZHANG Cong YOU Chongzhe ZOU Quentin FALCOZ | 2019 | Frontiers in Energy2019，13，4： | 3 |
| 15 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 16 | C/EBPαp30 plays transcriptional regulatory roles distinct from C/EBPαp42显示文摘CCAAT/enhancer 有约束力的蛋白质α(C/EBP α) 是 transcriptional 禁止细胞增殖的规章的因素,和其他的翻译开始生产二多肽, C/EBP α p 30 并且 C/EBP α p 42。由表示介绍, C/EBP α p 30specifically 禁止了基因的一个唯一的集合,这被揭示,包括 MPP11, p84N5 和 SMYD2,它没被 C/EBP α p 影响 42 在两根 QSG-7701 hepatocyte 房间线和 QGY-7703 hepatoma, cells.Semi 量的 RT-PCR 分析独立地证实了这些结果。Chromatinimmunoprecipitation 试金显示出 30 比 C/EBP α p 更强烈绑了在这些基因的倡导者的那 C/EBP α p 42。在 C/EBP α是调整的 down 的临床的 hepatoma 在样品,所有三基因明确地由 30 在上面的 C/EBP α p 禁止了调整。然而, MPP11, p84N5 和 SMYD2genes 的压抑可能直接不涉及 C/EBP α p 30-mediated 生长抑制。我们的数据建议 30 调整的那 C/EBP α p 目标基因的一个唯一的集合并且多于 C/EBP α p 的 dominant-negativeregulator 42。 | Chunxi Wang~1 Xiaotao Chen~1 Yanping Wang~1 Jialei Gong~1 Gengxi Hu ~1State Key Laboratory of Molecular Biology institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Graduate School of the Chinese Academy of Sciences,Shanghai 200031,China | 2007 | Cell Research2007，17，4： | 2 |
| 17 | Synthesis of novel substituted N-aryl benzamides as hA3G stabilizers and their inhibitory activities against hepatitis C virus replication显示文摘A series of novel amino-substituted N-aryl benzamide analogs were synthesized and evaluated for their ability to inhibit hepatitis C virus(HCV)replication in acutely infected Huh7.5 cells.Most of the substituted N-aryl benzamide compounds showed convincing anti-HCV activities.Compounds 1f,1g and 4c exhibited potent anti-replicative activity at low micromolar levels(IC_(50)=1.0–2.0μM)with selective indices(SI)greater than 40.Mechanistic analysis indicated that the active compounds increased intracellular hA3G protein levels and inhibited HCV replication in a dose-dependent manner.The results demonstrate that this series of substituted Naryl benzamide compounds warrant further investigation as inhibitors of HCV replication. | Yanping Li Zonggen Peng Lanhu Hao Zhouyi Wu Yanping Zhu Laixing Hu Jiandong Jiang Zhuorong Li | 2013 | Acta Pharmaceutica Sinica B2013，3，5： | 2 |
| 18 | Boosting sodium storage of mesoporous TiO2 nanostructure regulated by carbon quantum dots显示文摘It has been demonstrated that the conductivity and electrochemical properties of TiO2 nanomate rials can be significantly improved by an incorporation of carbon additives.In the study,we develop a novel Ndoped TiO2 mesoporous nanostructure via the addition of carbon quantum dots(CQDs)solution following a scalable hydrothermal process.The as-made TiO2 product shows well-defined morphology,high conductivity,large surface area,and abundant mesopores.When evaluated as anodes for sodiumion batteries,the CQDs@TiO2 product annealed at 500℃exhibits a superior sodium storage capability.It delivers a high reversible capacity of 168.8 mAh/g at 100 mA/g over 500 cycles and long cycling stability.The remarkable performance of CQDs@TiO2 mainly arises from the large surface area and mesoporous architecture constructed by ultrathin TiO2 nanosheets,as well as the full coope ration between CQDs and TiO2. | Minghong Wu Yanping Gao Yu Hu Bing Zhao Haijiao Zhang | 2020 | Chinese Chemical Letters2020，31，3： | 2 |
| 19 | An oncolytic adenovirus delivering TSLC1 inhibits Wnt signaling pathway and tumor growth in SMMC-7721 xenograft mice model显示文摘Tumor suppressor in lung cancer-1(TSLC1)was first identified as a tumor suppressor for lung cancer,and frequently downregulated in various types of cancers including hepatocellular carcinoma(HCC).The Wnt pathway plays a critical role in tumorigenesis,migration,and invasion in HCC.However,the function of TSLC1 in modulating Wnt signaling in HCC is unclear.In this study,we evaluated the effect of TSLC1-armed oncolytic adenovirus(S24-TSLC1)on the Wnt/β-catenin pathway,cell viability,invasion and migration abilities of HCC in vitro and the growth of SMMC-7721-xenografted tumor in mice model.We detected the expression of TSLC1 in tumor samples and HCC cell lines.The results showed that TSLC1 expression was low in HCC,but high in pericarcinomatous tissue and normal cells,which implied that TSLC1 is a tumor suppressor of liver cancer.S24-TSLC1 exhibited an antitumor effect on HCC cell growth in vitro,but did little damage to normal liver cells.Overexpression of TSLC1 downregulated the transcriptional activity of TCF4/β-catenin and inhibited the mRNA or protein expression of Wnt target genes cyclinD1 and c-myc.S24-TSLC1 also inhibited the invasion and migration of HCC cells.Animal experiments further confirmed that S24-TSLC1 significantly inhibited tumor growth of the SMMC-7721-xenografted tumor.In conclusion,TSLC1 could downregulate the Wnt signal pathway and suppress HCC cell growth,migration and invasion,suggesting that S24-TSLC1 may be a potent antitumor agent for future clinical trials in liver cancer treatment. | Yigang Wang Panpan Huang Yanping Hu Keni Guo Xiaoyuan Jia Biao Huang Xinyuan Liu Xianglei He Fang Huang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 2 |
| 20 | CO_2 sensing properties and mechanism of PrFeO_3 and NdFeO_3 thick film sensor显示文摘The CO_2 sensing of PrFeO_3 and NdFeO_3 sensors were investigated. Experimental results show that the resistances for PrFeO_3 and NdFeO_3 in CO_2 gas are larger than those in air and the responses for PrFeO_3and NdFeO_3 sensors increase with an increase in room-temperature relative humidity. When exposed to1000 ppm CO_2, the response of PrFeO_3 thick film based on nano-powders annealed at 700℃can reach8.44 at 160℃for the background of wet air with 58%of room-temperature relative humidity (RH),which is much larger than the corresponding value (3.03) in wet air with 25%RH. The sensing response S of NdFeO_3 thick-film sensor based on nano-powders annealed at 600℃to 3000 ppm CO_2 at the operating temperature 200℃can reach 2.36 for the background of wet air with 72%RH, which is larger than the corresponding value (1.83) in the air with 25%RH. Compared with other CO_2 sensing materials, the PrFeO_3 sensor has larger response at lower operating temperature for CO_2 gas and may be used as a new CO_2 sensing material. | Yanping Chen Dandan Wang Hongwei Qin Heng Zhang Zhongli Zhang Guangjun Zhou Chengyong Gao Jifan Hu | 2019 | Journal of Rare Earths2019，37，1： | 2 |
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